摘要/Abstract
Gracilioether家族天然产物与hippolachnin A都是从海洋海绵中分离得到的.Gracilioether家族天然产物具有良好的抗疟疾活性，而hippolachnin A具有良好的抗菌活性.它们有趣的结构和良好的生物活性吸引了化学家的关注.按照合成的策略分类，概括了gracilioether家族中具有三环骨架结构的天然产物和hippolachnin A的全合成研究.
关键词: gracilioether, hippolachnin A, 天然产物, 全合成
Gracilioethers and hippolachnin A were isolated from marine sponge. Gracilioethers showed antimalarial activity while hippolachnin A exhibited strong antifungal activity. Their fascinating structures and outstanding biological activities have attracted attentions from chemists. Progress on the synthesis of gracilioethers with tricyclic skeleton and hippolachnin A are reviewed in terms of the key strategies employed.
Key words: gracilioether, hippolachnin A, natural product, total synthesis
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