摘要/Abstract

从便宜、易得的手性氨基酸出发通过5至6步反应制备了一种新型手性钳形PNN类配体oxpma.该类手性配体含有2至3个手性中心.将其用于钯催化的烯丙基酯的不对称烯丙基烷基化反应，能够以高的对映选择性（最高可达96%）获得相应的手性目标产物.
关键词: PNN配体, 钳形配体, 不对称催化, 不对称烯丙基烷基化反应
tridentate P,N,N-donor pincer ligands bearing two or three stereocenters, 1-(4,5-dihydro-oxazol-2-yl)-N-(2-(diphenylphosphanyl)benzyl)methanamines (oxpma), were synthesized starting from readily available amino acids in five or six steps. They were applied in palladium-catalyzed asymmetric allylic alkylation of allylic acetates to afford the desired products with high enantioselectivities (up to 96% ee).
Key words: PNN ligand, pincer ligand, asymmetric catalysis, asymmetric allylic alkylation


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