摘要/Abstract

在室温条件下，使用双官能膦-金（I）催化剂催化邻苯二胺与炔烃进行亲核加成/环化反应，一步合成1，5-苯并二氮（艹卓）类化合物.该反应具有原子经济性高、原料简单易得、操作便捷及反应温和等优点.
关键词: 邻苯二胺, 炔烃, 双官能膦配体, 金催化, 1,5-苯并二氮(艹卓)
At room temperature, a bifunctional phosphine-gold(I) catalyst was used to catalyze the nucleophilic addition/cyclization reaction of o-phenylenediamines with alkynes to generate 1,5-benzodiazepines in one step. The reaction has the advantages of high atomic-economy, simple raw materials, convenient operation and mild reaction conditions.
Key words: phthaline diamine, alkyne, bifunctional phosphine ligand, gold catalysis, 1,5-benzodiazepine


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