摘要/Abstract

钯催化的芳基卤化物与N-亲核试剂的Buchwald-Hartwig反应以及铜催化的芳基硼酸与N-亲核试剂的Chan-Evans-Lam反应都是构建C-N键的有效方法.在醋酸钯/叔丁醇体系或醋酸铜/二氯甲烷体系中，芳基氯化物或芳基硼酸分别与二苯甲酮腙反应构筑C-N键，生成相应的芳基腙，芳基腙水解之后可得到芳基肼.该类反应提供了一条利用低毒性的化学试剂合成芳基肼的间接路径.
关键词: Buchwald-Hartwig反应, Chan-Evans-Lam反应, 芳基硼酸, 二苯甲酮腙
Palladium catalyzed Buchwald-Hartwig reactions between aryl halides and N-nucleophiles, and the copper catalyzed Chan-Evans-Lam reactions between aryl boronic acids and N-nucleophiles are all effective methods for constructing C-N bonds. Herein, under palladium acetate/tert-butanol system or copper acetate/dichloromethane system, benzophenone hydrazone can react with aryl chlorides and aryl boronic acids to afford corresponding aryl hydrazones, respectively. The obtained products are easily hydrolyzed to form aryl hydrazines, thus providing an indirect pathway to access aryl hydrazines from relatively less toxic reagents.
Key words: Buchwald-Hartwig reaction, Chan-Evans-Lam reaction, aryl boronic acid, benzophenone hydrazone


PDF全文下载地址:

点我下载PDF