摘要/Abstract

发展了一种廉价金属盐FeCl₂催化氧气氧化下，高效、环保且简洁合成多取异噁唑衍生物的新方法.通过对金属盐来源和碱等反应条件的优化，确立了最佳的反应条件.在此反应条件下合成了19个新型多取代3，5-二芳基异噁唑衍生物，并成功培养了一个单晶，产率在80%~90%之间.经过¹H NMR、¹³C NMR、元素分析及X单晶衍射确证了所得目标化合物的结构.
关键词: FeCl₂催化, 氧气氧化, 异噁唑, 杂环, N—O键形成
A simple, practical and highly efficient synthesis of multi substituted isoxazole derivatives via cheap metal salt FeCl₂-catalyzed direct aerobic oxidative has been developed. Nineteen novel multi-substituted 3,5-diaryl isoxazole derivtaves were synthesized and a single crystal was successfully cultivated. The products were get with about 70%~90% yields under mild conditions. The structures of products were fully characterized by ¹H NMR, ¹³C NMR, elemental analysis and X-ray crystal.
Key words: iron catalysis, oxygen oxidation, isoxazole, heterocycle, N-O bond formation


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