摘要/Abstract

报道了一种铁催化的酮类化合物的脱氧硼化反应，通过该方法制备一系列的非末端偕二硼化合物，并进一步将该方法应用到克级规模制备中.同时，以常用有机溶剂丙酮为原料制备了相应的非末端偕二硼化合物，并对该偕二硼化合物的C—B键进行选择性单官能团或双官能团化，以验证该类化合物在有机合成中的应用价值.
关键词: 铁催化, 烷基酮, 脱氧硼化, 偕二硼化合物
An iron catalyzed deoxygenative diborylation of ketones to access a variety of internal gem-diboronates has been developed. A scale-up synthesis of such gem-diboronates is also applicable under this condition. Meanwhile, common organic solvent acetone was used as start material to synthesize corresponding internal gem-diboronate, and further mono- or di-functionalization of such internal gem-diboronate has also been explored to demonstrate the synthetic potential of internal gem-diboronates.
Key words: iron catalysis, aliphatic ketone, deoxygenative borylation, gem-diboronate


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