摘要/Abstract

以二氟碘代丙酮类化合物为原料，利用硼氢化钠选择性还原得到高产率的二氟碘代醇类化合物.该合成方法具有反应条件温和，操作简单，产率高等特点，为合成更多的二氟取代醇类化合物试剂提供了简便的途径.
关键词: 二氟碘代苯乙酮, 硼氢化钠, 二氟碘代苯乙醇, 选择性还原
The synthesis of α,α,α-iodo-difluoromethyl alcohols via the high selective reduction of iododifluoromethyl ketones by NaBH₄ in methanol at 0℃ was reported. The reaction has some advantages, such as mild condition, simple synthetic route, and high yield. A convenient way to synthesize more difluoromethylation agents was provided.
Key words: iodo-difluoromethyl ketones, NaBH₄, iodo-difluoromethyl alcohol, selective reduction


PDF全文下载地址:

点我下载PDF