摘要/Abstract

2，8-二氧杂双环[3.3.1]壬烷结构单元存在于多种天然生物活性物质中.阳离子铝化合物[AlCl（CH₃CN）₅]²⁺-[（AlCl₄）₂]^2-·CH₃CN可方便地由AlCl₃在CH₃CN中室温反应得到.其可有效催化2-羟基查尔酮和萘酚的傅克烷基化/缩酮化反应，生成二芳基稠合2，8-二氧杂双环[3.3.1]壬烷，产率中等到高.该方法所用催化剂价廉、易得，转化效率较高，为合成2，8-二氧杂双环[3.3.1]壬烷化合物提供了一种实用的新方法.
关键词: 阳离子铝化合物, 路易斯酸, 催化, 2,8-二氧杂双环[3.3.1]壬烷, 合成
2,8-Dioxabicyclo[3.3.1]nonane exists in many natural biologically active materials. Cationic aluminum complex[AlCl(CH₃CN)₅]²⁺[(AlCl₄)₂]^2-·CH₃CN can be easily prepared via the reaction of AlCl₃ with CH₃CN at room temperature. It served as efficient catalyst for the tandem Friedel-Crafts alkylation/ketalization reaction of 2-hydroxychalcones with naphthols to produce diaryl-fused 2,8-dioxabicyclo[3.3.1]nonanes in moderate to high yields. This method provides a practical process to afford this type of biologically important compounds in good yields using easily available and inexpensive catalyst.
Key words: cationic aluminum complex, Lewis acid, catalysis, 2,8-dioxabicyclo[3.3.1]nonane, synthesis


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