摘要/Abstract

Cyanolide A和cocosolide是两个结构高度相似的具有对称结构的十六元内酯天然产物.Cyanolide A是从巴布亚新几内亚的Lyngbya bouillonii提取物中分离得到，具有良好的灭螺效果，可以有效阻断血吸虫病的传播，而cocosolide则是从关岛附近的金黄色的蓝藻提取物中分离.它们新颖的结构和良好的生理活性引起众多化学家的关注.根据氧杂迈克尔加成反应、氧鎓离子环化反应和过渡金属催化环化反应等四氢吡喃环构筑方法，综述了cyanolide A和cocosolide的合成工作.
关键词: Cyanolide A, Cocosolide, 全合成, 氧杂迈克尔加成, 氧鎓离子环化反应, 过渡金属催化的环化反应
Cyanolide A and cocosolide, two 16-membered dimeric macrolide xylopyranosides, were isolated from Guam and Papua New Guinea, respectively. Their fascinating structures and outstanding biological activities had attracted great attentions from chemists. The synthesis of cyanolide A and cocosolide is reviewed based on the construction methods of tetrahydropyran ring, which involves oxo-Michael addition reaction, oxo-carbenium cyclization and transition-metal catalyzed cyclization reactions.
Key words: cyanolide A, cocosolide, total synthesis, oxo-Michael addition, oxo-carbenium cyclization reaction, transition-metal catalyzed cyclization reaction


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