摘要/Abstract

1,2,4-三嗪类化合物是一类重要的含氮杂环化合物, 在医药、化工和材料领域具有广泛的应用, 因此, 1,2,4-三嗪类化合物的绿色高效合成日益引起科研工作者的关注. 通过串联环化反应, 避免中间体的后处理, 一锅合成三嗪类化合物是最高效直接的合成方法, 符合“步骤”与“原子”经济性高的绿色化学理念. 综述了基于串联环化反应构筑碳氮键以合成1,2,4-三嗪化合物的研究. 以过渡金属催化和非金属催化分类, 介绍了1,2,4-三嗪类化合物近十年的合成方法、反应机理及其应用, 并对三嗪环的合成进行了展望.
关键词: 1,2,4-三嗪, 串联环化, C—N键构筑, 过渡金属催化, 非金属催化
1,2,4-Triazine compounds are an important class of nitrogen-containing heterocyclic compounds. They have wide applications in the fields of medicine, chemicals and materials. Therefore, green and highly efficient synthesis of 1,2,4-triazine compounds is increasingly attracting the attention of researchers. By tandem cyclization reaction, the post-treatment of intermediate is avoided, and the one-pot synthesis of triazine compounds is the most efficient and direct synthesis method, which conforms to the concept of green chemistry for its step and atomic economy. The formation of C—N bond based on tandem cyclization to give 1,2,4-triazine compounds is reviewed. The synthetic method, reaction mechanism and application of 1,2,4-triazine compounds are introduced under transition-metal and metal-free conditions in the past ten years. The prospects of synthesis of triazine rings are also discussed.
Key words: 1,2,4-triazine, tandem cyclization, C—N bond formation, transition-metal catalysis, metal-free catalysis


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