摘要/Abstract
以商业购买的（R）-3-羟基-4-氯丁酸乙酯或者（S）-1，2-环氧戊烷为原料，经过6步反应，完成了天然产物类似物3-去羟基phomonol的合成，关键步骤包括格氏反应，Prins环化反应和钯催化分子内烷氧羰基化反应等，无保护基合成策略的应用缩短了合成步骤，提高了合成的效率.
关键词: 合成, 3-去羟基phomonol, Prins环化反应, 钯催化分子内烷氧羰基化反应
A concise synthesis of 3-dehydroxyphomonol has been accomplished in six steps from commercially available (R)-4-chloro-3-hydroxy-butyric acid ethyl ester or (S)-2-propyl-oxirane. The key steps involved Grignard reaction, Prins cyclization and palladium-catalyzed intramolecular alkoxycarbonylation to install the tetrahydropyran ring. The synthesis demonstrated an application of protecting-group-free strategy.
Key words: synthesis, 3-dehydroxyphomonol, Prins cyclization, palladium-catalyzed intramolecular alkoxycarbonylation
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