摘要/Abstract

Parvistemonine A为从对叶百部中分离得的百部生物碱.以化合物7为原料，通过路易斯酸催化的傅克及内酯化的串联反应，Vilsmeier-Haack及Julia-Kocienski烯烃化等6步反应首次完成了百部生物碱（±）-parvistemonine A的全合成工作，为parvistemonine A衍生物的合成和及其生物活性研究打下基础.
关键词: 天然产物, 百部生物碱, parvistemonine A, 化学合成
Parvistemonine A was isolated from Stemona parviflora. The total synthesis of racemic parvistemonine A was completed in 6 steps for the first time, employing compound 7 as the starting material. The synthetic strategy features a tandem Friedel-Crafts cyclization and lactonization, Vilsmeier-Haack and Julia-Kocienski olefination. This study laid the foundation for the synthesis of the parvistemonine A derivative and its biological activity research.
Key words: natural product, stemona alkaloids, parvistemonine A, chemical synthesis


PDF全文下载地址:

点我下载PDF