摘要/Abstract

亚胺又称席夫碱，广泛存在于天然产物、生物活性化合物和药物等分子结构中.亚胺中的C=N双键具有较高的反应活性，可作为氮源应用于不同类型的反应中，因此在生物、医药、染料和材料等方面都有重要应用.金属催化剂催化醇胺直接偶联制备亚胺因具有原子经济性高、绿色环保等优点，近年来获得了广泛关注并取得了重要进展.系统地总结和评述了近年来金属催化剂催化醇和胺直接偶联制备亚胺反应的研究进展，并对其未来发展方向进行了展望.
关键词: 亚胺, 醇, 胺, 金属催化
Imines are very important class of compounds and have been widely utilized in fine chemicals, pharmaceuticals and chemical industry. The C=N double bond in imine is an important nitrogen source in different types of reactions due to its high reactive activity. Due to its high atom economy, catalytic direct coupling of alcohols and amines to imines based on metal catalysts has attracted much attention and maken great progress in recent years. In this paper, the advances in direct coupling of alcohols and amines to imines catalyzed by metal catalysts are reviewed.
Key words: imine, alocohols, amines, metal catalysis


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