摘要/Abstract
报道了芳香末端炔烃与单膦酰基-保护二炔的选择性Hay偶联反应.Ph2P（O）的极性使得产物非对称1，3-二炔易与副产物分离.单膦酰基-保护二炔的低反应活性减少了自身氧化偶联，从而提高了目标产物的产率.很多芳香末端炔烃与单膦酰基-保护二炔都能应用于本Hay偶联反应，且相应非对称1，3-二炔产物的产率为中等到好.产物非对称1，3-二炔能用于合成非对称炔-二炔烃及环多炔烃.
关键词: Hay偶联, 非对称1,3-二炔, 末端炔烃, 膦酰保护基
A selective Hay coupling reaction of aromatic terminal acetylenes and monophosphoryl-protected diynes was developed. The polarity of Ph2P(O) realized facile isolation of the desired unsymmetrical 1,3-diynes from by-products. The low reactivity of monophosphoryl-protected diynes reduced the oxidative homocoupling of itself and enhanced the yields of desired products. A number of aromatic terminal acetylenes and monophosphoryl-protected diynes were tolerated in this reaction, and all the corresponding unsymmetrical 1,3-diynes could be obtained in moderate to good yields. The unsymmetrical 1,3-diynes could be applied to synthesize unsymmetrical yne-diynes and cyclic polyynes.
Key words: Hay coupling, unsymmetrical 1,3-diyne, terminal acetylene, phosphoryl protecting group
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