摘要/Abstract
在醋酸铜催化作用下，以抗坏血酸钠为还原剂，以醛、2，2-二甲基-1，3-二噁烷-4，6-二酮和苯乙炔为原料，通过包含Knoevenagel缩合与Conjugate加成反应的多组分反应，有效地合成了10种5-（1-苯基-3-苯基丙基-2-炔基）-2，2-二甲基-1，3-二噁烷-4，6-二酮衍生物.该工艺具有收率高（63%~86%）、反应温和、操作简单及环境友好等优点，为合成5-（3-苯基-1-苯基丙基-2-炔基）-2，2-二甲基-1，3-二噁烷-4，6-二酮衍生物提供了一种有效的方法.
关键词: 一锅法, 醋酸铜, 2,2-二甲基-1,3-二噁烷-4,6-二酮, 5-(1-苯基-3-苯基丙基-2-炔基)-2,2-二甲基-1,3-二噁烷-4,6-二酮
In the presence of copper acetate, ten 5-(1-phenyl-3-phenylprop-2-ynyl)-2,2-dimethyl-1,3-dioxane-4,6-dione derivatives were synthesized via the three component one-pot reaction of aldehydes with 2,2-dimethyl-1,3-dioxane-4,6-dione and phenylacetylene by using Na-ascorbate as a reductant. The reaction has the advantages of high yields (65%~86%), mild conditions, simple operation and environmental friendliness. It provides an effective method for the synthesis of 5-(1-phenyl-3-phenylprop-2-ynyl)-2,2-dimethyl-1,3-dioxane-4,6-dione derivatives.
Key words: one-pot, copper acetate, 2,2-dimethyl-1,3-dioxane-4,6-dione, 5-(1-phenyl-3-phenylprop-2-ynyl)-2,2-dimethyl-1,3-dioxane-4,6-dione
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