摘要/Abstract
以3-氧代戊二酸二酯、N，N-二甲基甲酰胺二甲基缩醛（DMF-DMA）、伯胺为原料，L-脯氨酸为催化剂，多组分一步构建了以4-羟基-2-吡啶酮为母核的一系列化合物，并通过核磁、高分辨质谱等确证了其结构.该方法操作简便，无需中间体的分离，为4-羟基-2-吡啶酮类化合物的合成提供了便捷的方法，且溶剂参与反应，从而丰富了母体5位取代基的多样性.
关键词: 4-羟基-2-吡啶酮, 多组分反应, 3-氧代戊二酸酯, 一锅法合成
A series of 4-hydroxyl-2-pyridone derivatives were synthesized via a one-pot and multicomponent reaction of dimethyl 3-oxopentanedioate, N, N-dimethylformamide dimethyl acetal (DMF-DMA) and primary amine in aliphatic alcohol by using L-proline as catalyst. The structures of these compounds were confirmed by NMR and HRMS. This work provides a convenient method for construction of pyridones with the advantages of operation simplicity, free of isolating intermediates etc. Moreover, the participation of solvent in the reaction enriched the diversity of 5-substitution in the pyridone backbone.
Key words: 4-hydroxyl-2-pyridone, multicomponent reaction, dimethyl 3-oxopentanedioate, one-pot synthesis
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