摘要/Abstract

以商业可获得的羧酸和异硫氰酸酯为原料，建立了一种温和、通用、高效的直接合成酰胺化合物的新方法.该方法避免了当量偶联试剂和金属催化剂的使用，特别适合于合成其他常规方法不易合成的大位阻和缺电子仲酰胺化合物.
关键词: 酰胺, 羧酸, 异硫氰酸酯, 合成方法学, 缺电子酰胺
A mild, general and efficient method for the direct synthesis of diverse amides from commercially available carboxylic acids and isothiocyanates has been developed. The strategy does not require stoichiometric amounts of coupling reagents or metal catalysts, and is especially for sterically hindered and electron-deficient secondary amides, which are otherwise challenging to synthesize.
Key words: amides, carboxylic acids, isothiocyanates, synthetic methods, electron-deficient amides


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