摘要/Abstract

以1，10-邻菲罗啉（1）为原料制备4，5-二氮芴-9-酮（2），并合成4，5-二氮杂芴（3）和9-亚甲基-4，5-二氮杂芴（5），再利用正丁基锂（或甲基锂）与上述两种二氮杂芴反应得到相应的锂盐，在－50℃下与旋光的环氧氯丙烷（ee>98%）反应得到光学纯的含二氮杂芴基取代末端环氧化合物，它们的ee值均大于98%.将4，5-二氮芴-9-酮与乙基溴化镁（或苯基溴化镁）反应，得到相应的叔醇.叔醇在氢氧化钾和四丁基溴化铵存在下，与旋光的环氧氯丙烷反应，也得到光学纯的含二氮杂芴基取代末端环氧化合物，ee值均大于97%.将末端环氧化合物在不同条件下聚合，得到分子量分布很窄的含二氮杂芴基的聚醚.通过核磁共振、元素分析、凝胶渗透色谱等手段对产物进行了表征，对影响聚合的相关因素做了探讨.
关键词: 环氧化合物, 手性, 不对称合成, 聚合
4,5-Diazafluoren-9-one (2), 4,5-diazafluorene (3) and 9-methylene-4,5-diazafluorene (5) were prepared by 1,10-Phenanthroline (1) as starting material. Using n-butyllithium to react with 3 (or using methyllithium to react with 5), the corresponding organic lithium salts could be given, and then, the optically active epichlorohydrin (ECH, ee>98%) was added dropwise at －50 ℃, according to regular treatment, the optically pure terminal epoxides (4 and 6) with diazafluorenyl substituent were obtained. The ee values of epoxides are larger than 98%. Using ethylmagnesium bromide (or phenylmagnesium bromide) to react with 2 in the presence of potassium hydroxide and tetrabutylammonium bromide, the corresponding substituted epoxy compounds (8a and 8b) were produced. The ee values of epoxides (8a and 8b) are larger than 97%. The epoxides (4, 6, 8a and 8b) were polymerized using KOH as an initiator and the polyethers with narrow molecular weight distributions (M_w/M_n＝1.04 to 1.10) were obtained. The products were analyzed by NMR, elemental analysis and GPC.
Key words: epoxide, chirality, asymmetric synthesis, polymerization


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