摘要/Abstract
三核N-杂环卡宾-钯（Ⅱ）化合物可以作为芳基氯化物参与的Buchwald-Hartwig胺化反应的有效催化剂前体.在催化剂用量为2.0 mol%的条件下，环状仲胺、芳香伯胺和伯胺与多种芳基氯化物均能顺利地发生胺化反应，以中等至优秀的收率得到目标产物.
关键词: N-杂环卡宾, 三核钯化合物, Buchwald-Hartwig胺化反应, 芳基氯化合物
The trinuclear N-heterocyclic carbene-palladium(Ⅱ) complexes were found to be the effective catalyst precursors for the Buchwald-Hartwig amination of aryl chlorides. With catalyst loading of 2.0 mol%, the amination of secondary and primary amines with a variety of electronically and structurally diverse aryl chlorides gave the desired products in moderate to excellent yields within hours.
Key words: N-heterocyclic carbene, trinuclear palladium complexes, Buchwald-Hartwig amination, aryl chlorides
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