xm:宣利江
xb:男
zc:研究员
xl:博士
dh:
cz:86-
dzyj:ljxuan@simm.ac.cn
grzy:
zjlb:研究员；新药；
zw:中国科学院上海药物研究所研究员、博士生导师、研究组长
txdz:上海市浦东新区张江高科技园区海科路501号,
grjj: 宣利江，博士，研究员。1967年生于浙江省海宁市，1995年毕业于中国科学院上海药物研究所，天然药物化学专业。长期从事天然活性化合物的发现和新药创制及中药现代化研究，发表论文八十余篇，获中国及美国专利授权5项，新药证书3项；培养硕士、博士30多名。丹参多酚酸盐及其粉针剂是他新药技术开发和产业化的成功案例。从根本上实现了从“模糊”到“清楚”、从“基于经验”到“基于证据”的创新中药的升级换代。该药于2005年获得新药证书，相关技术获得了中国和美国专利授权，被国家发改委列为中药现代化示范工程。截止2018年末，该药已应用于2000万以上病患，累计实现250亿以上销售。该药已进入09、17和19版国家基本医保目录，并成为国家中药保护品种。鉴于他新药研发的杰出成就，宣利江获得了包括国家技术发明二等奖（2011）、中国科学院杰出科技成就奖（2013）、上海市技术发明一等奖（2007）、谈家桢生命科学产业化奖（2014）、中国药学发展奖（2011）、国家中医药管理局突出贡献奖（2017）等一系列科技奖励，并获得上海市劳模（2015）和全国五一劳动奖章（2017），入选上海市领军人才（2015）和国家百千****才工程（2017）。
yjfx:产业化目标导向的天然药物化学研究。探索天然药用资源的药理作用物质基础，发现天然活性化合物及先导化合物，开展新药创制和中药现代化的研究。
dblz:近5年代表论文：1 Li HH, Li J, Zhang XJ, Li JM, Xi C, Wang WQ, Lu YL, Xuan LJ*. 23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9. Acta Pharmacol Sin. 2020. 41: 327-335.2 Yingluo Liu, Xiaoyu Zhou, Lijiang Xuan*. Magnesium lithospermate B ameliorates microcirculation perfusion in rats by promoting vascular NO production via activating the PI3K/AKT pathway. Acta Pharmacologica Sinica. 2019. 40:1010-1018.3 Fei Gao, Jiaomeng Li, Cong Xi, Huihui Li, Yingluo Liu, Yiping Wang* and Lijiang Xuan*. Magnesium lithospermate B protects the endothelium from inflammation-induced dysfunction through activation of Nrf2 pathway. Acta Pharmacologica Sinica. 2019. 40: 867-878.4 Zhihua Wang, Hao Liang, Haijie Cao, Bingjie Zhang, Jun Li, Wenqiong Wang, Shanshan Qin, Yuefei Wang, Lijiang Xuan,* Luhua Lai*, Wenqing Shui*. Efficient ligand discovery from natural herbs by integrating virtual screening, affinity mass spectrometry and targeted metabolomics. Analyst. 2019. 144: 2835-3160.5 Mike Okweesi Aggrey, Li Hui-Hui , Wang Wen-Qiong , Wang Yiping , Xuan Li-Jiang* . Indole alkaloid from Nauclea latifolia promotes LDL uptake in HepG2 cells by inhibiting PCSK9. Phytomedicine. 2019. 55: 264-268.6 Jiaojiao Wei, Wenqiong Wang, Weibin Song, Jun Li, Lijiang Xuan*. Three new indole alkaloids from Mappianthus iodoides. Phytochemistry Letters. 2018. 23: 1-47 Jiaojiao Wei, Weibin Song, Yefu Zhu, Bole Wei, Lijiang Xuan*. N, N-dimethyl-D-glucosamine as an efficient ligand for copper catalyzed Ullmann-type coupling of N-H heterocycles with aryl halides. Tetrahedron. 2018. 74(1): 19-27.8 Yong Zheng, Weibin Song, Yefu Zhu, Bole Wei, Lijiang Xuan*. Pd-catalyzed acetoxylation of γ-C(sp3)-H bonds of amines directed by a removable Bts-protecting group. Journal of Organic Chemistry. 2018. 83(4): 2448-2454.9 Yong Zheng, Weibin Song, Yefu Zhu, Bole Wei, Lijiang Xuan*. Pd-catalyzed intramolecular C(sp2)-H amination of phenylalanine moieties in dipeptides: synthesis of indoline-2-carboxylate-containing dipeptides. Organic & Biomolecular Chemistry. 2018. 16(14): 2402-2405.10 Wenqiong Wang, Yanpeng Yin, Jun Li, Lijiang Xuan*. Halimane-type dierpenoids from Vitex rotundifolia and their anti-hyperlipidemia activities. Phytochemistry. 2018. 146: 56-62.11 Wenqiong Wang, Shanshan Liu, Weibin Song, Jun Li, Lijiang Xuan*. Resin glycosides from the seeds of Ipomoea muricata and their multidrug resistance reversal activities. Phytochemistry. 2018. 149: 24-30.12 Qingqing Yuan, Shuai Tang, Weibin Song, Wenqiong Wang, Min Huang, Lijiang Xuan*. Crassins A-H, diterpenoids from the roots of Cronton crassifolius. Journal of Natural Products. 2017. 80(2): 254-260.13 Jun Li，Wenqiong Wang, Shuai Tang, Weibin Song, Ming Huang, Lijiang Xuan*. Pentasaccharide resin glycosides with multidrug resistance reversal activities from the seeds of Pharbitis nil. RSC Advances. 2017. 7(82): 52001-52009.14 Yong Zheng, Weibin Song, Lijiang Xuan*. The asymmetric total synthesis of (+)-salvianolic acid A. Tetrahedron. 2016. 72(33): 5047-5050.15 Wenqiong Wang, Lijiang Xuan*. ent-6,7-Secokaurane diterpenoids from Rabdosia serra and their cytotoxic activities. Phytochemistry. 2016. 122: 119-125
jyjl:上海医科大学药学院，学士
删除或更新信息，请邮件至freekaoyan#163.com(#换成@)
