xm:李序文
xb:男
zc:研究员
xl:博士
dh:-3317
cz:
dzyj:xwli@simm.ac.cn
grzy:
zjlb:
zw:
txdz:上海市浦东张江高科技园区祖冲之路555号
grjj:教育经历:2010.09-2013.12 法国巴黎第六大学 获博士学位2007.09-2010.07 华东师范大学 获硕士学位2003.09-2007.07 天津大学 获学士学位工作经历:2019.10-至今 研究员,中国科学院上海药物研究所2015.10-2019.09 副研究员,中国科学院上海药物研究所2015.05-2015.09 助理研究员,中国科学院上海药物研究所2014.05-2015.04 博士后,瑞士苏黎世联邦理工学院,合作导师:Erick M. Carreira 教授2013.12-2014.05 研究助理,法国国家科学研究中心,合作导师:Bastien Nay 研究员
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中国科学院上海药物研究所导师教师师资介绍简介-李序文
本站小编 Free考研考试/2021-02-10
yjfx:1. 化学生态学导向的活性海洋天然产物发现和复杂分子的结构解析2. 活性海洋天然产物的仿生全合成和功能导向合成3. 基于药用物质基础的海洋生物资源合理开发利用
dblz:1. Q. Wu,1 S.-W. Li,1 H. Xu,1 H. Wang, P. Hu, H. Zhang, C. Luo, K.-X. Chen, B. Nay,* Y.-W. Guo*, X.-W. Li*. Complex Polypropionates from a South China Sea Photosynthetic Mollusk: Isolation and Biomimetic Synthesis Highlighting Novel Rearrangements. Angewandte Chemie International Edition. 2020, DOI: 10.1002/anie..2. C.-L., Gao1, G.-G. Hou1, J. Liu1, T. Ru, Y.-Z. Xu, S.-Y. Zhao, H. Ye, L.-Y. Zhang, K.-X. Chen, Y.-W. Guo*, T. Pang*, X.-W. Li*. Synthesis and Target Identification of Benzoxepane Derivatives as Potential Anti-Neuroinflammatory Agents for Ischemic Stroke. Angewandte Chemie International Edition. 2020, 59, 2429-2439.3. G. Li, H. Li, W. Tang, Y.-W. Guo*, X.-W. Li*. Klyflaccilides A and B, Diterpenoids with 6/5/8/3 Fused Tetracyclic Carbon Skeleton from the Hainan Soft Coral Klyxum flaccidum. Organic Letters. 2019, 21, 5660-5664.4. Q. Wu, B. Nay, M. Yang, Y.-K. Ni, H. Wang, L.-G. Yao, X.-W. Li*. Marine sponges of the genus Stelletta as promising drug sources: Chemical and biological aspects. Acta Pharm. Sin. B. 2019. 9, 237-257.5. M. Yang,1 X.-L. Li,1 J.-R. Wang, X. Lei, W. Tang, X.-W. Li*, H. Sun*, Y.-W. Guo*. Sarcomililate A, an Unusual Diterpenoid with Tricyclo[11.3.0.02,16]hexadecane Carbon Skeleton, and Its Potential Biogenetic Precursors from the Hainan Soft Coral Sarcophyton mililatensis. Journal of Organic Chemistry. 2019. 84, 2568-2576.6. J. Liu,1 H. Li,1 K.-X. Chen, J.-P. Zuo, Y.-W. Guo*, W. Tang*, X.-W. Li*. Design and Synthesis of Marine Phidianidine Derivatives as Potential Immunosuppressive Agents. Journal of Medicinal Chemistry. 2018, 61, 11298-11308.7. F. Ye, J. Li, Y. Wu, Z.-D. Zhu, E. Mollo, M. Gavagnin. Y.-C. Gu, W.-L. Zhu, X.-W. Li*, Y.-W. Guo*. Sarinfacetamides A and B, Nitrogenous Diterpenoids with Tricyclo[6.3.1.01,5]dodecane Scaffold from the South China Sea Soft Coral Sarcophyton infundibuliforme. Organic Letters. 2018, 20, 2637-2640.8. D.-Y. Sun,1 G.-Y. Han,1 N.-N. Yang, L.-F. Lan, X.-W. Li*, Y.-W. Guo*. Racemic trinorsesquiterpenoids from the Beihai sponge Spongia officinalis: structure and biomimetic synthesis. Organic Chemistry Frontiers. 2018, 5, 1022-1027.9. F. Ye, Z.-D. Zhu, J.-S. Chen, J. Li, Y.-C. Gu, W.-L. Zhu, X.-W. Li*, Y.-W. Guo*. Xishacorenes A-C, Diterpenes with Bicyclo[3.3.1]nonane Nucleus from the Xisha Soft Coral Sinularia polydactyla. Organic Letters. 2017, 19, 4183-4186.10. D.-Y. Sun, G.-Y. Han, J.-X. Gong, B. Nay, X.-W. Li*, Y.-W. Guo*. Asymmetric Total Synthesis of Distaminolyne A and Revision of Its Absolute Configuration. Organic Letters. 2017, 19, 714-717.11. X.-W. Li, B. Nay.* Transition metal-promoted biomimetic steps in total syntheses. Natural Product Reports. 2014, 31, 533-549.12. X.-W. Li, A. Ear, B. Nay.* Hirsutellones and beyond: figuring out the biological and synthetic logics toward chemical complexity in fungal PKS-NRPS compounds. Natural Product Reports. 2013, 30, 765-782.13. X.-W. Li, A. Ear, L. Roger, N. Riache, A. Deville, B. Nay.* Bio-inspired formal synthesis of hirsutellones A-C featuring an electrophilic cyclization triggered by remote Lewis acid-activation. Chemistry-A European Journal. 2013, 19, 16389-16393.
jyjl:
gzjl:
ktxm:1.国家自然科学基金面上项目(),2017.01-2020.12,基于海洋来源的活性吲哚生物碱的发现,功能导向合成以及对糖尿病靶点PTP1B的选择性抑制活性研究2.国家自然科学基金青年基金(),2017.01-2019.12,中国南海软珊瑚中活性西松烷型二萜的合成和肿瘤多靶点抑制活性筛选3.国家自然科学基金国际合作与交流项目()(合作方:法国国家科研中心/巴黎综合理工大学Bastien Nay研究员),2018.01-2020.12,中国南海软体动物中化学成分的发现,功能导向合成及肿瘤多靶点抑制活性的筛选4.中国科协“青年人才托举工程”(2016QNRC001),2015.01-2017.12(人才基金)5.上海市浦江人才计划(16PJ**),2016.07-2018.06(人才基金)6.中国科学院青年创新促进会会员(**),2016.01-2019.12(人才基金)
ryhj:2019 中国药学会-施维雅青年药物化学奖2017 赛诺菲-中国科学院上海生命科学研究院优秀青年人才奖励基金2016 上海市“浦江人才计划”2015 中国科学院青年创新促进会会员2015 首批中国科协“青年人才托举工程”