dblz:代表性研究论文（Representative Publications 2015-2020）1.Feng HX, Hu LH, Zhu HW, Tao LX, Wu L, Zhao QY, Gao YM, Gong Q, Mao F, Li XK, Zhou H*, Li J*, Zhang HY*. Repurposing antimycotic ciclopirox olamine as a promising anti-Ischemic stroke agent. Acta Pharm Sin B. 2020;10:434-446.2.Hu LH, Feng HX, Zhang HG, Yu SD, Zhao QY, Wang W, Bao FX, Ding X, Hu JJ, Wang MJ, Xu YX, Wu ZR, Li XK, Tang Y, Mao F*, Chen XY, Zhang HY*, Li J*. Development of novel N-hydroxypyridone derivatives as potential anti-ischemic stroke agents. J Med Chem. 2020;63:1051-1067.3.Bao FX, Tao LX*, Zhang HY*. Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation. Cell Mol Neurobiol. 2019;39:1177-1186.4.Feng HX, Li CP, Shu SJ, Liu H*, Zhang HY*. A11, a novel diaryl acylhydrazone derivative, exerts neuroprotection against ischemic injury in vitro and in vivo. Acta Pharmacol Sin. 2019;40:160-1695.Fu W, Yan C, Guo ZQ, Zhang J, Zhang HY*, Tian H*, Zhu WH*. Rational Design of Near-Infrared Aggregation-Induced-Emission-Active Probes: In Situ Mapping of Amyloid-β Plaques with Ultrasensitivity and High-Fidelity. J Am Chem Soc. 2019;141:3171-3177.6.Xu YX, Zhang J, Wang H, Mao F, Bao KT, Liu WW, Zhu J, Li XK*, Zhang HY*, Li J*. Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer\'s Disease Agents. ACS Chem Neurosci. 2019;10:482-496.7.Huang XT, Liu X, Ye CY, Tao LX, Zhou H*, Zhang HY*. Iron-induced energy supply deficiency and mitochondrial fragmentation in neurons. J Neurochem. 2018;147:816-830.8.Chen YT, Chen WY, Huang XT, Xu YC*, Zhang HY*. Iron dysregulates APP processing accompanying with sAPPα cellular retention and β-secretase inhibition in rat cortical neurons. Acta Pharmacol Sin. 2018;39:177-183.9.Ren W, Zhang JJ, Peng C, Xiang HJ, Chen J1, Peng CY, Zhu WL, Huang RM*, Zhang HY*, Hu YH*. Fluorescent Imaging of β-Amyloid Using BODIPY Based Near-Infrared Off-On Fluorescent Probe. Bioconjug Chem. 2018;29:3459-3466.10.Xu YX, Wang H, Li XK, Dong SN, Liu WW, Gong Q, Wang TD, Tang Y, Zhu J, Li J*, Zhang HY*, Mao F*. Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer\'s disease. Eur J Med Chem. 2018;143:33-47.11.Ni W, Wang H, Li XK, Zheng XY, Wang MJ, Zhang J, Gong Q, Ling DZ, Mao F*, Zhang HY*, Li J*. Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5). ACS Chem Neurosci. 2018;9:1625-1636.12.Mao F, Wang H, Ni W, Zheng XY, Wang MJ, Bao KT, Ling DZ, Li XK, Xu YX, Zhang HY*, Li J*. Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer\'s Disease. ACS Chem Neurosci. 2018;9:328-345.13.Wu L, Wang HM, Li JL, Feng HX, Zhao WM, Zhang HY*. Dual anti-ischemic effects of rosmarinic acid n-butyl ester via alleviation of DAPK-p53-mediated neuronal damage and microglial inflammation. Acta Pharmacol Sin. 2017; 38: 459-468.14.Li XK, Wang H, Xu YX, Liu WW, Gong Q, Wang W, Qiu XX, Zhu J, Mao F, Zhang HY*, Li J*. Novel Vilazodone-Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer\'s Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation. ACS Chem Neurosci. 2017;8:2708-2721.15.Ren W, Xu M, Liang SH, Xiang H, Tang L, Zhang M, Ding D, Li X, Zhang H*, Hu Y*. Discovery of a novel fluorescent probe for the sensitive detection of β-amyloid deposits. Biosens Bioelectron. 2016;75:136-41.16.Li X, Wang H, Lu Z, Zheng X, Ni W, Zhu J, Fu Y, Lian F, Zhang N, Li J*, Zhang H*, Mao F*. Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents. J Med Chem. 2016;59:8326-44.17.Tang Y, Xiong J, Zhang JJ, Wang W, Zhang HY*, Hu JF*. Annotinolides A-C, Three Lycopodane-Derived 8,5-Lactones with Polycyclic Skeletons from Lycopodium annotinum. Org Lett. 2016;18:4376-9.18.Li JL, Wu L, Wu J, Feng HX, Wang HM, Fu Y, Zhang RJ, Zhang HY*, Zhao WM*. Caffeoyl Triterpenoid Esters as Potential Anti-ischemic Stroke Agents from Celastrus orbiculatus. J Nat Prod. 2016;79:2774-2779.19.Ye CY, Lei Y, Tang XC, Zhang HY*. Donepezil Attenuates A?-associated Mitochondrial Dysfunction and Reduces Mitochondrial A? accumulation in vivo and in vitro. Neuropharmacology. 2015;95:29-36.20.Ruan Z, Wang HM, Huang XT, Fu Y, Wu J, Ye CY, Li JL, Wu L, Gong Q, Zhao WM*, Zhang HY*. A novel caffeoyl triterpene attenuates cerebral ischemic injury with potent anti-inflammatory and hypothermic effects. J Neurochem. 2015;133:93-103. jyjl:中国科学院上海药物研究所，神经药理专业，博士
