中国科学院上海药物研究所导师教师师资介绍简介-蒙凌华

删除或更新信息，请邮件至freekaoyan#163.com(#换成@)

本站小编 Free考研考试/2021-02-10

xm:蒙凌华
xb:女
zc:研究员
xl:博士
dh:
cz:
dzyj:lhmeng@simm.ac.cn
grzy:
zjlb:研究员
zw:课题组长
txdz:上海浦东张江海科路501号　
grjj:主要从事分子靶向抗肿瘤药物特别是靶向PI3K/mTOR通路和肿瘤免疫调控创新药物的研究与开发，开展从药物研发、机制探讨和生物标志物探寻一体化的药物研究。在Cancer Res， Oncogene等学术期刊发表SCI 论文70余篇，SCI 他引达2000余次。获国内外专利授权28项。获得国家自然科学二等奖、上海市自然科学一等奖（均为第三完成人）等学术奖励。

yjfx:分子靶向抗肿瘤药物特别是靶向PI3K/mTOR通路和肿瘤免疫调控创新药物的研究与开发以及相关治疗学研究

dblz: 1.Xing H, Meng LH*. CRISPR-cas9: a powerful tool towards precision medicine in cancer treatment. Acta Pharmacol Sin. 2020;41:583-587 (Cover review）

2.Liu XL, Wang BB, Wang Y, Wang YX, Yang CH, Tan C, Zhang X, He QJ, Ding J*, Meng LH*. Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3Kα inhibition in breast cancer.Signal Transduct Target Ther. 2019 Nov 22;4:49.

3.Shi JJ, Xing H, Wang YX , Zhang X, Zhan QM, Geng MY, Ding J*, Meng LH*. PI3Kα Inhibitors Sensitize Esophageal Squamous Cell Carcinoma to Radiation by Abrogating Survival Signals in Tumor Cells and Tumor Microenvironment. Cancer Lett. 2019;459:145-155

4.Liu XL, Liu JL, Xu YC, Zhang X, Wang YX, Qing LH, Guo W, Ding J*, Meng LH*. Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CAH1047R accompanied with pro-tumorigenic secretome. Int J Cancer. 2019; 145:817-829

5.Wang YX, Li X, Liu XL, Chen Y, Yang CH, Tan C, Wang BB, Sun YM, Zhang X, Gao YL, Ding J*, Meng LH*. Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses Kras-mutated non-small cell lung cancer. Cancer Biol Med 2019; 16: 66-78.

6.Liu XL, Xu YC, Wang YX, Chen Y, Wang BB, Wang Y, Hu LD, Ma QY, Zhang YC, Sun YM, Gao YL, Yang CH, Ding J*, Meng LH*. Decrease in phosphorylated ERK indicates the therapeutic efficacy of a clinical PI3Kα-selective inhibitor CYH33 in breast cancer. Cancer Lett. 2018;433:273-282.

7.Xu YC, Wang X, Chen Y, Chen SM, Yang XY, Sun YM, Geng MY, Ding J*, Meng LH*. Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3Ka-selective Inhibitors in Breast Cancer. Theranostics 2017; 7:974-986

8.Wei M, Wang X, Song Z, Jiao M, Ding J, Meng LH*, Ao Zhang*. Targeting PI3Kδ: Emerging Therapy for Chronic Lymphocytic Leukemia and Beyond. Medicinal Research Reviews 2015; 35(4):720-52

jyjl:1992.9-1996.7华东师范大学生物系，获理学学士学位