xm:耿美玉
xb:女
zc:研究员
xl:博士
dh:-2426
cz:
dzyj:mygeng@simm.ac.cn
grzy:
zjlb:研究员；****；新药；
zw:学术所长
txdz:上海市浦东新区祖冲之路555号
grjj:耿美玉，中国科学院上海药物研究所学术所长、研究员、课题组长；国家“973”计划“糖化学糖生物学研究”项目首席科学家、“国家****科学基金”。主要从事抗阿尔茨海默病和抗肿瘤分子靶向药物研发和生物标志物研究，领衔研发的抗阿尔茨海默病药物正在临床III期研究，3个分子靶向抗肿瘤药物正在进行系统的临床前评价。系统阐明了数十个自主研发的分子靶向药物的新作用机制，发现了数个疗效预测与疗效监控生物标志物。在TiPS、J Nat Cancer Inst、Cancer Res、Intl J Cancer、Oncotarget、Mol Pharmacol、J Biol Chem、J Med Chem等SCI学术杂志上发表了100余篇论文。研究成果获国家技术发明奖一等奖一项（第五名）、“上海市优秀学科带头人”、“上海市领军人才”、“上海市五一巾帼创新奖”等多项奖励。2009年入选上海领军人才，2010年入选“上海市优秀学科带头人”，2013年被授予“有突出贡献中青年专家”称号。
yjfx:抗阿尔茨海默病和抗肿瘤新药研发及生物标志物研究
dblz:1.Wang X, Sun G, Feng T, Zhang J, Huang X, Wang T , Xie Z, Chu X, Yang J, Wang H, Chang Sh, Gong Y, Ruan L, Zhang G , Yan S, Lian W , Du C , Yang D , Zhang Q , Lin F, Liu J, Zhang H, Ge Ch, Xiao Sh, Ding J, Geng M*. Sodium Oligomannate Therapeutically Remodels Gut Microbiota and Suppresses Gut Bacterial Amino Acids-Shaped Neuroinflammation to Inhibit Alzheimer\'s Disease Progression. Cell Res,2019; 29 (10), 787-803.2.Wang X, Zhang M, Ping F, Liu H, Sun J, Wang Y, Shen A*, Ding J*, Geng M*. Identification and therapeutic intervention of coactivated anaplastic lymphoma kinase, fibroblast growth factor receptor 2, and ephrin type‐A receptor 5 kinases in hepatocellular carcinoma. Hepatology. 2019;69:573-586.3.Huang X , Yan J, Zhang M , Wang Y, Chen Y, Fu X, Wei R, Zheng X， Liu Zh, Zhang X; Yang H，Hao B, Shen Y, Su Y, Cong X, Huang M, Tan M*, Ding J*, Geng M*.Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-aberrant Solid Tumors, Cell, 2018;175(1):186-199.4.Lian Q, Xu J, Yan S, Huang M*, Ding H, Sun X, Ding J*, Sun B* and Geng M*. Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation. Cell Res 2017;27(6):784-800.5.Yue X, Ai J, Xu Y, Chen Y, Huang M, Yang X, Hu B, Zhang H, He Ch, Yang X, Tang W, Peng X, Dong L, Wang H, Fan J*, Ding J*, Geng M*. Polymeric immunoglobulin receptor promotes tumor growth in hepatocellular carcinoma. Hepatology. 2017;65(6):1948-1962.6.Chen Y, Wang Y, Zhang J, Su Y, Shen Y, Jiang D, Hou Y , Geng M*, and Ding J*. G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin . Nature Commun. 2017 8(1):27.7.Liu H, Ai J, Shen A, Chen Y, Wang X, Peng X, Chen H, Shen Y, Huang M*, Ding J*, Geng M*.c-Myc alteration determines the therapeutic response to FGFR inhibitors. Clin Cancer Res. 2017; 23(4):974-984.8.Zeng H, Qu J, Jin N, Xu J, Lin C, Yang X, He X, Tang S, Lan X, Yang X, Chen Z, Huang M*, Ding J*, Geng M*.Feedback activation of leukemia inhibitory factor receptor limits response to histone deacetylases inhibitors in breast cancer. Cancer Cell, 2016;30(3):459-73.9.Shen A, Wang L, Huang M, Sun J, Chen Y, Shen Y, Yang X, Wang X, Ding J*, Geng M*. c-Myc alterations confer therapeutic response and acquired resistance to c-Met inhibitors in MET-addicted cancers. Cancer Res, 2015 ,75(21):4548-59.10.Ai J, Tang Q, Wu Y, Xu Y, Feng T, Zhou R, Chen Y, Gao X, Zhu Q, Yue Xihua, Pan Q, Xu S, Li J, Huang M, Daugherty-Holtrop Jennifer, He Y, Xu H.Eric, Fan J*, Ding J*, Geng M*. The Role of Polymeric Immunoglobulin Receptor in Inflammation-Induced Tumor Metastasis of Human Hepatocellular Carcinoma. J Natl Cancer Inst. 103(22):1696-712, 2011.
jyjl:山东大学医学院（原山东医科大学）医学系 医学学士
删除或更新信息，请邮件至freekaoyan#163.com(#换成@)
