xm:冯林音
xb:女
zc:研究员
xl:博士
dh:
cz:
dzyj:lyfeng@simm.ac.cn
grzy:
zjlb:研究员
zw:中科院上海药物研究所研究组长、博士生导师
txdz:上海市祖冲之路555号
grjj:冯林音：1991年原上海医科大学获博士学位，1992年进入中国科学院上海脑研究所进行博士后研究，1997年晋升为研究员，博士生导师。作为课题负责人承担国家基础研究重大项目（973）、上海市重点项目、中科院先导专项、国家自然科学基金面上和上海市自然科学基金等项目；95年获国务院特殊津贴。迄今已发表研究论文50余篇，专利授权2项。

yjfx:1. 神经退行性疾病的药物筛选和靶点确证及药效学评价
(1) 缺血性脑卒中和帕金森病病理过程中的作用及其作为药物靶点确证和机制研究
(2) 缺血性脑卒中和帕金森病表观遗传学调控及药物作用机制的研究
dblz:1.Zhang Y., Wu Q., Zhang L., Wang Q., Yang Z., Liu J., Feng L.* Caffeic acid reduces A53T α-synuclein by activating JNK/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson’s disease. Pharmacological Research. 2019 Dec;150:104538. doi: 10.1016/j.phrs.2019.104538. Epub 2019 Nov 9.

2.Hong F., Zhao MX., Zhang L., Feng L. * Inhibition of Ezh2 in vitro and the decline of Ezh2 in developing midbrain promotes dopaminergic neurons differentiation through modifying H3K27me3. Stem Cell and Development, 2019, 28(10) :649-658

3.Yu X., Cheng G., Zhang L., Zhang Y., Wang Q., Zhao M., Zeng L., Hu Y*., Feng L.* N-Phenylquinazolin-2-amine Yhhu4952 as a novel promotor for oligodendrocyte differentiation and myelination. Sci Rep. 2018 Sep 19;8(1):14040. doi: 10.1038/s41598-018-32326-0.

4.Lu H., Cheng G., Hong F., Zhang L., Hu Y., and Feng L.* A Novel 2-Phenylamino -Quinazoline-Based Compound Expands the Neural Stem Cell Pool and Promotes the Hippocampal Neurogenesis and the Cognitive Ability of Adult Mice. Stem Cells. 2018 Aug;36(8):1273-1285. doi: 10.1002/stem.2843. Epub 2018 May 12.

5.Wu Q., Yang X., Zhang L., Zhang Y., Feng L* Nuclear accumulation of histone deacetylase 4 (HDAC4) exert neurotoxicity in models of Parkinson’s disease. Molecular Neurobiology 2017 54:6970–6983 DOI 10.1007/s12035-016-0199-2

6.Yang X., Wu Q., Zhang L., Feng L* Inhibition of Histone Deacetylase 3 (HDAC3) Mediates Ischemic Preconditioning and Protects Cortical Neurons against Ischemia in Rats. Frontiers in Molecular Neuroscience 2016, (9): 131

7.Zhang N, Zhang L, Feng L*, Yao L. The anxiolytic effect of essential oil of Cananga odorata exposure on mice and determination of its major active constituents. Phytomedicine. 2016 Dec 15; 23(14):1727-1734. Epub 2016 Oct 27.

8.Wu Q., Yang X., Zhang Y., Zhang L., Feng L* Chronic mild stress accelerates the progression of Parkinson\'s disease in A53T α-synuclein transgenic mice. Experimental Neurology 2016, 285 61–71

9.Sun Y., Hong F., Zhang L. Feng L.* The sphingosine-1-phosphate analogue, FTY-720, promotes the proliferation of embryonic neural stem cells, enhances hippocampal neurogenesis learning and memory abilities in adult mice. British Journal of Pharmacology 2016, 173 2793–2807

10.Jin L, Zhang LM, Xie KQ, Ye Y, Feng L*. Paeoniflorin suppresses the expression of ICAM-1 in endotoxin-treated human monocytic cells. Br J Pharmacol. 2011, 164: 694–703. [Epub ahead of print]

jyjl:1978.01 - 1982.12江西医学院医疗系本科，82年获医学学士学位