姓名：刘秀萍 博士
职称：教授
E-MAIL: xpliu1228@fudan.edu.cn
WWW: http://www.------

研究方向
1.乳腺癌侵袭转移和化疗耐药的分子机制。
2.蛋白乙酰化修饰在肝纤维化过程中的作用及分子机制。
重要学术贡献
乳腺癌侵袭转移和化疗耐药的分子机制研究: 1）提出和证实乳腺癌细胞对P-gp底物类化疗药物耐药的同时伴随癌细胞侵袭转移能力的增强，并揭示EMT在该过程中发挥着关键性作用。2）新发现和证实RACK1及一些非编码RNA分子在乳腺癌侵袭和转移过程中发挥着重要作用，并揭示了相应的分子机制。3）近期新研究首次发现lncRNA-RACGAP1P通过介导真基因调控癌细胞线粒体动态变化，进而促进乳腺癌侵袭和转移。
蛋白乙酰化修饰在肝纤维化过程中的作用及分子机制研究: 首次报道了C/EBP-α蛋白存在乙酰化修饰及确定了乙酰化位点，并证实其乙酰化修饰能促进激活的肝星状细胞凋亡参与肝纤维化过程。
荣誉与获奖
2011 ……复旦大学三八红旗手 （2009-2010年度）
2012 ……上海市育才奖
2013 ……上海市科学技术三等奖
2014 ……复旦大学基础医学院优秀本科生专业导师
2015 ……复旦大学比翼双飞模范佳侣
国内外学术团体任职
2010----现在 ……国家自然科学基金一审专家
2014----2018.8 ……上海医学会第四届医疗鉴定专家
2016.7--2019.6 ……上海市医学会病理学专科分会第十届委员会，委员兼秘书
2016.9--2020.2 ……中国研究型医院学会超微与分子病理学专业委员会，委员
受邀审稿学术刊物
2014-2018 ……《中华病理学杂志》第十届编辑委员会，编委
2016-2020 ……《诊断病理学杂志》第五届编委会，编委
发表论文
以通讯作者发表的论文：
1.Trichostatin A inhibits the activation of Hepatic stellate cells by Increasing C/EBP-α Acetylation in vivo and in vitro. Scientific Reports. 2018 accepted.
2.Extracellular 50-nucleotidase (CD73) promotes human breast cancer cells growth through AKT/GSK-3b/b-catenin/cyclinD1 signaling pathway. International Journal of Cancer. 2018 online.
3.Solute carrier family 35 member F2 is indispensable for papillary thyroid carcinoma progression through activation of transforming growth factor-b type I receptor/apoptosis signal-regulating kinase 1/mitogen-activated protein kinase signaling axis. Cancer Science. 2018; 109:642-655.
4.Activation of pluripotent genes in hepatic progenitor cells in the transition of nonalcoholic steatohepatitis to pre-malignant lesions. Laboratory Investigation. 2017; 1-7.
5.HCRP1 inhibits TGF-βinduced epithelial-mesenchymal transition in hepatocellular carcinoma. Int J Oncology. 2017; 50: 1233-1240.
6.Rab14 suppression mediated by miR-320a promotes cell proliferation and invasion/metastasis in human breast cancer. J Cancer. 2016; 7:2317-2326.
7.CA IX is upregulated in CoCl2-induced hypoxia and associated with cell invasive potential and a poor prognosis of breast cancer. Int J of Oncology. 2016; 48:271-280.
8.MicroRNA-320a inhibits breast cancer metastasis by targeting metadherin. Oncotarget. 2016; 7(25):38612-25.
9.Decreased HCRP1 promotes breast cancer metastasis by enhancing EGFR phosphorylation. Biochemical and Biophysical Research Communications. 2016, 477(2):222-8.
10.Overexpression of Ubiquitin Carboxyl Terminal Hydrolase-L1 Enhances Multidrug Resistance and Invasion/Metastasis in Breast Cancer by Activating the MAPK/Erk Signaling Pathway. Molecular Carcinogenesis. 2016; 55:1329-1342.
11.The long intergenic non-coding RNA APOC1P1-3 inhibits apoptosis through decreasing α-tubulin acetylation in breast cancer. Cell Death Disease. 2016; 7,e2236.
12.Epithelioid angisosarcoma: a clinicopathological study of 16 Chinese cases. Int J Clin Exp Pathol., 2015; 8(4):3901-3909.
13.The role of tumor-associated macrophages in breast carcinoma invasion and metasis. Int J Clin Pathol., 2015; 8(6):6656-6664.
14.Neurokinin-1 activation affects EGFR related signal transduction in triple negative breast cancer. Cellular Signalling. 2015; (27:1315-1324.
15.UCH-L1 involved in regulating the degradation of EGFR and promoting malignant properties in drug-resistant breast cancer. Int J Clin Exp Pathol., 2015; 8(10):1-8.
16.Expression of CPEB4 in invasive ductal breast carcinoma and its prognostic significance. OncoTargets and Therapy. 2015; 8: 3499-3506.
17.The absence of human papillomavirus in esophageal squamous cell carcinoma in East China. Int J Clin Exp Pathol., 2014; 15:4184-4193.
18.Loss of PPM1A expression enhances invasion and the epithelial-to-mesenchymal transition in bladder cancer by activating the TGF-β/Smad signaling pathway. Oncotarget. 2014; 5(14):5700-5711.
19.miR 320a is an independent prognostic biomarker for invasive breast cancer. Oncology Lerrers. 2014; 8: 1043-1050.
20.CD44/cellular prion protein interact in multidrug resistant breast cancer cells and correlate with responses to neoadjuvant chemotherapy in breast cancer patients. Molecular Carcinogenesis. 2014; 53(9):686-97.
21.C/EBP-αameliorates CCl4-induced liver fibrosis in mice through promoting apoptosis of hepatic stellate cells with little apoptotic effect on hepatocytes in vitro and in vivo. Apoptosis. 2012; 17: 492-502.
22.Involvement of NF-kappaB/miR-448 regulatory feedback loop in chemotherapy-induced epithelial-mesenchymal transition of breast cancer cells. Cell Death Differ., 2011; 18(1): 16-25.
23.RACK1 Promotes Breast Carcinoma Metastasis via Activation of the RhoA/Rho Kinase Pathway. Breast Cancer Res Treat., 2011; 126(3):555-63.
24.Loss of BCL2L10 protein expression as a prognostic predictor for poor clinical outcome in gastric carcinoma. Histopathology. 2010; 57(6): 814-824.
25.Cx26 expression correlates with less aggressive phenotype of intestinal type-gastric carcinomas. Int J Mol Med., 2010; 25: 709-716.
26.RACK1: A superior independent predictor for poor clinical outcome in breast cancer. Int J Cancer. 2010; 127(5): 1172-9.
27.RACK1 promotes breast carcinoma proliferation and invasion/metastasis in vitro and in vivo. Breast Cancer Res Treat., 2010; 123:375-386.
28.Overexpression and involvement of special AT-rich sequence binding protein 1 in multidrug resistance in human breast carcinoma cells. Cancer Sci., 2010; 101(1):80-86.
29.Twist1 Mediated Adriamycin-induced Epithelial-Mesenchymal Transition (EMT) Relates to Multidrug Resistance and Invasive Potential in Breast Cancer Cells. Clin Cancer Res., 2009; 15(8): 2657-65.
30.The role of P-glycoprotein/cellular prion protein interaction in multidrug resistant breast cancer cells treated with paclitaxel. Cell Mol Life Sci., 2009; 66:504-15.
以第一作者发表的论文
1.Two subtypes of mucinous colorectal carcinoma characterized by laser scanning cytometer and comparative genomic hybridization. Int J Oncol., 2014; 25(3): 615-21.
2.Inverse relationship between matrilysin expression and proliferative activity of cells in advanced gastric carcinoma. Human Pathology. 2002; 33(7):741-7.
3.Prognostic significance of matrix metalloproteinase-7 (MMP-7) expression at the invasive front in gastric carcinoma. Cancer Science. 2002; 93:291-295.
4.Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma. Histopathology. 2001; 39: 603-61.
5.Expression of p21WAF1/CIP1 and p53 proteins in gastric carcinoma:its relationships with cell proliferation activity and prognosis. Cancer Letters. 2001; 170 (2):183-189.
6.Expression of p53 protein as a prognostic indicator of reduced survival time in diffuse-type gastric carcinoma. Pathology International. 2001;51:440-444.