姓名：刘锋 博士
职称：研究员
E-MAIL: liuf@fudan.edu.cn
WWW: http://www.------
研究方向
1.肿瘤蛋白质组学
2.染色质重塑复合物与肿瘤发生发展
3.肿瘤微环境蛋白质组学
重要学术贡献
前期从事功能基因组分泌蛋白基因、造血干细胞蛋白质组学研究，参与日本血吸虫大规模转录组、蛋白质组和基因组研究，全面系统地绘制了血吸虫不同性别和生活周期基因表达谱，通过蛋白质组学研究揭示血吸虫与宿主相互作用、免疫逃避的分子特征，建立转录组和蛋白质整合数据库SjTPdb，为研究血吸虫生物学、致病机制、基因组结构和应用研究奠定基础。2010年研究方向转向肿瘤蛋白质组学与标志物、肿瘤微环境、肿瘤增殖/转移机制等研究，发现肿瘤相关成纤维细胞可能抑制肿瘤生长，发现FLNC、COL6A3、Spondin2等肿瘤标志物，揭示了染色质重塑复合物基因ARID1A在胃癌中的作用机制。获得了国家自然科学奖、上海市自然科学奖、中国青年科学奖等奖项。
荣誉与获奖
2013 国家自然科学奖二等奖
2013 上海市自然科学奖一等奖
2011 上海市“青年科技启明星”跟踪人才计划
2010 第十一届中国青年科学奖
2009 明治乳业生命科学奖（杰出奖）
2008 上海市科教党委系统第二届青年科技创新人才奖
2007 上海市“青年科技启明星”人才计划
国内外学术团体任职
2017- 上海市生物化学与分子生物学学会会员
受邀审稿学术刊物
2010-今 J Helminthology, Electrophoresis, Histopathology, Cancer Letter, Oncotarget, Molecular Medicine Reports, Oncology Reports, Scientific Reports, Cancer Medicine, Proteomics, J Cancer
受邀学术报告
2016 报告题目Proteomic characterization of plasma membrane proteomes of gastric cancer cells reveals that ASCT2 is involved in cancer metastasis by targeting WNT, 第15届国际蛋白质组学组织年会, 台北, 2016.9.18-2016.9.22
2012 Proteomic analysis of cancer-specific plasma membrane proteins identify NCAM as a potential gastric cancer biomarker, 第11届国际蛋白质组学年会, Hynes Convention Center, Boston, Massachusetts, USA., 2012.9.9-2012.9.13
发表论文
1.Wang XQ#, Tang ZX#, Yu D#, Cui SJ, Jiang YH, Zhang Q, Wang J, Yang PY*, Liu F*. Epithelial but not stromal expression of collagen alpha-1(III) is a diagnostic and prognostic indicator of colorectal carcinoma. Oncotarget. 2016;7(8):8823-8838.
2.Zhang Q#, Yan HB#, Wang J, Cui SJ, Wang XQ, Jiang YH, Feng L, Yang PY*, Liu F*. Chromatin remodeling gene AT-rich interactive domain-containing protein 1A suppresses gastric cancer cell proliferation by targeting PIK3CA and PDK1. Oncotarget. 2016;7(29):46127-46141
3.Yan HB#, Wang XF#, Zhang Q#, Tang ZQ, Jiang YH, Fan HZ, Sun YH*, Yang PY and Liu F*. Reduced expression of the chromatin remodeling gene ARID1A enhances gastric cancer cell migration and invasion via downregulation of E-cadherin transcription. Carcinogenesis. 2014, 35(4):867-876.
4.Chen SX#, Xu XE#, Wang XQ, Cui SJ, Xu LL, Jiang YH, Zhang Y, Yan HB, Zhang Q, Qiao J, Yang P-Y* and Liu F*. Identification of colonic fibroblast secretomes reveals secretory factors regulating colon cancer cell proliferation. J Proteomics. 2014, 110:155-171.
5.Schistosoma japonicum Genome S and Functional Analysis C. The Schistosoma japonicum genome reveals features of host-parasite interplay. Nature. 2009, 460(7253):345-351.
Authorship:
Genome annotation and evolution analysis: Yan Zhou#, Huajun Zheng#, Xiangyi Chen, Lei Zhang, Kai Wang, Jing Guo, Zhen Huang, Bo Zhang, Wei Huang, Ke Jin, Dou Tonghai, Masami Hasegawa, Li Wang, Yuan Zhang, Jie Zhou, Lin Tao, Zhiwei Cao, Yixue Li, Tomas Vinar, Brona Brejova, Dan Brown, Ming Li, David J. Miller, David Blair, Yang Zhong (Principal Investigator), Zhu Chen (Principal Investigator)
Functional genomics analysis: Feng Liu#, Wei Hu#, Zhi-Qin Wang#, Qin-Hua Zhang, Huai-Dong Song, Saijuan Chen, Xuenian Xu, Bing Xu, Zhuan Ju, Yu Cheng, Paul J. Brindley, Donald P. McManus, Zheng Feng (Principal Investigator), Ze-Guang Han (Principal Investigator)
Sequencing and assembly: Gang Lu#, Shuangxi Ren#, Yuezhu Wang, Wenyi Gu, Hui Kang, Jie Chen, Xiaoyun Chen, Shuting Chen, Lijun Wang, Jie Yan, Biyun Wang, Xinyan Lv, Lei Jin, Bofei Wang, Shiyin Pu, Xianglin Zhang, Wei Zhang, Qiuping Hu, Genfeng Zhu, Jun Wang, Jun Yu, Jian Wang, Huanmin Yang, Zemin Ning, Matthew Beriman, Chia-Lin Wei, Yijun Ruan, Guoping Zhao (Principal Investigator), Shengyue Wang (Principal Investigator)
6.Paper writing: Feng Liu, Yan Zhou, Zhi-Qin Wang, Gang Lu, Huajun Zheng, Paul J. Brindley, Donald P. McManus, David Blair, Qinhua Zhang, Yang Zhong, Shengyue Wang, Ze-Guang Han, and Zhu Chen
7.Liu F#, Cui SJ#, Hu W#, Feng Z, Wang ZQ and Han ZG*. Excretory/secretory proteome of the adult developmental stage of human blood fluke, Schistosoma japonicum. Mol Cell Proteomics. 2009, 8(6):1236-1251.
8.Liu F#, Lu J#, Hu W#, Wang SY, Cui SJ, Chi M, Yan Q, Wang XR, Song HD, Xu XN, Wang JJ, Zhang XL, Zhang X, Wang ZQ, Xue CL, Brindley PJ, McManus DP, Yang PY, Feng Z, Chen Z and Han ZG*. New perspectives on host-parasite interplay by comparative transcriptomic and proteomic analyses of Schistosoma japonicum. PLoS Pathog. 2006, 2(4):e29.
9.Liu F#, Lu J#, Fan HH#, Wang ZQ#, Cui SJ, Zhang GA, Chi M, Zhang X, Yang PY, Chen Z and Han ZG*. Insights into human CD34+ hematopoietic stem/progenitor cells through a systematically proteomic survey coupled with transcriptome. Proteomics. 2006, 6(9):2673-2692.
10.Hu W#, Yan Q#, Shen DK#, Liu F#, Zhu ZD#, Song HD#, Xu XR#, Wang ZJ, Rong YP, Zeng LC, Wu J, Zhang X, Wang JJ, Xu XN, Wang SY, Fu G, Zhang XL, Wang ZQ, Brindley PJ, McManus DP, Xue CL, Feng Z#, Chen Z, Han ZG*. Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource. Nat Genet. 2003, 35(2):139-147.
申请或授权专利
授权专利
1.刘锋; 杨芃原; 乔杰; 方彩云; 姜英华, 一种人结肠癌蛋白质标志物COL6A3的应用方法及其检测试剂盒, 2015.3.23, 中国, ZL 2015 1 **.7，授权时间2017
申请专利
1.刘锋; 杨芃原; 张倩; 王晓庆; 姜英华, 一种人结肠癌蛋白质标志物Spondin-2的检测方法及其检测试剂盒, 2016.3.9, 中国, CN7.6