姓名：陆利民 博士
职称：教授
E-MAIL: lulimin@shmu.edu.cn


研究方向
1.糖尿病肾病发病机制
2.慢性肾损伤及肾脏纤维化发生机制
重要学术贡献
糖尿病肾病发病中肾素-血管紧张素系统异常参与肾脏损伤的发生。课题组研究证实不仅血管紧张素II-AT1受体轴异常激活与糖尿病引起的肾损害有关，体内持续高糖状态下血管紧张素（1-7）-Mas受体轴功能下调也与肾脏损害有关。调节肾素血管-紧张素系统中功能上相互拮抗的血管紧张素II-AT1受体轴与血管紧张素（1-7）-Mas受体轴之间相互平衡是避免肾脏损害发生的关键。TGF-?在各种急慢性肾损伤发生中有十分重要的作用，在肾脏纤维化发展中，课题组研究结果证实重编程因子c-Myc在肾间质细胞中异常升高，通过调控其靶基因intergrin-?V参与TGF-?的激活，进而促进肾脏纤维化的发展。过度炎症反应是多种病因引起的慢性肾损伤的共同特征，课题组近期的研究还证实，Capase-11通过非经典炎性小体通路促进肾脏固有细胞炎性因子的成熟和释放，参与肾脏纤维化的发生和发展。
荣誉与获奖
2012 教育部霍英东基金会全国高校优秀青年教师三等奖
2013 中国生理学会张锡均基金会优秀学术论文奖
2014 中国高校科学技术进步二等奖（第2完成人）
2015 上海市科学技术进步二等奖（第9完成人）
国内外学术团体任职
2010-今 中国生理学会肾脏专业委员会 副主任委员
2010-今 中国生理学会教育工作委员会 委员
2018-今 上海市生理科学会 副理事长
2010-2014 中国生理学会青年工作委员会 副主任委员
2014-2018 上海市生理科学会 常务理事
受邀学术报告
2016 Transcriptional factor c-Myc was involved in RAS induced TGF-? activation in renal fibrosis，中国生理学会成立90周年庆典暨2016国际生理学学术大会，北京
发表论文
1.Miao N#, Wang B#, Xu D, Wang Y, Gan X, Zhou L, Xue H, Zhang W, Wang X, Lu L*. Caspase-11 Promotes Cisplatin-Induced Renal Tubular Apoptosis through a Caspase-3-dependent Pathway. AJP-Renal Physiol. 2018 Feb 1;314(2):F269-F279
2.Shen Y, Miao N, Wang B, Xu J, Gan X, Xu D, Zhou L, Xue H, Zhang W, Yang L, Lu L*. c-Myc promotes renal fibrosis by inducing integrin av-mediated transforming growth factor- signaling. Kidney International. 2017 Mar 92, 888–899
3.Zhang L, An XF, Ruan X, Huang DD, Zhou L, Xue H, Lu LM*, He M*. Inhibition of (pro)renin Receptor Contributes to Renoprotective Effects of Angiotensin II Type 1 Receptor Blockade in Diabetic Nephropathy. Front Physiol. 2017 Oct 6; 8:758.
4.Shen Y, Miao NJ, Xu JL, Gan XX, Xu D, Zhou L, Xue H, Zhang W, Lu LM*. N-acetylcysteine alleviates angiotensin II-mediated renal fibrosis in mouse obstructed kidneys. Acta Pharmacol Sin. 2016 May;37(5):637-44
5.Shen Y, Miao N, Xu J, Gan X, Xu D, Zhou L, Xue H, Zhang W, Lu L*. Metformin Prevents Renal Fibrosis in Mice with Unilateral Ureteral Obstruction and Inhibits Ang II-Induced ECM Production in Renal Fibroblasts. Int J Mol Sci. 2016 Jan 22;17(2).
6.Kong YL, Shen Y, Ni J, Shao DC, Miao NJ, Xu JL, Zhou L, Xue H, Zhang W, Wang XX*, Lu LM*. Activation of the IGF-1/IGF-1R pathway activation is involved in insulin deficiency-induced renal mesangial cell dysfunction. Acta Pharmacol Sin. 2016 Feb;37(2):217-27.
7.Shao D, Ni J, Shen Y, Liu J, Zhou L, Xue H, Huang Y, Zhang W*, Lu L*. CHOP mediates XBP1S-induced renal mesangial cell necrosis following high glucose treatment. Eur J Pharmacol. 2015 Jul 5;758:89-96.
8.Ni J, Shen Y, Wang Z, Shao DC, Liu J, Kong YL, Fu LJ, Zhou L, Xue H, Huang Y, Zhang W, Yu C, Lu LM*. P300-dependent STAT3 acetylation is necessary for angiotensin II-induced pro-fibrotic responses in renal tubular epithelial cells. Acta Pharmacol Sin. 2014 35(9):1157-66.
9.Ni J, Shen Y, Wang Z, Shao DC, Liu J, Fu LJ, Kong YL, Zhou L, Xue H, Huang Y, Zhang W, Yu C, Lu LM*. Inhibition of STAT3 acetylation is associated with angiotesin renal fibrosis in the obstructed kidney. Acta Pharmacol Sin. 2014 35(8):1045-54.
10.Xue H, Yuan P, Ni J, Li C, Shao D, Liu J, Shen Y, Wang Z, Zhou L, Zhang W, Huang Y, Yu C, Wang R, Lu L*. H2S Inhibits Hyperglycemia- Induced Intrarenal Renin- Angiotensin System Activation via Attenuation of Reactive Oxygen Species Generation. PLoS ONE. 2013 8(9):e74366.
11.Shao D, Liu J, Ni J, Wang Z, Shen Y, Zhou L, Huang Y, Wang J, Xue H, Zhang W, Lu L*. Suppression of XBP1S Mediates High Glucose-Induced Oxidative Stress and Extracellular Matrix Synthesis in Renal Mesangial Cell and Kidney of Diabetic Rats. PLoS ONE. 2013, 8(2): e56124
12.Wang Z, Ni J, Shao D, Liu J, Shen Y, Zhou L, Huang Y, Yu C, Wang J, Xue H, Lu L*. Elevated transcriptional co-activator p102 mediates angiotensin II type 1 receptor up-regulation and extracellular matrix overproduction in the high glucose-treated rat glomerular mesangial cells and isolated glomeruli. Eur J Pharmacol. 2013, 702: 208-17
13.Xue H, Zhou L, Yuan P, Wang Z, Ni J, Yao T, Wang J, Huang Y, Yu C, Lu L*. Counteraction between angiotensin II and angiotensin-(1-7) via activating angiotensin type I and Mas receptor on rat renal mesangial cells. Regul Pept. 2012, 177(1-3):12-20
14.Zhou L, Xue H, Wang Z, Ni J, Yao T, Huang Y, Yu C, Lu L*. Angiotensin-(1-7) attenuates high glucose-induced proximal tubular epithelial-to-mesenchymal transition via inhibiting ERK1/2 and p38 phosphorylation. Life Sci. 2012, 90(11-12):454-62.
15.Yuan P, Xue H, Zhou L, Qu L, Li C, Wang Z, Ni J, Yu C, Yao T, Huang Y, Wang R, Lu L*. Rescue of mesangial cells from high glucose-induced over-proliferation and extracellular matrix secretion by hydrogen sulfide. Nephrol Dial Transpl. 2011, 26(7):2119-26
16.Zhou L, Xue H, Yuan P, Ni J, Yu C, Huang Y, Lu LM*. Angiotensin AT1 receptor activation mediates high glucose-induced epithelial–mesenchymal transition in renal proximal tubular cells. Clin Exp Pharmacol Physiol. 2010, 37, e152–e157
17.Lu L, Li P, Yang C, Kurth T, Misale M, Skelton M, Moreno C, Roman RJ, Greene AS, Jacob HJ, Lazar J, Liang M, Cowley AW Jr*. Dynamic convergence and divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive hypertension. Physiol Genomics. 2010, 41(1):63-70
18.He M, Zhang L, Shao Y, Xue H, Zhou L, Wang X, Yu C, Yao T, Lu L*. Angiotensin II type 2 receptor mediated angiotensin II and high glucose induced decrease in renal prorenin/renin receptor expression. Mol Cell Endocrinol. 2010, 315: 188-194
19.Qu L, Xue H, Yuan P, Zhou L, Yao T, Huang Y, Lu L*. Adenosine 5’-triphosphate stimulates TGF-β1 increase via reactive oxygen species and ERK1/2 under high glucose condition in rat mesangial cells. Acta Pharmacol Sin. 2009, 30(12):1601-06
20.Xue H, Yuan P, Zhou L, Yao T, Huang Y, Lu L*. Effect of adrenotensin on cell proliferation is mediated by angiotensin II in cultured rat mesangial cells. Acta Pharmacol Sin. 2009, 30(8):1132-37
21.He M, Zhang L, Shao Y, Wang X, Huang Y, Yao T, Lu L*. Inhibition of renin/prorenin receptor attenuated mesangial cell proliferation and reduced associated fibrotic factor release. Eur J Pharmacol. 2009, 15; 606(1-3):155-61
22.Shao Y, He M, Zhou L, Yao T, Huang Y, Lu LM*. Chronic angiotensin (1-7) injection accelerates STZ-induced diabetic renal injury. Acta Pharmacol Sin. 2008, 29(7):829-37
23.Zhou L, Shao Y, Huang Y, Yao T, Lu L*. 17β-Estradiol inhibits angiotensin II-induced collagen synthesis of cultured rat cardiac fibroblasts via modulating angiotensin II receptors. Eur J Pharmacol. 2007, 567:186–92

学术专著
1.2016年《生理学》复旦大学出版社 主编 ISBN 978-7-309-12053-0
2.2015年《人体生理学》人民卫生出版社 篇主编 ISBN 978-7-117-20531-0
3.2005年《生理学》复旦大学出版社 主编 ISBN 7-309-04672-2
4.2002年《生理学概要》复旦大学出版社 主编 ISBN 7-309-03048-6