赵鑫锐
职称：副研究员
学历/学位：研究生、博士
电话：**
电子邮箱：zhaoxinrui@jiangnan.edu.cn


简介
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长期从事酵母以及大肠杆菌代谢工程的研究。近年来共发表SCI研究论文15篇，累计影响因子达38，他引130多次；申请发明专利6项，授权发明专利2项。现为Journal of Agricultural and Food Chemistry, Applied and Environmental Microbiology, Biotechnology and Bioengineering等杂志审稿人。



学习工作经历
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2002-2006 安徽大学，生物科学专业，理科学士
2007-2010 安徽大学，微生物学专业，理科硕士
2010-2014 江南大学，发酵工程专业，工科博士
2014-2016 江南大学，糖化学与糖药物工程研究室，博士后
2016-2018 韩国KAIST大学，Metabolic & Biomolecular Engineering Laboratory，博士后
2018-至今 江南大学，生物系统与生物加工工程研究室，副研究员



主要成果
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一、论文（论著）发表情况
部分代表性论文如下：
1. Zhao, X., Choi, K., Lee, S. *, Metabolic engineering of Escherichia coli for secretory production of free haem. Nat. Catal. doi: 10.1038/s41929-018-0126-1.
2. Zhao, X., Park, S., Yang. D., Lee, S. *, Synthetic biology for natural compounds. Biochemistry doi: 10.1021/acs.biochem.8b00569 (IF: 2.99).
3. Yang, M., Hong, H., Liu, S., Zhao, X., Wu, Z. *, 2018. Immobilization of Staphylococcus aureus sortase A on chitosan particles and its applications in peptide-to-peptide ligation and peptide cyclization. Molecules 23 (1), 192 (IF: 3.10)
4. Zhao, X., Hong, H., Cheng, X., Liu, S., Deng, T., Guo, Z., Wu, Z. *, 2017. One-step purification and immobilization of extracellularly expressed sortase A by magnetic particles to develop a robust and recyclable biocatalyst. Sci. Rep. 7, doi: 10.1038/s41598-017-06856-y. (IF: 4.26)
5. Zhao, X., Hong, H., Wu, Z. *, 2017. Efficient extracellular expression of transpeptidase sortase A in Pichia pastoris. Protein Expr. Purif. 133, 132-138. (IF: 1.35)
6. Wu, Z. *, Hong, H., Zhao, X., Wang, X., 2017. Efficient expression of sortase A from Staphylococcus aureus in Escherichia coli and its enzymatic characterizations. Bioresour. Bioprocess. 4, 13.
7. Wu, Z. *, Liu, S., Cheng, X., Zhao, X., Hong, H., 2017. High yield synthesis of cyclic analogues of antibacterial peptides P-113 by Sortase A-mediated ligation and their conformation studies. Chin. Chem. Lett. 28, 553-557. (IF: 1.93)
8. Wu, Z. *, Cheng, X., Hong, H., Zhao, X., Zhou, Z., 2017. New potent and selective alpha v beta(3) integrin ligands: Macrocyclic peptides containing RGD motif synthesized by sortase A-mediated ligation. Biorg. Med. Chem. Lett. 27, 1911-1913. (IF: 2.45)
9. Zhao, X., Zou, H., Chen, J., Du, G., Zhou, J. *. 2016. The modification of Gat1p in nitrogen catabolite repression to enhance non-preferred nitrogen utilization in Saccharomyces cerevisiae. Sci. Rep. 6, doi:10.1038/srep21603. (IF: 5.23)
10. Zhao, X., Zou, H., Du, G., Chen, J., Zhou, J. *. 2015. Effects of nitrogen catabolite repression-related amino acids on the flavour of rice wine. J. I. Brewing 121:581-588. (IF: 1.02)
11. Zhao, X., Zou, H., Fu, J., Zhou, J. *, Du, G. *, Chen, J.. 2014. Metabolic engineering of the regulators in nitrogen catabolite repression to reduce the production of ethyl carbamate in a model rice wine system. Appl. Environ. Microbiol. 80:392-398. (IF: 3.95)
12. Zhao, S., Zhao, X., Zou, H., Fu, J., Du, G. *, Zhou, J. *, Chen, J.. 2014. Comparative proteomic analysis of Saccharomyces cerevisiae under different nitrogen sources. J. Proteomics 101:102-112. (IF: 4.09)
13. Zhao, X., Zou, H., Fu, J., Chen, J., Zhou, J. *, Du, G. *. 2013. Nitrogen regulation involved in the accumulation of urea in Saccharomyces cerevisiae. Yeast 30:437-447. (IF: 1.96)
14. Zhao, X., Du, G. *, Zou, H., Fu, J., Zhou, J.*, Chen, J.. 2013. Progress in preventing the accumulation of ethyl carbamate in alcoholic beverages. Trends Food Sci. Technol. 32:97-107. (IF: 4.14)
15. Lv, Y., Zhao, X., Liu, L., Du, G. *, Zhou, J. *, Chen, J.. 2013. A simple procedure for protein ubiquitination detection in Saccharomyces cerevisiae: Gap1p as an example. J. Microbiol. Meth. 94:25-29. (IF: 2.16)
二、专利情况
1. 吴志猛，赵鑫锐，洪皓飞. 一种高效分泌表达转肽酶Sortase A的方法. 专利申请号：3.4
2. 吴志猛，赵鑫锐，洪皓飞，王珣. 一种利用重组大肠杆菌高效生产转肽酶Sortase A的方法. 专利申请号：2.8
3. 周景文，陈坚，堵国成，吕永坤，赵鑫锐.一种改造调控因子降低酵母尿素积累的方法. 专利申请号：9.1
4. 周景文，陈坚，堵国成，吕永坤，赵鑫锐.一种可降低黄酒发酵中氨基甲酸乙酯积累的方法. 专利申请号：1.4
5. 周景文，陈坚，堵国成，吕永坤，赵鑫锐.一种改造尿素代谢调控途径降低酿酒酵母尿素积累的方法. 专利申请号：6.0
6. 周景文，陈坚，堵国成，吕永坤，赵鑫锐.一种提高酿酒酵母非偏好型氮源利用的方法. 专利申请号：3.5
三、承担教学科研项目情况
1、国家重点研发计划，基于P450 调控的自由基反应催化合成氮、硫杂环分子
2、国家自然科学基金青年项目，酿酒酵母合成人源血红蛋白过程中血红素供给调控机制研究
3、江南大学自主科研计划重点项目，动态调控血红素供给高效合成猪肌红蛋白/血红蛋白关键问题研究
4、其他企业合作项目，主要集中在传统发酵酒类技术改良等方面，如 白酒大曲微生物菌群结构和酶系结构解析、白酒生产中氨基甲酸乙酯、乳酸含量的控制、啤酒生产中乙醛含量的控制等。

以上资料更新时间截止：2020年4月