熊 波 详细介绍
性别 男
职称 教授
最高学历 博士
毕业院校 中国科学院动物研究所
专业领域 动物繁殖学
联系方式 xiongbo@njau.edu.cn
研究方向 哺乳动物卵子成熟、受精及早期胚胎发育的分子基础和环境影响因素
参加学术团体
及任职情况 中国动物学会生殖生物学分会理事；中国动物学会细胞与分子显微技术分会理事;Journal of Animal Science and Biotechnology编委
承担项目 国家自然科学基金优秀青年科学基金项目；国家自然科学基金面上项目；国家重点研发计划生殖重点专项；江苏省自然科学基金青年项目；南京农业大学高层次人才启动经费
奖励及荣誉 中国畜牧兽医学会第二届井冈新秀（2019）；大北农青年****奖（2017）；美国国立卫生研究院Nancy Nossal研究奖（2013）；全国人口和计划生育优秀科技成果一等奖（2011）
论文论著
实验室长期从事哺乳动物卵子质量控制的分子机理研究，为解析卵子质量低下引起人类生育力和家畜繁殖力下降提供了重要的理论依据。主要学术成果包括：1）探明染色体黏合蛋白调控卵子成熟和染色体倍性的分子网络和信号通路；2）揭示受精的生物学基础和调控机制；3）解析卵子成熟与受精的环境影响因素。在Science Advances, Current Biology,Cell Reports, Nucleic Acids Research,PLoS Genetics 等国际权威学术期刊发表SCI论文70余篇，总引用超1800次。
人才培养方面，指导本科毕业实习18人，获得江苏省普通高校本科优秀毕业设计论文二等奖、校级优秀毕业论文特等奖（2人次）。指导本实验室研究生获得‘第一届大北农杯全国农林院校研究生学术科技作品竞赛’特等奖、‘第二届大北农杯全国农林院校研究生学术科技作品竞赛’一等奖，2020年南京农业大学研究生学术科技作品竞赛一等奖，南京农业大学瑞华杯最具影响力学生3人次，获得校优秀博士毕业论文1人次，国家奖学金2人次，校长奖学金5人次，学业一等奖学金31人次，以及各类企业奖学金。研究生每年参加国内外学术会议，做口头报告或墙报。本实验室完成毕设的本科生大多保研和出国深造，已毕业的4名博士生均获得优秀毕业生称号并在高校任职副教授（2人）和讲师（2人）。
欢迎热爱科研，有学术追求的同学报考本实验室研究生！


代表作
1.Zhou C, Miao Y, Cui Z, ShiYang X, Zhang Y,Xiong B*. The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.Sci Adv.2020 Apr 8;6(15):eaax3969.

2. Lu Y, Li S, Cui Z, Dai X, Zhang M, Miao Y, Zhou C, Ou X,Xiong B*. The cohesion establishment factor Esco1 acetylates α-tubulin to ensure proper spindle assembly in oocyte meiosis.Nucleic Acids Res.2018 Mar 16;46(5):2335-2346.

3. Lu Y, Dai X, Zhang M, Miao Y, Zhou C, Cui Z,Xiong B*. Cohesin acetyltransferase Esco2 regulates SAC and kinetochore functions via maintaining H4K16 acetylation during mouse oocyte meiosis.Nucleic Acids Res. 2017 Sep 19;45(16):9388-9397.

4. Miao Y, Cui Z, Gao Q, Rui R,Xiong B*. Nicotinamide mononucleotide supplementation reverses the declining quality of maternally aged oocytes.Cell Rep. 2020 Aug 4;32(5):107987.
5.Xiong B*, Zhao Y, Beall S, Sadusky AB, Dean J*. A Unique Egg Cortical Granule Localization Motif Is Required for Ovastacin Sequestration to Prevent Premature ZP2 Cleavage and Ensure Female Fertility in Mice.PLoS Genet. 2017 Jan 23;13(1):e**.


发表论文
1. Miao Y, Cui Z, Gao Q, Rui R, Xiong B*. Nicotinamide mononucleotide supplementation reverses the declining quality of maternally aged oocytes.Cell Rep. 2020 Aug 4;32(5):107987. (IF=8.8)
2.Zhou C, Miao Y, Cui Z, ShiYang X, Zhang Y,Xiong B*. The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.Sci Adv.2020 Apr 8;6(15):eaax3969.(IF=14.1)

3.ShiYang X, Miao Y, Cui Z, Lu Y, Zhou C, Zhang Y, Xiong B*. Casein kinase 2 modulates the spindle assembly checkpoint to orchestrate porcine oocyte meiotic progression. J Anim Sci Biotechnol. 2020 Apr 8;11:31.
4.Dai X, Qiu L, Zhao B, Gao Y, Mu Y, Chu Z, Du L, Xiong B*. Melatonin ameliorates the fertilization capacity of oocytes exposed to 17α-ethynylestradiol. Reprod Toxicol. 2020 Apr;93:61-67.
5. Zhang M^?, Lu Y^?, Chen Y^?, Zhang Y, XiongB*. Insufficiency of melatonin in follicular fluid is a reversible causefor advanced maternal age-related aneuploidy in oocytes. Redox Biol.2020 Jan;28:101327.(IF=9.9)
6.Zhang Y^?, Tan R^?, Wang L, Shi X, Li Y, Zhong X, He X, Xiong B*. Shoutai pills improve the quality of oocytes exposed to the chemotherapeutic drug Hydroxyurea. Aging (Albany NY). 2020 May 10;12.
7. Zhou C, Zhang X, Chen Y, Liu X, Sun Y, Xiong B*. Glutathionealleviates the cadmium exposure-caused porcine oocyte meiotic defects viaeliminating the excessive ROS. Environ Pollut. 2019 Sep 7;255(Pt1):113194.(IF=6.2)
8. Zhang M^?, ShiYang X^?, Zhang Y, Miao Y, Chen Y,Cui Z, Xiong B*. Coenzyme Q10 ameliorates the quality of postovulatoryaged oocytes by suppressing DNA damage and apoptosis. Free Radic Biol Med.2019 Nov 1;143:84-94.(IF=6.4)
9. Zhou C, Zhang X, Zhang Y, ShiYang X, Li Y, Shi X, Xiong B*.Vitamin C protects carboplatin-exposed oocytes from meiotic failure. Mol HumReprod. 2019 Oct 28;25(10):601-613.(IF=3.4)
10. Lu Y, Chen Y, Cui Z, Xiong B*. Distinct roles of cohesinacetyltransferases Esco1 and Esco2 in porcine oocyte meiosis I. Cell Cycle.2019 Oct;18(19):2481-2494.(IF=3.25)
11. Zhou C, Zhang X, ShiYang X, Wang H, Xiong B*. Tea polyphenolprotects against cisplatin-induced meiotic defects in porcine oocytes. Aging (Albany NY). 2019 Jul 13;11(13):4706-4719.(IF=5.5)
12. Miao Y^?, Wang P^?, Xie B^?, Yang M, LiS, Cui Z, Fan Y*, Li M*, Xiong B*. BRCA2 deficiency is apotential driver for human primary ovarian insufficiency. Cell Death Dis.2019 Jun 17;10(7):474.(IF=6.2)
13. Zhang Y, ShiYang X, Zhang Y, Li Y, Shi X, Xiong B*. Exposure toaristolochic acid I compromises the maturational competency of porcine oocytesvia oxidative stress-induced DNA damage. Aging (Albany NY). 2019 Apr19;11(8):2241-2252.(IF=5.5)
14. Cui Z, Yu L, Shi Yang X, Zhang Y, Shi X, Li Y, Chen Q*, Xiong B*.Brefeldin A impairs porcine oocyte meiotic maturation via interruption oforganelle dynamics. J Cell Physiol. 2019 Apr 4. doi: 10.1002/jcp.28611. (IF=4.5)
15. Li X, Gao M, He Y, Xiong B, Liu H, Gu L*. Intersectin-Cdc42interaction is required for orderly meiosis in porcine oocytes. J CellPhysiol. 2019 May;234(5):7492-7497.(IF=4.5)
16. Gu L, Li X, Liu X, Gao M, He Y, Xiong B, Liu H*. HDAC3inhibition disrupts the assembly of meiotic apparatus during porcine oocytematuration. J Cell Physiol. 2019 Jul;234(7):10178-10183.(IF=4.5)
17. Xie Y, Cheng M, Lu S, Yuan Q, Yang D, Chen Y, Pan C, Qiu Y*, XiongB*. Eg5 orchestrates porcine oocyte maturational progression by maintainingmeiotic organelle arrangement. Cell Div. 2018 May 24;13:4.(IF=4.05)
18. Lu Y, Li S, Cui Z, Dai X, Zhang M, Miao Y, Zhou C, Ou X, Xiong B*. The cohesion establishment factor Esco1 acetylates α-tubulin to ensure proper spindle assembly in oocyte meiosis. Nucleic Acids Res.2018 Mar 16;46(5):2335-2346.(IF=11.6)
19. Miao Y, Zhou C, Cui Z, Zhang M, ShiYang X, Lu Y, Xiong B*. Postovulatory aging causes the deterioration of porcine oocytes via induction of oxidative stress. FASEB J. 2018 Mar;32(3):1328-1337. (IF=5.498)
20. Miao Y, Zhou C, Bai Q, Cui Z, ShiYang X, Lu Y, Zhang M, Dai X, Xiong B*. The protective role of melatonin in porcine oocyte meiotic failure caused by the exposure to benzo(a)pyrene. Hum Reprod. 2018 Jan 1;33(1):116-127. (IF=5.5)
21. Miao Y^?, Zhou C^?, Cui Z^?, Tang L, ShiYang X, Lu Y, Zhang M, Dai X, Xiong B*. Dynein promotes porcine oocyte meiotic progression by maintaining cytoskeletal structures and cortical granule arrangement. Cell Cycle. 2017 Sep 21:1-7. (IF=3.53)
22. Zhang M, Miao Y, Chen Q, Cai M, Dong W, Dai X, Lu Y, Zhou C, Cui Z, Xiong B*. BaP exposure causes oocyte meiotic arrest and fertilization failure to weaken female fertility. FASEB J. 2017 Sep 13. (IF=5.498)
23. Lu Y, Dai X, Zhang M, Miao Y, Zhou C, Cui Z, Xiong B*. Cohesin acetyltransferase Esco2 regulates SAC and kinetochore functions via maintaining H4K16 acetylation during mouse oocyte meiosis. Nucleic Acids Res. 2017 Sep 19;45(16):9388-9397. (IF=11.6)
24. Zhang K^?,Lu Y^?, Jiang C^?, Liu W^?, Shu J, Chen X, Shi Y,Wang E, Wang L, Hu Q, Dai Y, Xiong B*.HDAC8 functions in spindle assembly during mouse oocyte meiosis. Oncotarget. 2017 Mar 21;8(12):20092-20102. (IF=5.168)
25. Zhang M, DaiX, Lu Y, Miao Y, Zhou C, Cui Z, Liu H, XiongB*. Melatonin protects oocyte quality from Bisphenol A-induceddeterioration in the mouse. J Pineal Res. 2017 Apr;62(3). (IF=15.2)
26. Dai X, Lu Y,Zhang M, Miao Y, Zhou C, Cui Z, Xiong B*.Melatonin improves the fertilization ability of post-ovulatory aged mouseoocytes by stabilizing ovastacin and Juno to promote sperm binding and fusion. Hum Reprod. 2017 Mar 1;32(3):598-606. (IF=5.5)
27. Miao Y, ZhouC, Cui Z, Dai X, Zhang M, Lu Y, Xiong B*.Smc1β is required for activation of SAC during mouse oocyte meiosis. Cell Cycle. 2017 Mar 19;16(6):536-544. (IF=3.53)
28. Xiong B*, Zhao Y, Beall S, Sadusky AB,Dean J*. A Unique Egg Cortical Granule Localization Motif Is Required forOvastacin Sequestration to Prevent Premature ZP2 Cleavage and Ensure FemaleFertility in Mice. PLoS Genet. 2017Jan 23;13(1):e**. (IF=7.48, co-corresponding author)
29. Zhang M, DaiX, Sun Y, Lu Y, Zhou C, Miao Y, Wang Y, XiongB*. Stag3 regulates microtubule stability to maintain euploidy during mouseoocyte meiotic maturation. Oncotarget.2017 Jan 3;8(1):1593-1602. (IF=5.168)
30. Dai X, ZhangM, Lu Y, Miao Y, Zhou C, Xiong B*.Cullin9 protects mouse eggs from aneuploidy by controlling microtubule dynamicsvia Survivin. BBA-Mol Cell Res. 2016Dec;1863(12): 2934-2941. (IF=5.26)
31. Dai X^?,Xiong H^?, Zhang M^?, Sun S, Xiong B*. Zfp207 is a Bub3 binding protein regulating meioticchromosome alignment in mouse oocytes. Oncotarget.2016 May 11; 7(21):30155-65.(IF=5.168)
32. Dai X, Zhang M, Lu Y, Miao Y, Zhou C, Sun S,Xiong B*. Melamine Impairs Female Fertility via Suppressing Protein Level of Juno in Mouse Eggs.PLoS One. 2015 Dec 3;10(12):e**.
33.Li X, Liu X, Gao M, Han L, Qiu D, Wang H, Xiong B, Sun SC, Liu H, Gu L*.HDAC3 promotes meiotic apparatus assembly in mouse oocytes by modulating tubulin acetylation. Development. 2017 Oct 15;144(20):3789-3797.(IF=6.06)
34. Zhang Y, Wang QC, Liu J, Xiong B, Cui XS, Kim NH, Sun SC. The small GTPase CDC42 regulates actin dynamics during porcine oocyte maturation. J Reprod Dev. 2017 Oct 18;63(5):505-510.
35. Pan MH, Wang F, Lu Y, Tang F, Duan X, Zhang Y, Xiong B, Sun SC*. FHOD1 regulates cytoplasmic actin-based spindle migration for mouse oocyte asymmetric cell division. J Cell Physiol. 2017 Jul 14. [Epub ahead of print]. (IF=4.08)
36. Zhou L, Baibakov B, Canagarajah B,Xiong B,Dean J*. Genetic mosaics and time-lapse imaging identify functions of histone H3.3 residues in mouse oocytes and embryos.Development.2017 Feb 1;144(3):519-528.(IF=6.06)
37. Liu X, Li X, Ma R,Xiong B, Sun SC, Liu H, Gu L*. Tristetraprolin functions in cytoskeletal organization during mouse oocyte maturation.Oncotarget. 2016 Aug 16;7(33):53330-53338.
38. Wang T, HanJ, Duan X, Xiong B, Cui XS, Kim NH,Liu HL, Sun SC*. The toxic effects and possible mechanisms of Bisphenol A onoocyte maturation of porcine in vitro. Oncotarget.2016 May 31;7(22):32554-65. 39. Duan X, LiuJ, Zhu CC, Wang QC, Cui XS, Kim NH, XiongB, Sun SC*. RhoA-mediated MLC2 regulates actin dynamics for cytokinesis inmeiosis. Cell Cycle. 2016;15(3):471-7.
40. Dai XX, DuanX, Cui XS, Kim NH, Xiong B, Sun SC*. Melamine Induces Oxidative Stress in Mouse Ovary. PLoS One. 2015 Nov 6;10(11):e**.
41. Wang F,Zhang L, Duan X, Zhang GL, Wang ZB, Wang Q, Xiong B, Sun SC*. RhoA-mediatedFMNL1 regulates GM130 for actin assembly and phosphorylates MAPK for spindleformation in mouse oocyte meiosis. CellCycle. 2015; 14(17):2835-43.
42. Liu J, WangQC, Han J, Xiong B, Sun SC*. Aflatoxin B1 is toxic to porcine oocytematuration. Mutagenesis. 2015Jul;30(4):527-35.
43. Wang QC, LiuJ, Duan X, Cui XS, Kim NH, Xiong B,Sun SC*. The Dynamin 2 inhibitor Dynasoreaffects the actin filament distribution during mouse early embryo development. J Reprod Dev. 2015 Feb 24;61(1):49-53.

2015年前：
1. Lu S, Lee KK,Harris B, Xiong B, Bose T, Saraf A,Hattem G, Florens L, Seidel C, Gerton JL*.Thecohesin acetyltransferase Eco1 coordinates rDNA replication and transcription. EMBO Rep. 2014 May;15(5):609-17.
2. Zhang Y, DuanX, Xiong B, Cui XS, Kim NH, Rui R,Sun SC*. ROCK inhibitor Y-27632 preventsporcine oocyte maturation. Theriogenology.2014 Jul 1; 82(1):49-56.
3. Hou YJ, Xiong B, Zheng WJ, Duan X, Cui XS, KimNH, Wang Q, Xu YX, Sun SC*. Oocyte quality inmice is affected by a mycotoxin-contaminated diet. Environ Mol Mutagen. 2014 May;55(4):354-62.
4. Hou YJ, ZhaoYY, Xiong B, Cui XS, Kim NH, Xu YX,Sun SC*. Mycotoxin-containing diet causesoxidative stress in the mouse. PLoS One.2013;8(3) : e60374.
5. Avella MA*, Xiong B,Dean J. The molecular basis of gamete recognition in mice and humans. Mol Hum Reprod. 2013 May;19(5):279-89.
6. Burkart A, Xiong B, Baibakov B, Jimenez-Movilla M,Dean J*. Ovastacin, a cortical granulemetalloendoprotease, cleaves ZP2 in the zona pellucida to prevent polyspermy. J Cell Biol. 2012 Apr 2;197(1): 37-44.
7. Xiong B*.Spc25- How kinetochore protein plays during oocyte meiosis. Cell Cycle. 2011 Apr 1; 10(7): 1028-9.
8. Xiong B, Lu S, Gerton JL*. Hos1 Is a Lysine Deacetylase for the Smc3 Subunitof Cohesin. Curr Biol. 2010 Sep 28;20(18): 1660-5.
9. Xiong B*, Gerton JL*. Regulators of the cohesin network. Annu Rev Biochem. 2010; 79: 131-53.(Co-corresponding author)
10. Lu S,Goering M, Gard S, Xiong B, McNairnAJ, Jaspersen SL, Gerton JL*. Eco1 isimportant for DNA damage repair in S. cerevisiae. Cell Cycle. 2010 Aug 15; 9(16): 3315-27.
11. Gard S,Light W, Xiong B, Bose T, McNairnAJ, Harris B, Fleharty B, Seidel C, Brickner J, Gerton JL*. Cohesinopathy mutations disrupt the subnuclearorganization of chromatin. J Cell Biol.2009 Nov 16; 187(4): 455-62.
12. Li S, Ou XH,Wang ZB, Xiong B, Tong JS, Wei L, LiM, Yuan J, Ouyang YC, Hou Y, Schatten H, Sun QY*.ERK3 is required for metaphase-anaphase transition in mouse oocyte meiosis. PLoS One. 2010 Sep 29; 5(9).
13. Yuan J, LiM, Wei L, Yin S, Xiong B, Li S, LinSL, Schatten H, Sun QY*. Astrin regulatesmeiotic spindle organization, spindle pole tethering and cell cycle progressionin mouse oocytes. Cell Cycle. 2009Oct 15; 8(20): 3384-95.
14. Xu BZ, Li M, Xiong B, Lin SL, Zhu JQ, Hou Y, ChenDY, Sun QY*. Involvement of Calcium/CalmodulinDependent Protein Kinase Kinase in Meiotic Maturation of Pig Oocytes. Anim Reprod Sci. 2009 Mar; 111(1):17-30.
15. Xiong B, Li S, Ai JS, Yin S, OuYang YC,Sun SC, Chen DY, Sun QY*. BRCA1 is requiredfor meiotic spindle assembly and spindle assembly checkpoint activation inmouse oocytes. Biol Reprod. 2008Oct; 79(4): 718-26.
16. Xiong B, Sun SC, Li M, Xu BZ, Lin SL,OuYang YC, Hou Y, Chen DY, Sun QY*.Involvement of Polo-like kinase 1 in MEK1/2-regulated spindle assembly duringmouse oocyte meiosis. Cell Cycle.2008 Jun 15; 7(12): 1804-9.
17. Xiong B, Yu LZ, Wang Q, Ai JS, Yin S,Liu JH, OuYang YC, Hou Y, Chen DY, Zou H, Sun QY*.Regulation of intracellular MEK1/2 translocation in mouse oocytes: cytoplasmicdynein/dynactin-mediated poleward transport and cyclin B degradation-dependentrelease from spindle poles. Cell Cycle.2007 Jun 15; 6(12): 1521-7. (Cover paper)
18. Yu LZ^?, Xiong B^?, Gao WX, WangCM, Zhong ZS, Huo LJ, Wang Q, Hou Y, Liu K, Liu J, Schatten H, Chen DY, Sun QY*. MEK1/2 regulates microtubule organization,spindle pole tethering and asymmetric division during mouse oocyte meioticmaturation. Cell Cycle. 2007 Feb 1;6(3): 330-8. (Co-first author)
19. Li M, Ai JS,Xu BZ, Xiong B, Yin S, Lin SL, HouY, Chen DY, Schatten H, Sun QY*. TestosteronePotentially Triggers Meiotic Resumption by Activation of Intra-Oocyte SRC andMAPK in Porcine Oocytes. Biol Reprod.2008 Nov; 79(5): 897-905.
20. Sun SC, Xiong B, Lu SS, Sun QY*. MEK1/2 is a critical regulator of microtubule assemblyand spindle organization during rat oocyte meiotic maturation. Mol Reprod Dev. 2008 Oct; 75(10):1542-8.
21. Ai JS, WangQ, Li M, Shi LH, Ola SI, Xiong B,Yin S, Chen DY, Sun QY*. Roles of Microtubulesand Microfilaments in Spindle Movements During Rat Oocyte Meiosis. J Reprod Dev. 2008 Oct; 54(5): 391-6.
22. Ai JS, WangQ, Yin S, Shi LH, Xiong B, OuYangYC, Hou Y, Chen DY, Schatten H, Sun QY*.Regulation of peripheral spindle movement and spindle rotation during mouseoocyte meiosis: new perspectives. MicroscMicroanal. 2008 Aug; 14(4): 349-56.
23. Li M, LiangCG, Xiong B, Xu BZ, Lin SL, Hou Y,Chen DY, Schatten H, Sun QY*. PI3-kinase andmitogen-activated protein kinase in cumulus cells mediate EGF-induced meioticresumption of porcine oocyte. DomestAnim Endocrinol. 2008 May; 34(4): 360-71.
24. Liu JH, YinS, Xiong B, Hou Y, Chen DY, Sun QY*. Aberrant DNA methylation imprints in abortedbovine clones. Mol Reprod Dev. 2008Apr; 75(4): 598-607.
25. Yin S, LiuJH, Ai JS, Xiong B, Wang Q, Hou Y,Chen DY, Sun QY*. Cdc20 is required for theanaphase onset of the first meiosis but not the second meiosis in mouseoocytes. Cell Cycle. 2007 Dec 1;6(23): 2990-2.
26. Tang LS,Wang Q, Xiong B, Hou Y, Zhang YZ,Sun QY, Wang SY*. Dynamic changes in histoneacetylation during sheep oocyte maturation. J Reprod Dev. 2007 Jun; 53(3): 555-61.
27. Wang Q, WangCM, Ai JS, Xiong B, Yin S, Hou Y,Chen DY, Schatten H, Sun QY*. Histonephosphorylation and pericentromeric histone modifications in oocyte meiosis. Cell Cycle. 2006 Sep; 5(17): 1974-82.