张立凡 详细介绍
性别 男
职称 副教授
最高学历 博士
毕业院校 中国农业大学
专业领域 动物遗传育种与繁殖
联系方式 lifanzhang@njau.edu.cn
研究方向 动物功能基因组学与分子育种
参加学术团体
及任职情况 中国畜牧兽医学会动物遗传育种学分会会员；中国农业生物技术学会动物生物技术分会会员；中国马业协会会员
承担项目 国家支撑计划子任务1项（主持）；中央高校基本科研业务费自主创新重点项目1项（主持）；国家自然科学基金青年基金项目1项（主持）
奖励及荣誉 2013年南京农业大学“钟山****”学术新秀；2011-2013年美国华盛顿州立大学访问助理科学家
论文论著
LiZ, Wei S, Li H, Wu K, Cai Z, Li D, Wei W, Li Q, Chen J, Liu H, Zhang L*. Genome-wide genetic structureand differentially selected regions among Landrace, Erhualian, and Meishan pigsusing specific-locus amplified fragment sequencing. Scientific Reports, 2017, 7(1):10063.

ChuW, Wei W, Han H, Gao Y, Liu K, Tian Y, Jiang Z, Zhang L, Chen J*. Muscle-specific downregulation of GR levelsinhibits adipogenesis in porcine intramuscular adipocyte tissue. ScientificReports. 2017, 7(1):510.

Zhang L*, Cai Y, Wei S, Ling Y, ZhuL, Li D, Cai Z*.Testosterone deficiencyinduces changes of the transcriptomes of visceral adipose tissue in miniature pigsfed a high-fat and high-cholesterol diet. International Journal of MolecularSciences. 2016, 17, 2125.

DuX, Zhang L, Li X, Pan Z, Liu H, Li Q.TGF-β signaling controls FSHR signaling-reduced ovarian granulosa cellapoptosis through the SMAD4/miR-143 axis. Cell Death Dis. 2016, 7(11):e2476.

Zhang L, Du X, Wei S, Li D, Li Q. Acomprehensive transcriptomic view on the role of SMAD4 gene by RNAi-mediatedknockdown in porcine follicular granulosa cells. Reproduction. 2016, 152(1):81-9.

WeiS, Du M, Jiang Z, Hausman GJ, Zhang L*, Dodson MV*. Long noncoding RNAs inregulating adipogenesis: new RNAs shed lights on obesity. Cellular andMolecular Life Sciences. 2016, 73(10): 2079-2087. doi:10.1007/s00018-016-2169-2. (Co-corresponding author)

ChuW, Wei W, Yu S, Han H, Shi X, Sun W, Gao Y, Zhang L, Chen J. C2C12 myotubes inhibit the proliferation anddifferentiation of 3T3-L1 preadipocytes by reducing the expression ofglucocorticoid receptor gene. Biochem Biophys Res Commun. 2016, 472(1): 68-74.

YuS, Chu W, Zhang L, Han H, Zhao R, WuW, Zhu J, Dodson MV, Wei W, Liu H, Chen J*. Identification of laying-relatedSNP markers in geese using RAD sequencing. PLoS One. 2015, 10(7): e**.

CaiZ, Jiang X, Pan Y, Chen L, Zhang L,Zhu K, Cai Y, Ling Y, Chen F, Xu X, Chen M*. Transcriptomic analysis of hepaticresponses to testosterone deficiency in miniature pigs fed a high-cholesteroldiet. BMC Genomics. 2015, 16(1): 1283.

CaiZ, Zhang L, Jiang X, Sheng Y, Xu N*.Differential miRNA expression profiles in the longissimus dorsi muscle betweenintact and castrated male pigs. Research in Veterinary Science. 2015, 99: 99-104.

Zhang L,Zhou X, Michal JJ, Ding B,Li R, Jiang Z*. Genome wide screening of candidate genes for improving pigletbirth weight using high and low estimated breeding value populations.International Journal of Biological Sciences. 2014, 10(3): 236-44.

Cai Z, Zhang L,Chen M, Jiang X, Xu N*. Castration-induced changes in microRNA expression profiles in subcutaneous adipose tissue of male pigs. Journal of Applied Genetics. 2014, 55(2): 259-66. (Co-first author)

Zhang L, Cai Z, Wei S, Zhou H, Zhou H, Jiang X, Xu N*. MicroRNA expression profiling of the porcine developing hypothalamus and pituitary tissue. International Journal of Molecular Sciences. 2013, 14(10): 20326-20339.

Wei S,Zhang L, Zhou X, Du M, Jiang Z, Hausman GJ, Bergen WG, Zan L*, Dodson MV*. Emerging roles of zinc finger proteins in regulating adipogenesis. Cellular and Molecular Life Sciences. 2013, 70(23): 4569-4584. (Co-first author)

Zhang L, Mousel MR, Wu X, Michal JJ, Zhou X, Ding B, Dodson MV, EI-Halawany N, Lewis GS, Jiang Z*. Genome-wide genetic diversity and differentially selected regions among Suffolk, Rambouillet, Columbia, Polypay, and Targhee Sheep. PLoS ONE. 2013, 8(6):e65942.

Zhang L, Michal JJ, O'Fallon JV, Pan Z, Gaskins CT, Reeves JJ, Busboom JR, Zhou X, Ding B, Dodson MV, Jiang Z*. Quantitative genomics of 30 complex phenotypes in Wagyu x Angus F1 progeny. International Journal of Biological Sciences, 2012; 8(6): 838-858.

Zhang LF, Jiang XL, Hua XC, Lu YP, Xu NY*. Molecular cloning, expression, and polymorphism of the porcine apolipoprotein A5 gene in a Jinhua × Pietrain F2reference population. Animal, 2010, 4: 523-529.

Zhang LF, Liu C, Bao HG, Zhao CJ, Lian LS, Xu NY, Wu Ch*. Hypoxic adaptation and myoglobin expression in heart tissue of Tibet chicken embryo. Journal of Animal and Veterinary Advances, 2010, 9(3): 529-534.

Zhang LF, Miao XT, Hua XC, Jiang XL, Lu YP, Xu NY*. Polymorphisms in 5' regulatory region of the porcine fat mass and obesity associated (FTO) gene is associated with intramuscular fat content in a Jinhua × Pietrain F2 reference population. Journal of Animal and Veterinary Advances, 2009, 8: 2329-2334.

Zhang LF, Lian LS, Zhao CJ, Li JY, Bao HG, Wu Ch*. Expression pattern of HIF1α mRNA in brain, heart and liver tissues of Tibet chicken embryo upon hypoxia by quantitative real-time PCR, 2007, Animal, 10(1): 1467-1471.

Zhang LF, Liu C, Lian LS, Zhao CJ, Bao HG,Wu Ch*. Neuroglobin mutation associated with hypoxia adaptation in Tibet chicken, 2007,Progress in Natural Science, 17(12): 1419-1424.

Liu C,Zhang LF, Li N*. The specific expression pattern of globin mRNAs in Tibetan chicken during late embryonic stage under hypoxia. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 2013, 164(4): 638-644.

Jiang XL,Zhang LF, Xu NY*, Zhai JP, Lv ZZ. Polymorphism of the porcine CGA gene and its association with growth and carcass traits. South African Journal for Animal Science, 2011, 41(3): 232-242.

Liu C, Zhang LF, Song ML, Bao HG, Zhao CJ, Li N*. Highly efficient dissociation of oxygen from hemoglobin in Tibetan chicken embryos compared with lowland chicken embryos incubated in hypoxia. Poultry Science, 2009, 88: 2689-2694.

Zhou X, Michal JJ, Zhang LF, Ding B, Lunney JK, Liu B, Jiang Z*. Interferon induced IFIT family genes in host antiviral defense. International Journal of Biological Sciences. 2013, 9(2): 200-208.

Cai ZW, Sheng YF, Zhang LF, Wang Y, Jiang XL, Lv ZZ and Xu NY*. Mapping, expression and regulation of the TRα gene in porcine adipose tissue. Genetics and Molecular Research, 2011, 10(3): 1320-1330.

Yao YC, Cai ZW, Zhang LF, Zhao CJ, Wu KL, Xu NY, Liu G, Wu Ch*. Effects of castration on androgen receptor, IGF-1a, MGF and Myostatin gene expression in skeletal muscles of male pigs. Asian-Australasian Journal of Animal Sciences, 2009, 22(8): 1069.

Bao HG, Zhao CJ, Zhang LF, Li JY, Wu CX*. Single-nucleotide polymorphisms of mitochondrially coded subunit genes of cytochrome c oxidase in five chicken breeds. Mitochondrial DNA, 2008, 19(5): 461-464.

Jiang XL, Wang Y, Chen Z, Cai ZW, Zhang LF, Zhou HM, Xu NY*. Polymorphisms in porcine TRH and TRHR gene and associations with growth and fatness traits. Livestock Science, 2012, 144: 67-73.

Jiang XL, Cai ZW, Zhao XF, Zhang LF, Chen Z, Wang Y, Guo XL and Xu NY*. Mapping, cDNA cloning and tissue expression of the porcine thyotropin-releasing hormone receptor gene. Animal Biotechnology, 2011, 22 (7): 30-36.

Cai ZW, Zhao XF, Yao YC, Jiang XL, Zhang LF, Xu NY and Wu CX*. Castration modulates leptin and its receptor in the hypothalamus from male pigs. Journal of Animal and Veterinary Advances, 2010, 9 (12): 1696-1701.

Jiang Z*, Zhou X, Michal JJ, Wu XL, Zhang LF, Zhang M, Ding B, Liu B, "Mano" Manoranjan VS, Neill JD, Harhay GP, Kehrli Jr. ME, Miller LC. 2013. Reactomes of porcine alveolar macrophages infected with porcine reproductive and respiratory syndrome virus. PLoS ONE, 8(3): e59229.