申明 详细介绍
性别 男
职称 副教授
最高学历 博士
毕业院校 南京农业大学
专业领域 动物遗传育种与繁殖
联系方式 Email: shenm2015@njau.edu.cn 逸夫楼2051
研究方向 哺乳动物卵泡发育的分子调控机制
参加学术团体
及任职情况 申明，男，浙江金华人。担任Journal of Pineal Research、Autophagy、Comprehensive Reviews in Food Science and Food Safety、Clinical and Translational Medicine、Frontiers in Cell and Developmental Biology、GENE、BMC Genetics、Animal Science Joural、Reproductive Science、International Journal of Radiation Biology、La Prensa Medica等国际期刊审稿人；受邀担任Frontiers in Cell and Developmental Biology杂志客座主编；英国生殖学会（SRF）会员；美国内分泌学会（Endocrine Society）会员；中国畜牧兽医学会动物繁殖学分会、动物遗传育种学分会、畜禽遗传标记学分会会员；国家自然科学基金项目评审专家
承担项目 1.国家自然科学基金面上项目，**，低氧在启动猪有腔卵泡闭锁过程中对颗粒细胞周期/凋亡的影响及其机制研究，2020.1-2023.12，57万，主持，在研；2.国家自然科学基金青年基金，**，FSH抑制氧化损伤猪卵巢颗粒细胞自噬的机制研究，2017.1-2019.12，20万，主持，在研；3.江苏省自然科学基金青年基金，BK**，线粒体自噬在FSH抑制卵巢颗粒细胞氧化损伤中的作用机制研究，2015.7-2018.6，20万，主持，已结题；4.中国博士后科学基金特别资助，2016T90476，FSH通过自噬调控小鼠颗粒细胞氧化损伤的机制研究，2016.7-2018.7，15万，主持，已结题；5.中国博士后基金面上项目，2015M581818，Foxo1对氧化应激诱导猪颗粒细胞自噬和凋亡的调控研究，2015.12-2017.12，5万，主持，已结题；6.江苏省博士后科研资助计划资助项目，**A，FSH介导的保护性自噬对氧化应激引起的小鼠卵巢颗粒细胞凋亡的调控机制研究，2015.7-2017.7，6万，主持，已结题；7.中央高校基本业务费，KJQN201705，FSH抑制氧化损伤猪卵巢颗粒细胞的自噬机制研究，2017.1-2019.12，10万，主持，在研；8.江苏省普通高校研究生科研创新基金（省立省助），CXZZ13_0306，Foxo1在小鼠卵泡闭锁中的作用机制研究，2013.5-2014.5，3万，主持，已结题；9.南京农业大学动物科技学院“青年拔尖人才”项目，DKQB201903，G0期颗粒细胞对低氧损伤抗性的机制研究，2019.4-2020.4，20万，主持，在研;10.国家自然科学基金面上项目，**，Ufm1泛素化样修饰系统E3连接酶--Ufl1缺失调控动物肝脏发育和原发性肝纤维化发生的分子机制，2020.1-2023.12，59万，参与，在研
奖励及荣誉 1.高等学校科学研究优秀成果二等奖，教育部，2019.1.15；2.第一届江苏省畜牧兽医研究生论坛优秀墙报一等奖、二等奖各一项（通讯作者），江苏省畜牧兽医学会，2019.9.21；3.第十九次全国动物遗传育种学术讨论会优秀墙报奖（通讯作者），中国畜牧兽医学会，2017.10.16；4.第二十次全国动物遗传育种学术讨论会优秀墙报奖（通讯作者），中国畜牧兽医学会，2019.12.8；5.南京市第十一届自然科学优秀学术论文奖，南京市科协，2015.11.4; 6.动物科技学院2019年度“新希望六和”奖教金；7.被International Conference on Women’s health, Gynecology and Obstetrics 2018、Obstetrics and Gynecology Conference 2019、Chemistry Frontiers 2019、International Conference on Animal Science & Veterinary Medicine (ICASVM -2020)、 BIT's 6th Annual World Congress of Animal Biotech (WCANB-2020)、World Congress of Women Health-2020 (WCWH-2020)、International Conference on Reproductive Health, Infertility and IVF 2020、中国畜牧兽医学会第四届“青年拔尖人才”学术论坛、江苏省细胞与发育生物学学会生殖专业委员会会议等国内、外学术会议邀请为speaker；8. 受Autophagy杂志主编、自噬领域权威专家Klionsky教授邀请参与自噬行业标准Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th edition)的编写（2021年）; 9.研究成果入选Reproduction杂志2019年度高被引论文。
论文论著
本人主要从事哺乳动物卵泡发育的分子调控机理研究。研究侧重点包括：1. 引起卵泡氧化损伤的信号通路与效应分子；2. 卵泡液因子对卵泡氧化损伤的调控机制；3. 抗氧化剂对动物繁殖性能的改善；4.卵泡低氧环境对卵泡发育的影响及机制；5.卵泡发育过程中卵母细胞与颗粒细胞互作机制；6.卵泡微环境影响卵泡发育的表观遗传机理。在973 课题、国家自然科学基金、江苏省自然科学基金等项目支持下，已在Autophagy（IF5=11.958）、Development（IF5=6.3）、Redox biology（IF5=9.038）、Journal of Biological Chemistry（IF5=5.498）、Cell Death & disease（IF5=6.187）、Faseb Journal （IF5=5.421）、Scientific Reports（IF5=5.525）、ENDOCRINOLOGY（IF5=4.130）、Biology of Reproduction（IF5=3.332）、Reproduction（IF5=3.5）、Theriogenology（IF5=2.316）等领域前20%或影响因子>5 的刊物发表第一/通讯作者论文多篇。研究工作得到国内外同行的肯定，已被多本英文著作如Endocrine Cells: Advances in Research and Application（第21-22 页，2013 年出版，出版社Scholarly EditionsTM）、World Clinics: Dermatology-Acne（第72 页，2013 年出版，出版社Jaypee Brothers Medical Pub）、International Review of Cell and Molecular Biology（第33 页，2018 年出版，出版社Academic Press）、IntechOpen Book Series Physiology, Volume 2: Endoplasmic Reticulum（第80-81页，2019 年出版，出版社IntechOpen）收录并介绍。相关研究成果对于认清卵泡发育/闭锁转换规律、丰富和完善繁殖学理论、提高动物繁殖性能以及治疗人类排卵障碍相关疾病都具有重要意义。
一、近5年内发表的3篇代表性论著
(1) Chengyu Li, Xueqin Meng, Shuo Liu, Weijian Li, Xue Zhang, Jilong Zhou, Wang Yao, Chao Dong, Zhaojun Liu, Jiaqi Zhou, Juan Li, Jingli Tao, Wangjun Wu, Ming Shen, Honglin Liu. (2020) Oocytes and hypoxanthine orchestrate the G2-M switch mechanism in ovarian granulosa cells, Development, accept,通讯作者, IF5=6.3
(2) Shen M; Cao Y; Jiang Y; Wei Y; Liu H. (2018) Melatonin protects mouse granulosa cells against oxidative damage by inhibiting FOXO1-mediated autophagy: Implication of an antioxidation-independent mechanism, Redox Biology, 18:138-157, 第一作者, IF5=9.038
(3) Shen M; Jiang Y; Guan Z; Cao Y; Li L; Liu H ; Sun SC. (2017) Protective mechanism of FSH against oxidative damage in mouse ovarian granulosa cells by repressing autophagy, Autophagy, 13(8): 1364~1385, 第一作者兼通讯作者, IF5=11.958


二、近5年内发表的其他论著
(1) Zhaojun Liu, Chengyu Li, Gang Wu, Weijian Li, Xuan Zhang, Jiaqi Zhou, Liangliang Zhang, Jingli Tao, Ming Shen, Honglin Liu. (2020) Involvement of JNK/FOXO1 pathway in apoptosis induced by severe hypoxia in porcine granulosa cells.Theriogenology, accept,通讯作者, IF5=2.316

(2) Chengyu Li, Zhaojun Liu, Weijian Li, Liangliang Zhang, Jilong Zhou, Minghong Sun, Jiaqi Zhou, Wang Yao, Xuan Zhang, Honghui Wang, Jingli Tao, Ming Shen, Honglin Liu. (2020) The FSH-HIF-1α-VEGF pathway is critical for ovulation and oocyte health but not necessary for follicular growth in mice. ENDOCRINOLOGY, accept, 通讯作者, IF5=4.130
(3) Li C, Zhou J, Liu Z, Zhou J, Yao W, Tao J, Shen M, Liu H. (2020) FSH prevents porcine granulosa cells from hypoxia-induced apoptosis via activating mitophagy through the HIF-1α-PINK1-Parkin pathway. Faseb Journal, Jan 20. doi:10.1096/fj.RRR, 通讯作者, IF5=5.421
(4) Daniel J. Klionsky, Amal Kamal Abdel-Aziz, ..., Ming Shen, et al. (2021) Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th edition). Autophagy, Feb 8;1-382, IF=11.100
(5) Rongyang Li, Bojiang Li, Ming Shen, Yan Cao, Xuan Zhang, Weijian Li, Jingli Tao, Feng Tang, Wangjun Wu, Honglin Liu. (2020) LncRNA **L19Rik inhibits differentiation and promotes proliferation of myoblast by sponging miR-125a-5p. Aging, accept, IF5=5.543
(6) Wei Y, Li W, Meng X, Zhang L, Shen M, Liu H. (2019) Corticosterone Injection Impairs Follicular Development, Ovulation and Steroidogenesis Capacity in Mice Ovary. Animals (Basel), Nov 29;9(12). pii: E1047, 通讯作者
(7) Li C,Liu Z,Zhou J,Meng X,Liu?S,Li W,Zhang X,Zhou J,Yao W,Dong C,Cao Y,Li R1,Chen B,Jiang A,Jiang Y,Ning C,Zhao F,Wei Y,Sun SC,Tao J,Wu W,Shen M,Liu H. (2019) IGF-I prevents HIF-1α-dependent G1/S arrest by activating cyclin E/CDK2 via the PI3K/AKT/FOXO1/Cdkn1b pathway in porcine?granulosa cells. Biology of Reproduction, Aug 22. pii: ioz162, 通讯作者, IF5=3.332
(8) Liu S; Shen M; Li C; Wei Y; Meng X; Li R; Cao Y; Wu W; Liu H. (2019) PKCδ contributes to oxidative stress-induced apoptosis in porcine ovarian granulosa cells via activating JNK. Theriogenology,Jun;131:89-95, IF5=2.316
(9) Zhao F; Wu W; Wei Q; Shen M; Li B; Jiang Y; Liu K; Liu H. (2018) Exogenous adrenocorticotropic hormone affects genome-wide DNA methylation and transcriptome of corpus luteum in sows, Faseb Journal, fjRRR, IF5=5.421
(10) Cao Y; Shen M; Jiang Y; Sun SC; Liu HL. (2018) Melatonin reduces oxidative damage in mouse granulosa cells via restraining JNK-dependent autophagy, Reproduction, 155(3): 307~319, 共同一作兼通讯作者, IF5=3.5
(11) Li B; Weng Q; Liu Z; Shen M; Zhang J; Wu W; Liu H. (2017) Selection of antioxidants against ovarian oxidative stress in mouse model, J Biochem Mol Toxicol, 31(12)
(12) Tang, Yiting; Pan, Bing; Zhou, Xin; Xiong, Kai; Gao, Qian; Huang, Lei; Xia, Ying; Shen, Ming; Yang, Shulin; Liu, Honglin; Tan, Tao; Ma, Jianjie; Xu, Xuehong; Mu, Yulian; Li, Kui. (2017) Wip1-dependent modulation of macrophage migration and phagocytosis, Redox Biology, 13:665-673, IF5=7.613
(13) Shen M; Jiang Y; Guan Z; Cao Y; Sun SC; Liu H. (2016) FSH protects mouse granulosa cells from oxidative damage by repressing mitophagy, Sci Rep, 6:38090~38090, 第一作者兼通讯作者, IF5=5.525
(14) 李烈川，申明，宁彩波，管志强，蒋毅，吴望军，刘红林. (2016) 过氧化氢诱导猪卵 巢颗粒细胞自噬及其对凋亡的影响, 南京农业大学学报, 39(5):814~818, 中文核心期刊
(15) Huang, Xian-Ju; Shen, Ming; Wang, Lizhong; Yu, Fengxiang; Wu, Wangjun; Liu, Hong-Lin. (2015) Effects of tributyltin chloride on developing mouse oocytes and preimplantation embryos, Microscopy and Microanalysis, 21(2):358~367
(16) Zhang JQ; Xing BS; Zhu CC; Shen M; Yu FX; Hong-Lin Liu. (2015) Protective effect of proanthocyanidin against oxidative ovarian damage induced by 3-nitropropionic acid in mice, Genet Mol Res, 14(1):2484~2494
(17) Yiting Tang; Kai Xiong; Ming Shen; Yulian Mu; Kui Li; Honglin Liu. (2015) CCAAT-enhancer binding protein (C/EBP) beta regulates insulin-like growth factor (IGF) 1 expression in porcine liver during prenatal and postnatal development, Mol Cell Biochem, 401(1-2):209~218
(18) Liu, Ze-Qun; Shen, Ming; Wu, Wang-Jun; Li, Bo-Jiang; Weng, Qian-Nan; Li, Mei ; Liu, Hong-Lin. (2015) Expression of PUMA in Follicular Granulosa Cells Regulated by FoxO1 Activation During Oxidative Stress, Reproductive Sciences, 22(6):696~705
(19) Yiting Tang; Lan Liu; Ming Sheng; Kai Xiong; Lei Huang; Qian Gao; Jingliang Wei; Tianwen Wu; Shulin Yang; Honglin Liu; Yulian Mu ; Kui Li. (2015) Wip1 knockout inhibits the proliferation and enhances the migration of bone marrow mesenchymal stem cells, Experimental Cell Research, 334(2):310~322
(20) Shen, M; Liu, Z; Li, B; Teng, Y; Zhang, J; Tang, Y; Sun, S-C ; Liu, H. (2014) Involvement of FoxO1 in the effects of follicle-stimulating hormone on inhibition of apoptosis in mouse granulosa cells, Cell Death & Disease, 5: e1475~e1475, 第一作者, IF5=6.187
(21) Lin F; Fu YH; Han J; Shen M; Du CW; Li R; Ma XS; Liu HL. (2014) Changes in the expression of Fox O1 and death ligand genes during follicular atresia in porcine ovary, Genet Mol Res, 13(3): 6638-6645
(22) Zhang, Jia-Qing; Shen, Ming; Zhu, Cheng-Cheng; Yu, Feng-Xiang; Liu, Ze-Qun; Ally, Nazim; Sun, Shao-Chen; Li, Kui; Liu, Hong-Lin. (2014) 3-Nitropropionic acid induces ovarian oxidative stress and impairs follicle in mouse,Plos One, 9(2):e86589~e86589
三、5年以外的代表性论著
(1) Shen, M; Lin, F; Zhang, J; Tang, Y; Chen, W. K ; Liu, H. (2012) Involvement of the upregulated FoxO1 expression in follicular granulosa cell apoptosis induced by oxidative stress, J Biol Chem, 287(31):25727~25740, 第一作者, IF5=5.498
(2) Lin, Fei; Li, Ran; Pan, Zeng Xiang; Zhou, Bo; Yu, De Bing; Wang, Xu Guang; Ma, Xue Shan; Han, Jing; Shen, Ming; Liu, Hong Lin. (2012) miR-26b promotes granulosa cell apoptosis by targeting ATM during follicular atresia in porcine ovary, PLos One, 7(6):e38640~e38640
(3) 刘泽; 高峰; 周光宏; 申明. (2012) 牛蒡子苷对分化的小鼠C2C12细胞的影响, 营养学报, (04): 395~399, 中文核心期刊