蔡亚非 详细介绍
性别 男
职称 教授
最高学历 博士
毕业院校 南京农业大学
专业领域 动物遗传育种与繁殖
联系方式 ycai@njau.edu.cn
研究方向 养牛学、奶牛遗传育种
参加学术团体
及任职情况 美国细胞生物学会会员、中国养牛学会会员、中国解剖学会理事
承担项目 近三年主持项目：1、江苏省南京市玄武区奶牛DHI测定中心基础建设项目（8ZG161）， 农业部畜禽良种工程基础建设项目，2016-2017；2、长三角地区生态优质高效乳业创新体系研究 [CX(17)1005]--课题一，江苏省农业科技自主创新资金项目（省财政厅），2017-2020；3、基于DHI技术建立江苏省良种奶牛数据库[ CX(18)3014]， 江苏省农业科技自主创新资金项目（省财政厅），2018-2021；4、奶牛生产性能测定（DHI）技术的研发与示范推广[SXG[2016]312]，江苏省农业三新工程项目，2016-2017；5、2016年度南京农业大学高层次人才引进项目（804090），2016-2020；6、DHI标准物质中致病微生物检测（HY0039），农业部全国畜牧总站，2017-2018；7、利用DHI技术测定江苏地区1000头奶牛（****），农业部全国畜牧总站，2018-2019；8、Ufm1泛素化样修饰系统E3连接酶--Ufl1缺失调控动物肝脏发育和原发性肝纤维化发生的分子机制，2020年度国家自然科学基金面上项目( **），2020-2023；9、Smad9基因在卵巢等级建立中的作用，2016年度国家自然科学基金面上项目( **），2016-2017；10、CIBZ基因在神经干细胞移植靶向性修复小鼠脊髓损伤中的作用，2014年度国家自然科学基金面上项目(**)，2014-2017；11、国家重点研发计划（2018YFC**）PI项目：特殊生物资源特征溯源数学模型的建立，2018-2021；
奖励及荣誉 南京农业大学高层次人才（2016）；省高校优秀中青年骨干教师（2010）;省首批企业科技特派员（2010）；省优秀青年科技创新奖（2012）
论文论著

1.Yang F, Chen F, Li L, Yan L, Badri T, Lv C, YuD, Zhang M, Jang X, Li J, Yuan L, Wang G, Li H, Li J*, Cai Y*. Three novel players：PTK2B, SYK and TNFRSF21 were identified to beinvolved in the regulation of bovine mastitis susceptibility via GWAS andpost-transcriptional analysis. Front Immunol. 2019; 10:1579.
2.Zhu H, Bhatt B, SivaprakasaS, Cai Y,Liu S, Kodeboyina S, Patel N, Savage N, Sharma A, Kaufman R, Li H, and SinghN*. Ufbp1 promotes plasma cell development and ER expansion by modulatingdistinct branches of UPR[J]. Nature Communications, 2019,10(1):1084.
3.Chen F, Xing C, Zhang W, Li J, Hu T, Li L,Li H*,Cai Y*. Salubrinal, a novel inhibitor of eIF-2αdephosphorylation, promotes erythropoiesis at early stage targeted byUfmylation pathway[J].J Cell Physiol,2019,1-11.DOI:10.1002/jcp.28493.
4. Cai Yafei*,ZhuGuangxun#,Liu Siyang ,Pan Zezheng,Quintero Michaela,PooleCandace J,Lu Chunwan,Zhu Huabin,Islam Bianca,RiggelenJanvan,Browning Darren,Liu Kebin,BlumbergRichard,Singh Nagendra&LiHonglin*. Indispensablerole of the Ubiquitin-fold modifier1-specific E3 ligase in maintainingintestinal homeostasis and controlling gut inflammation. Cell Discovery,(2019)5:7.DOI 10.1038/s41421-018-0070-x
5.Chen J, Xing C, Yan L, Wang Y, Wang H,Zhang Z, Yu D, Li J, Li H, Li J,Cai Y*.Transcriptomeprofiling reveals the role of ZBTB38 knock-down in human neuroblastoma.PeerJ,2019,7:e6352
6.LiJ,YueG,MaW,Zhang A,ZouJ,CaiY, TangX,WangJ,LiuJ,LiH,SuH.Ufm1-Specific LigaseUfl1 Regulates Endoplasmic Reticulum Homeostasis and Protects Against HeartFailure.Circ Heart Fail.2018 11(10):e004917.
7.Badri TM, Chen KL,AlsiddigMA,Li L1,Cai Y,Wang GL. Genetic polymorphism inHsp90AA1 gene is associated with the thermotolerance in Chinese Holstein cows.CellStress Chaperones.2018 Jul; 23(4):639-651.
8.YuDaolun, ZhangLi,WangHejian, ChenFanghui, ChenJie, ZhangZongmeng,LiJie, XingChaofeng, LiHonglin, LiJun,CaiYafei*.Apotential role for SMAD9 in goose follicular selection through regulation ofmRNA levels of luteinizing hormone receptor.Theriogenology, 135(2019): 204-212.
9.Zhang Li, Wang Hejian, Yu Daolun, ChenJie, Xing Chaofeng, Li Jie, Li Jun &Cai Yafei*.Theeffects of mouse ovarian granulosa cell function and related gene expression bysuppressing BMP/Smad signaling pathway.Animal Cells and Systems,2018; 22(5):317-323
10.Chen J,Yan L,WangH,Zhang Z,Yu D,Xing C,Li J,Li H,Li J,CaiY*. ZBTB38, a novel regulator of autophagy initiation targeted byRB1CC1/FIP200 in spinal cord injury.Gene.2018 Jul 31.678:8-16.
11.Zhang Z,Chen J,Chen F,YuD,Li R,Lv C,Wang H,Li H,Li J,Cai Y*Tauroursodeoxycholicacid alleviates secondary injury in the spinal cord via up-regulation of CIBZgene.Cell Stress Chaperones.2018. 23(4):551-560.
12.Zhu XL,Chen JJ,Han F,PanC,ZhuangTT,Cai YF,LuYP. Novel antidepressant effects of Paeonol alleviate neuronal injury withconcomitant alterations in BDNF, Rac1 and RhoA levels in chronic unpredictablemild stress rats.Psychopharmacology(Berl).2018 May12. doi: 10.1007/s00213-018-4915-7.
13. Cai Y*,LiJ,Zhang Z,Chen J,Zhu Y,Li R,Chen J,GaoL,Liu R,Teng Y.Zbtb38 is a novel target for spinal cord injury. Oncotarget.2017,Jul11;8(28):45356-45366.
14.Li J, Wang Q,Chen F, Wang H, Chen J,Huo JandCai Y*. SNPs of CD14 change the mastitis morbidity of ChineseHolstein.Molecular Medicine Reports.2017,16(6):9102-9110.
15.Teng Y,Cai Y,PiW,Gao L,Shay C. Augmentation of the anticancer activity of CYT997in human prostate cancer by inhibiting Src activity.J HematolOncol.2017 Jun 12;10(1):118.
16.Miller C,Cai Y,PattonT,Graves SH,Li H,Sabbatini ME. RCAD/BiP pathway is necessaryfor the proper synthesis of digestive enzymes and secretory function of theexocrine pancreas.Am J Physiol Gastrointest Liver Physiol.2017Mar 1;312(3):G314-G326.
17.Han F,Zhuang TT,ChenJJ,Zhu XL,Cai YF,Lu YP. Novel derivative of Paeonol, Paeononlsilatiesodium, alleviates behavioral damage and hippocampal dendritic injury inAlzheimer's disease concurrent with cofilin1/phosphorylated-cofilin1 andRAC1/CDC42 alterations in rats.PLoS One.2017;12(9):e**.
18. Cai Y,SinghN,Li H. Essential role of Ufm1 conjugation in the hematopoieticsystem.Exp Hematol.2016 Mar 24.44(6):442-446.
19.Lu Chunwan, Makala Levi, Wu Daqing,CaiYafei*. Targeting Translation: eIF4E as an Emerging Anti-Cancer DrugTarget.Expert Reviews in Molecular Medicine,2016,18(e2):1-13.
20.Xie X, Tang SC,Cai Y, Pi W,Deng L, Wu G, Chavanieu A, Teng Y. Suppression of breast cancer metastasisthrough the inactivation of ADP-ribosylation factor.Oncotarget,2016Sep 6;7(36):58111-58120.
21.da Silva SR, Paiva SL, Bancerz M,Geletu M, Lewis AM, Chen J,Cai Y, Lukkarila JL, Li H, Gunning PT.A selective inhibitor of the UFM1-activating enzyme, UBA5.BioorgMed ChemLett, 2016, 26(18):4542-7.
22. Cai Y, Pi W,Sivaprakasam S, Zhu X, Zhang M, Chen J, et al. UFBP1, a Key Component of theUfm1 Conjugation System, Is Essential for Ufmylation-Mediated Regulation ofErythroid Development.PLoS Genet, 2015, 11(11): e**.
23.Huang Pin, Lu Chunwan #, Li Jun ,Xu Jun,Liu Zaiqun, Wang Qiang, Wang Zhao, HuoJiayan, Li Honglin, Teng Yong,CaiYafei*. Mutations in HSP70-2 gene change the susceptibility to clinicalmastitis in Chinese Holstein.Gene,2015, 559(1):62-72.
24.Xu Jun, Li Jun #, Wang Haosen #, WangGuanglin #, Chen Jie, Huang Pin, Cheng Jienan, Gan Lu, Wang Zhao &CaiYafei*. A novel SMAD family protein, SMAD9 is involved in follicularinitiation and changes egg yield of geese via synonymous mutations in exon1 andintron2.Mol Biol Rep,2015, 42:289-302.
25.Zhang M, Zhu X, Zhang Y,Cai Y,Chen J, Sivaprakasam S, Gurav A, Pi W, Makala L, Wu J, Pace B, Tuan-Lo D,Ganapathy V, Singh N, Li H. RCAD/Ufl1, a Ufm1 E3 ligase, is essential forhematopoietic stem cell function and murine hematopoiesis.Cell DeathDiffer, 2015 May 8. 22(12):1922-34.
26. Cai Yafei, Li Jun, YangShiyong Li Ping, Zhang Xuan, Liu Honglin. CIBZ, a novel BTB domain-containingprotein, is involved in mouse spinal cord injury via mitochondrial pathwayindependent of p53 gene.PLoS ONE, 2012, 7(3): e33156.
27.Cheng Jienan, Li Jun, Zhang Wenxin,CaiYafei*, Wang Genlin.Mutations in lipopolysaccharide-binding protein(LBP) gene change the susceptibility to clinical mastitis in ChineseHolstein.Molecular Biology Reports,2012,39(10): 9601-9612.
28.Yang Fan, Li Lian, Liu Huiling,CaiYafei*, Wang Genlin.Polymorphism in theexon 4 ofβ-lactoglobulinvariant B precursor gene and its association with milk traits and proteinstructure in Chinese Holstein.Molecular Biology Reports,2012,29(4): 3957-3964.
29.Chen Jie, Liu Huiling,Cai Yafei*,Wang Genlin, Liu Honglin, Li Jing.Mutations in the exon 10 of Prolactinreceptor gene (PRLR) change the egg production performance in Wanjiang WhiteGoose.Molecular Biology Reports,2012, 39(1):475-483.
30. Cai Ya-Fei*, Fan Rui, HuaTian-Miao, Liu Hui-Ling, Li Jing. Nimodipine alleviates apoptosis-mediatedimpairments through mitochondrial pathway after spinal cord injury.CurrentZoology, 2011, 57(3):340-349.
31.Chen Jie, Wang Genlin,Cai Yafei*.HighMutation Rate in PRL Intron 2 Regulates the Egg-laying Performance in theTwo-line Hybrid Wanjiang White Goose,Journal of Applied AnimalResearch,2011, 39(3):175-180.
32.Liu Huiling, Li Jing, Yang Fan,CaiYafei*. Molecular Sexing of Endangered Cranes Based on CHD-W gene.Journalof Applied Animal Research,2011, 39(3): 212-217.
33.Liu Qinghua, Wang Yan,Cai Yafei*,Liu Huiling, Chen Jie, Li Ping, Cheng Jienan, Liu Honglin. T LymphocyteSelection is Indispensible for the Development of Goose Bursa ofFabricius.Current Research in Poultry Science, 2011,1(2):37-53.
34.Xu Shiyong, Sun Yan, Ding Hongmei, WangMeng,Cai Yafei*, Chen Jie, Liu Honglin. Efficient production oftransgenic chickens using self-inactive HIV-based lentiviral vectors.CurrentZoology, 2009, 55(5):383-387.
Cai Yafei, Liu Qinghua, XingGuangdong, Wang Genlin. Polymorphism of the promoter region of hsp70 gene andits relationship with the expression of HSP70mRNA, HSF1mRNA, Bcl-2mRNA andBax-αmRNA in lymphocytes in peripheral blood of heat shock dairy cows.Asian-AustralasianJournal of Animal Science, 2005, 18(5): 734-740.