张立慧，女，1988年生，讲师，2010年兰州大学生物技术专业本科毕业，2015年中国科学院生物物理研究所生物化学与分子生物学博士毕业，2015-2016年在中国科学院生物物理研究所担任助理研究员，2016-2019年在南京工业大学生物与制药工程学院担任助理研究员，2019年3月起在南京师范大学食品与制药工程学院担任讲师。
研究工作围绕工业微生物代谢过程中的关键酶展开，作为项目负责人承担江苏省自然科学基金青年基金1项，参与重点研发计划“食品安全关键技术研发”重点专项1项。发表论文如下：
1. Zhang Y, Li T, Zhang L, Shangguan F, Shi G, Wu X, Cui Y, Wang X, Wang X, Liu Y, Lu B, Wei T, Wang CC, Wang L*. (2019) Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer. EBioMedicine. 41:408-419.
2. Wu X, Zhang L, Miao Y, Yang J, Wang X, Wang CC, Feng J*, Wang L*. (2019) Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis. Redox Biol., 20:46-59
3. Ding X,* Xu X, Zhao Y, Zhang L, Yu Y, Huang F, Yin D, Huang H. (2017) Tumor targeted nanostructured lipid carrier co-delivering paclitaxel and indocyanine green for laser triggered synergetic therapy of cancer. RSC Adv., 35086-35095
4. Niu Y, Zhang L, Yu J, Wang CC*, Wang L*. (2016) Novel roles of the non-catalytic elements of yeast protein-disulfide isomerase in its interplay with endoplasmic reticulum oxidoreductin 1. J. Biol. Chem., 291(15):8283-94.
5. Zhang L^#, Niu Y^#, Zhu L, Fang J, Wang XE, Wang L*, Wang CC*. (2014) Different interaction modes for protein-disulfide isomerase (PDI) as an efficient regulator and a specific substrate of endoplasmic reticulum oxidoreductin-1α (Ero1α). J. Biol. Chem., 289(45):31188-31199.
6. Wang L*, Zhang L, Niu Y, Sitia R, Wang CC*. (2014) Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1α to promote oxidative protein folding. Antioxid. Redox Signal., 20(4):545-56.
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电子邮箱：zhanglihui@njnu.edu.cn
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