张文华 博士，助理研究员
南昌大学生命科学研究院恐惧与焦虑障碍研究室
邮箱：whzhang@ncu.edu.cn

教育经历:
1、2007-2014：华中科技大学生物化学与分子生物学专业博士学位
2、2003-2007：西南大学生命科学学院生物科学专业学士学位

工作经历:
2014至今 南昌大学生命科学研究院，助理研究员

目前主要研究方向:
恐惧和焦虑症是最为常见的神经精神疾病；大脑杏仁核和海马区作为与恐惧和焦虑症相关的两个最为重要的脑区，其结构与功能异常是导致恐惧和焦虑发生的重要因素。我们主要利用神经示踪剂、光遗传学、膜片钳技术以及动物行为学等手段，着重研究慢性应激介导的杏仁核及海马神经元结构和功能变化，以期阐明恐惧和焦虑症中的神经环路机制。

承担的科研题目及经费
1、2017.1-2019.12: 国家自然科学基金青年基金项目“Rap1在慢性应激致海马神经元结构和突触功能损伤中的作用与机制” （**）
2、2017.7-2019.6：江西省自然科学基金青年基金项目“Rap1在慢性应激导致小鼠焦虑样行为的作用及机制研究”（20171BAB214022）
3、2016.1-2017.12：江西省自然基金面上项目“毒蕈碱型乙酰胆碱M2受体通过网格蛋白非依赖的内吞分子机制研究”（20161BAB204166）
4、2016.1-2018.12：江西省教育厅基金一般项目“慢性应激激活海马Rap1机制及功能研究”（150175）

专利：
国内专利“一种细胞模型及其构建方法和在筛选抗神经紊乱性疾病药物中的应用”（专利号：ZL8.X，第二完成人), 2012

主要发表文章（IF为文章发表当年影响因子）

1. Jingjing He*, Wenhua Zhang*, Shiling Liu, Yifang Chen, Chenxi Liao, Qianqing Shen, Ping Hu. β-adrenergic receptor promotes cell proliferation in human glioblastoma cells. Oncology Letters, Accepted (*共同第一作者) 2017, (IF=1.39)
2. Wen-Hua Zhang, Jin Zhou, Han-Qing Pan, Xiao-Yang Wang, Wei-Zhu Liu, Jun-Yu Zhang, Xiao-Ping Ying, Bing-Xing Pan. δ subunit-containing GABAA receptor prevents overgeneralization of fear in adult mice. Learning Memory, 2017, 24:381-384 (IF=2.89)
3. Chen Song*, Wen-Hua Zhang*, Xue-Hui Wang, Jun-Yu Zhang, Xiao-Li Tian, Xiao-Ping Yin, Bing-Xing Pan. Acute stress enhances the glutamatergic transmission onto basoamygdala neurons embedded in distinct microcircuits. Molecular Brain, 2017 (IF=3.41) (*共同第一作者)
4. Zhi-Peng Liu, Qing-Hai He, Han-Qing Pan, Xiao-Bin Xu, Wen-Bing Chen, Ye He, Jin Zhou, Wen-Hua Zhang, Jun-Yu Zhang, Xiao-Ping Ying, Ren-Wen Han, Bao-Ming Li, Tian-Ming Gao1, Bing-Xing Pan. Delta Subunit-Containing Gamma-Aminobutyric Acid a Receptor Disinhibits Lateral Amygdala and Facilitates Fear Expression in Mice. Biological Psychiatry, 2017, 81(12):990-1002 (IF=11.41)
5. Xiao-Bin Xu, Shi-Jun Fan, Ye He, Xin Ke, Chen Song, Yao Xiao, Wen-Hua Zhang, Jun-Yu Zhang, Xiao-Ping Yin, Nobumasa Kato, Bing-Xing Pan. Loss of Hippocampal Oligodendrocytes Contributes to the Deficit of Contextual Fear Learning in Adult Rats Experiencing Early Bisphenol A Exposure. Molecular Neurobiology, 2017, 54(6):4524-4536 (IF=6.19)
6. Ping Hu*, Wenhua Zhang*, Hongbo Xin and Glenn Deng. Single Cell Isolation and Analysis. Frontiers in Cell and Development Biology, 2016,4:116 (*共同第一作者)
7. Ping Hu, Jingjing He, Shiling Liu, Meng Wang, Bingxing Pan, Wenhua Zhang#.β2 adrenergic receptor activation promotes the proliferation of A549 lung cancer cells via ERK/CREB pathway. Oncology Reports, 2016, 36:1757-1763 ( #通讯作者) (IF=2.49)
8. Wenhua Zhang, Chanjuan Xu, Haijun Tu, Yunyun Wang, Qian Sun, Ping Hu, Yongjian Hu, Philippe Rondard, Jianfeng Liu. GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Scientific Reports, 2015, 5:10468 (IF=5.58)
9. Zongyong Zhang*, Wenhua Zhang*, Siluo Huang*, Qian Sun, Yunyun Wang, Yongjian HU, Ninghua Sun, Yilei Zhang, Zhihua Jiang, Li Su, Jianfeng Liu. GABAB receptor promotes its own surface expression by recruiting a Rap1-dependent signaling cascade. Journal of Cell Science, 2015, 128:2302-2313 (*共同第一作者) (IF=5.43)
10. Min Wan*, Wenhua Zhang*, Yangli Tian, Chanjuan Xu, Tao Xu, Jianfeng Liu, Rongying Zhang. Unraveling a molecular determinant for clathrin-independent internalization and subsequent degradation of M2 mAChR. Scientific Reports, 2015, 5:11408(*共同第一作者) (IF=5.58)
11. Chanjuan Xu, Wenhua Zhang, Philippe Rondard, Jean Philippe Pin, Jianfeng Liu. Complex GABAB receptor complexes: how to generate multiple functionally distinctunits from a single receptor. Frontiers in Pharmacology. 2014; 5:12(IF=3.80)
12. Ping Hu, Bin Li, Wenhua Zhang, Yijian Li, Guang Li, Xinnong Jiang, Joanna Wdzieczak-Bakala, and Jianmiao Liu. AcSDKP regulates cell proliferation through PI3KCA/Akt signaling pathway. PLoS ONE, 2013, 8(11): e79321(IF=3.73)
13. Guillaume A. Baloucoune*, Lei Chun*, Wenhua Zhang*, Chanjuan Xu, Siluo Huang, Qian Sun, Yunyun Wang, Haijun Tu, and Jianfeng Liu. GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation. PLoS ONE, 2012, 7(6):e39698(*共同第一作者)(IF=4.09)
14. Chun Lei, Zhang Wenhua, Liu Jianfeng. Structure and ligand recognition of Class C GPCR. Acta Pharmacologica Sinica, 2012, 33:312-323(IF=1.95)
15. Xin Lin, Xin Li, Ming Jiang, linhai Chen, Chanjuan Xu, Wenhua Zhang, Han zhao, Bing Sun, Xiaoli Xu, Fajun Nan, Jianfeng Liu. An activity-based probe reveals dynamic protein-protein interactions mediate IGF-1R transactivation by GABAB receptor in neurons. Biochemical Journal, 2012, 443.627-634 (IF=4.90)
16. Haijun Tu, Chanjuan Xu, Wenhua Zhang, Qiuyao Liu, Philippe Rondard, Jean-Philippe Pin, Jianfeng Liu. GABAB receptor activation protects neurons from apoptosis via IGF-I receptor transactivation. Journal of Neuroscience. 2010, 30(2):749-59 (IF=7.18)
17. 张文华，孙倩，胡勇箭，刘剑峰. GABAB受体与跨膜受体交叉对话研究新进展.生物物理学报，2013; 29 (10).714-723（封面文章）
18. 张文华，王云云，丁明柳，刘剑峰. GABA受体与脆性X染色体综合征研究新进展.生物物理学报，2013; 29 (11).793-800
19. 蒋明, 黄思罗, 林昕, 春雷, 皮振钧, 孙兵, 张文华, 赵菡, 刘剑峰. GABAB 受体变构剂药学研究进展.现代生物医学进展, 2011; 14.2775-04


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