Yan YAN
阎言
PhD in Molecular Biology
Princeton University, 2010

Associate Professor
Division of Life Science



(852) 2358 5929
yany@ust.hk
Room 5511
Personal Web

---

Google Scholar
-1n_vjgAAAAJ

ORCID
0000-0002-3677-5006

Scopus ID
35112171400




Research Interest Publications Projects Teaching Assignment RPG Supervision Space used




Research Interest

---

Drosophila tumor model



Publications

---

All Years 22 2022 0 2021 0 2020 2 2019 3 2018 2 2017 6 2016 9

---

Expand All Collapse All


2020 2

Dynamically Tunable, Macroscopic Molecular Networks Enabled by Cellular Synthesis of 4-Arm Star-like Proteins
Matter, v. 2, (1), January 2020, p. 233-249
Yang, Zhongguang; Yang, Yang; Wang, Mo; Wang, Tingting; Fok, Hong Kiu Francis; Jiang, Bojing; Xiao, Wendi; Kou, Songzi; Guo, Yusong; Yan, Yan; Deng, Xin; Zhang, Wen-Bin; Sun, Fei Article
Molecular Mechanisms That Regulate Export of the Planar Cell-Polarity Protein Frizzled-6 Out of the Endoplasmic Reticulum
Journal of Biological Chemistry, v. 295, (27), July 2020, p. 8972-8987
Tang, Xiao; Zhang, Lina; Ma, Tianji; Wang, Mo; Li, Baiying; Jiang, Liwen; Yan, Yan; Guo, Yusong Article

2019 3

A Novel Histone H4 Variant H4G Regulates rDNA Transcription in Breast Cancer
Nucleic Acids Research, v. 47, (16), September 2019, p. 8399-8409
Long, Mengping; Sun, Xulun; Shi, Wenjin; An, Yanru; Leung, Tsz Chui Sophia; Ding, Dongbo; Cheema, Manjinder S.; MacPherson, Nicol; Nelson, Christopher J.; Ausio, Juan; Yan, Yan; Ishibashi, Toyotaka Article
Dynamic MAPK Signaling Activity Underlies a Transition From Growth Arrest to Proliferation in Drosophila Scribble Mutant Tumors
DMM Disease Models and Mechanism, v. 12, (8), August 2019, article number dmm040147
Ji, Tiantian; Zhang, Lina; Deng, Mingxi; Huang, Shengshuo; Wang, Ying; Pham, Tri Thanh; Smith, Andrew Alan; Sridhar, Varun; Cabernard, Clemens; Wang, Jiguang; Yan, Yan Article
Single cell transcriptomic landscapes of pattern formation, proliferation and growth in Drosophila wing imaginal discs
Development, v. 146, (18), September 2019, article number dev179754, p. 1-10
Deng, Mingxi; Wang, Ying; Zhang, Lina; Yang, Yang; Huang, Shengshuo; Wang, Jiguang; Ge, H.; Ishibashi, Toyotaka; Yan, Yan Article

2018 2

Serpin Facilitates Tumor-Suppressive Cell Competition by Blocking Toll-Mediated Yki Activation in Drosophila
Current Biology, v. 28, (11), June 2018, p. 1756-1767
Katsukawa, Mitsuko; Ohsawa, Shizue; Zhang, Lina; Yan, Yan; Igaki, Tatsushi Article
Molecular and cellular basis of Drosophila neuroblast delamination
Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, HKUST, June 2018
An, Yanru; Yang, Shaobo; Yan, Yan Conference paper

2017 6

Apical constriction is driven by a pulsatile apical myosin network in delaminating Drosophila neuroblasts
Development, v. 144, (12), June 2017, p. 2153-2164
An, Yanru; Xue, Guosheng; Yang, Shaobo; Deng, Mingxi; Zhou, Xiaowei; Yu, Weichuan; Ishibashi, Toyotaka; Zhang, Lei; Yan, Yan Article
Apical Constriction is Driven by a Pulsatile Apical Myosin Network in Delaminating Drosophila Neuroblasts
Journal of Cell Science, v. 130, (13), 2017, p. 2153-2164
An, Yanru; Xue, Guosheng; Yang, Shaobo; Deng, Mingxi; Zhou, Xiaowei; Yu, Weichuan; Ishibashi, Toyotaka; Zhang, Lei; Yan, Yan Article
Apical constriction is driven by a pulsatile apical myosin network in delaminating Drosophila neuroblasts
The 18th International Congress of Developmental Biology, Singapore, 18-22 June 2017
An, Yanru; Xue, Guosheng; Yang, Shaobo; Deng, Mingxi; Zhou, Xiaowei; Yu, Weichuan; Ishibashi, Toyotaka; Zhang, Lei; Yan, Yan Conference paper
Apical Constriction is Driven by a Pulsatile Apical Myosin Network in Delaminating Drosophila Neuroblasts
2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, The University of Hong Kong, Hong Kong, 16 June 2017
An, Yanru; Xue, Guosheng; Yang, Shaobo; Deng, Mingxi; Zhou, Xiaowei; Yu, Weichuan; Ishibashi, Toyotaka; Zhang, Lei; Yan, Yan Conference paper
Dscam4 is required for elimination of polarity-deficient cells in Drosophila
The 58th Annual Drosophila Research Conference, San Diego, USA, 29 March - 2 April 2017
Yan, Yan; Zhang, Lina; Wang,ying; Yang, Yang Conference paper
Molecular and cellular basis of Drosophila neuroblast delamination
Mechanisms of Development, v. 145, (Suppl.), July 2017, article number PS5.48, p. S158
An, Yanru; Xue, Guosheng; Ishibashi, Toyotaka; Yan, Yan Conference paper

2016 2

Quantitative analysis of myosin-driven apical constriction in delaminating neuroblasts
Genetics Society of America (GSA) 57th Annual Drosophila Research Conference, Orlando, FL, US., 13-17 July 2016
An, Yanru; Xue, Guosheng; Ishibashi, Toyotaka; Chris, Doe; Yan, Yan Conference paper
Quantitative analysis of myosin-driven apical constriction in delaminating neuroblasts
2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, 11 June 2016
An, Yanru; Xue, Guosheng; Ishibashi, Toyotaka; Chris, Doe; Yan, Yan Conference paper

2015 2

beta-Spectrin Regulates the Hippo Signaling Pathway and Modulates the Basal Actin Network
Journal of Biological Chemistry, v. 290, (10), March 2015, p. 6397-6407
Wong, Kin Lam Kenneth; Li, Wenyang; An, Yanru; Duan, Yangyang; Li, Zhuoheng; Kang, Yibin; Yan, Yan Article
Quantitative Analysis of Single Cell Delamination in Drosophila
Joint Symposium with Institute of Genetics and Developmental Biology, Chinese Academy of Science and Molecular Systems Biology Center, Lecture theater F, HKUST, 4-5 December 2015
Yan, Yan Conference paper

2014 1

Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex
Proceedings of the National Academy of Sciences of the United States of America, v. 111, (49), December 2014, p. 17444-17449
Li, Youjun; Wei, Zhiyi; Yan, Yan; Wan, Qingwen; Du, Quansheng; Zhang, Mingjie Article

2011 2

Drosophila PI4KIIIalpha is Required in Follicle Cells for Oocyte Polarization and Hippo Signaling
Development, v. 138, (9), 2011, May, p. 1697-1703
Yan, Yan; Denef, Natalie; Tang, Charm; Schuepbach, Trudi Article
Regulation of Somatic Myosin Activity by Protein Phosphatase 1 Beta Controls Drosophila Oocyte Polarization
Development, v. 138, (10), 2011, May, p. 1991-2001
Sun, Yi; Yan, Yan; Denef, Natalie; Schuepbach, Trudi Article

2010 1

Rabconnectin-3 Is a Functional Regulator of Mammalian Notch Signaling
Journal of Biological Chemistry, v. 285, (45), 2010, Nov, p. 34757-34764
Sethi, Nilay; Yan, Yan; Quek, Debra; Schupbach, Trudi; Kang, Yibin Article

2009 1

The Vacuolar Proton Pump, V-ATPase, Is Required for Notch Signaling and Endosomal Trafficking in Drosophila
Developmental Cell, v. 17, (3), 2009, Sep, p. 387-402
Yan, Yan; Denef, Natalie; Schupbach, Trudi Article


Expand All Collapse All


Article 2

Dynamically Tunable, Macroscopic Molecular Networks Enabled by Cellular Synthesis of 4-Arm Star-like Proteins
Matter, v. 2, (1), January 2020, p. 233-249
Yang, Zhongguang; Yang, Yang; Wang, Mo; Wang, Tingting; Fok, Hong Kiu Francis; Jiang, Bojing; Xiao, Wendi; Kou, Songzi; Guo, Yusong; Yan, Yan; Deng, Xin; Zhang, Wen-Bin; Sun, Fei
Molecular Mechanisms That Regulate Export of the Planar Cell-Polarity Protein Frizzled-6 Out of the Endoplasmic Reticulum
Journal of Biological Chemistry, v. 295, (27), July 2020, p. 8972-8987
Tang, Xiao; Zhang, Lina; Ma, Tianji; Wang, Mo; Li, Baiying; Jiang, Liwen; Yan, Yan; Guo, Yusong


Expand All Collapse All


Article 3

A Novel Histone H4 Variant H4G Regulates rDNA Transcription in Breast Cancer
Nucleic Acids Research, v. 47, (16), September 2019, p. 8399-8409
Long, Mengping; Sun, Xulun; Shi, Wenjin; An, Yanru; Leung, Tsz Chui Sophia; Ding, Dongbo; Cheema, Manjinder S.; MacPherson, Nicol; Nelson, Christopher J.; Ausio, Juan; Yan, Yan; Ishibashi, Toyotaka
Dynamic MAPK Signaling Activity Underlies a Transition From Growth Arrest to Proliferation in Drosophila Scribble Mutant Tumors
DMM Disease Models and Mechanism, v. 12, (8), August 2019, article number dmm040147
Ji, Tiantian; Zhang, Lina; Deng, Mingxi; Huang, Shengshuo; Wang, Ying; Pham, Tri Thanh; Smith, Andrew Alan; Sridhar, Varun; Cabernard, Clemens; Wang, Jiguang; Yan, Yan
Single cell transcriptomic landscapes of pattern formation, proliferation and growth in Drosophila wing imaginal discs
Development, v. 146, (18), September 2019, article number dev179754, p. 1-10
Deng, Mingxi; Wang, Ying; Zhang, Lina; Yang, Yang; Huang, Shengshuo; Wang, Jiguang; Ge, H.; Ishibashi, Toyotaka; Yan, Yan


Expand All Collapse All


Article 1

Serpin Facilitates Tumor-Suppressive Cell Competition by Blocking Toll-Mediated Yki Activation in Drosophila
Current Biology, v. 28, (11), June 2018, p. 1756-1767
Katsukawa, Mitsuko; Ohsawa, Shizue; Zhang, Lina; Yan, Yan; Igaki, Tatsushi

Conference paper 1

Molecular and cellular basis of Drosophila neuroblast delamination
Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, HKUST, June 2018
An, Yanru; Yang, Shaobo; Yan, Yan


Expand All Collapse All


Article 2

Apical constriction is driven by a pulsatile apical myosin network in delaminating Drosophila neuroblasts
Development, v. 144, (12), June 2017, p. 2153-2164
An, Yanru; Xue, Guosheng; Yang, Shaobo; Deng, Mingxi; Zhou, Xiaowei; Yu, Weichuan; Ishibashi, Toyotaka; Zhang, Lei; Yan, Yan
Apical Constriction is Driven by a Pulsatile Apical Myosin Network in Delaminating Drosophila Neuroblasts
Journal of Cell Science, v. 130, (13), 2017, p. 2153-2164
An, Yanru; Xue, Guosheng; Yang, Shaobo; Deng, Mingxi; Zhou, Xiaowei; Yu, Weichuan; Ishibashi, Toyotaka; Zhang, Lei; Yan, Yan

Conference paper 4

Apical constriction is driven by a pulsatile apical myosin network in delaminating Drosophila neuroblasts
The 18th International Congress of Developmental Biology, Singapore, 18-22 June 2017
An, Yanru; Xue, Guosheng; Yang, Shaobo; Deng, Mingxi; Zhou, Xiaowei; Yu, Weichuan; Ishibashi, Toyotaka; Zhang, Lei; Yan, Yan
Apical Constriction is Driven by a Pulsatile Apical Myosin Network in Delaminating Drosophila Neuroblasts
2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, The University of Hong Kong, Hong Kong, 16 June 2017
An, Yanru; Xue, Guosheng; Yang, Shaobo; Deng, Mingxi; Zhou, Xiaowei; Yu, Weichuan; Ishibashi, Toyotaka; Zhang, Lei; Yan, Yan
Dscam4 is required for elimination of polarity-deficient cells in Drosophila
The 58th Annual Drosophila Research Conference, San Diego, USA, 29 March - 2 April 2017
Yan, Yan; Zhang, Lina; Wang,ying; Yang, Yang
Molecular and cellular basis of Drosophila neuroblast delamination
Mechanisms of Development, v. 145, (Suppl.), July 2017, article number PS5.48, p. S158
An, Yanru; Xue, Guosheng; Ishibashi, Toyotaka; Yan, Yan


Expand All Collapse All


Conference paper 2

Quantitative analysis of myosin-driven apical constriction in delaminating neuroblasts
Genetics Society of America (GSA) 57th Annual Drosophila Research Conference, Orlando, FL, US., 13-17 July 2016
An, Yanru; Xue, Guosheng; Ishibashi, Toyotaka; Chris, Doe; Yan, Yan
Quantitative analysis of myosin-driven apical constriction in delaminating neuroblasts
2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, 11 June 2016
An, Yanru; Xue, Guosheng; Ishibashi, Toyotaka; Chris, Doe; Yan, Yan


Expand All Collapse All


Article 1

beta-Spectrin Regulates the Hippo Signaling Pathway and Modulates the Basal Actin Network
Journal of Biological Chemistry, v. 290, (10), March 2015, p. 6397-6407
Wong, Kin Lam Kenneth; Li, Wenyang; An, Yanru; Duan, Yangyang; Li, Zhuoheng; Kang, Yibin; Yan, Yan

Conference paper 1

Quantitative Analysis of Single Cell Delamination in Drosophila
Joint Symposium with Institute of Genetics and Developmental Biology, Chinese Academy of Science and Molecular Systems Biology Center, Lecture theater F, HKUST, 4-5 December 2015
Yan, Yan


Expand All Collapse All


Article 1

Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex
Proceedings of the National Academy of Sciences of the United States of America, v. 111, (49), December 2014, p. 17444-17449
Li, Youjun; Wei, Zhiyi; Yan, Yan; Wan, Qingwen; Du, Quansheng; Zhang, Mingjie


Expand All Collapse All


Article 2

Drosophila PI4KIIIalpha is Required in Follicle Cells for Oocyte Polarization and Hippo Signaling
Development, v. 138, (9), 2011, May, p. 1697-1703
Yan, Yan; Denef, Natalie; Tang, Charm; Schuepbach, Trudi
Regulation of Somatic Myosin Activity by Protein Phosphatase 1 Beta Controls Drosophila Oocyte Polarization
Development, v. 138, (10), 2011, May, p. 1991-2001
Sun, Yi; Yan, Yan; Denef, Natalie; Schuepbach, Trudi


Expand All Collapse All


Article 1

Rabconnectin-3 Is a Functional Regulator of Mammalian Notch Signaling
Journal of Biological Chemistry, v. 285, (45), 2010, Nov, p. 34757-34764
Sethi, Nilay; Yan, Yan; Quek, Debra; Schupbach, Trudi; Kang, Yibin


Expand All Collapse All


Article 1

The Vacuolar Proton Pump, V-ATPase, Is Required for Notch Signaling and Endosomal Trafficking in Drosophila
Developmental Cell, v. 17, (3), 2009, Sep, p. 387-402
Yan, Yan; Denef, Natalie; Schupbach, Trudi


Expand All Collapse All


2016 2

Quantitative analysis of myosin-driven apical constriction in delaminating neuroblasts
Genetics Society of America (GSA) 57th Annual Drosophila Research Conference, Orlando, FL, US., 13-17 July 2016
An, Yanru; Xue, Guosheng; Ishibashi, Toyotaka; Chris, Doe; Yan, Yan Conference paper
Quantitative analysis of myosin-driven apical constriction in delaminating neuroblasts
2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, 11 June 2016
An, Yanru; Xue, Guosheng; Ishibashi, Toyotaka; Chris, Doe; Yan, Yan Conference paper

2015 2

beta-Spectrin Regulates the Hippo Signaling Pathway and Modulates the Basal Actin Network
Journal of Biological Chemistry, v. 290, (10), March 2015, p. 6397-6407
Wong, Kin Lam Kenneth; Li, Wenyang; An, Yanru; Duan, Yangyang; Li, Zhuoheng; Kang, Yibin; Yan, Yan Article
Quantitative Analysis of Single Cell Delamination in Drosophila
Joint Symposium with Institute of Genetics and Developmental Biology, Chinese Academy of Science and Molecular Systems Biology Center, Lecture theater F, HKUST, 4-5 December 2015
Yan, Yan Conference paper

2014 1

Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex
Proceedings of the National Academy of Sciences of the United States of America, v. 111, (49), December 2014, p. 17444-17449
Li, Youjun; Wei, Zhiyi; Yan, Yan; Wan, Qingwen; Du, Quansheng; Zhang, Mingjie Article

2011 2

Drosophila PI4KIIIalpha is Required in Follicle Cells for Oocyte Polarization and Hippo Signaling
Development, v. 138, (9), 2011, May, p. 1697-1703
Yan, Yan; Denef, Natalie; Tang, Charm; Schuepbach, Trudi Article
Regulation of Somatic Myosin Activity by Protein Phosphatase 1 Beta Controls Drosophila Oocyte Polarization
Development, v. 138, (10), 2011, May, p. 1991-2001
Sun, Yi; Yan, Yan; Denef, Natalie; Schuepbach, Trudi Article

2010 1

Rabconnectin-3 Is a Functional Regulator of Mammalian Notch Signaling
Journal of Biological Chemistry, v. 285, (45), 2010, Nov, p. 34757-34764
Sethi, Nilay; Yan, Yan; Quek, Debra; Schupbach, Trudi; Kang, Yibin Article

2009 1

The Vacuolar Proton Pump, V-ATPase, Is Required for Notch Signaling and Endosomal Trafficking in Drosophila
Developmental Cell, v. 17, (3), 2009, Sep, p. 387-402
Yan, Yan; Denef, Natalie; Schupbach, Trudi Article


No Publications


No Publications






Teaching Assignment

---

2021-22 Winter 0 2021-22 Fall 4 2020-21 Summer 0 2020-21 Spring 5 2020-21 Winter 0 2020-21 Fall 5

---

LIFS4090 Developmental Biology
LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS6170 Special Topics in Molecular, Cell and Developmental Biology
LIFS6410A Seminar Enrichment Course


LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS4963 Biotechnology Capstone Project
LIFS5260 Biochemical and Molecular Basis of Diseases
LIFS6115D Current Topics in Development and Systems Biology
LIFS6410Z Seminar Enrichment Course


LIFS4090 Developmental Biology
LIFS4960 Biological Science Capstone Project
LIFS4963 Biotechnology Capstone Project
LIFS6170 Special Topics in Molecular, Cell and Developmental Biology
LIFS6410Y Seminar Enrichment Course


No Teaching Assignments


No Teaching Assignments


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)

---

All Supervisions Current RPGs Graduated RPGs

---

Current RPGs

---

Doctor of Philosophy YANG, Chen
Life Science( 2021 - )

DENG, Mingxi
Life Science( 2020 - )

WANG, Ying
Life Science( 2018 - )

YANG, Yang
Life Science( 2018 - )

---

Master of Philosophy HE, Jingjing
Life Science( 2021 - )

LIN, Yisha
Life Science( 2021 - )

---

Graduated RPGs

---

Doctor of Philosophy ZHANG, Lina
Life Science( Completed in 2021 )

JI, Tiantian
Life Science( Completed in 2020 )

AN, Yanru
Life Science( Completed in 2019 )

---

Master of Philosophy JIANG, Yiheng
Life Science( Completed in 2020 )

DENG, Mingxi
Life Science( Completed in 2019 )

YANG, Shaobo
Life Science( Completed in 2019 )









ProjectsFrom January 2020 to December 2022

---

All Projects 9 Leading Projects 6 Participating Projects 3

---

Stem cell-niche interactions in tissue maintenance and engineering


干细胞与微环境互作在组织维持和组织工程中的应用 Participating


RGC - Theme-based Research Scheme


Project Team (HKUST)
XIE Ting (Lead)
CHEUNG Tom
GUO Yusong
LEUNG Danny Chi Yeu
LIU Kai
MAK Ho Yi
SUN Fei
WEN Zilong
WU Angela Ruohao
WU Zhenguo
YAN Yan


2022 -




Construction of an optogenetic system for precise control of Notch signaling


基2020N365 对Notch信号通路进行精准量化调控的光遗传学体系的研究 Leading


Shenzhen Science and Technology Innovation Committee


Project Team (HKUST)
YAN Yan (Lead)


2020 -




The crosstalk between the fat body and imaginal disc tumors suppresses tumor growth in a Drosophila tumor model


果蝇脂肪组织对成虫盘肿瘤的抑制作用机理探究 Leading


RGC - General Research Fund


Project Team (HKUST)
YAN Yan (Lead)


2020 -




Mechanism of apical constriction during Drosophila neuroblast delamination


磷脂酰肌醇动态在果蝇胚胎单细胞离层中的机理研究 Leading


Shenzhen Science and Technology Innovation Committee


Project Team (HKUST)
YAN Yan (Lead)


2020 -




Notch signaling regulates Drosophila neuroblast delamination through Spire, Moesin, and Schip1


Notch信号通路对果蝇神经元干细胞离层的调控机理 Leading


RGC - General Research Fund


Project Team (HKUST)
YAN Yan (Lead)


2018 - 2021




Investigating the role of epithelial curvature in growth control


表皮细胞组织曲率调控生长作用初探 Leading


RGC - General Research Fund


Project Team (HKUST)
YAN Yan (Lead)


2017 - 2020




Mechanism of cell bompetition induced by cell polarity defects


细胞间竞争和肿瘤细胞消除机理研究 Leading


Shenzhen Science and Technology Innovation Committee


Project Team (HKUST)
YAN Yan (Lead)


2017 - 2020




Hong Kong Branch of National Engineering Research Center for Tissue Restoration & Reconstruction


国家人体组织功能重建工程技术研究中心香港分中心 Participating


Innovation and Technology Fund


Project Team (HKUST)
SUN Jianwei (Lead)
CHAU Ying
GUO Zhihong
HSING I-ming
IP Nancy Yuk-Yu
JIA Guocheng
KO Robert Kam Ming
KWOK Ryan Tsz Kin
LAM Wing Yip
LIANG Chun
LIN Nian
LUO Zhengtang
MI Yongli
TSIM Karl Wah Keung
WILLIAMS Ian Duncan
WU Hongkai
WU Zhenguo
YAN Henry He
YAN Yan
YANG Jinglei
YAO Shuhuai


2015 -




Mechanistic basis of synaptic development, signalling and neuro-disorders


神经突触的发育,信号转导及经神疾病的分子机理 Participating


RGC - Areas of Excellence Scheme


Project Team (HKUST)
WEN Zilong (Lead)
LIU Kai
QU Jianan
WU Zhenguo
YAN Yan


2013 -