Can YANG
杨灿
PhD in Electrical and Electronic Engineering
The Hong Kong University of Science and Technology, 2011

Associate Professor
Department of Mathematics



(852) 2358 7462
macyang@ust.hk
Room 3482
Personal Web

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Google Scholar
lRhpyeUAAAAJ

ORCID
0000-0003-3368-3082

ResearcherID
J-8790-2014

Scopus ID
55580390800




Research Interest Publications Projects Teaching Assignment RPG Supervision Space used




Research Interest

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Statistical machine learning
Applied statistics



Publications

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All Years 90 2022 0 2021 4 2020 10 2019 10 2018 3 2017 4 2016 59

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2021 4

A unified framework for cross-population trait prediction by leveraging the genetic correlation of polygenic traits
American Journal of Human Genetics, v. 108, (4), April 2021, p. 632-655
Cai, Mingxuan; Xiao, Jiashun; Zhang, Shunkang; Wan, Xiang; Zhao, Hongyu; Chen, Gang; Yang, Can Article
A Unified Primal Dual Active Set Algorithm for Nonconvex Sparse Recovery
Statistical Science, v. 36, (2), May 2021, p. 215-238
Huang, Jian; Jiao, Yuling; Jin, Bangti; Liu, Jin; Lu, Xiliang; Yang, Can Article
Accurate genetic and environmental covariance estimation with composite likelihood in genome-wide association studies
PLoS Genetics, v. 17, (1), January 2021, article number e1009293
Gao, Boran; Yang, Can; Liu, Jin; Zhou, Xiang Article
Using Collaborative Mixed Models to Account for Imputation Uncertainty in Transcriptome-Wide Association Studies
Epistasis: Methods and Protocols / Edited by Ka-Chun Wong. New York : Humana Press Inc, 2021, p. 93-103, Book series: Methods in Molecular Biology, v.2212
Shi, Xingjie; Yang, Can; Liu, Jin Book chapter

2020 10

A tissue-specific collaborative mixed model for jointly analyzing multiple tissues in transcriptome-wide association studies
Nucleic Acids Research, v. 48, (19), November 2020
Shi, Xingjie; Chai, Xiaoran; Yang, Yi; Cheng, Qing; Jiao, Yuling; Huang, Jian; Yang, Can; Liu, Jin Article
Bayesian Weighted Mendelian Randomization for Causal Inference Based on Summary Statistics
Bioinformatics, v. 36, (5), March 2020, p. 1501-1508
Zhao, Jia; Ming, Jingsi; Hu, Xianghong; Chen, Gang; Liu, Jin; Yang, Can Article
BIVAS: A Scalable Bayesian Method for Bi-Level Variable Selection With Applications
Journal of Computational and Graphical Statistics, v. 29, (1), January 2020, p. 40-52
Cai, Mingxuan; Dai, Mingwei; Ming, Jingsi; Peng, Heng; Liu, Jin; Yang, Can Article
CoMM-S²: A Collaborative Mixed Model Using Summary Statistics in Transcriptome-Wide Association Studies
Bioinformatics, v. 36, (7), April 2020, p. 2009-2016
Yang, Yi; Shi, Xingjie; Jiao, Yuling; Huang, Jian; Chen, Min; Zhou, Xiang; Sun, Lei; Lin, Xinyi; Yang, Can; Liu, Jin Article
Direct-To-Consumer Genetic Testing in China and Its Role in GWAS Discovery and Replication
Quantitative Biology, 18 July 2020
Kang, Kang; Sun, Xue; Wang, Lizhong; Yao, Xiaotian; Tang, Senwei; Deng, Junjie; Wu, Xiaoli; Yang, Can; Chen, Gang; WeGene Research Team Article
Exploring the Relationship Between Psychiatric Traits and the Risk of Mouth Ulcers Using Bi-Directional Mendelian Randomization
Frontiers in Genetics, v. 11, 16 December 2020, article number 608630
Wang, Kai; Ding, Lin; Yang, Can; Hao, Xingjie; Wang, Chaolong Article
IGREX for quantifying the impact of genetically regulated expression on phenotypes
NAR Genomics and Bioinformatics, v. 2, (1), March 2020, article number lqaa010
Cai, Mingxuan; Chen, Lin; Liu, Jin; Yang, Can Article
MR-LDP: a two-sample Mendelian randomization for GWAS summary statistics accounting for linkage disequilibrium and horizontal pleiotropy
NAR Genomics and Bioinformatics, v. 2, (2), June 2020, article number lqaa028
Cheng, Qing; Yang, Yi; Shi, Xingjie; Yeung, Kar-Fu; Yang, Can; Peng, Heng; Liu, Jin Article
Testing and Controlling for Horizontal Pleiotropy With Probabilistic Mendelian Randomization in Transcriptome-Wide Association Studies
Nature Communications, v. 11, (1), 1 December 2020, article number 3861
Yuan, Zhongshang; Zhu, Huanhuan; Zeng, Ping; Yang, Sheng; Sun, Shiquan; Yang, Can; Liu, Jin; Zhou, Xiang Article
Learning Hybrid Representations for Automatic 3D Vessel Centerline Extraction
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), v. 12266 LNCS, 2020, p. 24-34
He, Jiafa; Pan, Chengwei; Yang, Can; Zhang, Ming; Wang, Yang; Zhou, Xiaowei; Yu, Yizhou Conference paper

2019 10

CoMM: A Collaborative Mixed Model to Dissecting Genetic Contributions to Complex Traits by Leveraging Regulatory Information
Bioinformatics (Oxford, England), v. 35, (10), May 2019, p. 1644-1652
Yang, Can; Wan, Xiang; Lin, Xinyi; Chen, Mengjie; Zhou, Xiang; Liu, Jin Article
Detection of Cell-type-specific Risk-CpG Sites in Epigenome-wide Association Studies
Nature Communications, v. 10, (1), December 2019, article number 3113
Luo, Xiangyu; Yang, Can; Wei, Yingying Article
LPM: A Latent Probit Model to Characterize the Relationship Among Complex Traits Using Summary Statistics From Multiple GWASs and Functional Annotations
Bioinformatics, v. 36, (8), April 2020, p. 2506-2514
Ming, Jingsi; Wang, Tao; Yang, Can Article
Prediction analysis for microbiome sequencing data
Biometric Methodology, v. 75, (3), April 2019, p. 875-884
Wang, Tao; Yang, Can; Zhao, Hongyu Article
VIMCO: Variational Inference for Multiple Correlated Outcomes in Genome-wide Association Studies
Bioinformatics, v. 35, (19), October 2019, p. 3693-3700
Shi, Xingjie; Jiao, Yuling; Yang, Yi; Cheng, Chingyu; Yang, Can; Lin, Xinyi; Liu, Jin Article
Comparison of Facial Emotion Recognition Based on Image Visual Features and EEG Features
Communications in Computer and Information Science, v. 1006, 2019, p. 162-172
Long, Yanfang; Kong, Wanzeng; Ling, Wenfen; Yang, Can; Zhu, Jieyong Conference paper
Deep Generative Learning via Variational Gradient Flow
36th International Conference on Machine Learning, ICML 2019, (Part 6), 2019, p. 3661-3669
Gao, Yuan; Jiao, Yuling; Wang, Yang; Wang, Yao; Yang, Can; Zhang, Shunkang Conference paper
Deep Generative Learning via Variational Gradient Flow
Proceedings of Machine Learning Research, v. 97, 2019, p. 2093-2101
Gao, Yuan; Jiao, Yuling; Wang, Yang; Yang, Can; Zhang, Shunkang Conference paper
Facial Emotion Recognition Based on Brain and Machine Collaborative Intelligence
2019 IEEE International Conference on Computational Intelligence and Virtual Environments for Measurement Systems and Applications (CIVEMSA) / IEEE . IEEE, 2019, p. 1-5, Article number 9071606
Ling, Wenfen; Kong, Wanzeng; Long, Yanfang; Yang, Can; Jin, Xuanyu Conference paper
Visualizing Emotional States: A Method Based on Human Brain Activity
Communications in Computer and Information Science, v. 1072, 2019, p. 248-258
Long, Yanfang; Kong, Wanzeng; Jin, Xuanyu; Shang, Jili; Yang, Can Conference paper

2018 3

Joint Analysis of Individual-level and Summary-level GWAS Data by Leveraging Pleiotropy
Bioinformatics, v. 35, (10), May 2019, p. 1729-1736
Dai, Mingwei; Wan, Xiang; Peng, Hao; Wang, Yao; Liu, Yue; Liu, Jin; Xu, Zongben; Yang, Can Article
LPG: A four-group probabilistic approach to leveraging pleiotropy in genome-wide association studies
BMC Genomics, v. 19, (1), June 2018, article number 503, p. 1471-2164
Yang, Yi; Dai, Mingwei; Huang, Jian; Lin, Xinyi; Yang, Can; Chen, Min; Liu, Jin Article
LSMM: A Statistical Approach to Integrating Functional Annotations With Genome-wide Association Studies
Bioinformatics, v. 34, (16), August 2018, p. 2788-2796
Ming, Jingsi; Dai, Mingwei; Cai, Mingxuan; Wan, Xiang; Liu, Jin; Yang, Can Article

2017 4

IGESS: A Statistical Approach to Integrating Individual Level Genotype Data and Summary Statistics in Genome Wide Association Studies
Bioinformatics, v. 33, (18), 15 September 2017, p. 2882-2889
Dai, Mingwei; Ming, Jingsi; Cai, Mingxuan; Liu, Jin; Yang, Can; Wan, Xiang; Xu, Zongben Article
Leveraging Functional Annotations in Genetic Risk Prediction for Human Complex Diseases
PLoS Computational Biology, v. 13, (6), June 2017, article number e1005589, p. 1-16
Hu, Yiming; Lu, Qiongshi; Powles, Ryan; Yao, Xinwei; Yang, Can; Fang, Fang; Xu, Xinran; Zhao, Hongyu Article
LLR: A Latent Low-rank Approach to Colocalizing Genetic Risk Variants in Multiple GWAS
Bioinformatics, v. 33, (24), August 2017, p. 3878-3886
Liu, Jin; Wan, Xiang; Wang, Chaolong; Yang, Chao; Zhou, Xiaowei; Yang, Can Article
On Joint estimation of Gaussian graphical models for spatial and temporal data
Biometrics, v. 73, (3), September 2017, p. 769-779
Lin, Zhixiang; Wang, Tao; Yang, Can; Zhao, Hongyu Article

2016 12

Analyzing Association Mapping in Pedigree-based GWAS Using A Penalized Multi-trait Mixed Model
Genetic Epidemiology, v. 40, (5), July 2016, p. 382-393
Liu, Jin; Yang, Can; Shi, Xingjie; Li, Cong; Huang, Jian; Zhao, Hongyu; Ma, Shuangge Article
Computing Exact Permutation p-Values for Association Rules
Information Science, v. 346-347, June 2016, p. 146-162
Wu, Jun; He, Zengyou; Gu, Feiyang; Liu, Xiaoqing; Zhou, Jianyu; Yang, Can Article
Efficient Drug-Pathway Association Analysis via Integrative Penalized Matrix Decomposition
IEEE/ACM Transactions on Computational Biology and Bioinformatics, v. 13, (3), May-June 2016, article number 7172456, p. 531-540
Li, Cong; Yang, Can; Hather, Greg; Liu, Ray; Zhao, Hongyu Article
EPS: An Empirical Bayes Approach to Integrating Pleiotropy and Tissue-specific Information for Prioritizing Risk Genes
Bioinformatics, v. 32, (12), June 2016, p. 1856-1864
Liu, Jin; Wan, Xiang; Ma, Shuangge; Yang, Can Article
Exploring the Genetic Patterns of Complex Diseases via the Integrative Genome-wide Approach
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB), v. 13, (3), May-June 2016, article number 7164310, p. 557-564
Teng, Ben; Yang, Can; Liu, Jiming; Cai, Zhipeng; Wan, Xiang Article
Mathematical Design of a Novel Gesture-based Instruction/input Device Using Wave Detection
SIAM Journal on Imaging Sciences, v. 9, (2), June 2016, p. 822-841
Liu, Hongyu; Wang, Yuliang; Yang, Can Article
On high dimensional misspecified mixed model analysis in genome-wide association study
Annals of Statistics, v. 44, (5), October 2016, p. 2127-2160
Jiang, Jiming; Li, Cong; Paul, Debashis; Yang, Can; Zhao, Hongyu Article
Simultaneous dimension reduction and adjustment for confounding variation
Proceedings of the National Academy of Sciences of the United States of America, v. 113, (51), 20 December 2016, p. 14662-14667
Lin, Zhixiang; Yang, Can; Zhu, Ying; Duchi, John; Fu, Yao; Wang, Yong; Jiang, Bai; Zamanighomi, Mahdi; Xu, Xuming; Li, Mingfeng; Sestan, Nenad; Zhao, Hongyu; Wong, Wing Hung Article
Total Variation Regularized Tensor RPCA for Background Subtraction from Compressive Measurements
IEEE Transactions on Image Processing, v. 25, (9), September 2016, article number 7488247, p. 4075-4090
Cao, Wenfei; Wang, Yao; Sun, Jian; Meng, Deyu; Yang, Can; Cichoki, Andrzej; Xu, Zongben Article
eQTL mapping
Genome-Wide Association Studies: From Polymorphism to Personalized Medicine / Editor: Krishnarao Appasani. Cambridge : Cambridge University Press, 2016, p. 208-228
Chen, Mengjie; Yang, Can; Li, Cong; Zhao, Hongyu Book chapter
Introduction to Statistical Methods for Integrative Data Analysis in Genome-Wide Association Studies
Big Data Analytics in Genomics / Editor: Ka-Chun Wong. Cham : Springer International Publishing, 2016, p. 3-23
Yang, Can; Wan, Xiang; Liu, Jin; Ng, Michael Book chapter
Introduction to statistical methods in genome-wide association studies
Genome-Wide Association Studies: From Polymorphism to Personalized Medicine / Edited by Krishnarao Appasani; Foreword by Stephen W. Scherer, Peter M. Visscher. Cambridge University Press, 2016, p. 26-52, Ch. 3
Yang, Can; Li, Cong; Chung, Dongjun; Chen, Mengjie; Gelernter, Joel; Zhao, Hongyu Book chapter

2015 6

A Penalized Regression Approach for Integrative Analysis in Genome- Wide Association Studies
Journal of Biometrics & Biostatistics, v. 6, (2), May 2015, article number 228
Liu, J.; Wang, F.; Gao, X.; Zhang, H.; Wan, X.; Yang, Can Article
Dissecting Ancestry Genomic Background in Substance Dependence Genome-wide Association Studies
Pharmacogenomics, v. 16, (13), August 2015, p. 1487-1498
Polimanti, Renato; Yang, Can; Zhao, Hongyu; Gelernter, Joel Article
Folded-concave Penalization Approaches to Tensor Completion
Neurocomputing, v. 152, March 2015, p. 261-273
Cao, Wenfei; Wang, Yao; Yang, Can; Chang, Xiangyu; Han, Zhi; Xu, Zongben Article
Low-Rank Modeling and Its Applications in Image Analysis
ACM Computing Surveys, v. 47, (2), January 2015, article number 36
Zhou, Xiaowei; Yang, Can; Zhao, Hongyu; Yu, Weichuan Article
Pervasive Pleiotropy Between Psychiatric Disorders and Immune Disorders Revealed by Integrative Analysis of Multiple GWAS
Human Genetics, v. 134, (11-12), November 2015, p. 1195-1209
Wang, Qian; Yang, Can; Gelernter, Joel; Zhao, Hongyu Article
Drug-Pathway Association Analysis: Integration of High-Dimensional Transcriptional and Drug Sensitivity Profile
Integrating Omics Data / Edited by George Tseng, Debashis Ghosh, Xianghong Jasmine Zhou. New York, N.Y. : Cambridge University Press, 2015, p. 425-444
Li, Cong; Yang, Can; Hather, Greg; Liu, Ray; Zhao, Hongyu Book chapter

2014 8

An International Effort Towards Developing Standards for Best Practices in Analysis, Interpretation and Reporting of Clinical Genome Sequencing Results in the CLARITY Challenge
Genome Biology, v. 15, (3), March 2014, article number R53
Brownstein, Catherine A.; Yang, Can Article
Exploring the Genetic Architecture of Alcohol Dependence in African-Americans via Analysis of a Genomewide Set of Common Variants
Human Genetics, v. 133, (5), May 2014, p. 617-624
Yang, Can; Li, Cong; Kranzler, Henry R.; Farrer, Lindsay A.; Zhao, Hongyu; Gelernter, Joel Article
GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and Annotation
PLoS Genetics, v. 10, (11), November 2014, article number e1004787, p. 1-14
Chung, Dongjun; Yang, Can; Li, Cong; Gelernter, Joel; Zhao, Hongyu Article
Identification of Methylation Quantitative Trait Loci (mQTLs) Influencing Promoter DNA Methylation of Alcohol Dependence Risk Genes
Human Genetics, v. 133, (9), September 2014, p. 1093-1104
Zhang, Huiping; Wang, Fan; Kranzler, Henry R.; Yang, Can; Xu, Hongqin; Wang, Zuoheng; Zhao, Hongyu; Gelernter, Joel Article
Improving Genetic Risk Prediction by Leveraging Pleiotropy
Human Genetics, v. 133, (5), May 2014, p. 639-650
Li, Cong; Yang, Can; Gelernter, Joel; Zhao, Hongyu Article
A penalized linear mixed model for genomic prediction using pedigree structures
BMC Proceedings, v. 8, (Supplement 1), June 2014, article number S67
Yang, Can; Li, Cong; Chen, Mengjie; Chen, Xiaowei; Hou, Lin; Zhao, Hongyu Conference paper
Adjustment of familial relatedness in association test for rare variants
BMC Proceedings, v. 8, (Supplement 1), June 2014, article number S39
Li, Cong; Yang, Can; Chen, Mengjie; Chen, Xiaowei; Hou, Lin; Zhao, Hongyu Conference paper
Admixture mapping analysis in the context of GWAS with GAW18 data
BMC Proceedings, v. 8, (Supplement 1), June 2014
Chen, Mengjie; Yang, Can; Li, Cong; Hou, Lin; Chen, Xiaowei; Zhao, Hongyu Conference paper

2013 8

Accounting for Non-genetic Factors by Low-rank Representation and Sparse Regression for eQTL Mapping
Bioinformatics, v. 29, (8), April 2013, p. 1026-1034
Yang, Can; Wang, Lin; Zhang, Shuqin; Zhao, Hongyu Article
Archival Report: Genome-wide Association Study Identifies New Susceptibility Loci for Posttraumatic Stress Disorder
Biological Psychiatry, v. 74, (9), November 2013, p. 656-663
Xie, Pingxing; Kranzler, Henry R.; Yang, Can; Zhao, Hongyu; Farrer, Lindsay A.; Gelernter, Joel Article
Empirical Bayes Correction for the Winner's Curse in Genetic Association Studies
Genetic Epidemiology, v. 37, (1), January 2013, p. 60-68
Ferguson, John P.; Cho, Judy H.; Yang, Can; Zhao, Hongyu Article
HapBoost: A Fast Approach to Boosting Haplotype Association Analyses in Genome-Wide Association Studies
IEEE/ACM Transactions on Computational Biology and Bioinformatics, v. 10, (1), 2013, article number 6419694, p. 207-212
Wan, Xiang; Yang, Can; Yang, Qiang; Zhao, Hongyu; Yu, Weichuan Article
Moving Object Detection by Detecting Contiguous Outliers in the Low-Rank Representation
IEEE Transactions on Pattern Analysis and Machine Intelligence, v. 35, (3), March 2013, article number 6216381, p. 597-610
Zhou, Xiaowei; Yang, Can; Yu, Weichuan Article
Multisample aCGH Data Analysis via Total Variation and Spectral Regularization
IEEE/ACM Transactions on Computational Biology and Bioinformatics, v. 10, (1), January-February 2013, article number 6517420, p. 230-235
Zhou, Xiaowei; Yang, Can; Wan, Xiang; Zhao, Hongyu; Yu, Weichuan Article
ProteinLasso: A Lasso regression approach to protein inference problem in shotgun proteomics
Computational Biology and Chemistry, v. 43, April 2013, p. 46-54
Huang, Ting; Gong, Haipeng; Yang, Can; He, Zengyou Article
The Complete Compositional Epistasis Detection in Genome-wide Association Studies
BMC Genetics, v. 14, February 2013, article number 7
Wan, Xiang; Yang, Can; Yang, Qiang; Zhao, Hongyu; Yu, Weichuan Article

2012 3

Peptide Reranking with Protein-Peptide Correspondence and Precursor Peak Intensity Information
IEEE/ACM Transactions on Computational Biology and Bioinformatics, v. 9, (4), July-August 2012, article number 6202798, p. 1212-1219
Yang, Chao; He, Zengyou; Yang, Can; Yu, Weichuan Article
近邻自适应局部尺度的谱聚类算法
中国图象图形学报=Journal of Image and Graphics, v. 17, (4), 2012, p. 523-529
孔万增; 孙昌思核; 张建海; 胡三清; 杨灿 Article
Automatic Mitral Leaflet Tracking in Echocardiography by Outlier Detection in the Low-rank Representation
IEEE Conference on Computer Vision and Pattern Recognition, August 2012, article number 6247773, p. 972-979
Zhou, Xiaowei; Yang, Can; Yu, Weichuan Conference paper

2011 6

A Hidden Two-locus Disease Association Pattern in Genome-wide Association Studies
BMC bioinformatics, v. 12, (156), May 2011, article number 156, p. 1-14
Yang, Can; Wan, Xiang; Yang, Qiang; Xue, Hong; Tang, Nelson L.S.; Yu, Weichuan Article
A Partial Set Covering Model for Protein Mixture Identification Using Mass Spectrometry Data
IEEE/ACM Transactions on Computational Biology and Bioinformatics, v. 8, (2), March-April 2011, article number 5066962, p. 368-380
He, Zengyou; Yang, Can; Yu, Weichuan Article
GBOOST: a GPU-based Tool for Detecting Gene-gene Interactions in Genome-wide Case Control Studies
Bioinformatics, v. 27, (9), May 2011, article number btr114, p. 1309-1310
Yung, Ling Sing; Yang, Can; Wan, Xiang; Yu, Weichuan Article
Identifying Disease-associated SNP Clusters via Contiguous Outlier Detection
Bioinformatics, v. 27, (18), September 2011, article number btr424, p. 2578-2585
Yang, Can; Zhou, Xiaowei; Wan, Xiang; Yang, Qiang; Xue, Hong; Yu, Weichuan Article
Motif-All: Discovering All Phosphorylation Motifs
BMC Bioinformatics, v. 12, (supplement 1), February 2011, article number S22
He, Zengyou; Yang, Can; Guo, Guangyu; Li, Ning; Yu, Weichuan Article
The Choice of Null Distributions for Detecting Gene-Gene Interactions in Genome-Wide Association Studies
BMC Bioinformatics, v. 12, (Supplement 1), February 2011, article number S26
Yang, Can; Wan, Xiang; He, Zengyou; Yang, Qiang; Xue, Hong; Yu, Weichuan Conference paper

2010 6

A Regularized Method for Peptide Quantification
Journal of Proteome Research, v. 9, (5), May 2010, p. 2705-2712
Yang, Chao; Yang, Can; Yu, Weichuan Article
BOOST: A Fast Approach to Detecting Gene-Gene Interactions in Genome-wide Case-Control Studies
American Journal of Human Genetics, v. 87, (3), September 2010, p. 325-340
Wan, Xiang; Yang, Can; Yang, Qiang; Xue, Hong; Fan, Xiaodan; Tang, Nelson L.S.; Yu, Weichuan Article
Detecting Two-locus Associations Allowing for Interactions in Genome-wide Association Studies
Bioinformatics, v. 26, (20), August 2010, article number btq486, p. 2517-2525
Wan, Xiang; Yang, Can; Yang, Qiang; Xue, Hong; Tang, Nelson L.S.; Yu, Weichuan Article
Optimization-Based Peptide Mass Fingerprinting for Protein Mixture Identification
Journal of Computational Biology, v. 17, (3), March 2010, p. 221-235
He, Zengyou; Yang, Chao; Yang, Can; Qi, Robert Zhong; Tam, P.M.; Yu, Weichuan Article
Predictive Rule Inference for Epistatic Interaction Detection in Genome-wide Association Studies
Bioinformatics, v. 26, (1), January 2010, article number btp622, p. 30-37
Wan, Xiang; Yang, Can; Yang, Qiang; Xue, Hong; Tang, Nelson L.S.; Yu, Weichuan Article
Identifying Main Effects and Epistatic Interactions from Large-scale SNP Data via Adaptive Group Lasso
BMC Bioinformatics, v. 11, (Supplement 1), January 2010, article number S18
Yang, Can; Wan, Xiang; Yang, Qiang; Xue, Hong; Yu, Weichuan Conference paper

2009 2

MegaSNPhunter: a Learning Approach to Detect Disease Predisposition SNPs and High Level Interactions in Genome Wide Association Study
BMC Bioinformatics, v. 10, January 2009, article number 13
Wan, Xiang; Yang, Can; Yang, Qiang; Xue, Hong; Tang, Nelson L.S.; Yu, Weichuan Article
SNPharvester: a Filtering-based Approach for Detecting Epistatic Interactions in Genome-wide Association Studies
Bioinformatics, v. 25, (4), February 2009, p. 504-511
Yang, Can; He, Zengyou; Wan, Xiang; Yang, Qiang; Xue, Hong; Yu, Weichuan Article

2008 3

Peak bagging for peptide mass fingerprinting
Bioinformatics, v. 24, (10), May 2008, p. 1293-1299
He, Zengyou; Yang, Can; Yu, Weichuan Article
Model Free Data Mining
Data Mining and Knowledge Discovery Technologies / Edited by: David Taniar. Hershey, PA, USA : IGI Publishing, 2008, p. 224-252
Yang, Can; Meng, Jun; Zhu, Shanan; Dai, Mingwei Book chapter
GPC Algorithm and Queuing-selecting for Networked Level Control
IEEE International Conference on Control and Automation ICCA, 2008, p. 2626-2629
Kong, Wanzeng; Zhu, Shan-an; Yang, Can Conference paper

2006 3

Application of Generalized Predictive Control in Networked Control System
Journal of Zhejiang University: Science, v. 7, (2), February 2006, p. 225-233
Yang, Can; Zhu, Shan-an; Kong, Wan-zeng; Lu, Li-ming Article
Cluster-Based Input Selection for Transparent Fuzzy Modeling
International Journal of Data Warehousing and Mining, v. 2, (3), 2006, p. 57-75
Yang, Can; Meng, Jun; Zhu, Shanan Article
基于人类知识的多变量多层模煳解耦控制策略研究
Sixth World Congress on Intelligent Control and Automation, Danvers, MA, U.S. : Institute of Electrical and Electronics Engineers, Inc., 2006, p. 3867-3871
孟濬; 杨灿 Conference paper

2005 2

Optimal Fuzzy Modeling Based on Minimum Cluster Volume
ADMA 2005: Advanced Data Mining and Applications, Editors: Xue Li, Shuliang Wang, Zhao Yang Dong. Heidelberg : Springer Verlag, 2005, p. 232-239
Yang, Can; Meng, Jun Conference paper
Transparent Fuzzy Modeling Based on Minimum Cluster Volume
2005 International Conference on Control and Automation (ICCA), Danvers, MA : IEEE, 2005, p. 1120-1125
Yang, Can; Zhu, Shan-an; Meng, Jun; Lu, Li-ming Conference paper


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Article 3

A unified framework for cross-population trait prediction by leveraging the genetic correlation of polygenic traits
American Journal of Human Genetics, v. 108, (4), April 2021, p. 632-655
Cai, Mingxuan; Xiao, Jiashun; Zhang, Shunkang; Wan, Xiang; Zhao, Hongyu; Chen, Gang; Yang, Can
A Unified Primal Dual Active Set Algorithm for Nonconvex Sparse Recovery
Statistical Science, v. 36, (2), May 2021, p. 215-238
Huang, Jian; Jiao, Yuling; Jin, Bangti; Liu, Jin; Lu, Xiliang; Yang, Can
Accurate genetic and environmental covariance estimation with composite likelihood in genome-wide association studies
PLoS Genetics, v. 17, (1), January 2021, article number e1009293
Gao, Boran; Yang, Can; Liu, Jin; Zhou, Xiang

Book chapter 1

Using Collaborative Mixed Models to Account for Imputation Uncertainty in Transcriptome-Wide Association Studies
Epistasis: Methods and Protocols / Edited by Ka-Chun Wong. New York : Humana Press Inc, 2021, p. 93-103, Book series: Methods in Molecular Biology, v.2212
Shi, Xingjie; Yang, Can; Liu, Jin


Expand All Collapse All


Article 9

A tissue-specific collaborative mixed model for jointly analyzing multiple tissues in transcriptome-wide association studies
Nucleic Acids Research, v. 48, (19), November 2020
Shi, Xingjie; Chai, Xiaoran; Yang, Yi; Cheng, Qing; Jiao, Yuling; Huang, Jian; Yang, Can; Liu, Jin
Bayesian Weighted Mendelian Randomization for Causal Inference Based on Summary Statistics
Bioinformatics, v. 36, (5), March 2020, p. 1501-1508
Zhao, Jia; Ming, Jingsi; Hu, Xianghong; Chen, Gang; Liu, Jin; Yang, Can
BIVAS: A Scalable Bayesian Method for Bi-Level Variable Selection With Applications
Journal of Computational and Graphical Statistics, v. 29, (1), January 2020, p. 40-52
Cai, Mingxuan; Dai, Mingwei; Ming, Jingsi; Peng, Heng; Liu, Jin; Yang, Can
CoMM-S²: A Collaborative Mixed Model Using Summary Statistics in Transcriptome-Wide Association Studies
Bioinformatics, v. 36, (7), April 2020, p. 2009-2016
Yang, Yi; Shi, Xingjie; Jiao, Yuling; Huang, Jian; Chen, Min; Zhou, Xiang; Sun, Lei; Lin, Xinyi; Yang, Can; Liu, Jin
Direct-To-Consumer Genetic Testing in China and Its Role in GWAS Discovery and Replication
Quantitative Biology, 18 July 2020
Kang, Kang; Sun, Xue; Wang, Lizhong; Yao, Xiaotian; Tang, Senwei; Deng, Junjie; Wu, Xiaoli; Yang, Can; Chen, Gang; WeGene Research Team
Exploring the Relationship Between Psychiatric Traits and the Risk of Mouth Ulcers Using Bi-Directional Mendelian Randomization
Frontiers in Genetics, v. 11, 16 December 2020, article number 608630
Wang, Kai; Ding, Lin; Yang, Can; Hao, Xingjie; Wang, Chaolong
IGREX for quantifying the impact of genetically regulated expression on phenotypes
NAR Genomics and Bioinformatics, v. 2, (1), March 2020, article number lqaa010
Cai, Mingxuan; Chen, Lin; Liu, Jin; Yang, Can
MR-LDP: a two-sample Mendelian randomization for GWAS summary statistics accounting for linkage disequilibrium and horizontal pleiotropy
NAR Genomics and Bioinformatics, v. 2, (2), June 2020, article number lqaa028
Cheng, Qing; Yang, Yi; Shi, Xingjie; Yeung, Kar-Fu; Yang, Can; Peng, Heng; Liu, Jin
Testing and Controlling for Horizontal Pleiotropy With Probabilistic Mendelian Randomization in Transcriptome-Wide Association Studies
Nature Communications, v. 11, (1), 1 December 2020, article number 3861
Yuan, Zhongshang; Zhu, Huanhuan; Zeng, Ping; Yang, Sheng; Sun, Shiquan; Yang, Can; Liu, Jin; Zhou, Xiang

Conference paper 1

Learning Hybrid Representations for Automatic 3D Vessel Centerline Extraction
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), v. 12266 LNCS, 2020, p. 24-34
He, Jiafa; Pan, Chengwei; Yang, Can; Zhang, Ming; Wang, Yang; Zhou, Xiaowei; Yu, Yizhou


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Article 5

CoMM: A Collaborative Mixed Model to Dissecting Genetic Contributions to Complex Traits by Leveraging Regulatory Information
Bioinformatics (Oxford, England), v. 35, (10), May 2019, p. 1644-1652
Yang, Can; Wan, Xiang; Lin, Xinyi; Chen, Mengjie; Zhou, Xiang; Liu, Jin
Detection of Cell-type-specific Risk-CpG Sites in Epigenome-wide Association Studies
Nature Communications, v. 10, (1), December 2019, article number 3113
Luo, Xiangyu; Yang, Can; Wei, Yingying
LPM: A Latent Probit Model to Characterize the Relationship Among Complex Traits Using Summary Statistics From Multiple GWASs and Functional Annotations
Bioinformatics, v. 36, (8), April 2020, p. 2506-2514
Ming, Jingsi; Wang, Tao; Yang, Can
Prediction analysis for microbiome sequencing data
Biometric Methodology, v. 75, (3), April 2019, p. 875-884
Wang, Tao; Yang, Can; Zhao, Hongyu
VIMCO: Variational Inference for Multiple Correlated Outcomes in Genome-wide Association Studies
Bioinformatics, v. 35, (19), October 2019, p. 3693-3700
Shi, Xingjie; Jiao, Yuling; Yang, Yi; Cheng, Chingyu; Yang, Can; Lin, Xinyi; Liu, Jin

Conference paper 5

Comparison of Facial Emotion Recognition Based on Image Visual Features and EEG Features
Communications in Computer and Information Science, v. 1006, 2019, p. 162-172
Long, Yanfang; Kong, Wanzeng; Ling, Wenfen; Yang, Can; Zhu, Jieyong
Deep Generative Learning via Variational Gradient Flow
36th International Conference on Machine Learning, ICML 2019, (Part 6), 2019, p. 3661-3669
Gao, Yuan; Jiao, Yuling; Wang, Yang; Wang, Yao; Yang, Can; Zhang, Shunkang
Deep Generative Learning via Variational Gradient Flow
Proceedings of Machine Learning Research, v. 97, 2019, p. 2093-2101
Gao, Yuan; Jiao, Yuling; Wang, Yang; Yang, Can; Zhang, Shunkang
Facial Emotion Recognition Based on Brain and Machine Collaborative Intelligence
2019 IEEE International Conference on Computational Intelligence and Virtual Environments for Measurement Systems and Applications (CIVEMSA) / IEEE . IEEE, 2019, p. 1-5, Article number 9071606
Ling, Wenfen; Kong, Wanzeng; Long, Yanfang; Yang, Can; Jin, Xuanyu
Visualizing Emotional States: A Method Based on Human Brain Activity
Communications in Computer and Information Science, v. 1072, 2019, p. 248-258
Long, Yanfang; Kong, Wanzeng; Jin, Xuanyu; Shang, Jili; Yang, Can


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Article 3

Joint Analysis of Individual-level and Summary-level GWAS Data by Leveraging Pleiotropy
Bioinformatics, v. 35, (10), May 2019, p. 1729-1736
Dai, Mingwei; Wan, Xiang; Peng, Hao; Wang, Yao; Liu, Yue; Liu, Jin; Xu, Zongben; Yang, Can
LPG: A four-group probabilistic approach to leveraging pleiotropy in genome-wide association studies
BMC Genomics, v. 19, (1), June 2018, article number 503, p. 1471-2164
Yang, Yi; Dai, Mingwei; Huang, Jian; Lin, Xinyi; Yang, Can; Chen, Min; Liu, Jin
LSMM: A Statistical Approach to Integrating Functional Annotations With Genome-wide Association Studies
Bioinformatics, v. 34, (16), August 2018, p. 2788-2796
Ming, Jingsi; Dai, Mingwei; Cai, Mingxuan; Wan, Xiang; Liu, Jin; Yang, Can


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Article 4

IGESS: A Statistical Approach to Integrating Individual Level Genotype Data and Summary Statistics in Genome Wide Association Studies
Bioinformatics, v. 33, (18), 15 September 2017, p. 2882-2889
Dai, Mingwei; Ming, Jingsi; Cai, Mingxuan; Liu, Jin; Yang, Can; Wan, Xiang; Xu, Zongben
Leveraging Functional Annotations in Genetic Risk Prediction for Human Complex Diseases
PLoS Computational Biology, v. 13, (6), June 2017, article number e1005589, p. 1-16
Hu, Yiming; Lu, Qiongshi; Powles, Ryan; Yao, Xinwei; Yang, Can; Fang, Fang; Xu, Xinran; Zhao, Hongyu
LLR: A Latent Low-rank Approach to Colocalizing Genetic Risk Variants in Multiple GWAS
Bioinformatics, v. 33, (24), August 2017, p. 3878-3886
Liu, Jin; Wan, Xiang; Wang, Chaolong; Yang, Chao; Zhou, Xiaowei; Yang, Can
On Joint estimation of Gaussian graphical models for spatial and temporal data
Biometrics, v. 73, (3), September 2017, p. 769-779
Lin, Zhixiang; Wang, Tao; Yang, Can; Zhao, Hongyu


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Article 9

Analyzing Association Mapping in Pedigree-based GWAS Using A Penalized Multi-trait Mixed Model
Genetic Epidemiology, v. 40, (5), July 2016, p. 382-393
Liu, Jin; Yang, Can; Shi, Xingjie; Li, Cong; Huang, Jian; Zhao, Hongyu; Ma, Shuangge
Computing Exact Permutation p-Values for Association Rules
Information Science, v. 346-347, June 2016, p. 146-162
Wu, Jun; He, Zengyou; Gu, Feiyang; Liu, Xiaoqing; Zhou, Jianyu; Yang, Can
Efficient Drug-Pathway Association Analysis via Integrative Penalized Matrix Decomposition
IEEE/ACM Transactions on Computational Biology and Bioinformatics, v. 13, (3), May-June 2016, article number 7172456, p. 531-540
Li, Cong; Yang, Can; Hather, Greg; Liu, Ray; Zhao, Hongyu
EPS: An Empirical Bayes Approach to Integrating Pleiotropy and Tissue-specific Information for Prioritizing Risk Genes
Bioinformatics, v. 32, (12), June 2016, p. 1856-1864
Liu, Jin; Wan, Xiang; Ma, Shuangge; Yang, Can
Exploring the Genetic Patterns of Complex Diseases via the Integrative Genome-wide Approach
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB), v. 13, (3), May-June 2016, article number 7164310, p. 557-564
Teng, Ben; Yang, Can; Liu, Jiming; Cai, Zhipeng; Wan, Xiang
Mathematical Design of a Novel Gesture-based Instruction/input Device Using Wave Detection
SIAM Journal on Imaging Sciences, v. 9, (2), June 2016, p. 822-841
Liu, Hongyu; Wang, Yuliang; Yang, Can
On high dimensional misspecified mixed model analysis in genome-wide association study
Annals of Statistics, v. 44, (5), October 2016, p. 2127-2160
Jiang, Jiming; Li, Cong; Paul, Debashis; Yang, Can; Zhao, Hongyu
Simultaneous dimension reduction and adjustment for confounding variation
Proceedings of the National Academy of Sciences of the United States of America, v. 113, (51), 20 December 2016, p. 14662-14667
Lin, Zhixiang; Yang, Can; Zhu, Ying; Duchi, John; Fu, Yao; Wang, Yong; Jiang, Bai; Zamanighomi, Mahdi; Xu, Xuming; Li, Mingfeng; Sestan, Nenad; Zhao, Hongyu; Wong, Wing Hung
Total Variation Regularized Tensor RPCA for Background Subtraction from Compressive Measurements
IEEE Transactions on Image Processing, v. 25, (9), September 2016, article number 7488247, p. 4075-4090
Cao, Wenfei; Wang, Yao; Sun, Jian; Meng, Deyu; Yang, Can; Cichoki, Andrzej; Xu, Zongben

Book chapter 3

eQTL mapping
Genome-Wide Association Studies: From Polymorphism to Personalized Medicine / Editor: Krishnarao Appasani. Cambridge : Cambridge University Press, 2016, p. 208-228
Chen, Mengjie; Yang, Can; Li, Cong; Zhao, Hongyu
Introduction to Statistical Methods for Integrative Data Analysis in Genome-Wide Association Studies
Big Data Analytics in Genomics / Editor: Ka-Chun Wong. Cham : Springer International Publishing, 2016, p. 3-23
Yang, Can; Wan, Xiang; Liu, Jin; Ng, Michael
Introduction to statistical methods in genome-wide association studies
Genome-Wide Association Studies: From Polymorphism to Personalized Medicine / Edited by Krishnarao Appasani; Foreword by Stephen W. Scherer, Peter M. Visscher. Cambridge University Press, 2016, p. 26-52, Ch. 3
Yang, Can; Li, Cong; Chung, Dongjun; Chen, Mengjie; Gelernter, Joel; Zhao, Hongyu


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Article 5

A Penalized Regression Approach for Integrative Analysis in Genome- Wide Association Studies
Journal of Biometrics & Biostatistics, v. 6, (2), May 2015, article number 228
Liu, J.; Wang, F.; Gao, X.; Zhang, H.; Wan, X.; Yang, Can
Dissecting Ancestry Genomic Background in Substance Dependence Genome-wide Association Studies
Pharmacogenomics, v. 16, (13), August 2015, p. 1487-1498
Polimanti, Renato; Yang, Can; Zhao, Hongyu; Gelernter, Joel
Folded-concave Penalization Approaches to Tensor Completion
Neurocomputing, v. 152, March 2015, p. 261-273
Cao, Wenfei; Wang, Yao; Yang, Can; Chang, Xiangyu; Han, Zhi; Xu, Zongben
Low-Rank Modeling and Its Applications in Image Analysis
ACM Computing Surveys, v. 47, (2), January 2015, article number 36
Zhou, Xiaowei; Yang, Can; Zhao, Hongyu; Yu, Weichuan
Pervasive Pleiotropy Between Psychiatric Disorders and Immune Disorders Revealed by Integrative Analysis of Multiple GWAS
Human Genetics, v. 134, (11-12), November 2015, p. 1195-1209
Wang, Qian; Yang, Can; Gelernter, Joel; Zhao, Hongyu

Book chapter 1

Drug-Pathway Association Analysis: Integration of High-Dimensional Transcriptional and Drug Sensitivity Profile
Integrating Omics Data / Edited by George Tseng, Debashis Ghosh, Xianghong Jasmine Zhou. New York, N.Y. : Cambridge University Press, 2015, p. 425-444
Li, Cong; Yang, Can; Hather, Greg; Liu, Ray; Zhao, Hongyu


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Article 5

An International Effort Towards Developing Standards for Best Practices in Analysis, Interpretation and Reporting of Clinical Genome Sequencing Results in the CLARITY Challenge
Genome Biology, v. 15, (3), March 2014, article number R53
Brownstein, Catherine A.; Yang, Can
Exploring the Genetic Architecture of Alcohol Dependence in African-Americans via Analysis of a Genomewide Set of Common Variants
Human Genetics, v. 133, (5), May 2014, p. 617-624
Yang, Can; Li, Cong; Kranzler, Henry R.; Farrer, Lindsay A.; Zhao, Hongyu; Gelernter, Joel
GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and Annotation
PLoS Genetics, v. 10, (11), November 2014, article number e1004787, p. 1-14
Chung, Dongjun; Yang, Can; Li, Cong; Gelernter, Joel; Zhao, Hongyu
Identification of Methylation Quantitative Trait Loci (mQTLs) Influencing Promoter DNA Methylation of Alcohol Dependence Risk Genes
Human Genetics, v. 133, (9), September 2014, p. 1093-1104
Zhang, Huiping; Wang, Fan; Kranzler, Henry R.; Yang, Can; Xu, Hongqin; Wang, Zuoheng; Zhao, Hongyu; Gelernter, Joel
Improving Genetic Risk Prediction by Leveraging Pleiotropy
Human Genetics, v. 133, (5), May 2014, p. 639-650
Li, Cong; Yang, Can; Gelernter, Joel; Zhao, Hongyu

Conference paper 3

A penalized linear mixed model for genomic prediction using pedigree structures
BMC Proceedings, v. 8, (Supplement 1), June 2014, article number S67
Yang, Can; Li, Cong; Chen, Mengjie; Chen, Xiaowei; Hou, Lin; Zhao, Hongyu
Adjustment of familial relatedness in association test for rare variants
BMC Proceedings, v. 8, (Supplement 1), June 2014, article number S39
Li, Cong; Yang, Can; Chen, Mengjie; Chen, Xiaowei; Hou, Lin; Zhao, Hongyu
Admixture mapping analysis in the context of GWAS with GAW18 data
BMC Proceedings, v. 8, (Supplement 1), June 2014
Chen, Mengjie; Yang, Can; Li, Cong; Hou, Lin; Chen, Xiaowei; Zhao, Hongyu


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Article 8

Accounting for Non-genetic Factors by Low-rank Representation and Sparse Regression for eQTL Mapping
Bioinformatics, v. 29, (8), April 2013, p. 1026-1034
Yang, Can; Wang, Lin; Zhang, Shuqin; Zhao, Hongyu
Archival Report: Genome-wide Association Study Identifies New Susceptibility Loci for Posttraumatic Stress Disorder
Biological Psychiatry, v. 74, (9), November 2013, p. 656-663
Xie, Pingxing; Kranzler, Henry R.; Yang, Can; Zhao, Hongyu; Farrer, Lindsay A.; Gelernter, Joel
Empirical Bayes Correction for the Winner's Curse in Genetic Association Studies
Genetic Epidemiology, v. 37, (1), January 2013, p. 60-68
Ferguson, John P.; Cho, Judy H.; Yang, Can; Zhao, Hongyu
HapBoost: A Fast Approach to Boosting Haplotype Association Analyses in Genome-Wide Association Studies
IEEE/ACM Transactions on Computational Biology and Bioinformatics, v. 10, (1), 2013, article number 6419694, p. 207-212
Wan, Xiang; Yang, Can; Yang, Qiang; Zhao, Hongyu; Yu, Weichuan
Moving Object Detection by Detecting Contiguous Outliers in the Low-Rank Representation
IEEE Transactions on Pattern Analysis and Machine Intelligence, v. 35, (3), March 2013, article number 6216381, p. 597-610
Zhou, Xiaowei; Yang, Can; Yu, Weichuan
Multisample aCGH Data Analysis via Total Variation and Spectral Regularization
IEEE/ACM Transactions on Computational Biology and Bioinformatics, v. 10, (1), January-February 2013, article number 6517420, p. 230-235
Zhou, Xiaowei; Yang, Can; Wan, Xiang; Zhao, Hongyu; Yu, Weichuan
ProteinLasso: A Lasso regression approach to protein inference problem in shotgun proteomics
Computational Biology and Chemistry, v. 43, April 2013, p. 46-54
Huang, Ting; Gong, Haipeng; Yang, Can; He, Zengyou
The Complete Compositional Epistasis Detection in Genome-wide Association Studies
BMC Genetics, v. 14, February 2013, article number 7
Wan, Xiang; Yang, Can; Yang, Qiang; Zhao, Hongyu; Yu, Weichuan


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Article 2

Peptide Reranking with Protein-Peptide Correspondence and Precursor Peak Intensity Information
IEEE/ACM Transactions on Computational Biology and Bioinformatics, v. 9, (4), July-August 2012, article number 6202798, p. 1212-1219
Yang, Chao; He, Zengyou; Yang, Can; Yu, Weichuan
近邻自适应局部尺度的谱聚类算法
中国图象图形学报=Journal of Image and Graphics, v. 17, (4), 2012, p. 523-529
孔万增; 孙昌思核; 张建海; 胡三清; 杨灿

Conference paper 1

Automatic Mitral Leaflet Tracking in Echocardiography by Outlier Detection in the Low-rank Representation
IEEE Conference on Computer Vision and Pattern Recognition, August 2012, article number 6247773, p. 972-979
Zhou, Xiaowei; Yang, Can; Yu, Weichuan


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Article 5

A Hidden Two-locus Disease Association Pattern in Genome-wide Association Studies
BMC bioinformatics, v. 12, (156), May 2011, article number 156, p. 1-14
Yang, Can; Wan, Xiang; Yang, Qiang; Xue, Hong; Tang, Nelson L.S.; Yu, Weichuan
A Partial Set Covering Model for Protein Mixture Identification Using Mass Spectrometry Data
IEEE/ACM Transactions on Computational Biology and Bioinformatics, v. 8, (2), March-April 2011, article number 5066962, p. 368-380
He, Zengyou; Yang, Can; Yu, Weichuan
GBOOST: a GPU-based Tool for Detecting Gene-gene Interactions in Genome-wide Case Control Studies
Bioinformatics, v. 27, (9), May 2011, article number btr114, p. 1309-1310
Yung, Ling Sing; Yang, Can; Wan, Xiang; Yu, Weichuan
Identifying Disease-associated SNP Clusters via Contiguous Outlier Detection
Bioinformatics, v. 27, (18), September 2011, article number btr424, p. 2578-2585
Yang, Can; Zhou, Xiaowei; Wan, Xiang; Yang, Qiang; Xue, Hong; Yu, Weichuan
Motif-All: Discovering All Phosphorylation Motifs
BMC Bioinformatics, v. 12, (supplement 1), February 2011, article number S22
He, Zengyou; Yang, Can; Guo, Guangyu; Li, Ning; Yu, Weichuan

Conference paper 1

The Choice of Null Distributions for Detecting Gene-Gene Interactions in Genome-Wide Association Studies
BMC Bioinformatics, v. 12, (Supplement 1), February 2011, article number S26
Yang, Can; Wan, Xiang; He, Zengyou; Yang, Qiang; Xue, Hong; Yu, Weichuan


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Article 5

A Regularized Method for Peptide Quantification
Journal of Proteome Research, v. 9, (5), May 2010, p. 2705-2712
Yang, Chao; Yang, Can; Yu, Weichuan
BOOST: A Fast Approach to Detecting Gene-Gene Interactions in Genome-wide Case-Control Studies
American Journal of Human Genetics, v. 87, (3), September 2010, p. 325-340
Wan, Xiang; Yang, Can; Yang, Qiang; Xue, Hong; Fan, Xiaodan; Tang, Nelson L.S.; Yu, Weichuan
Detecting Two-locus Associations Allowing for Interactions in Genome-wide Association Studies
Bioinformatics, v. 26, (20), August 2010, article number btq486, p. 2517-2525
Wan, Xiang; Yang, Can; Yang, Qiang; Xue, Hong; Tang, Nelson L.S.; Yu, Weichuan
Optimization-Based Peptide Mass Fingerprinting for Protein Mixture Identification
Journal of Computational Biology, v. 17, (3), March 2010, p. 221-235
He, Zengyou; Yang, Chao; Yang, Can; Qi, Robert Zhong; Tam, P.M.; Yu, Weichuan
Predictive Rule Inference for Epistatic Interaction Detection in Genome-wide Association Studies
Bioinformatics, v. 26, (1), January 2010, article number btp622, p. 30-37
Wan, Xiang; Yang, Can; Yang, Qiang; Xue, Hong; Tang, Nelson L.S.; Yu, Weichuan

Conference paper 1

Identifying Main Effects and Epistatic Interactions from Large-scale SNP Data via Adaptive Group Lasso
BMC Bioinformatics, v. 11, (Supplement 1), January 2010, article number S18
Yang, Can; Wan, Xiang; Yang, Qiang; Xue, Hong; Yu, Weichuan


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Article 2

MegaSNPhunter: a Learning Approach to Detect Disease Predisposition SNPs and High Level Interactions in Genome Wide Association Study
BMC Bioinformatics, v. 10, January 2009, article number 13
Wan, Xiang; Yang, Can; Yang, Qiang; Xue, Hong; Tang, Nelson L.S.; Yu, Weichuan
SNPharvester: a Filtering-based Approach for Detecting Epistatic Interactions in Genome-wide Association Studies
Bioinformatics, v. 25, (4), February 2009, p. 504-511
Yang, Can; He, Zengyou; Wan, Xiang; Yang, Qiang; Xue, Hong; Yu, Weichuan


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Article 1

Peak bagging for peptide mass fingerprinting
Bioinformatics, v. 24, (10), May 2008, p. 1293-1299
He, Zengyou; Yang, Can; Yu, Weichuan

Book chapter 1

Model Free Data Mining
Data Mining and Knowledge Discovery Technologies / Edited by: David Taniar. Hershey, PA, USA : IGI Publishing, 2008, p. 224-252
Yang, Can; Meng, Jun; Zhu, Shanan; Dai, Mingwei

Conference paper 1

GPC Algorithm and Queuing-selecting for Networked Level Control
IEEE International Conference on Control and Automation ICCA, 2008, p. 2626-2629
Kong, Wanzeng; Zhu, Shan-an; Yang, Can


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Article 2

Application of Generalized Predictive Control in Networked Control System
Journal of Zhejiang University: Science, v. 7, (2), February 2006, p. 225-233
Yang, Can; Zhu, Shan-an; Kong, Wan-zeng; Lu, Li-ming
Cluster-Based Input Selection for Transparent Fuzzy Modeling
International Journal of Data Warehousing and Mining, v. 2, (3), 2006, p. 57-75
Yang, Can; Meng, Jun; Zhu, Shanan

Conference paper 1

基于人类知识的多变量多层模煳解耦控制策略研究
Sixth World Congress on Intelligent Control and Automation, Danvers, MA, U.S. : Institute of Electrical and Electronics Engineers, Inc., 2006, p. 3867-3871
孟濬; 杨灿


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Conference paper 2

Optimal Fuzzy Modeling Based on Minimum Cluster Volume
ADMA 2005: Advanced Data Mining and Applications, Editors: Xue Li, Shuliang Wang, Zhao Yang Dong. Heidelberg : Springer Verlag, 2005, p. 232-239
Yang, Can; Meng, Jun
Transparent Fuzzy Modeling Based on Minimum Cluster Volume
2005 International Conference on Control and Automation (ICCA), Danvers, MA : IEEE, 2005, p. 1120-1125
Yang, Can; Zhu, Shan-an; Meng, Jun; Lu, Li-ming


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2016 12

Analyzing Association Mapping in Pedigree-based GWAS Using A Penalized Multi-trait Mixed Model
Genetic Epidemiology, v. 40, (5), July 2016, p. 382-393
Liu, Jin; Yang, Can; Shi, Xingjie; Li, Cong; Huang, Jian; Zhao, Hongyu; Ma, Shuangge Article
Computing Exact Permutation p-Values for Association Rules
Information Science, v. 346-347, June 2016, p. 146-162
Wu, Jun; He, Zengyou; Gu, Feiyang; Liu, Xiaoqing; Zhou, Jianyu; Yang, Can Article
Efficient Drug-Pathway Association Analysis via Integrative Penalized Matrix Decomposition
IEEE/ACM Transactions on Computational Biology and Bioinformatics, v. 13, (3), May-June 2016, article number 7172456, p. 531-540
Li, Cong; Yang, Can; Hather, Greg; Liu, Ray; Zhao, Hongyu Article
EPS: An Empirical Bayes Approach to Integrating Pleiotropy and Tissue-specific Information for Prioritizing Risk Genes
Bioinformatics, v. 32, (12), June 2016, p. 1856-1864
Liu, Jin; Wan, Xiang; Ma, Shuangge; Yang, Can Article
Exploring the Genetic Patterns of Complex Diseases via the Integrative Genome-wide Approach
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB), v. 13, (3), May-June 2016, article number 7164310, p. 557-564
Teng, Ben; Yang, Can; Liu, Jiming; Cai, Zhipeng; Wan, Xiang Article
Mathematical Design of a Novel Gesture-based Instruction/input Device Using Wave Detection
SIAM Journal on Imaging Sciences, v. 9, (2), June 2016, p. 822-841
Liu, Hongyu; Wang, Yuliang; Yang, Can Article
On high dimensional misspecified mixed model analysis in genome-wide association study
Annals of Statistics, v. 44, (5), October 2016, p. 2127-2160
Jiang, Jiming; Li, Cong; Paul, Debashis; Yang, Can; Zhao, Hongyu Article
Simultaneous dimension reduction and adjustment for confounding variation
Proceedings of the National Academy of Sciences of the United States of America, v. 113, (51), 20 December 2016, p. 14662-14667
Lin, Zhixiang; Yang, Can; Zhu, Ying; Duchi, John; Fu, Yao; Wang, Yong; Jiang, Bai; Zamanighomi, Mahdi; Xu, Xuming; Li, Mingfeng; Sestan, Nenad; Zhao, Hongyu; Wong, Wing Hung Article
Total Variation Regularized Tensor RPCA for Background Subtraction from Compressive Measurements
IEEE Transactions on Image Processing, v. 25, (9), September 2016, article number 7488247, p. 4075-4090
Cao, Wenfei; Wang, Yao; Sun, Jian; Meng, Deyu; Yang, Can; Cichoki, Andrzej; Xu, Zongben Article
eQTL mapping
Genome-Wide Association Studies: From Polymorphism to Personalized Medicine / Editor: Krishnarao Appasani. Cambridge : Cambridge University Press, 2016, p. 208-228
Chen, Mengjie; Yang, Can; Li, Cong; Zhao, Hongyu Book chapter
Introduction to Statistical Methods for Integrative Data Analysis in Genome-Wide Association Studies
Big Data Analytics in Genomics / Editor: Ka-Chun Wong. Cham : Springer International Publishing, 2016, p. 3-23
Yang, Can; Wan, Xiang; Liu, Jin; Ng, Michael Book chapter
Introduction to statistical methods in genome-wide association studies
Genome-Wide Association Studies: From Polymorphism to Personalized Medicine / Edited by Krishnarao Appasani; Foreword by Stephen W. Scherer, Peter M. Visscher. Cambridge University Press, 2016, p. 26-52, Ch. 3
Yang, Can; Li, Cong; Chung, Dongjun; Chen, Mengjie; Gelernter, Joel; Zhao, Hongyu Book chapter

2015 6

A Penalized Regression Approach for Integrative Analysis in Genome- Wide Association Studies
Journal of Biometrics & Biostatistics, v. 6, (2), May 2015, article number 228
Liu, J.; Wang, F.; Gao, X.; Zhang, H.; Wan, X.; Yang, Can Article
Dissecting Ancestry Genomic Background in Substance Dependence Genome-wide Association Studies
Pharmacogenomics, v. 16, (13), August 2015, p. 1487-1498
Polimanti, Renato; Yang, Can; Zhao, Hongyu; Gelernter, Joel Article
Folded-concave Penalization Approaches to Tensor Completion
Neurocomputing, v. 152, March 2015, p. 261-273
Cao, Wenfei; Wang, Yao; Yang, Can; Chang, Xiangyu; Han, Zhi; Xu, Zongben Article
Low-Rank Modeling and Its Applications in Image Analysis
ACM Computing Surveys, v. 47, (2), January 2015, article number 36
Zhou, Xiaowei; Yang, Can; Zhao, Hongyu; Yu, Weichuan Article
Pervasive Pleiotropy Between Psychiatric Disorders and Immune Disorders Revealed by Integrative Analysis of Multiple GWAS
Human Genetics, v. 134, (11-12), November 2015, p. 1195-1209
Wang, Qian; Yang, Can; Gelernter, Joel; Zhao, Hongyu Article
Drug-Pathway Association Analysis: Integration of High-Dimensional Transcriptional and Drug Sensitivity Profile
Integrating Omics Data / Edited by George Tseng, Debashis Ghosh, Xianghong Jasmine Zhou. New York, N.Y. : Cambridge University Press, 2015, p. 425-444
Li, Cong; Yang, Can; Hather, Greg; Liu, Ray; Zhao, Hongyu Book chapter

2014 8

An International Effort Towards Developing Standards for Best Practices in Analysis, Interpretation and Reporting of Clinical Genome Sequencing Results in the CLARITY Challenge
Genome Biology, v. 15, (3), March 2014, article number R53
Brownstein, Catherine A.; Yang, Can Article
Exploring the Genetic Architecture of Alcohol Dependence in African-Americans via Analysis of a Genomewide Set of Common Variants
Human Genetics, v. 133, (5), May 2014, p. 617-624
Yang, Can; Li, Cong; Kranzler, Henry R.; Farrer, Lindsay A.; Zhao, Hongyu; Gelernter, Joel Article
GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and Annotation
PLoS Genetics, v. 10, (11), November 2014, article number e1004787, p. 1-14
Chung, Dongjun; Yang, Can; Li, Cong; Gelernter, Joel; Zhao, Hongyu Article
Identification of Methylation Quantitative Trait Loci (mQTLs) Influencing Promoter DNA Methylation of Alcohol Dependence Risk Genes
Human Genetics, v. 133, (9), September 2014, p. 1093-1104
Zhang, Huiping; Wang, Fan; Kranzler, Henry R.; Yang, Can; Xu, Hongqin; Wang, Zuoheng; Zhao, Hongyu; Gelernter, Joel Article
Improving Genetic Risk Prediction by Leveraging Pleiotropy
Human Genetics, v. 133, (5), May 2014, p. 639-650
Li, Cong; Yang, Can; Gelernter, Joel; Zhao, Hongyu Article
A penalized linear mixed model for genomic prediction using pedigree structures
BMC Proceedings, v. 8, (Supplement 1), June 2014, article number S67
Yang, Can; Li, Cong; Chen, Mengjie; Chen, Xiaowei; Hou, Lin; Zhao, Hongyu Conference paper
Adjustment of familial relatedness in association test for rare variants
BMC Proceedings, v. 8, (Supplement 1), June 2014, article number S39
Li, Cong; Yang, Can; Chen, Mengjie; Chen, Xiaowei; Hou, Lin; Zhao, Hongyu Conference paper
Admixture mapping analysis in the context of GWAS with GAW18 data
BMC Proceedings, v. 8, (Supplement 1), June 2014
Chen, Mengjie; Yang, Can; Li, Cong; Hou, Lin; Chen, Xiaowei; Zhao, Hongyu Conference paper

2013 8

Accounting for Non-genetic Factors by Low-rank Representation and Sparse Regression for eQTL Mapping
Bioinformatics, v. 29, (8), April 2013, p. 1026-1034
Yang, Can; Wang, Lin; Zhang, Shuqin; Zhao, Hongyu Article
Archival Report: Genome-wide Association Study Identifies New Susceptibility Loci for Posttraumatic Stress Disorder
Biological Psychiatry, v. 74, (9), November 2013, p. 656-663
Xie, Pingxing; Kranzler, Henry R.; Yang, Can; Zhao, Hongyu; Farrer, Lindsay A.; Gelernter, Joel Article
Empirical Bayes Correction for the Winner's Curse in Genetic Association Studies
Genetic Epidemiology, v. 37, (1), January 2013, p. 60-68
Ferguson, John P.; Cho, Judy H.; Yang, Can; Zhao, Hongyu Article
HapBoost: A Fast Approach to Boosting Haplotype Association Analyses in Genome-Wide Association Studies
IEEE/ACM Transactions on Computational Biology and Bioinformatics, v. 10, (1), 2013, article number 6419694, p. 207-212
Wan, Xiang; Yang, Can; Yang, Qiang; Zhao, Hongyu; Yu, Weichuan Article
Moving Object Detection by Detecting Contiguous Outliers in the Low-Rank Representation
IEEE Transactions on Pattern Analysis and Machine Intelligence, v. 35, (3), March 2013, article number 6216381, p. 597-610
Zhou, Xiaowei; Yang, Can; Yu, Weichuan Article
Multisample aCGH Data Analysis via Total Variation and Spectral Regularization
IEEE/ACM Transactions on Computational Biology and Bioinformatics, v. 10, (1), January-February 2013, article number 6517420, p. 230-235
Zhou, Xiaowei; Yang, Can; Wan, Xiang; Zhao, Hongyu; Yu, Weichuan Article
ProteinLasso: A Lasso regression approach to protein inference problem in shotgun proteomics
Computational Biology and Chemistry, v. 43, April 2013, p. 46-54
Huang, Ting; Gong, Haipeng; Yang, Can; He, Zengyou Article
The Complete Compositional Epistasis Detection in Genome-wide Association Studies
BMC Genetics, v. 14, February 2013, article number 7
Wan, Xiang; Yang, Can; Yang, Qiang; Zhao, Hongyu; Yu, Weichuan Article

2012 3

Peptide Reranking with Protein-Peptide Correspondence and Precursor Peak Intensity Information
IEEE/ACM Transactions on Computational Biology and Bioinformatics, v. 9, (4), July-August 2012, article number 6202798, p. 1212-1219
Yang, Chao; He, Zengyou; Yang, Can; Yu, Weichuan Article
近邻自适应局部尺度的谱聚类算法
中国图象图形学报=Journal of Image and Graphics, v. 17, (4), 2012, p. 523-529
孔万增; 孙昌思核; 张建海; 胡三清; 杨灿 Article
Automatic Mitral Leaflet Tracking in Echocardiography by Outlier Detection in the Low-rank Representation
IEEE Conference on Computer Vision and Pattern Recognition, August 2012, article number 6247773, p. 972-979
Zhou, Xiaowei; Yang, Can; Yu, Weichuan Conference paper

2011 6

A Hidden Two-locus Disease Association Pattern in Genome-wide Association Studies
BMC bioinformatics, v. 12, (156), May 2011, article number 156, p. 1-14
Yang, Can; Wan, Xiang; Yang, Qiang; Xue, Hong; Tang, Nelson L.S.; Yu, Weichuan Article
A Partial Set Covering Model for Protein Mixture Identification Using Mass Spectrometry Data
IEEE/ACM Transactions on Computational Biology and Bioinformatics, v. 8, (2), March-April 2011, article number 5066962, p. 368-380
He, Zengyou; Yang, Can; Yu, Weichuan Article
GBOOST: a GPU-based Tool for Detecting Gene-gene Interactions in Genome-wide Case Control Studies
Bioinformatics, v. 27, (9), May 2011, article number btr114, p. 1309-1310
Yung, Ling Sing; Yang, Can; Wan, Xiang; Yu, Weichuan Article
Identifying Disease-associated SNP Clusters via Contiguous Outlier Detection
Bioinformatics, v. 27, (18), September 2011, article number btr424, p. 2578-2585
Yang, Can; Zhou, Xiaowei; Wan, Xiang; Yang, Qiang; Xue, Hong; Yu, Weichuan Article
Motif-All: Discovering All Phosphorylation Motifs
BMC Bioinformatics, v. 12, (supplement 1), February 2011, article number S22
He, Zengyou; Yang, Can; Guo, Guangyu; Li, Ning; Yu, Weichuan Article
The Choice of Null Distributions for Detecting Gene-Gene Interactions in Genome-Wide Association Studies
BMC Bioinformatics, v. 12, (Supplement 1), February 2011, article number S26
Yang, Can; Wan, Xiang; He, Zengyou; Yang, Qiang; Xue, Hong; Yu, Weichuan Conference paper

2010 6

A Regularized Method for Peptide Quantification
Journal of Proteome Research, v. 9, (5), May 2010, p. 2705-2712
Yang, Chao; Yang, Can; Yu, Weichuan Article
BOOST: A Fast Approach to Detecting Gene-Gene Interactions in Genome-wide Case-Control Studies
American Journal of Human Genetics, v. 87, (3), September 2010, p. 325-340
Wan, Xiang; Yang, Can; Yang, Qiang; Xue, Hong; Fan, Xiaodan; Tang, Nelson L.S.; Yu, Weichuan Article
Detecting Two-locus Associations Allowing for Interactions in Genome-wide Association Studies
Bioinformatics, v. 26, (20), August 2010, article number btq486, p. 2517-2525
Wan, Xiang; Yang, Can; Yang, Qiang; Xue, Hong; Tang, Nelson L.S.; Yu, Weichuan Article
Optimization-Based Peptide Mass Fingerprinting for Protein Mixture Identification
Journal of Computational Biology, v. 17, (3), March 2010, p. 221-235
He, Zengyou; Yang, Chao; Yang, Can; Qi, Robert Zhong; Tam, P.M.; Yu, Weichuan Article
Predictive Rule Inference for Epistatic Interaction Detection in Genome-wide Association Studies
Bioinformatics, v. 26, (1), January 2010, article number btp622, p. 30-37
Wan, Xiang; Yang, Can; Yang, Qiang; Xue, Hong; Tang, Nelson L.S.; Yu, Weichuan Article
Identifying Main Effects and Epistatic Interactions from Large-scale SNP Data via Adaptive Group Lasso
BMC Bioinformatics, v. 11, (Supplement 1), January 2010, article number S18
Yang, Can; Wan, Xiang; Yang, Qiang; Xue, Hong; Yu, Weichuan Conference paper

2009 2

MegaSNPhunter: a Learning Approach to Detect Disease Predisposition SNPs and High Level Interactions in Genome Wide Association Study
BMC Bioinformatics, v. 10, January 2009, article number 13
Wan, Xiang; Yang, Can; Yang, Qiang; Xue, Hong; Tang, Nelson L.S.; Yu, Weichuan Article
SNPharvester: a Filtering-based Approach for Detecting Epistatic Interactions in Genome-wide Association Studies
Bioinformatics, v. 25, (4), February 2009, p. 504-511
Yang, Can; He, Zengyou; Wan, Xiang; Yang, Qiang; Xue, Hong; Yu, Weichuan Article

2008 3

Peak bagging for peptide mass fingerprinting
Bioinformatics, v. 24, (10), May 2008, p. 1293-1299
He, Zengyou; Yang, Can; Yu, Weichuan Article
Model Free Data Mining
Data Mining and Knowledge Discovery Technologies / Edited by: David Taniar. Hershey, PA, USA : IGI Publishing, 2008, p. 224-252
Yang, Can; Meng, Jun; Zhu, Shanan; Dai, Mingwei Book chapter
GPC Algorithm and Queuing-selecting for Networked Level Control
IEEE International Conference on Control and Automation ICCA, 2008, p. 2626-2629
Kong, Wanzeng; Zhu, Shan-an; Yang, Can Conference paper

2006 3

Application of Generalized Predictive Control in Networked Control System
Journal of Zhejiang University: Science, v. 7, (2), February 2006, p. 225-233
Yang, Can; Zhu, Shan-an; Kong, Wan-zeng; Lu, Li-ming Article
Cluster-Based Input Selection for Transparent Fuzzy Modeling
International Journal of Data Warehousing and Mining, v. 2, (3), 2006, p. 57-75
Yang, Can; Meng, Jun; Zhu, Shanan Article
基于人类知识的多变量多层模煳解耦控制策略研究
Sixth World Congress on Intelligent Control and Automation, Danvers, MA, U.S. : Institute of Electrical and Electronics Engineers, Inc., 2006, p. 3867-3871
孟濬; 杨灿 Conference paper

2005 2

Optimal Fuzzy Modeling Based on Minimum Cluster Volume
ADMA 2005: Advanced Data Mining and Applications, Editors: Xue Li, Shuliang Wang, Zhao Yang Dong. Heidelberg : Springer Verlag, 2005, p. 232-239
Yang, Can; Meng, Jun Conference paper
Transparent Fuzzy Modeling Based on Minimum Cluster Volume
2005 International Conference on Control and Automation (ICCA), Danvers, MA : IEEE, 2005, p. 1120-1125
Yang, Can; Zhu, Shan-an; Meng, Jun; Lu, Li-ming Conference paper


No Publications






Teaching Assignment

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2021-22 Winter 0 2021-22 Fall 2 2020-21 Summer 0 2020-21 Spring 2 2020-21 Winter 0 2020-21 Fall 2

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MATH4432 Statistical Machine Learning
MATH5472 Computer Age Statistical Inference with Applications


MAFS5340 Machine Learning and Its Applications
MFIT5010 Statistical Machine Learning


MATH4432 Statistical Machine Learning
MATH5472 Computer Age Statistical Inference with Applications


No Teaching Assignments


No Teaching Assignments


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)

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Current RPGs

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Doctor of Philosophy CHEN, Shi (co-supervision)
Data Science and Analytics( 2021 - )

FAN, Hongzhao (co-supervision)
Sustainable Energy and Environment( 2021 - )

GAO, Shihong (co-supervision)
Data Science and Analytics( 2021 - )

LIN, Jianxia (co-supervision)
Data Science and Analytics( 2021 - )

LIU, Hanmo (co-supervision)
Data Science and Analytics( 2021 - )

MAI, Shengwen (co-supervision)
Innovation, Policy and Entrepreneurship( 2021 - )

TIAN, Anxin (co-supervision)
Data Science and Analytics( 2021 - )

WANG, Zhiwei (co-supervision)
Mathematics( 2021 - )

ZHANG, Fa (co-supervision)
Mathematics( 2021 - )

ZHANG, Xiaomeng (co-supervision)
Data Science and Analytics( 2021 - )

HAN, Yuxuan (co-supervision)
Mathematics( 2020 - )

YU, Xinyi (co-supervision)
Mathematics( 2020 - )

HE, Jiafa
Mathematics( 2019 - )

QIAN, Yueqi (co-supervision)
Mathematics( 2019 - )

WAN, Xiaomeng
Mathematics( 2019 - )

WANG, Gefei
Mathematics( 2019 - )

YU, Zhiyuan
Mathematics( 2019 - )

ZHANG, Shunkang
Mathematics( 2019 - )

ZHAO, Jia
Mathematics( 2019 - )

ZHENG, Cong
Mathematics( 2019 - )

CAI, Mingxuan
Mathematics( 2018 - )

XIAO, Jiashun
Mathematics( 2018 - )

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Master of Philosophy CUI, Lihang (co-supervision)
Financial Technology( 2021 - )

WANG, Zhili (co-supervision)
Data Science and Analytics( 2021 - )









ProjectsFrom January 2020 to December 2022

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All Projects 13 Leading Projects 8 Participating Projects 5

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Development of Statistical Methods for constructing polygenic risk score in cross-population analysis


跨群体分析中多基因风险评分的统计方法研发 Leading


RGC - General Research Fund


Project Team (HKUST)
YANG Can (Lead)


2022 -




A Trading Bot By Ensemble Learning


一个集成学习的交易机器人 Participating


Innovation and Technology Fund


Project Team (HKUST)
CHEN Kani (Lead)
CAI Ning
WU Lixin
YANG Can


2021 -




Study of human genetic-variant hotspots map


人类基因组变异热点图谱研究 Leading


Guangdong Natural Science Foundation


Project Team (HKUST)
YANG Can (Lead)


2021 -




Guang Dong - Hong Kong - Macau Joint Laboratory on Data-Driven Fluid Mechanics and Its Engineering Applications


粤港澳数据驱动下的流体力学与工程应用联合实验室 Participating


Department of Science and Technology of Guangdong Province


Project Team (HKUST)
LI Larry
TONG Penger
TSE Kam Tim
WANG Yang
XU Kun
YANG Can


2021 -




The basic algorithm of big data analysis and calculation


大数据计算与分析的基础算法-课题2：超算环境下的线性方程组求解基础算法及回归分析算法研究 Participating


Ministry of Science and Technology of the People's Republic of China


Project Team (HKUST)
YANG Can


2020 -




A unified framework for Mendelian randomization accounting for sample overlapping, selection bias and horizontal pleiotropy


基於孟德尔随机化的统计学方法研究 Leading


RGC - General Research Fund


Project Team (HKUST)
YANG Can (Lead)


2020 -




Development of Statistical and Machine Learning Methods for Large Scale Genomic Data Analysis


人类基因组数据的统计与机器学习方法研发 Leading


Innovation and Technology Fund


Project Team (HKUST)
YANG Can (Lead)
BAO Zhigang
CAI Jianfeng
WANG Yang
XIA Dong
YAO Yuan
ZHANG Hai


2020 -




X-GPU: An Extreme GPU Cluster for Interdisciplinary Research on Molecular Dynamics Simulations and Genomics Studies


X-GPU:一个极高性能的GPU计算集群用於分子动力学模拟和基因组学的跨学科研究 Leading


RGC - Collaborative Research Fund


Project Team (HKUST)
YANG Can (Lead)
HAN Yilong
LUO Qiong
PAN Ding
SANDER Pedro
SU Haibin
WANG Jiguang
YAO Yuan
YU Weichuan


2020 -




A unified framework for quantifying impact of genetically regulated gene expression on complex phenotypes


用於量化遗传调节基因表达对复杂表型影响的统一框架研究 Leading


RGC - General Research Fund


Project Team (HKUST)
YANG Can (Lead)


2020 -




Statistical methods for dissecting genetic contributions to complex traits by leveraging regulatory information


运用调控信息剖析遗传对人类复杂性状影响的统计学方法研究 Leading


RGC - General Research Fund


Project Team (HKUST)
YANG Can (Lead)


2019 -




Advanced Data Analytics for Abnormal Detection of Semiconductor Devices


半导体器件异常检测的先进数据分析方法研究 Participating


Innovation and Technology Fund


Project Team (HKUST)
YAO Yuan (Lead)
YANG Can


2019 -




Big Data Analytic-based Remote Diagnosis Systems


基於大数据分析的远程诊断系统 Participating


Innovation and Technology Fund


Project Team (HKUST)
WANG Yang (Lead)
CHEN Lei
YANG Can
ZHANG Jiheng


2019 - 2021




A unified framework for exploring genetic architecture of human complex phenotypes using summary statistics


基于汇总统计量数据探索人类复杂性状遗传结构的统计学方法研究 Leading


RGC - General Research Fund


Project Team (HKUST)
YANG Can (Lead)


2018 - 2020