Yung Hou WONG
王殷厚
PhD in Pharmacology
University of Cambridge, 1989

Associate Dean of Science (Research, Graduate Studies & Administration)

Chair Professor
Division of Life Science

Director of Biotechnology Research Institute

Director of Molecular Neuroscience Center

Program Director of MSc Program in Biotechnology

Associate Director of Center for Aging Science



(852) 2358 7328
boyung@ust.hk
Room 5461
Personal Web

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ORCID
0000-0002-0123-7697

Scopus ID
35263245300




Research Interest Publications Projects Teaching Assignment RPG Supervision Space used




Research Interest

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Cell signaling



Publications

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All Years 369 2022 0 2021 3 2020 4 2019 5 2018 3 2017 8 2016 346

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2021 3

CTCF and EGR1 suppress breast cancer cell migration through transcriptional control of Nm23-H1
Scientific Reports, v. 11, (1), January 2021, article number 491
Wong, Ka Ming; Song, Jiaxing; Wong, Yung Hou Article
Modeling The Heterodimer Interfaces Of Melatonin Receptors
Frontiers in Cellular Neuroscience, v.15, 7 October 2021, article number 725296, p. 356-356
Tse, Lap Hang; Wong, Yung Hou Article
Re-examining the ‘Dissociation Model’ of G protein activation from the perspective of Gβγ signaling
FEBS Journal, v. 288, (8), April 2021, p. 2490-2501
Chung, Yin Kwan; Wong, Yung Hou Article

2020 4

Age Associated Decrease of MT-1 Melatonin Receptor in Human Dermal Skin Fibroblasts Impairs Protection Against UV-Induced DNA Damage
International Journal of Molecular Sciences, v. 21, (1), January 2020, article number 326
Dong, Kelly; Goyarts, Earl; Rella, Antonella; Pelle, Edward; Wong, Yung Hou; Pernodet, Nadine Article
Molecular basis defining the selectivity of substituted isoquinolinones for the melatonin MT₂ receptor
Biochemical Pharmacology, v. 177, July 2020, article number 114020
Chan, King Hang; Tse, Lap Hang; Huang, Xuhui; Wong, Yung Hou Article
Mutations at the dimer interface and surface residues of Nm23-H1 metastasis suppressor affect its expression and function
Molecular and Cellular Biochemistry, v. 474, (1-2), November 2020, p. 95-112
Li, Yuanjun; Liu, Wen; Saini, Vasu; Wong, Yung Hou Article
Anti-migratory effect of Nm23-H1 via exosomes
The International Society for Extracellular Vesicles, ISEV 2020, Virtual, 20-22 July 2020
Saini, Vasu; Wong, Yung Hou; Sun, Siu Nam Conference paper

2019 5

GPCRs in Autocrine and Paracrine Regulations
Frontiers in Endocrinology, v. 10, (JULY), July 2019, article number 428
Tse, Lap Hang; Wong, Yung Hou Article
Small molecules as drugs to upregulate metastasis suppressors in cancer cells
Current Medicinal Chemistry, v. 26, (32), November 2019, p. 5876-5899
Wong, Ka Ming; Song, Jiaxing; Saini, Vasu; Wong, Yung Hou Article
Generation of an effector-deficient Gαi1
2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 8 June 2019
Chung, Yin Kwan; Wong, Yung Hou Conference paper
The role of leukemia inhibitory factor (LIF) in the intercellular communication between neurons and astrocytes. Abstract P48.
2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 8 June 2019
Gu, Yishan; Wong, Yung Hou Conference paper
Unraveling the mechanism of RGS-induced upregulation of Nm23-H1. Abstract P68
2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 8 June 2019
Song, Jiaxing; Wong, Yung Hou Conference paper

2018 3

MT1 and MT2 melatonin receptors: heteromerization and functional significance
2018 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 25 June 2018
Tse, Lap Hang; Wong, Yung Hou Conference paper
Non-dissociable Gβ-Gα fusion proteins reveal different mechanisms of G protein activation
Gordon Research Conference - Phosphorylation and G-Protein Mediated Signaling Networks, New England, USA, 3-8 June 2018
Liu, Wen; Wong, Ka Ming; Chan, Siu Lung Anthony; Wong, Yung Hou Conference paper
Regulation of metastasis suppressor genes mediated by breast cancer derived exosomes
2018 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 25 June 2018
Saini, Vasu; Wong, Yung Hou Conference paper

2017 8

RGS19 Upregulates Nm23-H1/2 Metastasis Suppressors by Transcriptional Activation via the cAMP/PKA/CREB Pathway
Oncotarget, v. 8, (41), July 2017, p. 69945-69960
Li, Yuanjun; Song, Jiaxing; Tong, Yao; Chung, Sookjakim; Wong, Yung Hou Article
Role of G Protein-Coupled Receptors in the Regulation of Structural Plasticity and Cognitive Function
Molecules, v. 22, (7), July 2017, article number 1239
Leung, Ching Yiu Crystal; Wong, Yung Hou Article
Activation of PKA-dependent transcription factors by RGS19 upregulates metastasis suppressor Nm23-H1/2.
2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 16 June 2017
Song, Jiaxing; Wong, Yung Hou Conference paper
Back to the basics: the G protein cycle
2017 Biomedical Research Symposium of National Health Research Institutes (NHRI) 106年度国家卫生研究院生物医学学术研讨会, Taiwan, 14-15 August 2017
Wong, Yung Hou; Liu, Wen; Chan, Siu Lung Anthony; Wong, Ka Ming Conference paper
Differential G protein subunit dissociation mechanisms suggest possible family-wise selective Gβγ signaling
2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 16 June 2017
Liu, Wen; Li, Jiayue; Zhou, Longyin; Wong, Yung Hou Conference paper
Functional characterization of heteromerization effects of melatonin receptors
2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 16 June 2017
Tse, Lap Hang; Ng, Siu Wang; Chan, King Hang; Wong, Yung Hou Conference paper
Gq signaling pathway of melatonin receptor in islets of Langerhans
2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 16 June 2017
Gu, Yishan; Chan, Sze Man; Wong, Yung Hou Conference paper
Transcriptional and post-transcriptional regulation of NME1 in cancer metastasis.
2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 16 June 2017
Wong, Yung Hou; Wong, Ka Ming Conference paper

2016 9

Anxiety and Depression with Neurogenesis Defects in Exchange Protein Directly Activated by cAMP 2-Deficient Mice are Ameliorated by a Selective Serotonin Reuptake Inhibitor, Prozac
Translational Psychiatry, v. 6, (9), September 2016, article number e881
Zhou, L.; Ma, Sukling; Yeung, Patrick Ka Kit; Wong, Yung Hou; Tsim, Karl Wah Keung; So, K. F.; Lam, L.C.W.; Chung, S.K. Article
Differential Regulation of CXCL8 Production by Different G Protein Subunits with Synergistic Stimulation by G_i^- and G_q^-Regulated Pathways
Journal of Molecular Biology, v. 428, (19), September 2016, p. 3869-3884
Chan, Anthony Siu Lung; Lau, Wai In; Szeto, Aydan C.H.; Wang, Jiuling; Wong, Yunghou Article
Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling
Proceedings of the National Academy of Sciences of the United States of America, v. 113, (7), February 2016, p. 1937-1942
Li, Songshan; Yang, Chao; Zhang, Li; Gao, Xin; Wang, Xuejie; Liu, Wen; Wang, Yuqi; Jiang, Songshan; Wong, Yung Hou; Zhang, Yifeng; Liu, Kai Article
Quantitative Analysis of Nucleosides and Nucleobases in Deer Antler: Variation in Different Species
Pharmaceutica Analytica Acta, v. 7, (4), April 2016, article number 1000474
Bi, Dan; Zhang, L.M.L.; Tang, Wai Lun; Duan, Ran; Leung, Ka Wing; Dong, Tingxia; Wong, Yung Hou; Lin, Huangquan; Tsim, Karl Wah Keung Article
Regulator of G Protein Signaling 20 Enhances Cancer Cell Aggregation, Migration, Invasion and Adhesion
Cellular Signalling, v. 28, (11), November 2016, p. 1663-1672
Yang, Lei; Lee, Mei Ki; Leung, Man Hon Manton; Wong, Yung Hou Article
Cdk5 Activity is Required for EphB-mediated Synaptogenesis
The 46th Annual Meeting of the Society for Neuroscience, San Diego, USA, 12-16 November 2016
Chen, Yu; Wong, Yung Hou; Fu, Wing Yu; Fu, Kit Yu; Ip, Nancy Yuk-Yu Conference paper
Flavonoids Induce the Expression of Acetylcholinesterase in Cultured Osteoblasts
Chemico-Biological Interactions, v. 259, (B), 25 November 2016, p. 295-300
Xu, Miranda Li; Bi, Wenchuan; Kong, Yeung Yeung Ava; Dong, Ting Xia; Wong, Yung Hou; Tsim, Karl Wah Keung Conference paper
Functional assessment of MT2 melatonin receptor variants that are associated with type 2 diabetes
Neuroscience Symposium 2016 & Annual Scientific Conference of The Hong Kong Society of Neurosciences, Hong Kong, May, 2016
Wu, Y.; Chan, K.H.; Wong, Yung Hou Conference paper
The role of RGS20 in cell cycle regulation and angiogenesis
2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Lee Shau Kee Building, The Chinese University of Hong Kong, Hong Kong, 11 June 2016
Leung, M.; Alim, A.S.; Xu, R.; Wong, Yung Hou Conference paper

2015 15

Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on Gα_i3
Molecular and Cellular Biochemistry, v. 401, (1-2), March 2015, p. 27-38
Tse, Man Kit; Morris, Christina Jane; Zhang, Mingjie; Wong, Yung Hou Article
An intact helical domain is required for Gα₁₄ to stimulate phospholipase Cβ
BMC Structural Biology, v. 15, (1), September 2015, article number 18
Kwan, Dawna HT; Wong, Ka Ming; Chan, Anthony Siu Lung; Yung, Lisa Ying; Wong, Yung Hou Article
Association of activated Gα_q to the tumor suppressor Fhit is enhanced by phospholipase Cβ
BMC Cancer, v. 15, (1), October 2015, article number 775
Zuo, Hao; Wong, Yung Hou Article
Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons
Neurobiology of Disease, v. 73, January 2015, p. 366-376
Li, Songshan; He, Qinghai; Wang, Hao; Tang, Xuming; Ho, Kam Wing; Gao, Xin; Zhang, Qian; Shen, Yang; Cheung, Annie; Wong, Francis; Wong, Yung Hou; Ip, Nancy Yuk-yu; Jiang, Liwen; Yung, Wing Ho; Liu, Kai Article
Metastasis suppressors Nm23H1 and Nm23H2 differentially regulate neoplastic transformation and tumorigenesis
Cancer Letters, v. 361, (2), June 2015, p. 207-217
Tong, Yao; Yung, Lisa Ying; Wong, Yung Hou Article
Regulatory functions of Nm23-H2 in tumorigenesis: insights from biochemical to clinical perspectives
Naunyn-Schmiedeberg's Archives of Pharmacology, v. 388, (2), February 2015, p. 243-256
Li, Yuanjun; Tong, Yao; Wong, Yung Hou Article
RAS Genes
Encyclopedia of Cancer: a Springer Live Reference / Manfred Schwab. Berlin, Heidelberg : Springer, 2015, p. 1-6
Wong, Yung Hou; Pellicer, Angel; Liu, Wen Book chapter
Activation Of Phospholipase Cβ By NonDissociable Gq Proteins
ASCEPT-BPS Joint Scientific Meeting 2015, University of Hong Kong, 19-21 May 2015
Wong, Yung Hou; Liu, W.; Chan, Siu Lung Anthony; Poon, Lydia See Wing; Wong, K.M. Conference paper
Functional characterization of type 2 diabetes associated MTNRIB variants
2015 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 23 May 2015
Wu, Y.; Chan, K.H.; Wong, Yung Hou Conference paper
Inhibition of oncogenic Ras-induced tumorigenesis by Nm23 metastasis suppressors
The 2nd Annual Meeting of the International Ovarian Cancer Consortium and the Symposium on Tumor Microenvironment and Therapy Resistance, University of Oklahoma Health Sciences Center, Oklahoma City, USA, 16-18 August 2015
Wong, Y.H.; Li, Y. Conference paper
Involvement of G proteins in asymmetric cell division during neurogenesis
2015 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 23 May 2015
Yip, J.L.K.; Lee, M.M.K.; Wong, Yung Hou Conference paper
Molecular determinants of selective ligand binding at the human melatonin receptor
ASCEPT-BPS Joint Scientific Meeting (ASCEPT-BPS 2015), The University of Hong Kong, 19-21 May 2015
Chan, King Hang; Wong, Yung Hou Conference paper
Non-dissociable Gβ-Gα Fusion Proteins Reveal Different Mechanisms Of G Protein Activation
ASCEPT-BPS Joint Scientific Meeting (ASCEPT-BPS 2015), The University of Hong Kong, 19-21 May 2015
Liu, Wen; Chan, Siu Lung Anthony; Wong, Ka Ming; Wong, Yung Hou Conference paper
Post-transcriptional regulation of the regulator of G protein signaling 19 (RGS19) and metastasis suppressor Nm23 in cancer by microRNAs
2015 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 23 May 2015
Wong, Ka Ming; Wong, Yung Hou Conference paper
Role of surface residues on defining the functional specificity of Nm23 metastasis suppressors
ASCEPT-BPS Joint Scientific Meeting (ASCEPT-BPS 2015), The University of Hong Kong, 19-21 May 2015
Li, Yuanjun; Wong, Yung Hou Conference paper

2014 11

Angiotensin-[1-12] interacts with angiotensin type I receptors
Neuropharmacology, v. 81, June 2014, p. 267-273
Chan, King Hang; Chen, Yi Hung; Zhang, Ying; Wong, Yung Hou; Dun, Nae J. Article
Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management
NeuroSignals, v. 22, (1), May 2014, p. 52-63
Ip, Fanny Chui Fun; Ng, Yu Pong; An, Hui Jin; Dai, Ying; Pang, Hai Hong; Hu, Yue Qing; Chin, Allison C.; Harley, Calvin B.; Wong, Yung Hou; Ip, Nancy Yuk-Yu Article
Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via Toll-like receptor-4 dependent pathways
Neuroscience, v. 267, May 2014, p. 241-251
Tse, Kai Hei; Chow, K.B.S.; Leung, W.K.; Wong, Yung Hou; Wise, H. Article
Primary Sensory Neurons Regulate Toll-like receptor-4-dependent Activity of Glial Cells in Dorsal Root Ganglia
Neuroscience, v. 279, October 2014, p. 10-22
Tse, Kai-Hei; Chow, K.B.S.; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen Article
Synthesis and Functional Characterization of Substituted Isoquinolinones as MT₂-Selective Melatoninergic Ligands
PLoS ONE, v. 9, (12), December 2014, article number 0113638
Hu, Yueqing; Chan, King Hang; He, Xixin; Ho, Maurice Kwok Chung; Wong, Yung Hou Article
Activation of Gq without Subunits Dissociation
2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The University of Hong Kong, Hong Kong, 14 June 2014
Liu, Wen; Wong, Yung Hou Conference paper
Activation of PLCβ by a Non-dissociable Gq Protein
Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, Hong Kong, The University of Hong Kong, Hong Kong, 12-14 June 2014
Liu, W.; Chan, Siu Lung Anthony; Wong, K.M.; Wong, Yung Hou Conference paper
ENStem - A Cells as a Model for Studying Neurogenesis
Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, The University of Hong Kong, Hong Kong, 12-14 June 2014
Yip, J.L.K.; Lee, M.M.K.; Wong, Yung Hou Conference paper
Multi-faceted Metastasis Suppressor Nm23 is Up-regulated by RGS19 via Activating Transcription Factors
The 2014 Physiology Symposium and Joint Scientific Meeting of The Hong Kong Society of Neurosciences and The Biophysical Society of Hong Kong (HKSN-BSHK), The University of Hong Kong, Hong Kong, 12-14 June 2014
Li, Y.; Wong, Yung Hou Conference paper
RGS19 Up-regulates Nm23-H1/2 Expression via Stimulating Multiple Transcriptional Factors
Hong Kong Inter-University Biochemistry Postgraduate Symposium 2014, The University of Hong Kong, 14 June 2014
Li, Yuanjun; Wong, Yung Hou Conference paper
RGS20 as a Modulator of Tumorigenesis and Angiogenesis
2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The University of Hong Kong, Hong Kong, 14 June 2014
Leung, Man Hon Manton; Yang, Lei; Wong, Yung Hou Conference paper

2013 17

A Molecular and Chemical Perspective in Defining Melatonin Receptor Subtype Selectivity
International Journal of Molecular Sciences, v. 14, (9), September 2013, p. 18385-18406
Chan, King Hang; Wong, Yung Hou Article
Activation of Gα_q subunits up-regulates the expression of the tumor suppressor Fhit
Cellular Signalling, v. 25, (12), December 2013, p. 2440-2452
Zuo, Hao; Chan, Anthony Siu Lung; Ammer, Hermann; Wong, Yung Hou Article
Activation state-dependent interaction between Gα_q subunits and the Fhit tumor suppressor
Cell Communication and Signaling, v. 11, (1), August 2013, article number 59
Zuo, Hao; Chan, Grace P.W.; Zhu, Jing; Yeung, Wendy Wing Shan; Chan, Anthony Siu Lung; Ammer, Hermann; Wong, Yung Hou Article
Characterization of Substituted Phenylpropylamides as Highly Selective Agonists at the Melatonin MT2 Receptor
Current Medicinal Chemistry, v. 20, (2), January 2013, p. 289-300
Chan, King Hang; Hu, Sharry Y.; Ho, Maurice K C; Wong, Yung Hou Article
Development of substituted N-[3-(3-methoxylphenyl)propyl] amides as MT₂-selective melatonin agonists: Improving metabolic stability
Bioorganic and Medicinal Chemistry, v. 21, (2), January 2013, p. 547-552
Hu, Yueqing; Zhu, Jing; Chan, King Hang; Wong, Yung Hou Article
Gβγ-mediated activation of protein kinase D exhibits subunit specificity and requires Gβγ-responsive phospholipase Cβ isoforms
Cell Communication and Signaling, v. 11, (1), April 2013, article number 22
Lau, Winnie Wai In; Chan, Anthony Siu Lung; Poon, Lydia See Wing; Zhu, Jing; Wong, Yung Hou Article
Isolated dorsal root ganglion neurones inhibit receptor-dependent adenylyl cyclase activity in associated glial cells
British Journal of Pharmacology, v. 168, (3), February 2013, p. 746-760
Ng, Kai Yu; Yeung, Barry Ho Sing; Wong, Yung Hou; Wise, Helen Article
Neuronal Functions of Activators of G Protein Signaling
NeuroSignals, v. 21, (3-4), May 2013, p. 259-271
Tse, Man Kit; Wong, Yung Hou Article
Regulator of G protein signaling 19 suppresses Ras-induced neoplastic transformation and tumorigenesis
Cancer Letters, v. 339, (1), October 2013, p. 33-41
Wang, Yingchun; Tong, Yao; Tso, Prudence H.; Wong, Yung Hou Article
RGS19 inhibits Ras signaling through Nm23H1/2-mediated phosphorylation of the kinase suppressor of Ras
Cellular Signalling, v. 25, (5), May 2013, p. 1064-1074
Tso, Ha Prudence; Wang, Yingchun; Yung, Ying Lisa; Tong, Yao; Lee, Mei Ki Maggie; Wong, Yung Hou Article
Development of novel melatoninergics as circadian rhythm sleep disorder therapeutics
New Developments in Melatonin Research / Editors: Dario Acuna-Castroviejo, Iryna Rusanova, Germaine Escames. Nova Science Publishers, Inc., 2013, p. 53-76
Chan, King Hang; Cheung, Annie Suet Ting; Ho, Maurice K.C.; Wong, Yung Hou Book chapter
High-throughput screening in traditional Chinese medicine-based drug discovery
Antitumor Potential and Other Emerging Medicinal Properties of Natural Compounds / Editors: Evandro Fei Fang, Tzi Bun Ng. Dordrecht : Springer Science+Business Media, 2013, p. 387-404
Wong, Catherine Chi Kit; Wong, Yung Hou Book chapter
Nm23 Mediates RGS19-induced Suppression of Ras Signaling
The 9th International Congress of the NDP Kinase/Nm23/awd Gene Family, Boston, USA, 31 July - 4 August 2013
Wong, Yung Hou Conference paper
Regulation of STAT3 by GPCRs Involves Interleukin-6 Autocrine Signaling
The 7th IDRC Symposium, Seoul, Korea, 26-27 August 2013
Wong, Yung Hou Conference paper
Sensory Neurons Regulate Toll-like Receptor 4 (TLR4) Signaling in Glia Derived from Dorsal Root Ganglia (DRG)
2013 Annual Meeting of Society for Neuroscience, San Diego, USA, 9-13 November 2013
Tse, Kai Hei; Chow, Kevin Bing Shui; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen Conference paper
Toll-like Receptor 4 (TLR4) Differentially Regulates Cox-1 and Cox-2 to Enhance Prostanoid Production by Primary Sensory Neurons
2013 Annual Meeting of Hong Kong Society for Immunology, Hong Kong, 25 May, 2013
Tse, Kai Hei; Chow, Kevin Bing Shui; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen Conference paper
Toll-like Receptor 4 (TLR4) Increases Expression of Inflammatory Mediators in Primary Sensory Neurons via Activation of a MyD88-dependent Signaling Pathway
Acta Pharmacologica Sinica, v. 34, July 2013, p. 116
Wise, Helen; Chow, Kevin Bing Shui; Tse, Kai Hei; Leung, Wai Keung; Wong, Yung Hou Conference paper

2012 11

Activation of ras-dependent signaling pathways by G_14^-coupled receptors requires the adaptor protein TPR1
Journal of Cellular Biochemistry, v. 113, (11), November 2012, p. 3486-3497
Kwan, Dawna H.T.; Yung, Lisa Y.; Ye, Richard D.; Wong, Yung Hou Article
Astragaloside IV and Cycloastragenol Stimulate the Phosphorylation of Extracellular Signal-Regulated Protein Kinase in Multiple Cell Types
Planta Medica, v. 78, (2), January 2012, p. 115-121
Yung, Ying Lisa; Lam, Wing See; Ho, Maurice K.C.; Hu, Sharry Y.; Ip, Fanny C.F.; Pang, Haihong; Chin, Allison; Harley, Calvin B.; Ip, Nancy Yuk-yu; Wong, Yung Hou Article
CCR1-Mediated STAT3 Tyrosine Phosphorylation and CXCL8 Expression in THP-1 Macrophage-like Cells Involve Pertussis Toxin-Insensitive Gα_14/16 Signaling and IL-6 Release
Journal of Immunology, v. 189, (11), December 2012, p. 5266-5276
Lee, Mei Ki; Chui, Ricky K.S.; Tam, Issan Y.S.; Lau, Alaster H.Y.; Wong, Yung Hou Article
Elevated expression of RGS19 impairs the responsiveness of stress-activated protein kinases to serum
Molecular and Cellular Biochemistry, v. 362, (1-2), March 2012, p. 159-168
Ip, Angel K.C.; Tso, Ha; Lee, Mei Ki; Wong, Yung Hou Article
Interleukin-6 autocrine signaling mediates melatonin MT_1/2 receptor-induced STAT3 Tyr⁷⁰⁵ phosphorylation
Journal of Pineal Research, v. 52, (4), May 2012, p. 477-489
Lau, Wai In; Ng, Johnson K.Y.; Lee, Mei Ki; Chan, Siu Lung Anthony; Wong, Yung Hou Article
Pharmacokinetics, oral bioavailability and metabolism of a novel isoquinolinone-based melatonin receptor agonist in rats
Xenobiotica, v. 42, (11), November 2012, p. 1138-1150
Zhu, Jing; Hu, Sharry Y.; Ho, Maurice K.C.; Wong, Yung Hou Article
Prostacyclin Receptor-Dependent Inhibition of Human Erythroleukemia Cell Differentiation is STAT3-Dependent
Prostaglandins Leukotrienes and Essential Fatty Acids, v. 86, (3), March 2012, p. 119-126
Lau, Alaster H.Y.; Lai, Henry K.H.; Yeung, Barry H.S.; Leung, Sze Lee; Tsang, Suk Ying; Wong, Yung Hou; Wise, Helen Article
Rapid Uptake and Degradation of CXCL12 Depend on CXCR7 Carboxyl-terminal Serine/Threonine Residues
Journal of Biological Chemistry, v. 287, (34), August 2012, p. 28362-28377
Hoffmann, Frauke; Mueller, Wiebke; Schuetz, Dagmar; Penfold, Mark E.; Wong, Yung Hou; Schulz, Stefan; Stumm, Ralf Article
Activated Gαq subunits interact with the tumor suppressor Fhit and increase its expression and phosphorylation
Stephenson Cancer Center Mini Conference on Tumor Microenvironment and Drug Discovery, 2-3 Dec 2012, Oklahoma, USA, Abstract T1
Wong, Yung Hou Conference paper
Expression of Toll-like receptor 4 signaling components in adult rat dorsal root ganglion cells
Hong Kong-Taiwan Physiology Symposium 2012 and Joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, June 2012, p. 40
Tse, Kai Hei; Chow, Kevin Bing Shui; Ng, K. Y.; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen Conference paper
Novel interaction between signal transducing G proteins and the Fhit tumor suppressor
8th Asia Pacific Multidisciplinary Meeting for Cancer Research, May 11 2012, Hong Kong, Abstract T4
Wong, Yung Hou Conference paper

2011 11

3-Methoxylphenylpropyl amides as novel receptor subtype-selective melatoninergic ligands: characterization of physicochemical and pharmacokinetic properties
Xenobiotica, v. 41, (1), January 2011, p. 35-45
Zhu, Jing; Hu, Yueqing; Ho, Maurice K.C.; Wong, Yung Hou Article
Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRα2 isoforms
Cellular Signalling, v. 23, (11), November 2011, p. 1727-1737
Wan, Guoqiang; Zhou, Lihan; Lim, Qing `En; Wong, Yung Hou; Too, Heng-Phon Article
Expression of Gα_z in C2C12 Cells Restrains Myogenic Differentiation
Cellular Signalling, v. 23, (2), February 2011, p. 389-397
Mei, Hua; Ho, Kwok Chung Maurice; Yung, Ying; Wu, Zhenguo; Ip, Nancy Yuk-yu; Wong, Yung Hou Article
Glial cells isolated from dorsal root ganglia express prostaglandin E₂ (EP₄) and prostacyclin (IP) receptors
European Journal of Pharmacology, v. 661, (1-3), July 2011, p. 42-48
Ng, Kai Yu; Wong, Yung Hou; Wise, Helen Article
Gα₁₆ interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling
BMC Structural Biology, v. 11, April 2011, article number 17
Liu, A.M.F.; Lo, Kin H.; Guo, Emily X.; Ho, Maurice K.C.; Ye, Richard D.; Wong, Yung Hou Article
RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signaling
Cancer Letters, v. 309, (2), October 2011, p. 199-208
Tso, Prudence H.; Yung, Lisa Y.; Wang, Yingchun; Wong, Yung Hou Article
Regulation of Chemotaxis by Heterotrimeric G proteins
Chemotaxis: Types, Clinical Significance, and Mathematical Models / Edited by Timothy C. Williams. Hauppauge, N.Y.: Nova Science Publishers, c2011, p.109-134
Lee, Maggie M.K.; Wong, Yung Hou Book chapter
Nm23-H1 inhibits oncogene-induced neoplastic transformation
Second Inter-University Biochemistry Postgraduate Symposium, 11 Jun 2011, Hong Kong, Abstract P-U005
Tong, Yao; Wong, Yung Hou Conference paper
Regulation of Fhit by Gq family proteins
Second Inter-University Biochemistry Postgraduate Symposium, 11 Jun 2011, Hong Kong, Abstract P-U011
Zuo, H.; Chan, Anthony S.L.; Wong, Yung Hou Conference paper
The expression of Toll-like receptor 4 in rat dorsal root ganglia
Annual Scientific Meeting of the Hong Kong Society of Immunology, Hong Kong, 7 May 2011
Chow, KB; Chu, TCH; Leung, WK; Wong, Yung Hou; Wise, Helen Conference paper
Understanding the role of RGS20 in tumorigenesis
Second Inter-University Biochemistry Postgraduate Symposium, 11 Jun 2011, Hong Kong, Abstract P-U004
Yang, L.; Wong, Yung Hou Conference paper

2010 17

Activation of STAT3 by specific Gα subunits and multiple Gβγ dimers
International Journal of Biochemistry and Cell Biology, v. 42, (6), June 2010, p. 1052-1059
Yuen, J.W.F.; Poon, Lydia See Wing; Chan, Siu Lung Anthony; Yu, Frances W.Y.; Lo, Kin H.; Wong, Yung Hou Article
Gα₁₆ activates Ras by forming a complex with tetratricopeptide repeat 1 (TPR1) and Son of Sevenless (SOS)
Cellular Signalling, v. 22, (10), October 2010, p. 1448-1458
Liu, A.M.F.; Lo, Kin H.; Lee, Mei Ki; Wang, Yingchun; Yeung, Wendy W.S.; Ho, Maurice K.C.; Su, Yan; Ye, Richard D.; Wong, Yung Hou Article
Gα₁₆ interacts with Class IA phosphatidylinositol 3-kinases and inhibits Akt signaling
Cellular Signalling, v. 22, (9), September 2010, p. 1379-1387
Yeung, Wing Shan; Wong, Yung Hou Article
In Search of Novel and Therapeutically Significant Melatoninergic Ligands
Frontiers in CNS Drug Discovery, v. 1, 2010, p. 600-610
Mody, Sejal M.; Hu, Sharry Y.; Ho, Maurice K.C.; Wong, Yung Hou Article
In vitro Intestinal Absorption and First-pass Intestinal and Hepatic Metabolism of Cycloastragenol, a Potent Small Molecule Telomerase Activator
Drug Metabolism and Pharmacokinetics, v. 25, (5), November 2010, p. 477-486
Zhu, Jing; Lee, Stephanie; Ho, Maurice K.C.; Hu, Yueqing; Pang, Haihong; Ip, Fanny C.F.; Chin, Allison C.; Harley, Calvin B.; Ip, Nancy Yuk-Yu; Wong, Yung Hou Article
Nerve Growth Factor-Induced Differentiation of PC12 Cells Is Accompanied by Elevated Adenylyl Cyclase Activity
NeuroSignals, v. 18, (1), September 2010, p. 32-42
Yung, H.S.; Lai, K.H.; Chow, Kevin B.S.; Ip, Nancy Yuk-Yu; Tsim, Karl Wah Keung; Wong, Yung Hou; Wu, Zhenguo; Wise, Helen Article
RGS19 enhances cell proliferation through its C-terminal PDZ motif
Cellular Signalling, v. 22, (11), November 2010, p. 1700-1707
Tso, Ha; Wang, Yingchun; Wong, Sivia Y.S.; Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou Article
Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT₂-selective melatonin ligands
Bioorganic and Medicinal Chemistry Letters, v. 20, (8), April 2010, p. 2582-2585
Hu, Yueqing; Ho, Kwok Chung Maurice; Chan, King Hang; New, David C.; Wong, Yung Hou Article
The role of glial cells in influencing neurite extension by dorsal root ganglion cells
Neuron Glia Biology, v. 6, (1), February 2010, p. 19-29
Ng, Kai-Yu; Wong, Yung Hou; Wise, Helen Article
Functional Impacts of Signal Integration: Regulation of Inflammation-related Transcription Factors by Heterotrimeric G Proteins
Molecular to Modular Tumor Therapy: Tumors are Reconstructible Communicatively Evolving Systems / Edited by Albrecht Reichle. Dordrecht: Springer Science+Business Media B.V., 2010, p.161-189
Yeung, Wing Shan; Ho, Maurice K.C.; Wong, Yung Hou Book chapter
An investigation into the role of AGS3 in opiate tolerance and dependency
28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract PS13
Tse, Man Kit; Morris, Christina J.; Wong, Yung Hou Conference paper
Characterization of subtype-selective melatoninergic ligands with novel non-indoleamine scaffolds
PepCon 2010, 20-22 March 2010, Beijing, China
Ho, Maurice K.C.; Hu, Sharry Y.; Chan, King Hang; Zhu, Jing; Wong, Yung Hou Conference paper
Characterization of subtype-selective melatoninergic ligands with novel non-indoleamine scaffolds
Hong Kong Biochemistry Postgraduate Student Conference, 15 May 2010, Hong Kong, Abstract BCH10-A45
Hu, Sharry Y.; Ho, Maurice K.C.; Chan, King Hang; New, David C.; Wong, Yung Hou Conference paper
Differential activation of G protein family members: GTPgammaS triggers subunit dissociation of Gi3 but not Gq.
28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract T6
Chan, Siu Lung Anthony; Poon, Lydia See Wing; Wong, Yung Hou Conference paper
Functional coupling of Melatonin receptors with G16 leads to independent phosphorylation of Tyr-705 and Ser-727 on STAT3
The 28th Hong Kong Society of Neuroscience (HKSN) Annual Meeting, 7-8 June 2010, Hong Kong, Abstract T6
Lau, Winnie W.I.; Chan, Anthony S.L.; Wong, Yung Hou Conference paper
Melatonin MT1 receptor induces Fhit phosphorylation through the pertussis toxin-insensitive G16 protein
28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract T6
Zuo, H.; Chan, Siu Lung Anthony; Wong, Yung Hou Conference paper
Structure-activity relationships of novel subtype-selective melatoninergic ligands with novel non-indoleamine scaffolds
28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract Y6
Chan, King Hang013378; Ho, Maurice K.C.; Hu, Sharry Y.; Wong, Yung Hou Conference paper

2009 31

A Hematopoietic Perspective on the Promiscuity and Specificity of Gα₁₆ Signaling
NeuroSignals, v. 17, (1), February 2009, p. 71-81
Su, Yan; Ho, Maurice K.C.; Wong, Yung Hou Article
CCR1-mediated activation of nuclear factor-κB in THP-1 monocytic cells involves pertussis toxin-insensitive Gα₁₄ and Gα₁₆ signaling cascades
Journal of Leukocyte Biology, v. 86, (6), December 2009, p. 1319-1329
Lee, Mei Ki; Wong, Yung Hou Article
Differential and Synergistic Effect of Nerve Growth Factor and cAMP on the Regulation of Early Response Genes during Neuronal Differentiation
NeuroSignals, v. 17, (2), May 2009, p. 111-120
Ng, Yu Pong; Wu, Zhenguo; Wise, Helen; Tsim, Karl Wah Keung; Wong, Yung Hou; Ip, Nancy Yuk-Yu Article
G Protein signaling controls the differentiation of multiple cell lineages
BioFactors, v. 35, (3), May 2009, p. 232-238
Wang, Kepeng; Wong, Yung Hou Article
Gβ₃ forms distinct dimers with specific Gγ subunits and preferentially activates the β₃ isoform of phospholipase C
Cellular Signalling, v. 21, (5), May 2009, p. 737-744
Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou Article
Multiple G_i Proteins Participate in Nerve Growth Factor-Induced Activation of c-Jun N-terminal Kinases in PC12 Cells
Neurochemical Research, v. 34, (6), June 2009, p. 1101-1112
Tso, Ha; Morris, Christina Jane; Yung, Ying; Ip, Nancy Yuk-Yu; Wong, Yung Hou Article
Multiplex fluorimetric assays for monitoring algal toxins
Journal of the Marine Biological Association of the United Kingdom, v. 89, (2), March 2009, p. 287-293
Mak, Carmen K.M.; Yeung, Patrick K.K.; Kwok, Chun Man; Wong, Yung Hou; Wong, Joseph T.Y. Article
Regulation of mTOR and p70 S6 kinase by the muscarinic M4 receptor in PC12 cells
Cell Biology International, v. 33, (2), February 2009, p. 230-238
Chan, Grace P.W.; Wu, Eddy H.T.; Wong, Yung Hou Article
Regulation of transcription factors by heterotrimeric G proteins
Current Molecular Pharmacology, v. 2, (1), 2009, p. 19-31
Ho, Maurice K.C.; Su, Yan; Yeung, Wing Shan; Wong, Yung Hou Article
Reporter Gene Assays
Methods in Molecular Biology (Clifton, N.J.), v. 486, 2009, p. 109-123
Liu, A.M.F.; New, David C.; Lo, Kin H.; Wong, Yung Hou Article
The RhoA-specific guanine nucleotide exchange factor p63RhoGEF binds to activated Gα₁₆ and inhibits the canonical phospholipase Cβ pathway
Cellular Signalling, v. 21, (8), August 2009, p. 1317-1325
Yeung, Wing Shan; Wong, Yung Hou Article
Effect of cicaprost on differentiation of human erythroleukemia (HEL) cells
12th Scientific Meeting of the Hong Kong Pharmacology Society, Hong Kong, Abstract P10, 12-15 June 2009
Lai, K.H.; Lau, H.Y.A.; Tsang, Shui Ying; Wong, Yung Hou; Wise, H. Conference paper
Effects of Activator of G-protein Signaling 3 upon K-Opioid Receptor Signaling
The 27th Annual Meeting of the Hong Kong Society of Neuroscience (HKSN), Hong Kong, China. January 11-15, 2009
Tse, Man Kit; Wong, Yung Hou; Morris, Christina J. Conference paper
GAIP inhibits Ras signaling and tumor formation
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-47, 11-15 January 2009
Wang, Y.; Tso, Ha; Wong, Yung Hou Conference paper
Galphaq subunits interact with the Fhit tumor suppressor
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-40, 11-15 January 2009
Chan, G.P.W.; Chan, W.W.I.; Wong, Yung Hou Conference paper
Galphaz-regulated myogenic and osteogenic differentiation of C2C12 cells
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-45, 11-15 January 2009
Wang, K.; Yung, Ying; Ho, Maurice K.C.; Wong, Yung Hou Conference paper
GPCR signaling: role in cell proliferation and differentiation
12th Scientific Meeting of the Hong Kong Pharmacology Society, Hong Kong, Abstract PL2, 12-15 June 2009
Wong, Yung Hou Conference paper
Identification of Novel Binding Partners of GAIP
The 27th Annual Meeting of the Hong Kong Society of Neuroscience (HKSN), Hong Kong, China. January 11-15, 2009
Leung, Sing; Morris, Christina J.; Wong, Yung Hou Conference paper
In vitro pharmacological characterizations of novel receptor subtype-spepcific melatoninergic ligands
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-39, 11-15 January 2009
Zhu, Jing; Ho, Maurice K.C.; Hu, Sharry Y.; Wong, Yung Hou Conference paper
Melatonin MT1 and MT2 knockout mice exhibit impaired circadian rhythm re-entrainment
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-48, 11-15 January 2009
Xu, Y.; Ho, Maurice K.C.; Wong, Yung Hou Conference paper
Melatonin MT1 Receptor-mediated PKD Activation
Gordon Research Conferences on Mechanisms Of Cell Signalling - Towards Understanding Signalling Networks, 23-28 August, Oxford, UK
Chan, Siu Lung Anthony; Lau, Wai In; Wong, Yung Hou Conference paper
Melatonin MT2 receptor activates STAT3 through the pertussis toxin-insensitive G16 protein
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-39, 11-15 January 2009
Chan, Siu Lung Anthony; Lau, Wai In; Wong, Yung Hou Conference paper
Molecular determinants for G betagamma-induced activation of phospholipase C-beta isoforms
The 6th Asian Biophysics Association Symposium & 27th Hong Kong Society of Neuroscience Annual Meeting
Poon, See Wing; Chan, Anthony S.L.; Wong, Yung Hou Conference paper
Molecular determinants for Gbetagamma-induced activation of phospholipase C isoforms
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-46, 11-15 January 2009
Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou Conference paper
Prostanoid-stimulated cAMP production in rat dorsal root ganglion cells: role of non-neuronal cells
12th Scientific Meeting of the Hong Kong Pharmacology Society, Hong Kong, Abstract P6, 12-15 June 2009
Ng, K.Y.; Wong, Yung Hou; Wise, Helen Conference paper
RhoA-specific guanine nucleotide exchange factor p63RhoGEF modulates Galpha16 signaling
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-52, 11-15 January 2009
Yeung, Wing Shan; Wong, Yung Hou Conference paper
Role of non-neuronal cells on influencing neurite extension by rat dorsal root ganglion cell neurons
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-23, 11-15 January 2009
Ng, K.Y.; Wong, Yung Hou; Wise, Helen Conference paper
Role of PKC in melatonin receptor-mediated STAT3 activation
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract S16-7, 11-15 January 2009
Lau, Wai In; Chan, Siu Lung Anthony; Wong, Yung Hou Conference paper
Structure-activity relationships of novel melatonin MT2 subtype-selective ligands with non-indoleamine scaffolds
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-44, 11-15 January 2009
Chan, S.K.H.; Ho, Maurice K.C.; Wong, Yung Hou Conference paper
Targeting RGS proteins for the modulation of GPCR signaling
12th SCBA International Symposium, Taiwan, Abstract 7B-4, 14-18 June 2009
Wong, Yung Hou Conference paper
TPR1 is required for Galphaq-mediated Ras signaling
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-38, 11-15 January 2009
Kwan, D.H.T.; Liu, A.M.F.; Wong, Yung Hou Conference paper

2008 14

Activation of the human FPRL-1 receptor promotes Ca²⁺ mobilization in U87 astrocytoma cells
Neurochemical Research, v. 33, (1), January 2008, p. 125-133
Kwan, Dawna H.T.; Kam, Angel Y.F.; Wong, Yung Hou Article
Differential involvement of Gα₁₆ in CC chemokine-induced stimulation of phospholipase Cβ, ERK, and chemotaxis
Cellular Signalling, v. 20, (6), June 2008, p. 1179-1189
Tian, Yaji; Lee, Maggie M.K.; Yung, Lisa Y.; Allen, Rodger A.; Slocombe, Patrick M.; Twomey, Breda M.; Wong, Yung Hou Article
Mutations on the switch III region and the alpha3 helix of Galpha₁₆ differentially affect receptor coupling and regulation of downstream effectors
Journal of Molecular Signaling, v. 3, November 2008, article number 17
Yu, May Y.M.; Ho, Maurice K.C.; Liu, A.M.F.; Wong, Yung Hou Article
Naturally Occurring Phenylethanoid Glycosides: Potential Leads for New Therapeutics
Current Medicinal Chemistry, v. 15, (25), October 2008, p. 2592-2613
Fu, Guangmiao; Pang, Haihong; Wong, Yung Hou Article
Nerve growth factor-induced stimulation of p38 mitogen-activated protein kinase in PC12 cells is partially mediated via G_i/o proteins
Cellular Signalling, v. 20, (8), August 2008, p. 1538-1544
Yung, Ying; Tso, Ha; Wu, Eddy H.T.; Yu, Jowie C.H.; Ip, Nancy Yuk-Yu; Wong, Yung Hou Article
Prostacyclin receptor-induced STAT3 phosphorylation in human erythroleukemia cells is mediated via Gα_s and Gα₁₆ hybrid signaling
Cellular Signalling, v. 20, (11), November 2008, p. 2095-2106
Lo, Kin H.; Liu, A.M.F.; Wise, Helen; Wong, Yung Hou Article
AGS3 modulation of ERK phosphorylation by the kappa-opioid receptor
9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS21, 25-26 March 2008
Morris, Christina Jane; Wong, Yung Hou Conference paper
AGS3 Modulation of ERK Phosphorylation by the Kappa-Opioid Receptor
The 39th Annual International Narcotics Research Conference (INRC), Charleston, SC. USA. July 13-18, 2008
Morris, Christina J.; Tse, Man Kit; Wong, Yung Hou Conference paper
Formation of specific G protein Betagamma-dimers and their corresponding activation of phospholipase C isoforms
9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS24, 25-26 March 2008
Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou Conference paper
Galpha14 signaling through TPR1: a structural and functional perspective
9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS22, 25-26 March 2008
Kwan, D.H.T.; Wong, Yung Hou Conference paper
GAlphaz Inhibits Myogenic Differentiation of C2C12 Cells
The 9th AEARU Workshop on Molecular Biology and Biotechnology, Hong Kong, 25 - 26 March 2008
Ho, Kwok Chung Maurice; Mei, Hua; Yung, Ying; Wu, Zhenguo; Ip, Nancy Yuk-Yu; Wong, Yung Hou Conference paper
Influence of glial cells on stress-induced neurite retraction in rat dorsal root ganglion cells
APSN 2008, Shanghai, China, Abstract, 24-26 June 2008
Ng, K.Y.; Wong, Yung Hou; Wise, Helen Conference paper
Melatonin MT1 receptor-mediated STAT3 activation through Galpha16
9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS25, 25-26 March 2008
Lau, Wai In; Chan, Siu Lung Anthony; Wong, Yung Hou Conference paper
Nerve growth factor-induced differentiation of rat pheochromocytoma (PC12) cells leads to changes in adenylyl cyclase activity
APSN 2008, Shanghai, China, Abstract, 24-26 June 2008
Lai, K.H.; Yung, H.S.; Wong, Yung Hou; Wise, Helen Conference paper

2007 12

Dopaminergic and adrenergic toxicities on SK-N-MC human neuroblastoma cells are mediated through G protein signaling and oxidative stress
Apoptosis, v. 12, (1), January 2007, p. 167-179
Chan, Siu Lung Anthony; Ng, Linda W.C.; Poon, Lydia See Wing; Chan, Winnie W.Y.; Wong, Yung Hou Article
Expression of G protein beta subunits in rat skeletal muscle after nerve injury: Implication in the regulation of neuregulin signaling
Neuroscience, v. 146, (2), May 2007, p. 594-603
Lok, Ka Chun; Fu, Amy Kit Yu; Ip, Fanny Chun Fun; Wong, Yung Hou; Ip, Nancy Yuk-Yu Article
Formyl peptide receptor like 1 differentially requires mitogen-activated protein kinases for the induction of glial fibrillary acidic protein and interleukin-1α in human U87 astrocytoma cells
Cellular Signalling, v. 19, (10), October 2007, p. 2106-2117
Kam, Angel Y.F.; Tse, Timothy T.M.; Kwan, Dawna H.T.; Wong, Yung Hou Article
Formyl peptide-receptor like-1 requires lipid raft and extracellular signal-regulated protein kinase to activate inhibitor-κB kinase in human U87 astrocytoma cells
Journal of Neurochemistry, v. 103, (4), November 2007, p. 1553-1566
Kam, Angel Y.F.; Liu, Andrew M.F.; Wong, Yung Hou Article
G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis
FEBS Journal, v. 274, (23), December 2007, p. 6025-6036
New, David C.; Wu, Kelvin; Kwok, Alice W.S.; Wong, Yung Hou Article
In search of novel and therapeutically significant melatoninergic ligands
Recent Patents on CNS Drug Discovery, v. 2, (3), November 2007, p. 241-245
Mody, Sejal M.; Hu, Sharry Y.; Ho, Maurice K.C.; Wong, Yung Hou Article
Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression
Journal of Molecular Signaling, v. 2, February 2007, article number 2
New, David C.; Wong, Yung Hou Article
NRG induces membrane targeting of Gαz in muscle: implication in myogenesis
NeuroReport, v. 18, (14), September 2007, p. 1433-1436
Lok, Ka Chun; Fu, Kit Yu; Ip, Fanny C.F.; Wong, Yung Hou; Ip, Nancy Yuk-Yu Article
Adenylyl cyclase activity during NGF-induced differentiation of rat pheochromocytoma (PC12) cells
Croucher Advanced Study Institute on Movement Disorders: Basic and Clinical Sciences, Hong Kong., 27 November - 1 December 2007
Yung, H.S.; Lai, K.H.; Wong, Yung Hou; Wise, Helen Conference paper
Drug Development Candidate TAT2 Activates Telomerase in Primary Neuronal Cultures
Abstract P052
An, Hui Jin; Ip, Fanny C.F.; Hu, Sharry Y; Ho, Maurice K C; Chin, A.C.; Harley, C.B.; Wong, Yung Hou; Ip, Nancy Yuk-Yu Conference paper
Identification of subtype-selective melatonin receptor ligands from traditional Chinese medicine
MGH-HKU-Nature Forum. Molecular Medicine and Biopharma Opportunities, Hong Kong, 5-6 March 2007. Abstract P042.
Ho, Maurice K.C.; New, David C.; Hu, Sharry Y.; Pang, Haihong; Wong, Yung Hou Conference paper
Knowledge-Based Drug Discovery: Identification of Novel Leads From Traditional Chinese Medicine
MGH-HKU-Nature Forum. Molecular Medicine and Biopharma Opportunities, Hong Kong, 5 - 6 March 2007
Pang, Haihong; Hu, Sharry Y.; Ho, Maurice K C; Ip, Fanny C.F.; An, Hui Jin; Ip, Nancy Yuk-Yu; Wong, Yung Hou Conference paper

2006 28

Activation of muscarinic M₄ receptor augments NGF-induced pro-survival Akt signaling in PC12 cells
Cellular Signalling, v. 18, (3), March 2006, p. 258-293
Wu, Eddy H.T.; Wong, Yung Hou Article
Activation of STAT3 by Gα_s Distinctively Requires Protein Kinase A, JNK, and Phosphatidylinositol 3-Kinase
Journal of Biological Chemistry, v. 281, (47), November 2006, p. 35812-35825
Liu, A.M.F.; Lo, Kin H.; Wong, Cecilia S.S.; Morris, Christina; Wise, Helen; Wong, Yung Hou Article
CKBM stimulates MAPKs but inhibits LPS-induced IFN-γ in lymphocytes
Phytotherapy Research, v. 20, (9), September 2006, p. 725-731
Chan, Siu Lung Anthony; Yip, Eric C.H.; Yung, Ying; Pang, Haihong; Luk, Sharon C.W.; Pang, Shin F.; Wong, Yung Hou Article
Constitutively active α subunits of G_q/11 and G_2/13 families inhibit activation of the pro-survival Akt signaling cascade
FEBS Journal, v. 273, (11), June 2006, p. 2388-2398
Wu, Eddy H.T.; Tam, Becky H.L.; Wong, Yung Hou Article
GABA_B heterodimeric receptors promote Ca²⁺ influx via store-operated channels in rat cortical neurons and transfected chinese hamster ovary cells
Neuroscience, v. 137, (4), 2006, p. 1347-1358
New, David C.; An, Hui Jin; Ip, Nancy Yuk-Yu; Wong, Yung Hou Article
Involvement of calcium mobilization from caffeine-sensitive stores in mechanically induced cell cycle arrest in the dinoflagellate Crypthecodinium cohnii
Cell Calcium, v. 39, (3), March 2006, p. 259-274
Yeung, Patrick Ka Kit; Lam, Connie Mo Ching; Ma, Zhiyi; Wong, Yung Hou; Wong, Joseph T.Y. Article
Opioid receptor-like (ORL1) receptor utilizes both G(0A) and G(0B) for signal transduction
Protein & Peptide Letters, v. 13, (5), May 2006, p. 437-441
Tso, Ha; Wong, Yung Hou Article
Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: A mechanism requiring PTX-insensitive G proteins, ERK and JNK
Cellular Signalling, v. 18, (3), March 2006, p. 307-317
Lo, Kin H.; Wise, Helen; Wong, Yung Hou Article
Protocatechuic acid induces cell death in HepG2 hepatocellular carcinoma cells through a c-Jun N-terminal kinase-dependent mechanism
Cell Biology and Toxicology, v. 22, (4), July 2006, p. 293-302
Yip, E.C.H.; Chan, Siu Lung Anthony; Pang, Haihong; Tam, Y.K.; Wong, Yung Hou Article
The aqueous extract of Radix Glycyrrhizae stimulates mitogen-activated protein kinases and nuclear factor-kappa B in Jurkat T-cells and THP-1 monocytic cells
American Journal of Chinese Medicine, v. 34, (2), 2006, p. 263-278
Chan, Siu Lung Anthony; Pang, Haihong; Yip, Eric Chun Hung; Tam, Yunkau; Wong, Yung Hou Article
Transcriptional activation of c-Fos by constitutively active Gα₁₆QL through a STAT1-dependent pathway
Cellular Signalling, v. 18, (12), December 2006, p. 2143-2153
Lo, Kin H.; Wong, Yung Hou Article
Tuberin: A Stimulus-Regulated Tumor Suppressor Protein Controlled by a Diverse Array of Receptor Tyrosine Kinases and G Protein-Coupled Receptors
NeuroSignals, v. 15, (5), July 2006, p. 217-227
Wu, Eddy H.T.; Wu, Kelvin K.H.; Wong, Yung Hou Article
G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity [Book review]
ChemMedChem, v. 1, (7), July 2006, p. 741-742
Wong, Yung Hou Book review
A time-dependent loss of prostaglandin EP3 receptors in PC12 cells during neuroal differentiation
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Yung, H.S.; Wong, Yung Hou; Wise, Helen Conference paper
Apoptosis of human neuroblastoma SK-N-MC cells induced by dopamine and norepinephrine
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Chan, Siu Lung Anthony; Ng, L.W.C.; Poon, Lydia See Wing; Chan, W.W.Y.; Wong, Yung Hou Conference paper
Axin Is Involved in Nerve Growth Factor-Induced Differentiation of PC12 Cells
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies & Annual Meeting of Hong Kong Society of Neurosciences, Hong Kong, 30 November - 2 December 2006
Ng, Yu Pong; Lin, Shengcai; Fu, Kit Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu Conference paper
Cell-based Fluorimetric assays for monitoring Gembierddiscus toxins
Proceedings of the Third International Conference on the Prevention and Management of Harmful Algal blooms in the South China Sea, p1-5. June, 2006. The Association on Harmful Algal Blooms in the South China Sea
Mak, Carmen K.M.; Yeung, Patrick K.K.; Wong, Yung Hou; Wong, Joseph T.Y. Conference paper
Co-stimulation of Galphas alters Galpha16-mediated STAT3 activation.
Croucher Advanced Study Institute on Signaling in Cell Growth and Differentiation, Hong Kong, Abstract., 2006
Wong, Yung Hou Conference paper
Ga sub(16) Binds to RhoA-Specific Guanine Nucleotide Exchange Factor p63RhoGEF and Competes with the Canonical PLC/PKC Pathway
46th Annual Meeting of the American Society for Cell Biology, San Diego Convention center, San Diego, California (USA), 9-13 Dec 2006
Yeung, W.W.S.; Wong, Yung Hou Conference paper
Ga sub(s) Mediates b sub(2)-Adrenergic Receptor-Induced Stat3 Phosphorylation
4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS 2006), Cheung Kung Hai Conference Centre, Hong Kong City (Hong Kong-S.A.R of China), 30 Nov-2 Dec 2006
Liu, A.M.F.; Lo, Kin H.; Wong, C.S.S.; Morris, Christina Jane; Wise, Helen; Wong, Yung Hou Conference paper
Galpha14 interacts with tetratricopeptide repeat 1 for Ras signaling
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, Nov ember 30 - December 2, 2006. Abstract.
Kwan, D.H.T.; Wong, Yung Hou Conference paper
Galpha16 binds to RhoA-specific guanine nucleotide exchange factor p63RhoGEF and competes with the canonical PLC/PKC pathway
45th Annual Meeting of the American Society for Cell Biology, San Diego, USA, 13-17 December 2006. Abstract 67.
Yeung, Wing Shan; Wong, Yung Hou Conference paper
Modulation of kappa-opioid signaling by RGS proteins
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Tso, Ha; Wong, Yung Hou Conference paper
Opioid-induced pro-survival signals and the Akt/Tuberin pathway
Intl Narcotics Res Conf, Minnesota, USA, 9-14 July 2006, Abstract S II-5
Wong, Yung Hou Conference paper
p63RhoGEF, a membrane-bound guanine nucleotide exchange factor, modulates signaling by heterotrimeric G proteins
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, Nov 30 - Dec 2, 2006, Abstract
Yeung, Wing Shan; Wong, Yung Hou Conference paper
Regulatory mechanism of mTOR and p70 S6 kinase by muscarinic M4 receptors in PC12 cells
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Chan, G.P.W.; Wu, Eddy H.T.; Wong, Yung Hou Conference paper
Role of Axin in Nerve Growth Factor-Induced Differentiation of PC12 Cells
The 5th Gordon Research Conference on 'Molecular and Cellular Neurobiology', Hong Kong, 11 - 16 June 2006
Ng, Yu Pong; Lin, Shengcai; Fu, Kit Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu Conference paper
The down-regulation of prostaglandin EP3 receptor subtype during neuronal differentiation
IUPHAR 2006, Beijing, China, Abstract
Yung, H.S.; Wong, Yung Hou; Wise, Helen Conference paper

2005 33

Activation of nuclear factor κB by somatostatin type 2 receptor in pancreatic acinar AR42J cells involves Gα₁₄ and multiple signaling components: A mechanism requiring protein kinase C, calmodulin-dependent kinase II, ERK, and c-Src
Journal of Biological Chemistry, v. 280, (41), October 2005, p. 34617-34625
Liu, A.M.F.; Wong, Yung Hou Article
Activation of δ-, κ-, and μ-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells
Biochemical and Biophysical Research Communications, v. 334, (3), September 2005, p. 838-844
Wu, Eddy H.T.; Wong, Yung Hou Article
An aqueous extract of the popular Chinese nutraceutical Kwei Ling Ko (Tortoise shell-Rhizome Jelly) activates the PPARγ pathway and down-regulates the NFκB activity
Phytomedicine, v. 12, (10), November 2005, p. 748-759
Yip, Eric Chun Hung; Liu, A.M.F; Wong, Joseph T.Y.; Wong, Yung Hou Article
Carvacrol and eugenol differentially stimulate intracellular Ca²⁺ mobilization and mitogen-activated protein kinases in Jurkat T-cells and monocytic THP-1 cells
Planta medica, v. 71, (7), July 2005, p. 634-639
Chan, Siu Lung Anthony; Pang, Haihong; Yip, Eric Chun Hung; Tam, Yunkau; Wong, Yung Hou Article
Chimeric and Promiscuous G Proteins in Drug Discovery and the Deorphanization of GPCRs
Drug Design Reviews Online, v. 2, (1), February 2005, p. 66-79
New, David C.; Wong, Yung Hou Article
G_q-Mediated Activation of c-Jun N-Terminal Kinase by the Gastrin-Releasing Peptide-Preferring Bombesin Receptor Is Inhibited upon Costimulation of the G_s-Coupled Dopamine D₁ Receptor in COS-7 Cells
Molecular Pharmacology, v. 68, (5), November 2005, p. 1354-1364
Chan, Siu Lung Anthony; Wong, Yung Hou Article
Immuno-regulatory effects of CKBM on the activities of mitogen-activated protein kinases and the release of cytokines in THP-1 monocytic cells
Biological and Pharmaceutical Bulletin, v. 28, (9), September 2005, p. 1645-1650
Chan, Siu Lung Anthony; Yip, Eric Chun Hung; Yung, Ying; Pang, Haihong; Luk, Sharon; Pang, Shiufun; Wong, Yung Hou Article
Integration of G protein signals by extracellular signal-regulated protein kinases in SK-N-MC neuroepithelioma cells
Journal of Neurochemistry, v. 94, (5), August 2005, p. 1457-1470
Chan, Siu Lung Anthony; Yeung, Wendy W.S.; Wong, Yung Hou Article
Involvement of G_i/o Proteins in Nerve Growth Factor-Stimulated Phosphorylation and Degradation of Tuberin in PC-12 Cells and Cortical Neurons
Molecular Pharmacology, v. 67, (4), April 2005, p. 1195-1205
Wu, Eddy H.T.; Wong, Yung Hou Article
Mu-Opioid Receptor-Mediated Phosphorylation of IκB Kinase in Human Neuroblastoma SH-SY5Y Cells
NeuroSignals, v. 14, (3), July 2005, p. 136-142
Liu, A.M.F.; Wong, Yung Hou Article
Pertussis toxin-sensitive G_i/o proteins are involved in nerve growth factor-induced pro-survival Akt signaling cascade in PC12 cells
Cellular Signalling, v. 17, (7), July 2005, p. 881-890
Wu, Eddy H.T.; Wong, Yung Hou Article
Molecular Basis of Opioid Actions: Regulation of Mitogen-activated Protein Kinases
Recent Developments in Pain Research, 2005 / Edited by Anna Capasso. Research Signpost Publishers, 2005, p. 41-58
Chan, Siu Lung Anthony; New, David C.; Wong, Yung Hou Book chapter
Activated Galpha11, Galpha12, and Galpha13 inhibit activation of the pro-survival AKT signaling cascade
24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract P-25.
Tam, H.L.; Wu, Eddy H.T.; Wong, Yung Hou Conference paper
Activation of muscarinic M4 receptor augments NGF-induced pro-survival Akt signaling in PC12 cells
24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract O-12.
Wu, Eddy H.T.; Wong, Yung Hou Conference paper
Activation of the human FPRL-1 receptor promotes Ca2+ mobilization and stimulates mitogen-activated protein kinases in U87 astrocytoma cells.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P-9., 2005
Kwan, Dawna H.T.; Kam, Angel Y.F.; Wong, Yung Hou Conference paper
Differential regulation of signal transducers and activators of transcription by G protein subunits
24th Scientific Meeting of the Kong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract P-37.
Yuen, J.W.F.; Wong, Yung Hou Conference paper
Expression profiling of Galphaz-regulated genes
24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., 13-14 January 2005, Abstract P-23.
Mei, H.; Ho, Maurice K.C.; Yung, Ying; Wong, Yung Hou Conference paper
Function of Galphaz in muscle differentiation
HKU/HKUST/Cambridge University Joint Research Retreat, Hong Kong., 10-12 March 2005
Mei, H.; Ho, Maurice K.C.; Yung, Ying; Wong, Yung Hou Conference paper
G14-mediated stimulation of NFkappaB by the type 2 somatostatin receptor
24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract P-29
Liu, A.M.L.; Wong, Yung Hou Conference paper
Identification of Critical Early Genes Involved in Nerve Growth Factor-Induced PC12 Differentiation
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5 - 6 December 2005
Xiao, Fang; Ng, Yu Pong; Tsim, Karl Wah Keung; Wise, Helen; Wong, Yung Hou; Ip, Nancy Yuk-Yu; Wu, Zhenguo Conference paper
Involvement of Gi/o proteins in nerve growth factor-stimulated phosphorylation and degradation of tuberin in PC12 cells
HKU/HKUST/Cambridge University Joint Research Retreat, Hong Kong, 10-12 March 2005
Wu, Eddy H.T.; Wong, Yung Hou Conference paper
New perspectives in G protein signaling: regulation of protein kinases and transcription factors.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Plenary Lecture I., 2005
Wong, Yung Hou Conference paper
NGF-Induced Neuronal Differentiation of PC12 Cells: Delineation of Signaling Molecules and Mapping of Pathways.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5 - 6 December 2005
Leung, W.K.W.; Choi, Chi Yan; Ip, Nancy Yuk-Yu; Wu, Zhenguo; Wong, Yung Hou; Cheung, P.T.; Tsim, Karl Wah Keung Conference paper
Overexpression of Galphaz Inhibits Muscle Differentiation
Abstract P-14
Mei, Hua; Wu, Zhenguo; Ip, Nancy Yuk-Yu; Wong, Yung Hou Conference paper
Regulation of STAT3 phosphorylation by Galphas.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong. Abstract P3., 2005
Lo, Kin H.; Liu, A.M.F.; Wise, Helen; Wong, Yung Hou Conference paper
Role of Axin in Nerve Growth Factor-Stimulated Neurite Outgrowth
Abstract O-2.
Ng, Yu Pong; Lin, Shengcai; Fu, Wing Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu Conference paper
Role of Calmodulin-Dependent Kinase II in Nerve Growth Factor-Induced Differentiation of PC12 Cells.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5-6 December 2005
Kam, Yuet Fong; Yung, Ying; Wu, Eddy H.T.; Ng, Yu Pong; Wu, Zhenguo; Tsim, Karl Wah Keung; Wise, Helen; Ip, Nancy Yuk-Yu; Wong, Yung Hou Conference paper
Screening for NMDA Receptor Antagonists Using Traditional Chinese Medicine
Abstract P-7
Ip, Fanny C.F.; An, Hui Jin; Chan, Agnes Wing Sze; Tong, Pui Sze; Hu, Sharry Y.; Wong, Yung Hou; Ip, Nancy Yuk-Yu Conference paper
Stimulation of mitogen-activated protein kinases by the human FPRL-1 receptor
24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., 13-14 January 2005, Abstract P-27.
Kam, Angel Y.F.; Tse, T.T.M.; New, David C.; Wong, Yung Hou Conference paper
Synergistic activation of extracellular signal-regulated kinase by Gi- and Gq-coupled receptors in SK-N-MC neuroepithelioma cells
HKU/HKUST/Cambridge University Joint Research Retreat, Hong Kong, 10-12 March 2005
Yeung, Wing Shan; Wong, Yung Hou Conference paper
Synergistic activation of extracellular signal-regulated kinase by Gi- and Gq-coupled receptors in SK-N-MC neuroepithelioma cells
24th Scientific Meeting of the Hong Kong Society of Neurosciences Hong Kong, 13-14 January 2005, Abstract P-33
Yeung, Wing Shan; Chan, Siu Lung Anthony; Wong, Yung Hou Conference paper
The effect of NGF-induced differentiation on the expression of prostanoid receptors in PC12 cells.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P-19., 2005
Yung, H.S.; Wong, Yung Hou; Wise, Helen Conference paper
Unraveling chemokine signaling for drug discovery.
Pacifichem 2005, Hawaii, USA., 15-20 December 2005
Wong, Yung Hou Conference paper

2004 18

Characterization of CHO cells stably expressing a Gα_16/z Chimera for high throughput screening of GPCRs
Assay and Drug Development Technologies, v. 2, (3), June 2004, p. 269-280
New, David C.; Wong, Yung Hou Article
Differential chemokine activation of CC chemokine receptor 1-regulated pathways: ligand selective activation of Gα₁₄-coupled pathways
European Journal of Immunology, v. 34, (3), March 2004, p. 785-795
Tian, Yaji; New, David C.; Yung, Ying; Allen, Rodger A.; Slocombe, Patrick M.; Twomey, Breda M.; Lee, Mei Ki; Wong, Yung Hou Article
Epidermal growth factor differentially augments G_i-mediated stimulation of c-Jun N-terminal kinase activity
British Journal of Pharmacology, v. 142, (4), June 2004, p. 635-646
Chan, Siu Lung Anthony; Wong, Yung Hou Article
G₁₆-mediated Activation of Nuclear Factor κB by the Adenosine A₁ Receptor Involves c-Src, Protein Kinase C, and ERK Signaling
Journal of Biological Chemistry, v. 279, (51), December 2004, p. 53196-53204
Liu, A.M.F.; Wong, Yung Hou Article
Gβγ signaling and Ca²⁺ mobilization co-operate synergistically in a Sos and Rac-dependent manner in the activation of JNK by G_q-coupled receptors
Cellular Signalling, v. 16, (7), July 2004, p. 823-836
Chan, Siu Lung Anthony; Wong, Yung Hou Article
Identification of a stretch of six divergent amino acids on the α5 helix of Gα₁₆ as a major determinant of the promiscuity and efficiency of receptor coupling
Biochemical Journal, v. 380, (2), June 2004, p. 361-369
Ho, Maurice K.C.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Wong, Yung Hou Article
Phosphatidylinositol-3 kinase is distinctively required for μ-, but not κ-opioid receptor-induced activation of c-Jun N-terminal kinase
Journal of Neurochemistry, v. 89, (2), April 2004, p. 391-402
Kam, Angel Y.F.; Chan, Siu Lung Anthony; Wong, Yung Hou Article
Prostacyclin receptor-mediated activation of extracellular signal-regulated kinases 1 and 2
Cellular Signalling, v. 16, (4), April 2004, p. 477-486
Chu, Kit-Man; Chow, Kevin B.S.; Wong, Yung Hou; Wise, Helen Article
Regulation of STAT3 by μ-opioid receptors in human neuroblastoma SH-SY5Ycells
NeuroReport, v. 15, (9), June 2004, p. 1431-1435
Yuen, Jessie W.F.; So, Ivy Y.W.; Kam, Angel Y.F.; Wong, Yung Hou Article
Replacement of the α5 helix of Gα₁₆ with Gα_s-specific sequences enhances promiscuity of Gα₁₆ toward G_s-coupled receptors
Cellular Signalling, v. 16, (1), January 2004, p. 51-62
Hazari Anjali Ajaykumar; Lowes, Vicki L.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Ho, Maurice K.C.; Wong, Yung Hou Article
Signal Transducer and Activator of Transcription 3 Activation by the δ-Opioid Receptor via Gα₁₄ Involves Multiple Intermediates
Molecular Pharmacology, v. 65, (6), June 2004, p. 1487-1439
Lo, Kin H.; Wong, Yung Hou Article
κ-Opioid Receptor Signals through Src and Focal Adhesion Kinase to Stimulate c-Jun N-Terminal Kinases in Transfected COS-7 Cells and Human Monocytic THP-1 Cells
Journal of Pharmacology and Experimental Therapeutics, v. 310, (1), July 2004, p. 301-310
Kam, Angel Y.F.; Chan, Siu Lung Anthony; Wong, Yung Hou Article
Atypical regulation of calcium signals in astrocytoma 1321N1 cells expressing the purinergic P2Y12 receptor.
The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Hong Kong, Abstract B-P33-15, 4-7 February
Ho, Maurice K.C.; Simon, J.; Barnard, E.A.; Wong, Yung Hou Conference paper
Gi family members participate in nerve growth factor-mediated translational control in PC12 cells
Gordon Research Conference on Molecular & Cellular Neurobiology, Hong Kong, P65, 6-11 June
Wu, Eddy H.T.; Wong, Yung Hou Conference paper
Opioid-mediated regulation of protein kinases and transcription factors
The 3rd Meeting of Asian Pacific Opioid Symposium on Molecular Basis of Opioid Tolerance and Dependence, Kyoto, Japan, 18 July 2004, Abstract
Wong, Yung Hou Conference paper
Purinergic regulations of mitogen-activated protein kinases and calcium mobilization in rat brain capillary endothelial B10 cells
The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Hong Kong, Abstract B-P33-12, 4-7 February
Wong, Yung Hou; Ho, Maurice K.C.; Leung, E.H.Y.; Simon, J.; Barnard, E.A. Conference paper
Regulation of nuclear factor kappaB and STAT3 by mu-opioid receptors in human neuroblastoma SH-SY5Y cells
Intl Narcotics Res Conf, Kyoto, Japan, 18-23 July 2004, Abstract P-52
Wong, Yung Hou; Liu, A.M.F.; Yuen, J.W.F.; Kam, A.Y.F. Conference paper
Requirement of Gi/o proteins and phosphatidylinositol-3-kinase in nerve growth factor-induced tuberin phosphorylation and degradation
The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Hong Kong, Abstract B-P33-4, 4-7 February
Wu, Eddy H.T.; Wong, Yung Hou Conference paper

2003 17

BML-190 and AM251 act as inverse agonists at the human cannabinoid CB₂ receptor: signalling via cAMP and inositol phosphates
FEBS Letters, v. 536, (1-3), February 2003, p. 157-160
New, David C.; Wong, Yung Hou Article
CC chemokine receptor-coupled signalling pathways
生物化学与生物物理学报=Acta Biochimica et Biophysica Sinica, v. 2003, (09), 2003, p. 779-788
New, David C.; Wong, Yung Hou Article
Constitutively Active Gα₁₆ Stimulates STAT3 via a c-Src/JAK- and ERK-dependent Mechanism
Journal of Biological Chemistry, v. 278, (52), December 2003, p. 52154-52165
Lo, Kin H.; Cheung, Helen; Wong, Yung Hou Article
G Protein-Linked Effector and Second Messenger Systems Involved in Melatonin Signal Transduction
NeuroSignals, v. 12, (2), March 2003, p. 59-70
New, David C.; Tsim, Siu T.; Wong, Yung Hou Article
Gα_16/z chimeras efficiently link a wide range of G protein-coupled receptors to calcium mobilization
Journal of Biomolecular Screening, v. 8, (1), February 2003, p. 39-49
Liu, A.M.F.; Ho, Maurice K.C.; Wong, Cecilia S.S.; Chan, Jasmine H.P.; Pau, Anson H.M.; Wong, Yung Hou Article
Molecular basis of opioid dependence: Role of signal regulation by G-proteins
Clinical and Experimental Pharmacology and Physiology, v. 30, (5-6), May-June 2003, p. 307-316
Tso, Ha; Wong, Yung Hou Article
Rac and Cdc42-dependent regulation of c-Jun N-terminal kinases by the delta-opioid receptor
Journal of Neurochemistry, v. 84, (3), February 2003, p. 503-513
Kam, Angel Y.F.; Chan, Siu Lung Anthony; Wong, Yung Hou Article
Regulation of STAT3 activity by G₁₆-coupled receptors
Biochemical and Biophysical Research Communications, v. 303, (3), April 2003, p. 920-925
Wu, Eddy H.T.; Lo, Kin H.; Wong, Yung Hou Article
Reporter gene assays and their applications to bioassays of natural products
Phytotherapy Research, v. 17, (5), May 2003, p. 439-448
New, David C.; Miller-martini, David M.; Wong, Yung Hou Article
The first and third intracellular loops together with the carboxy terminal tail of the delta-opioid receptor contribute toward functional interaction with G₁₆
Journal of Neurochemistry, v. 87, (3), November 2003, p. 697-708
Chan, Anthony S.L.; Law, Ping Y.; Loh, Horace H.; Ho, Peter N.N.; Wu, Wai-Man; Chan, Joy S.C.; Wong, Yung Hou Article
The β6/α5 regions of Gα_i2 and Gα_oA increase the promiscuity of Gα₁₆ but are insufficient for pertussis toxin-catalyzed ADP-ribosylation
European Journal of Pharmacology, v. 473, (2-3), July 2003, p. 105-115
Wong, Cecilia S.S.; Ho, Maurice K.C.; Wong, Yung Hou Article
Activation of STAT3 by hematopoietic-specific G proteins
10th Congress of Federation of Asian & Oceanian Biochemists and Molecular Biologists, India, Abstract S27, 7-11 December
Wong, Yung Hou; Lo, Kin H. Conference paper
Constitutively active Galpha16 stimulates STAT1 via a c-Src/JAK- and ERK-dependent mechanism
43rd Annual Meeting of the American Society for Cell Biology, San Francisco, USA, Abstract 1573, 13-17 December
Lo, Kin H.; Wong, Yung Hou Conference paper
Pertussis toxin-sensitive Gi/o proteins are involved in nerve growth factor-induced Akt signaling cascade in PC12 cells
23rd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract OP3, 9-10 December
Wu, E.H.T.; Wong, Yung Hou Conference paper
Pertussis toxin-sensitive Gi/o proteins participate in nerve growth factor-induced activation of survival Akt kinase and nuclear factor kappaB
43rd Annual Meeting of the American Society for Cell Biology, San Francisco, USA, Abstract 67, 13-17 December
Wu, E.H.T.; Wong, Yung Hou Conference paper
STAT3 activation by the delta-opioid receptor via Galpha14 involves c-Src/JAK- and ERK-dependent pathways
23rd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PP9, 9-10 December
Lo, Kin H.; Wong, Yung Hou Conference paper
The Roles of G-Proteins in the Formation of Neuromuscular Junction and Myogenesis
The 23rd Annual Scientific Conference of the Hong Kong Society of Neuroscience, Hong Kong, 9 - 10 December 2003
Lok, Ka Chun; Fu, Wing Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu Conference paper

2002 19

Characterization and Channel Coupling of the P2Y₁₂Nucleotide Receptor of Brain Capillary Endothelial Cells
Journal of Biological Chemistry, v. 277, (35), August 2002, p. 37390-31400
Simon, Joseph; Filippov, Alexander K.; G?ransson, Sara A.; Wong, Yung Hou; Frelin, Christian; Michel, Anton D.; Brown, David A.; Barnard, Eric A. Article
Co-Expressions of Different Opioid Receptor Types Differentially Modulate Their Signaling via G₁₆
NeuroSignals, v. 11, (2), March-April 2002, p. 115-122
Ho, Maurice K.C.; New, David C.; Wong, Yung Hou Article
Constitutive activation of the opioid receptor-like (ORL₁) receptor by mutation of Asn133 to tryptophan in the third transmembrane region
Journal of Neurochemistry, v. 83, (6), December 2002, p. 1461-1470
Kam, Kenneth Wan Lung; New, David C.; Wong, Yung Hou Article
Integration of Signals from Receptor Tyrosine Kinases and G Protein-Coupled Receptors
NeuroSignals, v. 11, (1), January-February 2002, p. 5-19
Lowes, Vicki L.; Ip, Nancy Yuk-Yu; Wong, Ying Hou Article
Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins
Cellular Signalling, v. 14, (3), March 2002, p. 249-257
Chan, Siu Lung Anthony; Lai, Frank; Lo, Kin H.; Voyno-yasenetskaya, Tatyana A.; Stanbridge, Eric John; Wong, Yung Hou Article
Molecular determinants for the differential coupling of Gα₁₆ to the melatonin MT1, MT2 and Xenopus Mel1c receptors
Journal of Neurochemistry, v. 80, (5), March 2002, p. 436-745
Lai, Frank; Mody, Sejal M.; Yung, Ying; Kam, Jason Y.M.; Pang, Celia Sook Fun; Pang, Shiufun; Wong, Yung Hou Article
Prostanoid Signal Integration and Cross Talk
NeuroSignals, v. 11, (1), January-February 2002, p. 20-28
Wise, Helen; Wong, Yung Hou; Jones, Robert Leslie Article
Signal Diversification by the Neuronal-Specific Gz Protein.
Neuro-Signals, 11: 170-171
Wong, Yung Hou Article
The ORL₁ Receptor: Molecular Pharmacology and Signalling Mechanisms
NeuroSignals, v. 11, (4), July 2002, p. 197-212
New, David C.; Wong, Yung Hou Article
G protein structure diversity
Structure and Function of GPCRs in the Nervous System / 63-86
Ho, Maurice K.C.; Wong, Yung Hou Book chapter
Atypical G protein signaling: The path to kinases
Croucher Advanced Study Institute on Cell Signaling and Gene Transcription, Croucher Foundation, Hong Kong, S2
Wong, Yung Hou Conference paper
BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor
22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P10
New, David C.; Wong, Yung Hou Conference paper
Expressions of regulators of G protein signaling RGSZ1 and GAIP augment neuronal differentiation of PC12 cells
22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P12
Ho, Maurice K.C.; Wu, Eddy H.T.; Wong, Yung Hou Conference paper
Involvement of G Protein Signaling Pathway at the Neuromuscular Junctions
Abstract P11
Lok, Ka C.; Fu, Wing Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu Conference paper
mu-Opioid receptor-mediated activation of c-Jun N-terminal kinase requires phosphatidylinositol 3-kinase
22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P13
Kam, Yuet Fong; Wong, Yung Hou Conference paper
Nerve Growth Factor-Dependent Activation of C-Jun N-Terminal Kinase in PC12 Cells Is Mediated via Pertussis Toxin-Sensitive G Proteins
Abstract O19
Tso, Ha; Yung, Ying; Yu, Jowie C.H.; Ip, Nancy Yuk-Yu; Wong, Yung Hou Conference paper
Regulation of STAT3 activity by ORL1 receptor through Galpha16
22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract O6
Wu, Eddy H.T.; Lo, Kin H.; Wong, Yung Hou Conference paper
Signal diversification by the neuronal-specific Gz protein
Croucher Advanced Study Institute on Molecular Neuroscience Hong Kong University of Science and Technology
Wong, Yung Hou Conference paper
The application of Galpha16/Z chimeras in high-throughput drug screening
Third International Symposium for Chinese Medicinal Chemists, Hong Kong, December
New, David C.; Ho, Maurice K.C.; Dai, Wei M.; Wong, Yung Hou Conference paper

2001 19

A reporter gene assay for the detection of phytoestrogens in traditional Chinese medicine
Phytotherapy Research, v. 15, (6), September 2001, p. 487-492
Miller-martini, David M; Chan, Robbie Y.K.; Ip, Nancy Yuk-Yu; Sheu, S.J.; Wong, Yung Hou Article
Bacterial formyl peptide mediated chemotaxis and extracellular acidification in shrimp haemocytes
Developmental and Comparative Immunology, v. 25, (4), May 2001, p. 269-277
Yip, Eric Chun Hung; Wong, Yung Hou; Wong, Joseph T.Y. Article
Chimeric Gα_q subunits can distinguish the long form of the Xenopus Mel1c melatonin receptor from the mammalian mt1 and MT2 melatonin receptors
Journal of Pineal Research, v. 30, (3), April 2001, p. 171-179
Lai, Frank P.L.; Mody, Sejal M.; Yung, Ying; Pang, Celia Sook Fun; Pang, Shiufun; Wong, Yung Hou Article
G_z signaling: Emerging divergence from G_i signaling
Oncogene, v. 20, (13 REV. ISS. 1), March 2001, p. 1615-1625
Ho, Maurice K.C.; Wong, Yung Hou Article
Gα₁₄ links a variety of G_i- and G_s-coupled receptors to the stimulation of phospholipase C
British Journal of Pharmacology, v. 132, (7), April 2001, p. 1431-1440
Ho, Maurice K.C.; Yung, Ying; Chan, Joy S.C.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Wong, Yung Hou Article
Opioid-induced adenylyl cyclase supersensitization in human embryonic kidney 293 cells requires pertussis toxin-sensitive G proteins other than G_i1 and G_i3
Neuroscience Letters, v. 299, (1-2), February 2001, p. 25-28
Tso, Ha; Wong, Yung Hou Article
Prostacyclin receptor-independent inhibition of phospholipase C activity by non-prostanoid prostacyclin mimetics
British Journal of Pharmacology, v. 134, (7), December 2001, p. 1375-1384
Chow, Kevin B.S.; Wong, Yung Hou; Wise, Helen Article
Role of extracellular signal-regulated kinases in opioid-induced adenylyl cyclase superactivation in human embryonic kidney 293 cells
Neuroscience Letters, v. 316, (1), December 2001, p. 13-16
Tso, Ha; Wong, Yung Hou Article
The Cyclic AMP-Mediated Expression of Acetylcholinesterase in Myotubes Shows Contrasting Activation and Repression between Avian and Mammalian Enzymes
Molecular and Cellular Neuroscience, v. 17, (4), April 2001, p. 732-745
Choi, Roy Chi Yan; Siow, Nina Lam; Zhu, Shangquan; Wan, David Chi Cheong; Wong, Yung Hou; Tsim, Karl Wah Keung Article
Applications of chimeric and mutant Ga16 subunits in ligand screening for orphan G protein-coupled receptors.
7th Annual Conference of the Society for Biomolecular Screening, Baltimore, USA., Abstract 10012
Wong, Yung Hou; Ho, Maurice K.C. Conference paper
Neuronal Gz protein differentially regulates mitogen-activated protein kinases and signal transducers and activators of transcription
21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P38
Ho, Maurice K.C.; Lo, Kin H.; Chan, Siu Lung Anthony; Tso, Ha; Wong, Yung Hou Conference paper
Rac and Cdc42-dependent regulation of c-Jun N-terminal kinase by the opioid receptors.
International Symposium on Cell Signaling - from diseases to drug discovery, Hong Kong.
Kam, Angel Y.F.; Wong, Yung Hou Conference paper
Regulation of STAT3 activity by heterotrimeric G proteins of the Gq subfamily.
21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., Abstract P26
Wong, Yung Hou; Lo, Kin H.; Ho, Maurice K.C. Conference paper
Replacement of the C-terminal residues of Ga16 with Gai2 or Gao1 residues enhances its promiscuity for receptor recognition.
21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., Abstract P25
Wong, Cecilia S.S.; Pau, Anson H.M.; Wong, Yung Hou Conference paper
Selected mutations in the a5 helix of Ga16 increase its promiscuity for receptors
21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract 37
Chan, Jasmine H.P.; Ho, Maurice K.C.; Wong, Yung Hou Conference paper
Selected mutations of the a5 helix of Ga16 improves the coupling of Gi-linked receptor
International Symposium on Cell Signaling - from diseases to drug discovery, Hong Kong
Ho, Maurice K.C.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Wong, Yung Hou Conference paper
Signaling from opioid receptors to c-Jun N-terminal kinase requires the small GTP-binding proteins Rac and Cdc42.
41st Annual Meeting of the American Society for Cell Biology, Washington, USA., Abstract 1233
Kam, Angel Y.F.; Wong, Yung Hou Conference paper
Suppression of prostacyclin receptor-mediated phospholipase C stimulation by Ga14.
21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., Abstract P39
Lee, Mei Ki; Joshi, Sushma A.; Wise, Helen; Wong, Yung Hou Conference paper
The regulation of c-Jun N-terminal kinase by opioid receptors involves Rac and Cdc42
21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract 24
Kam, Angel Y.F.; Wong, Yung Hou Conference paper

2000 13

Activation of B-Raf and Regulation of the Mitogen-activated Protein Kinase Pathway by the G_o α chain
Molecular Biology of the Cell, v. 11, (4), April 2000, p. 1129-1142
Antonelli, Valeria; Bernasconi, Francesca; Wong, Yung Hou; Vallar, Lucia Article
Cloning of a novel G-protein-coupled receptor from the sea anemone nervous system
Biochemical and Biophysical Research Communications, v. 271, (3), May 2000, p. 761-769
New, David C.; Wong, Yung Hou; Wong, Joseph T.Y. Article
Deciphering the role of G_i2 in opioid-induced adenylyl cyclase supersensitization
NeuroReport, v. 11, (14), September 2000, p. 3213-3217
Tso, Ha; Wong, Yung Hou Article
Evidence for transduction of mu but not kappa opioid modulation of extracellular signal-regulated kinase activity by G_z and G₁₂ proteins
Cellular Signalling, v. 12, (7), July 2000, p. 481-489
Belcheva, Mariana M.; Wong, Yung Hou; Coscia, Carmine J. Article
G_z Can Mediate the Acute Actions of μ- and κ-Opioids but Is Not Involved in Opioid-Induced Adenylyl Cyclase Supersensitization
Journal of Pharmacology and Experimental Therapeutics, v. 295, (1), October 2000, p. 168-176
Tso, Ha; Wong, Yung Hou Article
Immunoglobulin G1 Fc Fragment-Tagged Human Opioid Receptor-Like Receptor Retains the Ability to Inhibit cAMP Accumulation
Biological Signals and Receptors, v. 9, (5), September-October 2000, p. 240-247
Yung, Ying; Tsim, Karl Wah Keung; Pei, Gang; Wong, Yung Hou Article
Incorporation of Gα_z-specific sequence at the carboxyl terminus increases the promiscuity of Gα₁₆ toward G_i-coupled receptors
Molecular Pharmacology, v. 57, (1), January 2000, p. 13-23
Mody, Sejal M.; Ho, Maurice K.C.; Joshi, Sushma A.; Wong, Yung Hou Article
Molecular mechanisms and regulation of opioid receptor signaling
Annual Review of Pharmacology and Toxicology, v. 40, April 2000, p. 389-430
Law, Pingyee; Wong, Yung Hou; Loh, Horace Article
Preactivation Permits Subsequent Stimulation of Phospholipase C by G,sub>i-Coupled Receptors
Molecular Pharmacology, v. 57, (4), April 2000, p. 700-708
Chan, Joy S.C.; Lee, Jonathan W.M.; Ho, Maurice K.C.; Wong, Yung Hou Article
Regulation of Adenylyl Cyclase, ERK1/2, and CREB by G_z Following Acute and Chronic Activation of the δ-Opioid Receptor
Journal of Neurochemistry, v. 74, (4), April 2000, p. 1685-1693
Tso, Ha; Yung, Ying; Wong, Yung Hou Article
Regulation of C-jun N-terminal kinase by the ORL₁ receptor through multiple G proteins
Journal of Pharmacology and Experimental Therapeutics, v. 295, (3), December 2000, p. 11094-1100
Chan, Siu Lung Anthony; Wong, Yung Hou Article
The Amino Terminus of Gα_z is Required for Receptor Recognition, Whereas its α4/β6 Loop Is Essential for Inhibition of Adenylyl Cyclase
Molecular Pharmacology, v. 58, (5), November 2000, p. 993-1000
Ho, Maurice K.C.; Wong, Yung Hou Article
The Effect of Protein Kinase C Activation on G_z-Mediated Regulation of Type 2 and 6 Adenylyl Cyclases
Biological Signals and Receptors, v. 9, (1), January-February 2000, p. 21-28
Ho, Maurice K.C.; Chan, Joy S.C.; Yung, Ying; Wong, Yung Hou Article

1999 7

Alanine-23 of transducin α subunit is involved in defining the affinity for βγ complex
NeuroReport, v. 10, (7), May 1999, p. 1561-1564
Ho, Maurice K C; Wong, Yung Hou Article
Alanine-23 of transducin α subunit is involved in defining the affinity for βγ complex
NeuroReport, v. 10, (9), June 1999, p. 1993-1996
Ho, Maurice Kwok Chung; Wong, Yung Hou Article
Chronic activation of ORL₁ receptor induces supersensitization of adenylyl cyclase
NeuroReport, v. 10, (14), September 1999, p. 2901-2905
Chan, Robbie; Wong, Yung Hou Article
Disruption of receptor-mediated activation of G protein by mutating a conserved arginine residue in the switch II region of the α subunit
Journal of Neurochemistry, v. 73, (5), November 1999, p. 2101-2109
Ho, Maurice K.C.; Yung, Ying; Wong, Yung Hou Article
G_L1 (Gα₁₄) couples the opioid receptor-like₁ receptor to stimulation of phospholipase C
Journal of Pharmacology and Experimental Therapeutics, v. 288, (1), January 1999, p. 232-238
Yung, Ying; Joshi, Sushma A.; Chan, Robbie Y.K.; Chan, Joy S.C.; Pei, Gang; Wong, Yung Hou Article
Mutational analysis of the structure and function of opioid receptors
Biopolymers - Peptide Science Section, v. 51, (6), 1999, p. 440-455
Law, Pingyee; Wong, Yung Hou; Loh, Horace Article
Stimulation of phospholipase C by the cloned μ, δ and κ opioid receptors via chimeric Gα_q mutants
European Journal of Neuroscience, v. 11, (2), January 1999, p. 383-388
Joshi, Sushma; Lee, Jonathan W.M.; Wong, Yung Hou Article

1998 8

Chimeric Gα_q mutants harboring the last five carboxy-terminal residues of Gα_i2 or Gα_o are resistant to pertussis toxin-catalyzed ADP-ribosylation
FEBS Letters, v. 441, (1), December 1998, p. 67-70
Joshi, Sushma A.; Fan, Kenneth P.K.; Ho, Vannessa W.S.; Wong, Yung Hou Article
Differential coupling of μ-, δ-, and κ-opioid receptors to Gα₁₆- mediated stimulation of phospholipase C
Journal of Neurochemistry, v. 70, (5), May 1998, p. 2203-2211
Lee, Jonathan W.M.; Joshi, Sushma A.; Chan, Joy S.C.; Wong, Yung Hou Article
Evidence for heterotrimeric G proteins in sea anemones
Molecular Marine Biology and Biotechnology, v. 7, (1), March 1998, p. 31-38
New, David C.; Mcgaughey Nicola Jane; Wong, Yung Hou; Wong, Joseph T.Y. Article
Molecular and cellular analyses of melatonin receptor-mediated cAMP signaling in rat corpus epididymis
Journal of Pineal Research, v. 25, (4), December 1998, p. 219-228
Li, Lili; Xu, Jianning; Wong, Yung Hou; Wong, Joseph T.Y.; Pang, Shiufun; Shiu, Stephen Yuen Wing Article
Pertussis Toxin-Insensitive Signaling of the ORL₁ Receptor: Coupling to G_z and G₁₆ Proteins
Journal of Neurochemistry, v. 71, (5), November 1998, p. 2203-2210
Chan, Joy S.C.; Yung, Ying; Lee, Jonathan W.M.; Wu, Yalan; Pei, Gang; Wong, Yung Hou Article
Regulation of calcium influx and phospholipase C activity by indoleamines in dinoflagellate Crypthecodinium cohnii
Journal of Pineal Research, v. 24, (3), April 1998, p. 152-161
Tsim, Siu-Tai; Wong, Joseph T.Y.; Wong, Yung Hou Article
Structure and Function of the Pertussis-Toxin-Insensitive G_z Protein
Biological Signals and Receptors, v. 7, (2), March-April 1998, p. 80-89
Ho, Maurice K.C.; Wong, Yung Hou Article
The calcitonin gene-related peptide-induced acetylcholinesterase synthesis in cultured chick myotubes is mediated by cyclic AMP
Journal of Neurochemistry, v. 71, (1), July 1998, p. 152-160
Choi, Roy Chi Yan; Yung, Lisa Ying; Dong, Tina Ting Xia; Wan, David C.C.; Wong, Yung Hou; Tsim, Karl Wah Keung Article

1997 5

Calcium ion dependency and the role of inositol phosphates in melatonin-induced encystment of dinoflagellates
Journal of Cell Science, v. 110, (12), June 1997, p. 1387-1393
Tsim, Siu Tai; Wong, Joseph T.Y.; Wong, Yung Hou Article
Functional Role of Amino-Terminal Serine¹⁶ and Serine²⁷ of Gα_z in Receptor and Effector Coupling
Journal of Neurochemistry, v. 68, (6), June 1997, p. 2514-2522
Ho, Maurice K.C.; Wong, Yung Hou Article
Melatonin and 5-methoxytryptamine induced muscular contraction in sea anemones
Journal of Experimental Zoology, v. 279, (3), October 1997, p. 201-207
Tsang, Wai Hung; Mcgaughey Nicola Jane; Wong, Yung Hou; Wong, Joseph T.Y. Article
Receptor-induced βγ release from fatty acylation-deficient mutants of Gα_z
NeuroReport, v. 8, (4), March 1997, p. 937-940
Beck, Helga I.; Chan, Joy S.C.; Wong, Yung Hou Article
Role of Amino- and Carboxyl-Terminal Regions of G_αz in the Recognition of G_i-Coupled Receptors
Molecular Pharmacology, v. 52, (1), July 1997, p. 38-45
Tsu Rachel Caroline; Ho, Maurice K.C.; Yung, Ying; Joshi, Sushma A.; Wong, Yung Hou Article

1996 6

CGP 52608-induced cyst formation in dinoflagellates: Possible involvement of a nuclear receptor for melatonin
Journal of Pineal Research, v. 21, (2), September 1996, p. 101-107
Tsim, Siu Tai; Wong, Joseph T.Y.; Wong, Yung Hou Article
Effects of Dibutyryl cAMP and Bacterial Toxins on Indoleamine-Induced Encystment of Dinoflagellates
Biological Signals, v. 5, (1), January-February 1996, p. 22-29
Tsim, Siu Tai; Wong, Joseph T.Y.; Wong, Yung Hou Article
G_i-mediated stimulation of type II adenylyl cyclase is augmented by G_q-coupled receptor activation and phorbol ester treatment
Journal of Neuroscience, v. 16, (4), February 1996, p. 1317-1323
Tsu, Rachel Caroline; Wong, Yung Hou Article
Inverse agonistic effect of ICI-174,864 on the cloned delta-opioid receptor: Role of G protein and adenylyl cyclase activation
Molecular Pharmacology, v. 50, (6), December 1996, p. 1651-1657
Chiu, Tillie T.; Yung, Ying; Wong, Yung Hou Article
Possible involvement of G proteins in indoleamine-induced encystment in dinoflagellates
Molecular Marine Biology and Biotechnology, v. 5, (2), June 1996, p. 162-167
Tsim, Siu Tai; Yung, Ying; Wong, Joseph T.Y.; Wong, Yung Hou Article
The G Protein Linkage of Melatonin Receptors
Frontiers of Hormone Research, v. 21, 1996, p. 147-153
Wong, Yung Hou Article

1995 7

Activation of Type II Adenylyl Cyclase by the Cloned μ‐Opioid Receptor: Coupling to Multiple G Proteins
Journal of Neurochemistry, v. 65, (6), December 1995, p. 2682-2689
Chan, Joy S.C.; Chiu, Tillie T.; Wong, Yung Hou Article
Differential coupling of the formyl peptide receptor to adenylate cyclase and phospholipase C by the pertussis toxin-insensitive G_z protein
Biochemical Journal, v. 309, (1), July 1995, p. 331-339
Tsu, Rachel Caroline; Lai, H.W.L.; Allen, Rodger A.; Wong, Yung Hou Article
GZ coupling to the rat κ-opioid receptor
FEBS Letters, v. 360, (1), February 1995, p. 97-99
Lai, Helen W.L.; Minami, Masabumi; Satoh, Masamichi; Wong, Yung Hou Article
Mutant α subunit of G(z) transforms Swiss 3T3 cells
Oncogene, v. 10, (10), May 1995, p. 1927-1933
Wong, Yung Hou; Chan, Joy S.C.; Yung, Ying; Bourne, Henry R. Article
Regulation of multiple effectors by the cloned δ-opioid receptor: Stimulation of phospholipase C and type II adenylyl cyclase
Journal of Neurochemistry, v. 64, (6), June 1995, p. 2700-2707
Tsu, Rachel Caroline; Chan, Joy S.C.; Wong, Yung Hou Article
Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through G_i and G_z proteins
FEBS Letters, v. 372, (1), September 1995, p. 99-102
Yung, Ying; Tsim, Siu Tai; Wong, Yung Hou Article
Stimulation of type II adenylyl cyclase by chemoattractant formyl peptide and C5a receptors
Molecular Pharmacology, v. 47, (4), April 1995, p. 835-841
Tsu, Rachel Caroline; Allen, Rodger A.; Wong, Yung Hou Article

1994 2

G_i Assays in Transfected Cells
Methods in Enzymology, v. 238, (C), January 1994, p. 81-94
Wong, Yung Hou Article
Indolemine-induced encystment in dinoflagellates
J. Mar. Biol. Ass. U.K, v. 74, 1994, p. 467-469
Wong, J.T.Y.; Wong, Yung Hou Article

1992 4

Detection of Coincident Signals by G Proteins and Adenylyl Cyclase
Cold Spring Harbor Symposia on Quantitative Biology, v. 57, 1992, p. 145-148
Bourne, H.R.; Lustig, K.; Wong, Yung Hou; Conklin, B.R. Article
Gz-mediated hormonal inhibition of cyclic AMP accumulation
Science, v. 255, (5042), January 1992, p. 339-342
Wong, Yung Hou; Conklin, B.R.; Bourne, H.R. Article
Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C
Journal of Biological Chemistry, v. 267, (1), January 1992, p. 31-34
Conklin, B.R.; Chabre, O.; Wong, Yung Hou; Federman, A.; Bourne, H.R. Article
The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase
Journal of Biological Chemisty, v. 267, (29), October 1992, p. 20831-20834
Hung, D.T.; Wong, Yung Hou; Vu, T.K.; Coughlin, S.R. Article

1991 3

A mutant α subunit of G_i2 induces neoplastic transformation of rat-1 cells
Proceedings of the National Academy of Sciences of the United States of America, v. 88, (16), August 1991, p. 7031-7035
Pace, A.M.; Wong, Yung Hou; Barnard, E.A. Article
G protein oncogenes
In: Origins of Human Cancer: A Comprehensive Review, 1991, p. 327-333
Bourne, H.R.; Goretzki, P.; Landis, C.; Lyons, J.; McCormick, F.; Pace, A.; Wong, Yung Hou Article
Mutant α subunits of G_i2 inhibit cyclic AMP accumulation
Nature, v. 351, (6321), May 1991, p. 63-65
Wong, Yung Hou; Federman, Alex; Pace, Ann M.; Zachary, Ian; Evans, Tony; Pouysségur, Jacques; Bourne, Henry R. Article

1990 1

Agonist-selective protection of the opioid receptor-coupled G protein from inactivation by 5'-p-fluorosulphonylbenzoyl guanosine
Journal of Neurochemistry, v. 54, (1), January 1990, p. 39-45
Wong, Yung Hou; Demoliou-mason, C.D.; Hanley, M.R.; Barnard, E.A. Article

1989 3

Opioid receptor-G protein interactions: pertussis toxin, Li+ effects and reconstitution studies
Li+ effects and reconstitution studies. Adv. Biosci, v. 75, 1989, p. 153-156
Wong, Yung Hou; Demoliou-Mason, C.D.; Barnard, E.A. Article
Opioid Receptors in Magnesium-Digitonin-Solubilized Rat Brain Membranes Are Tightly Coupled to a Pertussis Toxin-Sensitive Guanine Nucleotide-Binding Protein
Journal of Neurochemistry, v. 52, (4), April 1989, p. 0999-1009
Wong, Yung Hou; Demoliou-mason, C.D.; Barnard, E.A. Article
Uncoupling of the opioid receptor-G protein complexes by 5'-p-fluorosulphonylbenzoyl guanosine
Adv. Biosci., v. 75, 1989, p. 133-136
Wong, Yung Hou; Demoliou-Mason, C.D.; Barnard, E.A. Article

1988 2

A complex of opioid receptor with G protein, characterized in digitonin solution
In: Regulatory Roles of Opioid Peptides, Edited by Illes P and Farsang C. 1988, p. 131-144
Wong, Yung Hou; Demoliou-Mason, C.D.; Barnard, E.A. Article
ADP-ribosylation with pertussis toxin modulates the GTP-sensitive opioid ligand binding in digitonin-soluble extracts of rat brain membranes
Journal of Neurochemistry, v. 51, (1), July 1988, p. 114-121
Wong, Yung Hou; Demoliou-mason, C.D.; Barnard, E.A. Article

1987 1

Bradykinin stimulation of inositol phosphate and calcium responses is insensitive to pertussis toxin in NG115-401L neuronal cells
Biochemical and Biophysical Research Communications, v. 148, (1), October 1987, p. 412-416
Jackson, Trevor R.; Patterson, Sean I.; Wong, Yung Hou; Hanley, Michael R. Article

1986 1

Effects of hypoxaemia and hyperoxaemia on some cardiovascular responses of rats to adrenaline
Archives of Physiology and Biochemistry, v. 94, (5), 1986, p. 323-329
Dai, S.; Wong, Yung Hou; Ogle, C.W. Article

1985 1

Effects of Hypoventilation on the Cardiovascular Responses of Rats to Adrenaline and Acetylcholine
Pharmacology, v. 30, (6), 1985, p. 314-319
Dai, S.; Wong, Yung Hou Article


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Article 3

CTCF and EGR1 suppress breast cancer cell migration through transcriptional control of Nm23-H1
Scientific Reports, v. 11, (1), January 2021, article number 491
Wong, Ka Ming; Song, Jiaxing; Wong, Yung Hou
Modeling The Heterodimer Interfaces Of Melatonin Receptors
Frontiers in Cellular Neuroscience, v.15, 7 October 2021, article number 725296, p. 356-356
Tse, Lap Hang; Wong, Yung Hou
Re-examining the ‘Dissociation Model’ of G protein activation from the perspective of Gβγ signaling
FEBS Journal, v. 288, (8), April 2021, p. 2490-2501
Chung, Yin Kwan; Wong, Yung Hou


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Article 3

Age Associated Decrease of MT-1 Melatonin Receptor in Human Dermal Skin Fibroblasts Impairs Protection Against UV-Induced DNA Damage
International Journal of Molecular Sciences, v. 21, (1), January 2020, article number 326
Dong, Kelly; Goyarts, Earl; Rella, Antonella; Pelle, Edward; Wong, Yung Hou; Pernodet, Nadine
Molecular basis defining the selectivity of substituted isoquinolinones for the melatonin MT₂ receptor
Biochemical Pharmacology, v. 177, July 2020, article number 114020
Chan, King Hang; Tse, Lap Hang; Huang, Xuhui; Wong, Yung Hou
Mutations at the dimer interface and surface residues of Nm23-H1 metastasis suppressor affect its expression and function
Molecular and Cellular Biochemistry, v. 474, (1-2), November 2020, p. 95-112
Li, Yuanjun; Liu, Wen; Saini, Vasu; Wong, Yung Hou

Conference paper 1

Anti-migratory effect of Nm23-H1 via exosomes
The International Society for Extracellular Vesicles, ISEV 2020, Virtual, 20-22 July 2020
Saini, Vasu; Wong, Yung Hou; Sun, Siu Nam


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Article 2

GPCRs in Autocrine and Paracrine Regulations
Frontiers in Endocrinology, v. 10, (JULY), July 2019, article number 428
Tse, Lap Hang; Wong, Yung Hou
Small molecules as drugs to upregulate metastasis suppressors in cancer cells
Current Medicinal Chemistry, v. 26, (32), November 2019, p. 5876-5899
Wong, Ka Ming; Song, Jiaxing; Saini, Vasu; Wong, Yung Hou

Conference paper 3

Generation of an effector-deficient Gαi1
2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 8 June 2019
Chung, Yin Kwan; Wong, Yung Hou
The role of leukemia inhibitory factor (LIF) in the intercellular communication between neurons and astrocytes. Abstract P48.
2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 8 June 2019
Gu, Yishan; Wong, Yung Hou
Unraveling the mechanism of RGS-induced upregulation of Nm23-H1. Abstract P68
2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 8 June 2019
Song, Jiaxing; Wong, Yung Hou


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Conference paper 3

MT1 and MT2 melatonin receptors: heteromerization and functional significance
2018 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 25 June 2018
Tse, Lap Hang; Wong, Yung Hou
Non-dissociable Gβ-Gα fusion proteins reveal different mechanisms of G protein activation
Gordon Research Conference - Phosphorylation and G-Protein Mediated Signaling Networks, New England, USA, 3-8 June 2018
Liu, Wen; Wong, Ka Ming; Chan, Siu Lung Anthony; Wong, Yung Hou
Regulation of metastasis suppressor genes mediated by breast cancer derived exosomes
2018 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 25 June 2018
Saini, Vasu; Wong, Yung Hou


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Article 2

RGS19 Upregulates Nm23-H1/2 Metastasis Suppressors by Transcriptional Activation via the cAMP/PKA/CREB Pathway
Oncotarget, v. 8, (41), July 2017, p. 69945-69960
Li, Yuanjun; Song, Jiaxing; Tong, Yao; Chung, Sookjakim; Wong, Yung Hou
Role of G Protein-Coupled Receptors in the Regulation of Structural Plasticity and Cognitive Function
Molecules, v. 22, (7), July 2017, article number 1239
Leung, Ching Yiu Crystal; Wong, Yung Hou

Conference paper 6

Activation of PKA-dependent transcription factors by RGS19 upregulates metastasis suppressor Nm23-H1/2.
2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 16 June 2017
Song, Jiaxing; Wong, Yung Hou
Back to the basics: the G protein cycle
2017 Biomedical Research Symposium of National Health Research Institutes (NHRI) 106年度国家卫生研究院生物医学学术研讨会, Taiwan, 14-15 August 2017
Wong, Yung Hou; Liu, Wen; Chan, Siu Lung Anthony; Wong, Ka Ming
Differential G protein subunit dissociation mechanisms suggest possible family-wise selective Gβγ signaling
2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 16 June 2017
Liu, Wen; Li, Jiayue; Zhou, Longyin; Wong, Yung Hou
Functional characterization of heteromerization effects of melatonin receptors
2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 16 June 2017
Tse, Lap Hang; Ng, Siu Wang; Chan, King Hang; Wong, Yung Hou
Gq signaling pathway of melatonin receptor in islets of Langerhans
2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 16 June 2017
Gu, Yishan; Chan, Sze Man; Wong, Yung Hou
Transcriptional and post-transcriptional regulation of NME1 in cancer metastasis.
2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Hong Kong, 16 June 2017
Wong, Yung Hou; Wong, Ka Ming


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Article 5

Anxiety and Depression with Neurogenesis Defects in Exchange Protein Directly Activated by cAMP 2-Deficient Mice are Ameliorated by a Selective Serotonin Reuptake Inhibitor, Prozac
Translational Psychiatry, v. 6, (9), September 2016, article number e881
Zhou, L.; Ma, Sukling; Yeung, Patrick Ka Kit; Wong, Yung Hou; Tsim, Karl Wah Keung; So, K. F.; Lam, L.C.W.; Chung, S.K.
Differential Regulation of CXCL8 Production by Different G Protein Subunits with Synergistic Stimulation by G_i^- and G_q^-Regulated Pathways
Journal of Molecular Biology, v. 428, (19), September 2016, p. 3869-3884
Chan, Anthony Siu Lung; Lau, Wai In; Szeto, Aydan C.H.; Wang, Jiuling; Wong, Yunghou
Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling
Proceedings of the National Academy of Sciences of the United States of America, v. 113, (7), February 2016, p. 1937-1942
Li, Songshan; Yang, Chao; Zhang, Li; Gao, Xin; Wang, Xuejie; Liu, Wen; Wang, Yuqi; Jiang, Songshan; Wong, Yung Hou; Zhang, Yifeng; Liu, Kai
Quantitative Analysis of Nucleosides and Nucleobases in Deer Antler: Variation in Different Species
Pharmaceutica Analytica Acta, v. 7, (4), April 2016, article number 1000474
Bi, Dan; Zhang, L.M.L.; Tang, Wai Lun; Duan, Ran; Leung, Ka Wing; Dong, Tingxia; Wong, Yung Hou; Lin, Huangquan; Tsim, Karl Wah Keung
Regulator of G Protein Signaling 20 Enhances Cancer Cell Aggregation, Migration, Invasion and Adhesion
Cellular Signalling, v. 28, (11), November 2016, p. 1663-1672
Yang, Lei; Lee, Mei Ki; Leung, Man Hon Manton; Wong, Yung Hou

Conference paper 4

Cdk5 Activity is Required for EphB-mediated Synaptogenesis
The 46th Annual Meeting of the Society for Neuroscience, San Diego, USA, 12-16 November 2016
Chen, Yu; Wong, Yung Hou; Fu, Wing Yu; Fu, Kit Yu; Ip, Nancy Yuk-Yu
Flavonoids Induce the Expression of Acetylcholinesterase in Cultured Osteoblasts
Chemico-Biological Interactions, v. 259, (B), 25 November 2016, p. 295-300
Xu, Miranda Li; Bi, Wenchuan; Kong, Yeung Yeung Ava; Dong, Ting Xia; Wong, Yung Hou; Tsim, Karl Wah Keung
Functional assessment of MT2 melatonin receptor variants that are associated with type 2 diabetes
Neuroscience Symposium 2016 & Annual Scientific Conference of The Hong Kong Society of Neurosciences, Hong Kong, May, 2016
Wu, Y.; Chan, K.H.; Wong, Yung Hou
The role of RGS20 in cell cycle regulation and angiogenesis
2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Lee Shau Kee Building, The Chinese University of Hong Kong, Hong Kong, 11 June 2016
Leung, M.; Alim, A.S.; Xu, R.; Wong, Yung Hou


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Article 6

Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on Gα_i3
Molecular and Cellular Biochemistry, v. 401, (1-2), March 2015, p. 27-38
Tse, Man Kit; Morris, Christina Jane; Zhang, Mingjie; Wong, Yung Hou
An intact helical domain is required for Gα₁₄ to stimulate phospholipase Cβ
BMC Structural Biology, v. 15, (1), September 2015, article number 18
Kwan, Dawna HT; Wong, Ka Ming; Chan, Anthony Siu Lung; Yung, Lisa Ying; Wong, Yung Hou
Association of activated Gα_q to the tumor suppressor Fhit is enhanced by phospholipase Cβ
BMC Cancer, v. 15, (1), October 2015, article number 775
Zuo, Hao; Wong, Yung Hou
Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons
Neurobiology of Disease, v. 73, January 2015, p. 366-376
Li, Songshan; He, Qinghai; Wang, Hao; Tang, Xuming; Ho, Kam Wing; Gao, Xin; Zhang, Qian; Shen, Yang; Cheung, Annie; Wong, Francis; Wong, Yung Hou; Ip, Nancy Yuk-yu; Jiang, Liwen; Yung, Wing Ho; Liu, Kai
Metastasis suppressors Nm23H1 and Nm23H2 differentially regulate neoplastic transformation and tumorigenesis
Cancer Letters, v. 361, (2), June 2015, p. 207-217
Tong, Yao; Yung, Lisa Ying; Wong, Yung Hou
Regulatory functions of Nm23-H2 in tumorigenesis: insights from biochemical to clinical perspectives
Naunyn-Schmiedeberg's Archives of Pharmacology, v. 388, (2), February 2015, p. 243-256
Li, Yuanjun; Tong, Yao; Wong, Yung Hou

Book chapter 1

RAS Genes
Encyclopedia of Cancer: a Springer Live Reference / Manfred Schwab. Berlin, Heidelberg : Springer, 2015, p. 1-6
Wong, Yung Hou; Pellicer, Angel; Liu, Wen

Conference paper 8

Activation Of Phospholipase Cβ By NonDissociable Gq Proteins
ASCEPT-BPS Joint Scientific Meeting 2015, University of Hong Kong, 19-21 May 2015
Wong, Yung Hou; Liu, W.; Chan, Siu Lung Anthony; Poon, Lydia See Wing; Wong, K.M.
Functional characterization of type 2 diabetes associated MTNRIB variants
2015 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 23 May 2015
Wu, Y.; Chan, K.H.; Wong, Yung Hou
Inhibition of oncogenic Ras-induced tumorigenesis by Nm23 metastasis suppressors
The 2nd Annual Meeting of the International Ovarian Cancer Consortium and the Symposium on Tumor Microenvironment and Therapy Resistance, University of Oklahoma Health Sciences Center, Oklahoma City, USA, 16-18 August 2015
Wong, Y.H.; Li, Y.
Involvement of G proteins in asymmetric cell division during neurogenesis
2015 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 23 May 2015
Yip, J.L.K.; Lee, M.M.K.; Wong, Yung Hou
Molecular determinants of selective ligand binding at the human melatonin receptor
ASCEPT-BPS Joint Scientific Meeting (ASCEPT-BPS 2015), The University of Hong Kong, 19-21 May 2015
Chan, King Hang; Wong, Yung Hou
Non-dissociable Gβ-Gα Fusion Proteins Reveal Different Mechanisms Of G Protein Activation
ASCEPT-BPS Joint Scientific Meeting (ASCEPT-BPS 2015), The University of Hong Kong, 19-21 May 2015
Liu, Wen; Chan, Siu Lung Anthony; Wong, Ka Ming; Wong, Yung Hou
Post-transcriptional regulation of the regulator of G protein signaling 19 (RGS19) and metastasis suppressor Nm23 in cancer by microRNAs
2015 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 23 May 2015
Wong, Ka Ming; Wong, Yung Hou
Role of surface residues on defining the functional specificity of Nm23 metastasis suppressors
ASCEPT-BPS Joint Scientific Meeting (ASCEPT-BPS 2015), The University of Hong Kong, 19-21 May 2015
Li, Yuanjun; Wong, Yung Hou


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Article 5

Angiotensin-[1-12] interacts with angiotensin type I receptors
Neuropharmacology, v. 81, June 2014, p. 267-273
Chan, King Hang; Chen, Yi Hung; Zhang, Ying; Wong, Yung Hou; Dun, Nae J.
Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management
NeuroSignals, v. 22, (1), May 2014, p. 52-63
Ip, Fanny Chui Fun; Ng, Yu Pong; An, Hui Jin; Dai, Ying; Pang, Hai Hong; Hu, Yue Qing; Chin, Allison C.; Harley, Calvin B.; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via Toll-like receptor-4 dependent pathways
Neuroscience, v. 267, May 2014, p. 241-251
Tse, Kai Hei; Chow, K.B.S.; Leung, W.K.; Wong, Yung Hou; Wise, H.
Primary Sensory Neurons Regulate Toll-like receptor-4-dependent Activity of Glial Cells in Dorsal Root Ganglia
Neuroscience, v. 279, October 2014, p. 10-22
Tse, Kai-Hei; Chow, K.B.S.; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen
Synthesis and Functional Characterization of Substituted Isoquinolinones as MT₂-Selective Melatoninergic Ligands
PLoS ONE, v. 9, (12), December 2014, article number 0113638
Hu, Yueqing; Chan, King Hang; He, Xixin; Ho, Maurice Kwok Chung; Wong, Yung Hou

Conference paper 6

Activation of Gq without Subunits Dissociation
2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The University of Hong Kong, Hong Kong, 14 June 2014
Liu, Wen; Wong, Yung Hou
Activation of PLCβ by a Non-dissociable Gq Protein
Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, Hong Kong, The University of Hong Kong, Hong Kong, 12-14 June 2014
Liu, W.; Chan, Siu Lung Anthony; Wong, K.M.; Wong, Yung Hou
ENStem - A Cells as a Model for Studying Neurogenesis
Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, The University of Hong Kong, Hong Kong, 12-14 June 2014
Yip, J.L.K.; Lee, M.M.K.; Wong, Yung Hou
Multi-faceted Metastasis Suppressor Nm23 is Up-regulated by RGS19 via Activating Transcription Factors
The 2014 Physiology Symposium and Joint Scientific Meeting of The Hong Kong Society of Neurosciences and The Biophysical Society of Hong Kong (HKSN-BSHK), The University of Hong Kong, Hong Kong, 12-14 June 2014
Li, Y.; Wong, Yung Hou
RGS19 Up-regulates Nm23-H1/2 Expression via Stimulating Multiple Transcriptional Factors
Hong Kong Inter-University Biochemistry Postgraduate Symposium 2014, The University of Hong Kong, 14 June 2014
Li, Yuanjun; Wong, Yung Hou
RGS20 as a Modulator of Tumorigenesis and Angiogenesis
2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The University of Hong Kong, Hong Kong, 14 June 2014
Leung, Man Hon Manton; Yang, Lei; Wong, Yung Hou


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Article 10

A Molecular and Chemical Perspective in Defining Melatonin Receptor Subtype Selectivity
International Journal of Molecular Sciences, v. 14, (9), September 2013, p. 18385-18406
Chan, King Hang; Wong, Yung Hou
Activation of Gα_q subunits up-regulates the expression of the tumor suppressor Fhit
Cellular Signalling, v. 25, (12), December 2013, p. 2440-2452
Zuo, Hao; Chan, Anthony Siu Lung; Ammer, Hermann; Wong, Yung Hou
Activation state-dependent interaction between Gα_q subunits and the Fhit tumor suppressor
Cell Communication and Signaling, v. 11, (1), August 2013, article number 59
Zuo, Hao; Chan, Grace P.W.; Zhu, Jing; Yeung, Wendy Wing Shan; Chan, Anthony Siu Lung; Ammer, Hermann; Wong, Yung Hou
Characterization of Substituted Phenylpropylamides as Highly Selective Agonists at the Melatonin MT2 Receptor
Current Medicinal Chemistry, v. 20, (2), January 2013, p. 289-300
Chan, King Hang; Hu, Sharry Y.; Ho, Maurice K C; Wong, Yung Hou
Development of substituted N-[3-(3-methoxylphenyl)propyl] amides as MT₂-selective melatonin agonists: Improving metabolic stability
Bioorganic and Medicinal Chemistry, v. 21, (2), January 2013, p. 547-552
Hu, Yueqing; Zhu, Jing; Chan, King Hang; Wong, Yung Hou
Gβγ-mediated activation of protein kinase D exhibits subunit specificity and requires Gβγ-responsive phospholipase Cβ isoforms
Cell Communication and Signaling, v. 11, (1), April 2013, article number 22
Lau, Winnie Wai In; Chan, Anthony Siu Lung; Poon, Lydia See Wing; Zhu, Jing; Wong, Yung Hou
Isolated dorsal root ganglion neurones inhibit receptor-dependent adenylyl cyclase activity in associated glial cells
British Journal of Pharmacology, v. 168, (3), February 2013, p. 746-760
Ng, Kai Yu; Yeung, Barry Ho Sing; Wong, Yung Hou; Wise, Helen
Neuronal Functions of Activators of G Protein Signaling
NeuroSignals, v. 21, (3-4), May 2013, p. 259-271
Tse, Man Kit; Wong, Yung Hou
Regulator of G protein signaling 19 suppresses Ras-induced neoplastic transformation and tumorigenesis
Cancer Letters, v. 339, (1), October 2013, p. 33-41
Wang, Yingchun; Tong, Yao; Tso, Prudence H.; Wong, Yung Hou
RGS19 inhibits Ras signaling through Nm23H1/2-mediated phosphorylation of the kinase suppressor of Ras
Cellular Signalling, v. 25, (5), May 2013, p. 1064-1074
Tso, Ha Prudence; Wang, Yingchun; Yung, Ying Lisa; Tong, Yao; Lee, Mei Ki Maggie; Wong, Yung Hou

Book chapter 2

Development of novel melatoninergics as circadian rhythm sleep disorder therapeutics
New Developments in Melatonin Research / Editors: Dario Acuna-Castroviejo, Iryna Rusanova, Germaine Escames. Nova Science Publishers, Inc., 2013, p. 53-76
Chan, King Hang; Cheung, Annie Suet Ting; Ho, Maurice K.C.; Wong, Yung Hou
High-throughput screening in traditional Chinese medicine-based drug discovery
Antitumor Potential and Other Emerging Medicinal Properties of Natural Compounds / Editors: Evandro Fei Fang, Tzi Bun Ng. Dordrecht : Springer Science+Business Media, 2013, p. 387-404
Wong, Catherine Chi Kit; Wong, Yung Hou

Conference paper 5

Nm23 Mediates RGS19-induced Suppression of Ras Signaling
The 9th International Congress of the NDP Kinase/Nm23/awd Gene Family, Boston, USA, 31 July - 4 August 2013
Wong, Yung Hou
Regulation of STAT3 by GPCRs Involves Interleukin-6 Autocrine Signaling
The 7th IDRC Symposium, Seoul, Korea, 26-27 August 2013
Wong, Yung Hou
Sensory Neurons Regulate Toll-like Receptor 4 (TLR4) Signaling in Glia Derived from Dorsal Root Ganglia (DRG)
2013 Annual Meeting of Society for Neuroscience, San Diego, USA, 9-13 November 2013
Tse, Kai Hei; Chow, Kevin Bing Shui; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen
Toll-like Receptor 4 (TLR4) Differentially Regulates Cox-1 and Cox-2 to Enhance Prostanoid Production by Primary Sensory Neurons
2013 Annual Meeting of Hong Kong Society for Immunology, Hong Kong, 25 May, 2013
Tse, Kai Hei; Chow, Kevin Bing Shui; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen
Toll-like Receptor 4 (TLR4) Increases Expression of Inflammatory Mediators in Primary Sensory Neurons via Activation of a MyD88-dependent Signaling Pathway
Acta Pharmacologica Sinica, v. 34, July 2013, p. 116
Wise, Helen; Chow, Kevin Bing Shui; Tse, Kai Hei; Leung, Wai Keung; Wong, Yung Hou


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Article 8

Activation of ras-dependent signaling pathways by G_14^-coupled receptors requires the adaptor protein TPR1
Journal of Cellular Biochemistry, v. 113, (11), November 2012, p. 3486-3497
Kwan, Dawna H.T.; Yung, Lisa Y.; Ye, Richard D.; Wong, Yung Hou
Astragaloside IV and Cycloastragenol Stimulate the Phosphorylation of Extracellular Signal-Regulated Protein Kinase in Multiple Cell Types
Planta Medica, v. 78, (2), January 2012, p. 115-121
Yung, Ying Lisa; Lam, Wing See; Ho, Maurice K.C.; Hu, Sharry Y.; Ip, Fanny C.F.; Pang, Haihong; Chin, Allison; Harley, Calvin B.; Ip, Nancy Yuk-yu; Wong, Yung Hou
CCR1-Mediated STAT3 Tyrosine Phosphorylation and CXCL8 Expression in THP-1 Macrophage-like Cells Involve Pertussis Toxin-Insensitive Gα_14/16 Signaling and IL-6 Release
Journal of Immunology, v. 189, (11), December 2012, p. 5266-5276
Lee, Mei Ki; Chui, Ricky K.S.; Tam, Issan Y.S.; Lau, Alaster H.Y.; Wong, Yung Hou
Elevated expression of RGS19 impairs the responsiveness of stress-activated protein kinases to serum
Molecular and Cellular Biochemistry, v. 362, (1-2), March 2012, p. 159-168
Ip, Angel K.C.; Tso, Ha; Lee, Mei Ki; Wong, Yung Hou
Interleukin-6 autocrine signaling mediates melatonin MT_1/2 receptor-induced STAT3 Tyr⁷⁰⁵ phosphorylation
Journal of Pineal Research, v. 52, (4), May 2012, p. 477-489
Lau, Wai In; Ng, Johnson K.Y.; Lee, Mei Ki; Chan, Siu Lung Anthony; Wong, Yung Hou
Pharmacokinetics, oral bioavailability and metabolism of a novel isoquinolinone-based melatonin receptor agonist in rats
Xenobiotica, v. 42, (11), November 2012, p. 1138-1150
Zhu, Jing; Hu, Sharry Y.; Ho, Maurice K.C.; Wong, Yung Hou
Prostacyclin Receptor-Dependent Inhibition of Human Erythroleukemia Cell Differentiation is STAT3-Dependent
Prostaglandins Leukotrienes and Essential Fatty Acids, v. 86, (3), March 2012, p. 119-126
Lau, Alaster H.Y.; Lai, Henry K.H.; Yeung, Barry H.S.; Leung, Sze Lee; Tsang, Suk Ying; Wong, Yung Hou; Wise, Helen
Rapid Uptake and Degradation of CXCL12 Depend on CXCR7 Carboxyl-terminal Serine/Threonine Residues
Journal of Biological Chemistry, v. 287, (34), August 2012, p. 28362-28377
Hoffmann, Frauke; Mueller, Wiebke; Schuetz, Dagmar; Penfold, Mark E.; Wong, Yung Hou; Schulz, Stefan; Stumm, Ralf

Conference paper 3

Activated Gαq subunits interact with the tumor suppressor Fhit and increase its expression and phosphorylation
Stephenson Cancer Center Mini Conference on Tumor Microenvironment and Drug Discovery, 2-3 Dec 2012, Oklahoma, USA, Abstract T1
Wong, Yung Hou
Expression of Toll-like receptor 4 signaling components in adult rat dorsal root ganglion cells
Hong Kong-Taiwan Physiology Symposium 2012 and Joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, June 2012, p. 40
Tse, Kai Hei; Chow, Kevin Bing Shui; Ng, K. Y.; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen
Novel interaction between signal transducing G proteins and the Fhit tumor suppressor
8th Asia Pacific Multidisciplinary Meeting for Cancer Research, May 11 2012, Hong Kong, Abstract T4
Wong, Yung Hou


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Article 6

3-Methoxylphenylpropyl amides as novel receptor subtype-selective melatoninergic ligands: characterization of physicochemical and pharmacokinetic properties
Xenobiotica, v. 41, (1), January 2011, p. 35-45
Zhu, Jing; Hu, Yueqing; Ho, Maurice K.C.; Wong, Yung Hou
Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRα2 isoforms
Cellular Signalling, v. 23, (11), November 2011, p. 1727-1737
Wan, Guoqiang; Zhou, Lihan; Lim, Qing `En; Wong, Yung Hou; Too, Heng-Phon
Expression of Gα_z in C2C12 Cells Restrains Myogenic Differentiation
Cellular Signalling, v. 23, (2), February 2011, p. 389-397
Mei, Hua; Ho, Kwok Chung Maurice; Yung, Ying; Wu, Zhenguo; Ip, Nancy Yuk-yu; Wong, Yung Hou
Glial cells isolated from dorsal root ganglia express prostaglandin E₂ (EP₄) and prostacyclin (IP) receptors
European Journal of Pharmacology, v. 661, (1-3), July 2011, p. 42-48
Ng, Kai Yu; Wong, Yung Hou; Wise, Helen
Gα₁₆ interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling
BMC Structural Biology, v. 11, April 2011, article number 17
Liu, A.M.F.; Lo, Kin H.; Guo, Emily X.; Ho, Maurice K.C.; Ye, Richard D.; Wong, Yung Hou
RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signaling
Cancer Letters, v. 309, (2), October 2011, p. 199-208
Tso, Prudence H.; Yung, Lisa Y.; Wang, Yingchun; Wong, Yung Hou

Book chapter 1

Regulation of Chemotaxis by Heterotrimeric G proteins
Chemotaxis: Types, Clinical Significance, and Mathematical Models / Edited by Timothy C. Williams. Hauppauge, N.Y.: Nova Science Publishers, c2011, p.109-134
Lee, Maggie M.K.; Wong, Yung Hou

Conference paper 4

Nm23-H1 inhibits oncogene-induced neoplastic transformation
Second Inter-University Biochemistry Postgraduate Symposium, 11 Jun 2011, Hong Kong, Abstract P-U005
Tong, Yao; Wong, Yung Hou
Regulation of Fhit by Gq family proteins
Second Inter-University Biochemistry Postgraduate Symposium, 11 Jun 2011, Hong Kong, Abstract P-U011
Zuo, H.; Chan, Anthony S.L.; Wong, Yung Hou
The expression of Toll-like receptor 4 in rat dorsal root ganglia
Annual Scientific Meeting of the Hong Kong Society of Immunology, Hong Kong, 7 May 2011
Chow, KB; Chu, TCH; Leung, WK; Wong, Yung Hou; Wise, Helen
Understanding the role of RGS20 in tumorigenesis
Second Inter-University Biochemistry Postgraduate Symposium, 11 Jun 2011, Hong Kong, Abstract P-U004
Yang, L.; Wong, Yung Hou


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Article 9

Activation of STAT3 by specific Gα subunits and multiple Gβγ dimers
International Journal of Biochemistry and Cell Biology, v. 42, (6), June 2010, p. 1052-1059
Yuen, J.W.F.; Poon, Lydia See Wing; Chan, Siu Lung Anthony; Yu, Frances W.Y.; Lo, Kin H.; Wong, Yung Hou
Gα₁₆ activates Ras by forming a complex with tetratricopeptide repeat 1 (TPR1) and Son of Sevenless (SOS)
Cellular Signalling, v. 22, (10), October 2010, p. 1448-1458
Liu, A.M.F.; Lo, Kin H.; Lee, Mei Ki; Wang, Yingchun; Yeung, Wendy W.S.; Ho, Maurice K.C.; Su, Yan; Ye, Richard D.; Wong, Yung Hou
Gα₁₆ interacts with Class IA phosphatidylinositol 3-kinases and inhibits Akt signaling
Cellular Signalling, v. 22, (9), September 2010, p. 1379-1387
Yeung, Wing Shan; Wong, Yung Hou
In Search of Novel and Therapeutically Significant Melatoninergic Ligands
Frontiers in CNS Drug Discovery, v. 1, 2010, p. 600-610
Mody, Sejal M.; Hu, Sharry Y.; Ho, Maurice K.C.; Wong, Yung Hou
In vitro Intestinal Absorption and First-pass Intestinal and Hepatic Metabolism of Cycloastragenol, a Potent Small Molecule Telomerase Activator
Drug Metabolism and Pharmacokinetics, v. 25, (5), November 2010, p. 477-486
Zhu, Jing; Lee, Stephanie; Ho, Maurice K.C.; Hu, Yueqing; Pang, Haihong; Ip, Fanny C.F.; Chin, Allison C.; Harley, Calvin B.; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Nerve Growth Factor-Induced Differentiation of PC12 Cells Is Accompanied by Elevated Adenylyl Cyclase Activity
NeuroSignals, v. 18, (1), September 2010, p. 32-42
Yung, H.S.; Lai, K.H.; Chow, Kevin B.S.; Ip, Nancy Yuk-Yu; Tsim, Karl Wah Keung; Wong, Yung Hou; Wu, Zhenguo; Wise, Helen
RGS19 enhances cell proliferation through its C-terminal PDZ motif
Cellular Signalling, v. 22, (11), November 2010, p. 1700-1707
Tso, Ha; Wang, Yingchun; Wong, Sivia Y.S.; Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou
Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT₂-selective melatonin ligands
Bioorganic and Medicinal Chemistry Letters, v. 20, (8), April 2010, p. 2582-2585
Hu, Yueqing; Ho, Kwok Chung Maurice; Chan, King Hang; New, David C.; Wong, Yung Hou
The role of glial cells in influencing neurite extension by dorsal root ganglion cells
Neuron Glia Biology, v. 6, (1), February 2010, p. 19-29
Ng, Kai-Yu; Wong, Yung Hou; Wise, Helen

Book chapter 1

Functional Impacts of Signal Integration: Regulation of Inflammation-related Transcription Factors by Heterotrimeric G Proteins
Molecular to Modular Tumor Therapy: Tumors are Reconstructible Communicatively Evolving Systems / Edited by Albrecht Reichle. Dordrecht: Springer Science+Business Media B.V., 2010, p.161-189
Yeung, Wing Shan; Ho, Maurice K.C.; Wong, Yung Hou

Conference paper 7

An investigation into the role of AGS3 in opiate tolerance and dependency
28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract PS13
Tse, Man Kit; Morris, Christina J.; Wong, Yung Hou
Characterization of subtype-selective melatoninergic ligands with novel non-indoleamine scaffolds
PepCon 2010, 20-22 March 2010, Beijing, China
Ho, Maurice K.C.; Hu, Sharry Y.; Chan, King Hang; Zhu, Jing; Wong, Yung Hou
Characterization of subtype-selective melatoninergic ligands with novel non-indoleamine scaffolds
Hong Kong Biochemistry Postgraduate Student Conference, 15 May 2010, Hong Kong, Abstract BCH10-A45
Hu, Sharry Y.; Ho, Maurice K.C.; Chan, King Hang; New, David C.; Wong, Yung Hou
Differential activation of G protein family members: GTPgammaS triggers subunit dissociation of Gi3 but not Gq.
28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract T6
Chan, Siu Lung Anthony; Poon, Lydia See Wing; Wong, Yung Hou
Functional coupling of Melatonin receptors with G16 leads to independent phosphorylation of Tyr-705 and Ser-727 on STAT3
The 28th Hong Kong Society of Neuroscience (HKSN) Annual Meeting, 7-8 June 2010, Hong Kong, Abstract T6
Lau, Winnie W.I.; Chan, Anthony S.L.; Wong, Yung Hou
Melatonin MT1 receptor induces Fhit phosphorylation through the pertussis toxin-insensitive G16 protein
28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract T6
Zuo, H.; Chan, Siu Lung Anthony; Wong, Yung Hou
Structure-activity relationships of novel subtype-selective melatoninergic ligands with novel non-indoleamine scaffolds
28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract Y6
Chan, King Hang013378; Ho, Maurice K.C.; Hu, Sharry Y.; Wong, Yung Hou


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Article 11

A Hematopoietic Perspective on the Promiscuity and Specificity of Gα₁₆ Signaling
NeuroSignals, v. 17, (1), February 2009, p. 71-81
Su, Yan; Ho, Maurice K.C.; Wong, Yung Hou
CCR1-mediated activation of nuclear factor-κB in THP-1 monocytic cells involves pertussis toxin-insensitive Gα₁₄ and Gα₁₆ signaling cascades
Journal of Leukocyte Biology, v. 86, (6), December 2009, p. 1319-1329
Lee, Mei Ki; Wong, Yung Hou
Differential and Synergistic Effect of Nerve Growth Factor and cAMP on the Regulation of Early Response Genes during Neuronal Differentiation
NeuroSignals, v. 17, (2), May 2009, p. 111-120
Ng, Yu Pong; Wu, Zhenguo; Wise, Helen; Tsim, Karl Wah Keung; Wong, Yung Hou; Ip, Nancy Yuk-Yu
G Protein signaling controls the differentiation of multiple cell lineages
BioFactors, v. 35, (3), May 2009, p. 232-238
Wang, Kepeng; Wong, Yung Hou
Gβ₃ forms distinct dimers with specific Gγ subunits and preferentially activates the β₃ isoform of phospholipase C
Cellular Signalling, v. 21, (5), May 2009, p. 737-744
Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou
Multiple G_i Proteins Participate in Nerve Growth Factor-Induced Activation of c-Jun N-terminal Kinases in PC12 Cells
Neurochemical Research, v. 34, (6), June 2009, p. 1101-1112
Tso, Ha; Morris, Christina Jane; Yung, Ying; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Multiplex fluorimetric assays for monitoring algal toxins
Journal of the Marine Biological Association of the United Kingdom, v. 89, (2), March 2009, p. 287-293
Mak, Carmen K.M.; Yeung, Patrick K.K.; Kwok, Chun Man; Wong, Yung Hou; Wong, Joseph T.Y.
Regulation of mTOR and p70 S6 kinase by the muscarinic M4 receptor in PC12 cells
Cell Biology International, v. 33, (2), February 2009, p. 230-238
Chan, Grace P.W.; Wu, Eddy H.T.; Wong, Yung Hou
Regulation of transcription factors by heterotrimeric G proteins
Current Molecular Pharmacology, v. 2, (1), 2009, p. 19-31
Ho, Maurice K.C.; Su, Yan; Yeung, Wing Shan; Wong, Yung Hou
Reporter Gene Assays
Methods in Molecular Biology (Clifton, N.J.), v. 486, 2009, p. 109-123
Liu, A.M.F.; New, David C.; Lo, Kin H.; Wong, Yung Hou
The RhoA-specific guanine nucleotide exchange factor p63RhoGEF binds to activated Gα₁₆ and inhibits the canonical phospholipase Cβ pathway
Cellular Signalling, v. 21, (8), August 2009, p. 1317-1325
Yeung, Wing Shan; Wong, Yung Hou

Conference paper 20

Effect of cicaprost on differentiation of human erythroleukemia (HEL) cells
12th Scientific Meeting of the Hong Kong Pharmacology Society, Hong Kong, Abstract P10, 12-15 June 2009
Lai, K.H.; Lau, H.Y.A.; Tsang, Shui Ying; Wong, Yung Hou; Wise, H.
Effects of Activator of G-protein Signaling 3 upon K-Opioid Receptor Signaling
The 27th Annual Meeting of the Hong Kong Society of Neuroscience (HKSN), Hong Kong, China. January 11-15, 2009
Tse, Man Kit; Wong, Yung Hou; Morris, Christina J.
GAIP inhibits Ras signaling and tumor formation
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-47, 11-15 January 2009
Wang, Y.; Tso, Ha; Wong, Yung Hou
Galphaq subunits interact with the Fhit tumor suppressor
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-40, 11-15 January 2009
Chan, G.P.W.; Chan, W.W.I.; Wong, Yung Hou
Galphaz-regulated myogenic and osteogenic differentiation of C2C12 cells
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-45, 11-15 January 2009
Wang, K.; Yung, Ying; Ho, Maurice K.C.; Wong, Yung Hou
GPCR signaling: role in cell proliferation and differentiation
12th Scientific Meeting of the Hong Kong Pharmacology Society, Hong Kong, Abstract PL2, 12-15 June 2009
Wong, Yung Hou
Identification of Novel Binding Partners of GAIP
The 27th Annual Meeting of the Hong Kong Society of Neuroscience (HKSN), Hong Kong, China. January 11-15, 2009
Leung, Sing; Morris, Christina J.; Wong, Yung Hou
In vitro pharmacological characterizations of novel receptor subtype-spepcific melatoninergic ligands
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-39, 11-15 January 2009
Zhu, Jing; Ho, Maurice K.C.; Hu, Sharry Y.; Wong, Yung Hou
Melatonin MT1 and MT2 knockout mice exhibit impaired circadian rhythm re-entrainment
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-48, 11-15 January 2009
Xu, Y.; Ho, Maurice K.C.; Wong, Yung Hou
Melatonin MT1 Receptor-mediated PKD Activation
Gordon Research Conferences on Mechanisms Of Cell Signalling - Towards Understanding Signalling Networks, 23-28 August, Oxford, UK
Chan, Siu Lung Anthony; Lau, Wai In; Wong, Yung Hou
Melatonin MT2 receptor activates STAT3 through the pertussis toxin-insensitive G16 protein
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-39, 11-15 January 2009
Chan, Siu Lung Anthony; Lau, Wai In; Wong, Yung Hou
Molecular determinants for G betagamma-induced activation of phospholipase C-beta isoforms
The 6th Asian Biophysics Association Symposium & 27th Hong Kong Society of Neuroscience Annual Meeting
Poon, See Wing; Chan, Anthony S.L.; Wong, Yung Hou
Molecular determinants for Gbetagamma-induced activation of phospholipase C isoforms
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-46, 11-15 January 2009
Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou
Prostanoid-stimulated cAMP production in rat dorsal root ganglion cells: role of non-neuronal cells
12th Scientific Meeting of the Hong Kong Pharmacology Society, Hong Kong, Abstract P6, 12-15 June 2009
Ng, K.Y.; Wong, Yung Hou; Wise, Helen
RhoA-specific guanine nucleotide exchange factor p63RhoGEF modulates Galpha16 signaling
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-52, 11-15 January 2009
Yeung, Wing Shan; Wong, Yung Hou
Role of non-neuronal cells on influencing neurite extension by rat dorsal root ganglion cell neurons
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-23, 11-15 January 2009
Ng, K.Y.; Wong, Yung Hou; Wise, Helen
Role of PKC in melatonin receptor-mediated STAT3 activation
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract S16-7, 11-15 January 2009
Lau, Wai In; Chan, Siu Lung Anthony; Wong, Yung Hou
Structure-activity relationships of novel melatonin MT2 subtype-selective ligands with non-indoleamine scaffolds
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-44, 11-15 January 2009
Chan, S.K.H.; Ho, Maurice K.C.; Wong, Yung Hou
Targeting RGS proteins for the modulation of GPCR signaling
12th SCBA International Symposium, Taiwan, Abstract 7B-4, 14-18 June 2009
Wong, Yung Hou
TPR1 is required for Galphaq-mediated Ras signaling
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-38, 11-15 January 2009
Kwan, D.H.T.; Liu, A.M.F.; Wong, Yung Hou


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Article 6

Activation of the human FPRL-1 receptor promotes Ca²⁺ mobilization in U87 astrocytoma cells
Neurochemical Research, v. 33, (1), January 2008, p. 125-133
Kwan, Dawna H.T.; Kam, Angel Y.F.; Wong, Yung Hou
Differential involvement of Gα₁₆ in CC chemokine-induced stimulation of phospholipase Cβ, ERK, and chemotaxis
Cellular Signalling, v. 20, (6), June 2008, p. 1179-1189
Tian, Yaji; Lee, Maggie M.K.; Yung, Lisa Y.; Allen, Rodger A.; Slocombe, Patrick M.; Twomey, Breda M.; Wong, Yung Hou
Mutations on the switch III region and the alpha3 helix of Galpha₁₆ differentially affect receptor coupling and regulation of downstream effectors
Journal of Molecular Signaling, v. 3, November 2008, article number 17
Yu, May Y.M.; Ho, Maurice K.C.; Liu, A.M.F.; Wong, Yung Hou
Naturally Occurring Phenylethanoid Glycosides: Potential Leads for New Therapeutics
Current Medicinal Chemistry, v. 15, (25), October 2008, p. 2592-2613
Fu, Guangmiao; Pang, Haihong; Wong, Yung Hou
Nerve growth factor-induced stimulation of p38 mitogen-activated protein kinase in PC12 cells is partially mediated via G_i/o proteins
Cellular Signalling, v. 20, (8), August 2008, p. 1538-1544
Yung, Ying; Tso, Ha; Wu, Eddy H.T.; Yu, Jowie C.H.; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Prostacyclin receptor-induced STAT3 phosphorylation in human erythroleukemia cells is mediated via Gα_s and Gα₁₆ hybrid signaling
Cellular Signalling, v. 20, (11), November 2008, p. 2095-2106
Lo, Kin H.; Liu, A.M.F.; Wise, Helen; Wong, Yung Hou

Conference paper 8

AGS3 modulation of ERK phosphorylation by the kappa-opioid receptor
9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS21, 25-26 March 2008
Morris, Christina Jane; Wong, Yung Hou
AGS3 Modulation of ERK Phosphorylation by the Kappa-Opioid Receptor
The 39th Annual International Narcotics Research Conference (INRC), Charleston, SC. USA. July 13-18, 2008
Morris, Christina J.; Tse, Man Kit; Wong, Yung Hou
Formation of specific G protein Betagamma-dimers and their corresponding activation of phospholipase C isoforms
9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS24, 25-26 March 2008
Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou
Galpha14 signaling through TPR1: a structural and functional perspective
9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS22, 25-26 March 2008
Kwan, D.H.T.; Wong, Yung Hou
GAlphaz Inhibits Myogenic Differentiation of C2C12 Cells
The 9th AEARU Workshop on Molecular Biology and Biotechnology, Hong Kong, 25 - 26 March 2008
Ho, Kwok Chung Maurice; Mei, Hua; Yung, Ying; Wu, Zhenguo; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Influence of glial cells on stress-induced neurite retraction in rat dorsal root ganglion cells
APSN 2008, Shanghai, China, Abstract, 24-26 June 2008
Ng, K.Y.; Wong, Yung Hou; Wise, Helen
Melatonin MT1 receptor-mediated STAT3 activation through Galpha16
9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS25, 25-26 March 2008
Lau, Wai In; Chan, Siu Lung Anthony; Wong, Yung Hou
Nerve growth factor-induced differentiation of rat pheochromocytoma (PC12) cells leads to changes in adenylyl cyclase activity
APSN 2008, Shanghai, China, Abstract, 24-26 June 2008
Lai, K.H.; Yung, H.S.; Wong, Yung Hou; Wise, Helen


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Article 8

Dopaminergic and adrenergic toxicities on SK-N-MC human neuroblastoma cells are mediated through G protein signaling and oxidative stress
Apoptosis, v. 12, (1), January 2007, p. 167-179
Chan, Siu Lung Anthony; Ng, Linda W.C.; Poon, Lydia See Wing; Chan, Winnie W.Y.; Wong, Yung Hou
Expression of G protein beta subunits in rat skeletal muscle after nerve injury: Implication in the regulation of neuregulin signaling
Neuroscience, v. 146, (2), May 2007, p. 594-603
Lok, Ka Chun; Fu, Amy Kit Yu; Ip, Fanny Chun Fun; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Formyl peptide receptor like 1 differentially requires mitogen-activated protein kinases for the induction of glial fibrillary acidic protein and interleukin-1α in human U87 astrocytoma cells
Cellular Signalling, v. 19, (10), October 2007, p. 2106-2117
Kam, Angel Y.F.; Tse, Timothy T.M.; Kwan, Dawna H.T.; Wong, Yung Hou
Formyl peptide-receptor like-1 requires lipid raft and extracellular signal-regulated protein kinase to activate inhibitor-κB kinase in human U87 astrocytoma cells
Journal of Neurochemistry, v. 103, (4), November 2007, p. 1553-1566
Kam, Angel Y.F.; Liu, Andrew M.F.; Wong, Yung Hou
G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis
FEBS Journal, v. 274, (23), December 2007, p. 6025-6036
New, David C.; Wu, Kelvin; Kwok, Alice W.S.; Wong, Yung Hou
In search of novel and therapeutically significant melatoninergic ligands
Recent Patents on CNS Drug Discovery, v. 2, (3), November 2007, p. 241-245
Mody, Sejal M.; Hu, Sharry Y.; Ho, Maurice K.C.; Wong, Yung Hou
Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression
Journal of Molecular Signaling, v. 2, February 2007, article number 2
New, David C.; Wong, Yung Hou
NRG induces membrane targeting of Gαz in muscle: implication in myogenesis
NeuroReport, v. 18, (14), September 2007, p. 1433-1436
Lok, Ka Chun; Fu, Kit Yu; Ip, Fanny C.F.; Wong, Yung Hou; Ip, Nancy Yuk-Yu

Conference paper 4

Adenylyl cyclase activity during NGF-induced differentiation of rat pheochromocytoma (PC12) cells
Croucher Advanced Study Institute on Movement Disorders: Basic and Clinical Sciences, Hong Kong., 27 November - 1 December 2007
Yung, H.S.; Lai, K.H.; Wong, Yung Hou; Wise, Helen
Drug Development Candidate TAT2 Activates Telomerase in Primary Neuronal Cultures
Abstract P052
An, Hui Jin; Ip, Fanny C.F.; Hu, Sharry Y; Ho, Maurice K C; Chin, A.C.; Harley, C.B.; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Identification of subtype-selective melatonin receptor ligands from traditional Chinese medicine
MGH-HKU-Nature Forum. Molecular Medicine and Biopharma Opportunities, Hong Kong, 5-6 March 2007. Abstract P042.
Ho, Maurice K.C.; New, David C.; Hu, Sharry Y.; Pang, Haihong; Wong, Yung Hou
Knowledge-Based Drug Discovery: Identification of Novel Leads From Traditional Chinese Medicine
MGH-HKU-Nature Forum. Molecular Medicine and Biopharma Opportunities, Hong Kong, 5 - 6 March 2007
Pang, Haihong; Hu, Sharry Y.; Ho, Maurice K C; Ip, Fanny C.F.; An, Hui Jin; Ip, Nancy Yuk-Yu; Wong, Yung Hou


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Article 12

Activation of muscarinic M₄ receptor augments NGF-induced pro-survival Akt signaling in PC12 cells
Cellular Signalling, v. 18, (3), March 2006, p. 258-293
Wu, Eddy H.T.; Wong, Yung Hou
Activation of STAT3 by Gα_s Distinctively Requires Protein Kinase A, JNK, and Phosphatidylinositol 3-Kinase
Journal of Biological Chemistry, v. 281, (47), November 2006, p. 35812-35825
Liu, A.M.F.; Lo, Kin H.; Wong, Cecilia S.S.; Morris, Christina; Wise, Helen; Wong, Yung Hou
CKBM stimulates MAPKs but inhibits LPS-induced IFN-γ in lymphocytes
Phytotherapy Research, v. 20, (9), September 2006, p. 725-731
Chan, Siu Lung Anthony; Yip, Eric C.H.; Yung, Ying; Pang, Haihong; Luk, Sharon C.W.; Pang, Shin F.; Wong, Yung Hou
Constitutively active α subunits of G_q/11 and G_2/13 families inhibit activation of the pro-survival Akt signaling cascade
FEBS Journal, v. 273, (11), June 2006, p. 2388-2398
Wu, Eddy H.T.; Tam, Becky H.L.; Wong, Yung Hou
GABA_B heterodimeric receptors promote Ca²⁺ influx via store-operated channels in rat cortical neurons and transfected chinese hamster ovary cells
Neuroscience, v. 137, (4), 2006, p. 1347-1358
New, David C.; An, Hui Jin; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Involvement of calcium mobilization from caffeine-sensitive stores in mechanically induced cell cycle arrest in the dinoflagellate Crypthecodinium cohnii
Cell Calcium, v. 39, (3), March 2006, p. 259-274
Yeung, Patrick Ka Kit; Lam, Connie Mo Ching; Ma, Zhiyi; Wong, Yung Hou; Wong, Joseph T.Y.
Opioid receptor-like (ORL1) receptor utilizes both G(0A) and G(0B) for signal transduction
Protein & Peptide Letters, v. 13, (5), May 2006, p. 437-441
Tso, Ha; Wong, Yung Hou
Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: A mechanism requiring PTX-insensitive G proteins, ERK and JNK
Cellular Signalling, v. 18, (3), March 2006, p. 307-317
Lo, Kin H.; Wise, Helen; Wong, Yung Hou
Protocatechuic acid induces cell death in HepG2 hepatocellular carcinoma cells through a c-Jun N-terminal kinase-dependent mechanism
Cell Biology and Toxicology, v. 22, (4), July 2006, p. 293-302
Yip, E.C.H.; Chan, Siu Lung Anthony; Pang, Haihong; Tam, Y.K.; Wong, Yung Hou
The aqueous extract of Radix Glycyrrhizae stimulates mitogen-activated protein kinases and nuclear factor-kappa B in Jurkat T-cells and THP-1 monocytic cells
American Journal of Chinese Medicine, v. 34, (2), 2006, p. 263-278
Chan, Siu Lung Anthony; Pang, Haihong; Yip, Eric Chun Hung; Tam, Yunkau; Wong, Yung Hou
Transcriptional activation of c-Fos by constitutively active Gα₁₆QL through a STAT1-dependent pathway
Cellular Signalling, v. 18, (12), December 2006, p. 2143-2153
Lo, Kin H.; Wong, Yung Hou
Tuberin: A Stimulus-Regulated Tumor Suppressor Protein Controlled by a Diverse Array of Receptor Tyrosine Kinases and G Protein-Coupled Receptors
NeuroSignals, v. 15, (5), July 2006, p. 217-227
Wu, Eddy H.T.; Wu, Kelvin K.H.; Wong, Yung Hou

Book review 1

G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity [Book review]
ChemMedChem, v. 1, (7), July 2006, p. 741-742
Wong, Yung Hou

Conference paper 15

A time-dependent loss of prostaglandin EP3 receptors in PC12 cells during neuroal differentiation
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Yung, H.S.; Wong, Yung Hou; Wise, Helen
Apoptosis of human neuroblastoma SK-N-MC cells induced by dopamine and norepinephrine
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Chan, Siu Lung Anthony; Ng, L.W.C.; Poon, Lydia See Wing; Chan, W.W.Y.; Wong, Yung Hou
Axin Is Involved in Nerve Growth Factor-Induced Differentiation of PC12 Cells
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies & Annual Meeting of Hong Kong Society of Neurosciences, Hong Kong, 30 November - 2 December 2006
Ng, Yu Pong; Lin, Shengcai; Fu, Kit Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Cell-based Fluorimetric assays for monitoring Gembierddiscus toxins
Proceedings of the Third International Conference on the Prevention and Management of Harmful Algal blooms in the South China Sea, p1-5. June, 2006. The Association on Harmful Algal Blooms in the South China Sea
Mak, Carmen K.M.; Yeung, Patrick K.K.; Wong, Yung Hou; Wong, Joseph T.Y.
Co-stimulation of Galphas alters Galpha16-mediated STAT3 activation.
Croucher Advanced Study Institute on Signaling in Cell Growth and Differentiation, Hong Kong, Abstract., 2006
Wong, Yung Hou
Ga sub(16) Binds to RhoA-Specific Guanine Nucleotide Exchange Factor p63RhoGEF and Competes with the Canonical PLC/PKC Pathway
46th Annual Meeting of the American Society for Cell Biology, San Diego Convention center, San Diego, California (USA), 9-13 Dec 2006
Yeung, W.W.S.; Wong, Yung Hou
Ga sub(s) Mediates b sub(2)-Adrenergic Receptor-Induced Stat3 Phosphorylation
4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS 2006), Cheung Kung Hai Conference Centre, Hong Kong City (Hong Kong-S.A.R of China), 30 Nov-2 Dec 2006
Liu, A.M.F.; Lo, Kin H.; Wong, C.S.S.; Morris, Christina Jane; Wise, Helen; Wong, Yung Hou
Galpha14 interacts with tetratricopeptide repeat 1 for Ras signaling
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, Nov ember 30 - December 2, 2006. Abstract.
Kwan, D.H.T.; Wong, Yung Hou
Galpha16 binds to RhoA-specific guanine nucleotide exchange factor p63RhoGEF and competes with the canonical PLC/PKC pathway
45th Annual Meeting of the American Society for Cell Biology, San Diego, USA, 13-17 December 2006. Abstract 67.
Yeung, Wing Shan; Wong, Yung Hou
Modulation of kappa-opioid signaling by RGS proteins
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Tso, Ha; Wong, Yung Hou
Opioid-induced pro-survival signals and the Akt/Tuberin pathway
Intl Narcotics Res Conf, Minnesota, USA, 9-14 July 2006, Abstract S II-5
Wong, Yung Hou
p63RhoGEF, a membrane-bound guanine nucleotide exchange factor, modulates signaling by heterotrimeric G proteins
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, Nov 30 - Dec 2, 2006, Abstract
Yeung, Wing Shan; Wong, Yung Hou
Regulatory mechanism of mTOR and p70 S6 kinase by muscarinic M4 receptors in PC12 cells
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Chan, G.P.W.; Wu, Eddy H.T.; Wong, Yung Hou
Role of Axin in Nerve Growth Factor-Induced Differentiation of PC12 Cells
The 5th Gordon Research Conference on 'Molecular and Cellular Neurobiology', Hong Kong, 11 - 16 June 2006
Ng, Yu Pong; Lin, Shengcai; Fu, Kit Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu
The down-regulation of prostaglandin EP3 receptor subtype during neuronal differentiation
IUPHAR 2006, Beijing, China, Abstract
Yung, H.S.; Wong, Yung Hou; Wise, Helen


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Article 11

Activation of nuclear factor κB by somatostatin type 2 receptor in pancreatic acinar AR42J cells involves Gα₁₄ and multiple signaling components: A mechanism requiring protein kinase C, calmodulin-dependent kinase II, ERK, and c-Src
Journal of Biological Chemistry, v. 280, (41), October 2005, p. 34617-34625
Liu, A.M.F.; Wong, Yung Hou
Activation of δ-, κ-, and μ-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells
Biochemical and Biophysical Research Communications, v. 334, (3), September 2005, p. 838-844
Wu, Eddy H.T.; Wong, Yung Hou
An aqueous extract of the popular Chinese nutraceutical Kwei Ling Ko (Tortoise shell-Rhizome Jelly) activates the PPARγ pathway and down-regulates the NFκB activity
Phytomedicine, v. 12, (10), November 2005, p. 748-759
Yip, Eric Chun Hung; Liu, A.M.F; Wong, Joseph T.Y.; Wong, Yung Hou
Carvacrol and eugenol differentially stimulate intracellular Ca²⁺ mobilization and mitogen-activated protein kinases in Jurkat T-cells and monocytic THP-1 cells
Planta medica, v. 71, (7), July 2005, p. 634-639
Chan, Siu Lung Anthony; Pang, Haihong; Yip, Eric Chun Hung; Tam, Yunkau; Wong, Yung Hou
Chimeric and Promiscuous G Proteins in Drug Discovery and the Deorphanization of GPCRs
Drug Design Reviews Online, v. 2, (1), February 2005, p. 66-79
New, David C.; Wong, Yung Hou
G_q-Mediated Activation of c-Jun N-Terminal Kinase by the Gastrin-Releasing Peptide-Preferring Bombesin Receptor Is Inhibited upon Costimulation of the G_s-Coupled Dopamine D₁ Receptor in COS-7 Cells
Molecular Pharmacology, v. 68, (5), November 2005, p. 1354-1364
Chan, Siu Lung Anthony; Wong, Yung Hou
Immuno-regulatory effects of CKBM on the activities of mitogen-activated protein kinases and the release of cytokines in THP-1 monocytic cells
Biological and Pharmaceutical Bulletin, v. 28, (9), September 2005, p. 1645-1650
Chan, Siu Lung Anthony; Yip, Eric Chun Hung; Yung, Ying; Pang, Haihong; Luk, Sharon; Pang, Shiufun; Wong, Yung Hou
Integration of G protein signals by extracellular signal-regulated protein kinases in SK-N-MC neuroepithelioma cells
Journal of Neurochemistry, v. 94, (5), August 2005, p. 1457-1470
Chan, Siu Lung Anthony; Yeung, Wendy W.S.; Wong, Yung Hou
Involvement of G_i/o Proteins in Nerve Growth Factor-Stimulated Phosphorylation and Degradation of Tuberin in PC-12 Cells and Cortical Neurons
Molecular Pharmacology, v. 67, (4), April 2005, p. 1195-1205
Wu, Eddy H.T.; Wong, Yung Hou
Mu-Opioid Receptor-Mediated Phosphorylation of IκB Kinase in Human Neuroblastoma SH-SY5Y Cells
NeuroSignals, v. 14, (3), July 2005, p. 136-142
Liu, A.M.F.; Wong, Yung Hou
Pertussis toxin-sensitive G_i/o proteins are involved in nerve growth factor-induced pro-survival Akt signaling cascade in PC12 cells
Cellular Signalling, v. 17, (7), July 2005, p. 881-890
Wu, Eddy H.T.; Wong, Yung Hou

Book chapter 1

Molecular Basis of Opioid Actions: Regulation of Mitogen-activated Protein Kinases
Recent Developments in Pain Research, 2005 / Edited by Anna Capasso. Research Signpost Publishers, 2005, p. 41-58
Chan, Siu Lung Anthony; New, David C.; Wong, Yung Hou

Conference paper 21

Activated Galpha11, Galpha12, and Galpha13 inhibit activation of the pro-survival AKT signaling cascade
24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract P-25.
Tam, H.L.; Wu, Eddy H.T.; Wong, Yung Hou
Activation of muscarinic M4 receptor augments NGF-induced pro-survival Akt signaling in PC12 cells
24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract O-12.
Wu, Eddy H.T.; Wong, Yung Hou
Activation of the human FPRL-1 receptor promotes Ca2+ mobilization and stimulates mitogen-activated protein kinases in U87 astrocytoma cells.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P-9., 2005
Kwan, Dawna H.T.; Kam, Angel Y.F.; Wong, Yung Hou
Differential regulation of signal transducers and activators of transcription by G protein subunits
24th Scientific Meeting of the Kong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract P-37.
Yuen, J.W.F.; Wong, Yung Hou
Expression profiling of Galphaz-regulated genes
24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., 13-14 January 2005, Abstract P-23.
Mei, H.; Ho, Maurice K.C.; Yung, Ying; Wong, Yung Hou
Function of Galphaz in muscle differentiation
HKU/HKUST/Cambridge University Joint Research Retreat, Hong Kong., 10-12 March 2005
Mei, H.; Ho, Maurice K.C.; Yung, Ying; Wong, Yung Hou
G14-mediated stimulation of NFkappaB by the type 2 somatostatin receptor
24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract P-29
Liu, A.M.L.; Wong, Yung Hou
Identification of Critical Early Genes Involved in Nerve Growth Factor-Induced PC12 Differentiation
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5 - 6 December 2005
Xiao, Fang; Ng, Yu Pong; Tsim, Karl Wah Keung; Wise, Helen; Wong, Yung Hou; Ip, Nancy Yuk-Yu; Wu, Zhenguo
Involvement of Gi/o proteins in nerve growth factor-stimulated phosphorylation and degradation of tuberin in PC12 cells
HKU/HKUST/Cambridge University Joint Research Retreat, Hong Kong, 10-12 March 2005
Wu, Eddy H.T.; Wong, Yung Hou
New perspectives in G protein signaling: regulation of protein kinases and transcription factors.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Plenary Lecture I., 2005
Wong, Yung Hou
NGF-Induced Neuronal Differentiation of PC12 Cells: Delineation of Signaling Molecules and Mapping of Pathways.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5 - 6 December 2005
Leung, W.K.W.; Choi, Chi Yan; Ip, Nancy Yuk-Yu; Wu, Zhenguo; Wong, Yung Hou; Cheung, P.T.; Tsim, Karl Wah Keung
Overexpression of Galphaz Inhibits Muscle Differentiation
Abstract P-14
Mei, Hua; Wu, Zhenguo; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Regulation of STAT3 phosphorylation by Galphas.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong. Abstract P3., 2005
Lo, Kin H.; Liu, A.M.F.; Wise, Helen; Wong, Yung Hou
Role of Axin in Nerve Growth Factor-Stimulated Neurite Outgrowth
Abstract O-2.
Ng, Yu Pong; Lin, Shengcai; Fu, Wing Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Role of Calmodulin-Dependent Kinase II in Nerve Growth Factor-Induced Differentiation of PC12 Cells.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5-6 December 2005
Kam, Yuet Fong; Yung, Ying; Wu, Eddy H.T.; Ng, Yu Pong; Wu, Zhenguo; Tsim, Karl Wah Keung; Wise, Helen; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Screening for NMDA Receptor Antagonists Using Traditional Chinese Medicine
Abstract P-7
Ip, Fanny C.F.; An, Hui Jin; Chan, Agnes Wing Sze; Tong, Pui Sze; Hu, Sharry Y.; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Stimulation of mitogen-activated protein kinases by the human FPRL-1 receptor
24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., 13-14 January 2005, Abstract P-27.
Kam, Angel Y.F.; Tse, T.T.M.; New, David C.; Wong, Yung Hou
Synergistic activation of extracellular signal-regulated kinase by Gi- and Gq-coupled receptors in SK-N-MC neuroepithelioma cells
HKU/HKUST/Cambridge University Joint Research Retreat, Hong Kong, 10-12 March 2005
Yeung, Wing Shan; Wong, Yung Hou
Synergistic activation of extracellular signal-regulated kinase by Gi- and Gq-coupled receptors in SK-N-MC neuroepithelioma cells
24th Scientific Meeting of the Hong Kong Society of Neurosciences Hong Kong, 13-14 January 2005, Abstract P-33
Yeung, Wing Shan; Chan, Siu Lung Anthony; Wong, Yung Hou
The effect of NGF-induced differentiation on the expression of prostanoid receptors in PC12 cells.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P-19., 2005
Yung, H.S.; Wong, Yung Hou; Wise, Helen
Unraveling chemokine signaling for drug discovery.
Pacifichem 2005, Hawaii, USA., 15-20 December 2005
Wong, Yung Hou


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Article 12

Characterization of CHO cells stably expressing a Gα_16/z Chimera for high throughput screening of GPCRs
Assay and Drug Development Technologies, v. 2, (3), June 2004, p. 269-280
New, David C.; Wong, Yung Hou
Differential chemokine activation of CC chemokine receptor 1-regulated pathways: ligand selective activation of Gα₁₄-coupled pathways
European Journal of Immunology, v. 34, (3), March 2004, p. 785-795
Tian, Yaji; New, David C.; Yung, Ying; Allen, Rodger A.; Slocombe, Patrick M.; Twomey, Breda M.; Lee, Mei Ki; Wong, Yung Hou
Epidermal growth factor differentially augments G_i-mediated stimulation of c-Jun N-terminal kinase activity
British Journal of Pharmacology, v. 142, (4), June 2004, p. 635-646
Chan, Siu Lung Anthony; Wong, Yung Hou
G₁₆-mediated Activation of Nuclear Factor κB by the Adenosine A₁ Receptor Involves c-Src, Protein Kinase C, and ERK Signaling
Journal of Biological Chemistry, v. 279, (51), December 2004, p. 53196-53204
Liu, A.M.F.; Wong, Yung Hou
Gβγ signaling and Ca²⁺ mobilization co-operate synergistically in a Sos and Rac-dependent manner in the activation of JNK by G_q-coupled receptors
Cellular Signalling, v. 16, (7), July 2004, p. 823-836
Chan, Siu Lung Anthony; Wong, Yung Hou
Identification of a stretch of six divergent amino acids on the α5 helix of Gα₁₆ as a major determinant of the promiscuity and efficiency of receptor coupling
Biochemical Journal, v. 380, (2), June 2004, p. 361-369
Ho, Maurice K.C.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Wong, Yung Hou
Phosphatidylinositol-3 kinase is distinctively required for μ-, but not κ-opioid receptor-induced activation of c-Jun N-terminal kinase
Journal of Neurochemistry, v. 89, (2), April 2004, p. 391-402
Kam, Angel Y.F.; Chan, Siu Lung Anthony; Wong, Yung Hou
Prostacyclin receptor-mediated activation of extracellular signal-regulated kinases 1 and 2
Cellular Signalling, v. 16, (4), April 2004, p. 477-486
Chu, Kit-Man; Chow, Kevin B.S.; Wong, Yung Hou; Wise, Helen
Regulation of STAT3 by μ-opioid receptors in human neuroblastoma SH-SY5Ycells
NeuroReport, v. 15, (9), June 2004, p. 1431-1435
Yuen, Jessie W.F.; So, Ivy Y.W.; Kam, Angel Y.F.; Wong, Yung Hou
Replacement of the α5 helix of Gα₁₆ with Gα_s-specific sequences enhances promiscuity of Gα₁₆ toward G_s-coupled receptors
Cellular Signalling, v. 16, (1), January 2004, p. 51-62
Hazari Anjali Ajaykumar; Lowes, Vicki L.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Ho, Maurice K.C.; Wong, Yung Hou
Signal Transducer and Activator of Transcription 3 Activation by the δ-Opioid Receptor via Gα₁₄ Involves Multiple Intermediates
Molecular Pharmacology, v. 65, (6), June 2004, p. 1487-1439
Lo, Kin H.; Wong, Yung Hou
κ-Opioid Receptor Signals through Src and Focal Adhesion Kinase to Stimulate c-Jun N-Terminal Kinases in Transfected COS-7 Cells and Human Monocytic THP-1 Cells
Journal of Pharmacology and Experimental Therapeutics, v. 310, (1), July 2004, p. 301-310
Kam, Angel Y.F.; Chan, Siu Lung Anthony; Wong, Yung Hou

Conference paper 6

Atypical regulation of calcium signals in astrocytoma 1321N1 cells expressing the purinergic P2Y12 receptor.
The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Hong Kong, Abstract B-P33-15, 4-7 February
Ho, Maurice K.C.; Simon, J.; Barnard, E.A.; Wong, Yung Hou
Gi family members participate in nerve growth factor-mediated translational control in PC12 cells
Gordon Research Conference on Molecular & Cellular Neurobiology, Hong Kong, P65, 6-11 June
Wu, Eddy H.T.; Wong, Yung Hou
Opioid-mediated regulation of protein kinases and transcription factors
The 3rd Meeting of Asian Pacific Opioid Symposium on Molecular Basis of Opioid Tolerance and Dependence, Kyoto, Japan, 18 July 2004, Abstract
Wong, Yung Hou
Purinergic regulations of mitogen-activated protein kinases and calcium mobilization in rat brain capillary endothelial B10 cells
The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Hong Kong, Abstract B-P33-12, 4-7 February
Wong, Yung Hou; Ho, Maurice K.C.; Leung, E.H.Y.; Simon, J.; Barnard, E.A.
Regulation of nuclear factor kappaB and STAT3 by mu-opioid receptors in human neuroblastoma SH-SY5Y cells
Intl Narcotics Res Conf, Kyoto, Japan, 18-23 July 2004, Abstract P-52
Wong, Yung Hou; Liu, A.M.F.; Yuen, J.W.F.; Kam, A.Y.F.
Requirement of Gi/o proteins and phosphatidylinositol-3-kinase in nerve growth factor-induced tuberin phosphorylation and degradation
The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Hong Kong, Abstract B-P33-4, 4-7 February
Wu, Eddy H.T.; Wong, Yung Hou


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Article 11

BML-190 and AM251 act as inverse agonists at the human cannabinoid CB₂ receptor: signalling via cAMP and inositol phosphates
FEBS Letters, v. 536, (1-3), February 2003, p. 157-160
New, David C.; Wong, Yung Hou
CC chemokine receptor-coupled signalling pathways
生物化学与生物物理学报=Acta Biochimica et Biophysica Sinica, v. 2003, (09), 2003, p. 779-788
New, David C.; Wong, Yung Hou
Constitutively Active Gα₁₆ Stimulates STAT3 via a c-Src/JAK- and ERK-dependent Mechanism
Journal of Biological Chemistry, v. 278, (52), December 2003, p. 52154-52165
Lo, Kin H.; Cheung, Helen; Wong, Yung Hou
G Protein-Linked Effector and Second Messenger Systems Involved in Melatonin Signal Transduction
NeuroSignals, v. 12, (2), March 2003, p. 59-70
New, David C.; Tsim, Siu T.; Wong, Yung Hou
Gα_16/z chimeras efficiently link a wide range of G protein-coupled receptors to calcium mobilization
Journal of Biomolecular Screening, v. 8, (1), February 2003, p. 39-49
Liu, A.M.F.; Ho, Maurice K.C.; Wong, Cecilia S.S.; Chan, Jasmine H.P.; Pau, Anson H.M.; Wong, Yung Hou
Molecular basis of opioid dependence: Role of signal regulation by G-proteins
Clinical and Experimental Pharmacology and Physiology, v. 30, (5-6), May-June 2003, p. 307-316
Tso, Ha; Wong, Yung Hou
Rac and Cdc42-dependent regulation of c-Jun N-terminal kinases by the delta-opioid receptor
Journal of Neurochemistry, v. 84, (3), February 2003, p. 503-513
Kam, Angel Y.F.; Chan, Siu Lung Anthony; Wong, Yung Hou
Regulation of STAT3 activity by G₁₆-coupled receptors
Biochemical and Biophysical Research Communications, v. 303, (3), April 2003, p. 920-925
Wu, Eddy H.T.; Lo, Kin H.; Wong, Yung Hou
Reporter gene assays and their applications to bioassays of natural products
Phytotherapy Research, v. 17, (5), May 2003, p. 439-448
New, David C.; Miller-martini, David M.; Wong, Yung Hou
The first and third intracellular loops together with the carboxy terminal tail of the delta-opioid receptor contribute toward functional interaction with G₁₆
Journal of Neurochemistry, v. 87, (3), November 2003, p. 697-708
Chan, Anthony S.L.; Law, Ping Y.; Loh, Horace H.; Ho, Peter N.N.; Wu, Wai-Man; Chan, Joy S.C.; Wong, Yung Hou
The β6/α5 regions of Gα_i2 and Gα_oA increase the promiscuity of Gα₁₆ but are insufficient for pertussis toxin-catalyzed ADP-ribosylation
European Journal of Pharmacology, v. 473, (2-3), July 2003, p. 105-115
Wong, Cecilia S.S.; Ho, Maurice K.C.; Wong, Yung Hou

Conference paper 6

Activation of STAT3 by hematopoietic-specific G proteins
10th Congress of Federation of Asian & Oceanian Biochemists and Molecular Biologists, India, Abstract S27, 7-11 December
Wong, Yung Hou; Lo, Kin H.
Constitutively active Galpha16 stimulates STAT1 via a c-Src/JAK- and ERK-dependent mechanism
43rd Annual Meeting of the American Society for Cell Biology, San Francisco, USA, Abstract 1573, 13-17 December
Lo, Kin H.; Wong, Yung Hou
Pertussis toxin-sensitive Gi/o proteins are involved in nerve growth factor-induced Akt signaling cascade in PC12 cells
23rd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract OP3, 9-10 December
Wu, E.H.T.; Wong, Yung Hou
Pertussis toxin-sensitive Gi/o proteins participate in nerve growth factor-induced activation of survival Akt kinase and nuclear factor kappaB
43rd Annual Meeting of the American Society for Cell Biology, San Francisco, USA, Abstract 67, 13-17 December
Wu, E.H.T.; Wong, Yung Hou
STAT3 activation by the delta-opioid receptor via Galpha14 involves c-Src/JAK- and ERK-dependent pathways
23rd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PP9, 9-10 December
Lo, Kin H.; Wong, Yung Hou
The Roles of G-Proteins in the Formation of Neuromuscular Junction and Myogenesis
The 23rd Annual Scientific Conference of the Hong Kong Society of Neuroscience, Hong Kong, 9 - 10 December 2003
Lok, Ka Chun; Fu, Wing Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu


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Article 9

Characterization and Channel Coupling of the P2Y₁₂Nucleotide Receptor of Brain Capillary Endothelial Cells
Journal of Biological Chemistry, v. 277, (35), August 2002, p. 37390-31400
Simon, Joseph; Filippov, Alexander K.; G?ransson, Sara A.; Wong, Yung Hou; Frelin, Christian; Michel, Anton D.; Brown, David A.; Barnard, Eric A.
Co-Expressions of Different Opioid Receptor Types Differentially Modulate Their Signaling via G₁₆
NeuroSignals, v. 11, (2), March-April 2002, p. 115-122
Ho, Maurice K.C.; New, David C.; Wong, Yung Hou
Constitutive activation of the opioid receptor-like (ORL₁) receptor by mutation of Asn133 to tryptophan in the third transmembrane region
Journal of Neurochemistry, v. 83, (6), December 2002, p. 1461-1470
Kam, Kenneth Wan Lung; New, David C.; Wong, Yung Hou
Integration of Signals from Receptor Tyrosine Kinases and G Protein-Coupled Receptors
NeuroSignals, v. 11, (1), January-February 2002, p. 5-19
Lowes, Vicki L.; Ip, Nancy Yuk-Yu; Wong, Ying Hou
Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins
Cellular Signalling, v. 14, (3), March 2002, p. 249-257
Chan, Siu Lung Anthony; Lai, Frank; Lo, Kin H.; Voyno-yasenetskaya, Tatyana A.; Stanbridge, Eric John; Wong, Yung Hou
Molecular determinants for the differential coupling of Gα₁₆ to the melatonin MT1, MT2 and Xenopus Mel1c receptors
Journal of Neurochemistry, v. 80, (5), March 2002, p. 436-745
Lai, Frank; Mody, Sejal M.; Yung, Ying; Kam, Jason Y.M.; Pang, Celia Sook Fun; Pang, Shiufun; Wong, Yung Hou
Prostanoid Signal Integration and Cross Talk
NeuroSignals, v. 11, (1), January-February 2002, p. 20-28
Wise, Helen; Wong, Yung Hou; Jones, Robert Leslie
Signal Diversification by the Neuronal-Specific Gz Protein.
Neuro-Signals, 11: 170-171
Wong, Yung Hou
The ORL₁ Receptor: Molecular Pharmacology and Signalling Mechanisms
NeuroSignals, v. 11, (4), July 2002, p. 197-212
New, David C.; Wong, Yung Hou

Book chapter 1

G protein structure diversity
Structure and Function of GPCRs in the Nervous System / 63-86
Ho, Maurice K.C.; Wong, Yung Hou

Conference paper 9

Atypical G protein signaling: The path to kinases
Croucher Advanced Study Institute on Cell Signaling and Gene Transcription, Croucher Foundation, Hong Kong, S2
Wong, Yung Hou
BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor
22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P10
New, David C.; Wong, Yung Hou
Expressions of regulators of G protein signaling RGSZ1 and GAIP augment neuronal differentiation of PC12 cells
22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P12
Ho, Maurice K.C.; Wu, Eddy H.T.; Wong, Yung Hou
Involvement of G Protein Signaling Pathway at the Neuromuscular Junctions
Abstract P11
Lok, Ka C.; Fu, Wing Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu
mu-Opioid receptor-mediated activation of c-Jun N-terminal kinase requires phosphatidylinositol 3-kinase
22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P13
Kam, Yuet Fong; Wong, Yung Hou
Nerve Growth Factor-Dependent Activation of C-Jun N-Terminal Kinase in PC12 Cells Is Mediated via Pertussis Toxin-Sensitive G Proteins
Abstract O19
Tso, Ha; Yung, Ying; Yu, Jowie C.H.; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Regulation of STAT3 activity by ORL1 receptor through Galpha16
22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract O6
Wu, Eddy H.T.; Lo, Kin H.; Wong, Yung Hou
Signal diversification by the neuronal-specific Gz protein
Croucher Advanced Study Institute on Molecular Neuroscience Hong Kong University of Science and Technology
Wong, Yung Hou
The application of Galpha16/Z chimeras in high-throughput drug screening
Third International Symposium for Chinese Medicinal Chemists, Hong Kong, December
New, David C.; Ho, Maurice K.C.; Dai, Wei M.; Wong, Yung Hou


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Article 9

A reporter gene assay for the detection of phytoestrogens in traditional Chinese medicine
Phytotherapy Research, v. 15, (6), September 2001, p. 487-492
Miller-martini, David M; Chan, Robbie Y.K.; Ip, Nancy Yuk-Yu; Sheu, S.J.; Wong, Yung Hou
Bacterial formyl peptide mediated chemotaxis and extracellular acidification in shrimp haemocytes
Developmental and Comparative Immunology, v. 25, (4), May 2001, p. 269-277
Yip, Eric Chun Hung; Wong, Yung Hou; Wong, Joseph T.Y.
Chimeric Gα_q subunits can distinguish the long form of the Xenopus Mel1c melatonin receptor from the mammalian mt1 and MT2 melatonin receptors
Journal of Pineal Research, v. 30, (3), April 2001, p. 171-179
Lai, Frank P.L.; Mody, Sejal M.; Yung, Ying; Pang, Celia Sook Fun; Pang, Shiufun; Wong, Yung Hou
G_z signaling: Emerging divergence from G_i signaling
Oncogene, v. 20, (13 REV. ISS. 1), March 2001, p. 1615-1625
Ho, Maurice K.C.; Wong, Yung Hou
Gα₁₄ links a variety of G_i- and G_s-coupled receptors to the stimulation of phospholipase C
British Journal of Pharmacology, v. 132, (7), April 2001, p. 1431-1440
Ho, Maurice K.C.; Yung, Ying; Chan, Joy S.C.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Wong, Yung Hou
Opioid-induced adenylyl cyclase supersensitization in human embryonic kidney 293 cells requires pertussis toxin-sensitive G proteins other than G_i1 and G_i3
Neuroscience Letters, v. 299, (1-2), February 2001, p. 25-28
Tso, Ha; Wong, Yung Hou
Prostacyclin receptor-independent inhibition of phospholipase C activity by non-prostanoid prostacyclin mimetics
British Journal of Pharmacology, v. 134, (7), December 2001, p. 1375-1384
Chow, Kevin B.S.; Wong, Yung Hou; Wise, Helen
Role of extracellular signal-regulated kinases in opioid-induced adenylyl cyclase superactivation in human embryonic kidney 293 cells
Neuroscience Letters, v. 316, (1), December 2001, p. 13-16
Tso, Ha; Wong, Yung Hou
The Cyclic AMP-Mediated Expression of Acetylcholinesterase in Myotubes Shows Contrasting Activation and Repression between Avian and Mammalian Enzymes
Molecular and Cellular Neuroscience, v. 17, (4), April 2001, p. 732-745
Choi, Roy Chi Yan; Siow, Nina Lam; Zhu, Shangquan; Wan, David Chi Cheong; Wong, Yung Hou; Tsim, Karl Wah Keung

Conference paper 10

Applications of chimeric and mutant Ga16 subunits in ligand screening for orphan G protein-coupled receptors.
7th Annual Conference of the Society for Biomolecular Screening, Baltimore, USA., Abstract 10012
Wong, Yung Hou; Ho, Maurice K.C.
Neuronal Gz protein differentially regulates mitogen-activated protein kinases and signal transducers and activators of transcription
21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P38
Ho, Maurice K.C.; Lo, Kin H.; Chan, Siu Lung Anthony; Tso, Ha; Wong, Yung Hou
Rac and Cdc42-dependent regulation of c-Jun N-terminal kinase by the opioid receptors.
International Symposium on Cell Signaling - from diseases to drug discovery, Hong Kong.
Kam, Angel Y.F.; Wong, Yung Hou
Regulation of STAT3 activity by heterotrimeric G proteins of the Gq subfamily.
21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., Abstract P26
Wong, Yung Hou; Lo, Kin H.; Ho, Maurice K.C.
Replacement of the C-terminal residues of Ga16 with Gai2 or Gao1 residues enhances its promiscuity for receptor recognition.
21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., Abstract P25
Wong, Cecilia S.S.; Pau, Anson H.M.; Wong, Yung Hou
Selected mutations in the a5 helix of Ga16 increase its promiscuity for receptors
21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract 37
Chan, Jasmine H.P.; Ho, Maurice K.C.; Wong, Yung Hou
Selected mutations of the a5 helix of Ga16 improves the coupling of Gi-linked receptor
International Symposium on Cell Signaling - from diseases to drug discovery, Hong Kong
Ho, Maurice K.C.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Wong, Yung Hou
Signaling from opioid receptors to c-Jun N-terminal kinase requires the small GTP-binding proteins Rac and Cdc42.
41st Annual Meeting of the American Society for Cell Biology, Washington, USA., Abstract 1233
Kam, Angel Y.F.; Wong, Yung Hou
Suppression of prostacyclin receptor-mediated phospholipase C stimulation by Ga14.
21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., Abstract P39
Lee, Mei Ki; Joshi, Sushma A.; Wise, Helen; Wong, Yung Hou
The regulation of c-Jun N-terminal kinase by opioid receptors involves Rac and Cdc42
21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract 24
Kam, Angel Y.F.; Wong, Yung Hou


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Article 13

Activation of B-Raf and Regulation of the Mitogen-activated Protein Kinase Pathway by the G_o α chain
Molecular Biology of the Cell, v. 11, (4), April 2000, p. 1129-1142
Antonelli, Valeria; Bernasconi, Francesca; Wong, Yung Hou; Vallar, Lucia
Cloning of a novel G-protein-coupled receptor from the sea anemone nervous system
Biochemical and Biophysical Research Communications, v. 271, (3), May 2000, p. 761-769
New, David C.; Wong, Yung Hou; Wong, Joseph T.Y.
Deciphering the role of G_i2 in opioid-induced adenylyl cyclase supersensitization
NeuroReport, v. 11, (14), September 2000, p. 3213-3217
Tso, Ha; Wong, Yung Hou
Evidence for transduction of mu but not kappa opioid modulation of extracellular signal-regulated kinase activity by G_z and G₁₂ proteins
Cellular Signalling, v. 12, (7), July 2000, p. 481-489
Belcheva, Mariana M.; Wong, Yung Hou; Coscia, Carmine J.
G_z Can Mediate the Acute Actions of μ- and κ-Opioids but Is Not Involved in Opioid-Induced Adenylyl Cyclase Supersensitization
Journal of Pharmacology and Experimental Therapeutics, v. 295, (1), October 2000, p. 168-176
Tso, Ha; Wong, Yung Hou
Immunoglobulin G1 Fc Fragment-Tagged Human Opioid Receptor-Like Receptor Retains the Ability to Inhibit cAMP Accumulation
Biological Signals and Receptors, v. 9, (5), September-October 2000, p. 240-247
Yung, Ying; Tsim, Karl Wah Keung; Pei, Gang; Wong, Yung Hou
Incorporation of Gα_z-specific sequence at the carboxyl terminus increases the promiscuity of Gα₁₆ toward G_i-coupled receptors
Molecular Pharmacology, v. 57, (1), January 2000, p. 13-23
Mody, Sejal M.; Ho, Maurice K.C.; Joshi, Sushma A.; Wong, Yung Hou
Molecular mechanisms and regulation of opioid receptor signaling
Annual Review of Pharmacology and Toxicology, v. 40, April 2000, p. 389-430
Law, Pingyee; Wong, Yung Hou; Loh, Horace
Preactivation Permits Subsequent Stimulation of Phospholipase C by G,sub>i-Coupled Receptors
Molecular Pharmacology, v. 57, (4), April 2000, p. 700-708
Chan, Joy S.C.; Lee, Jonathan W.M.; Ho, Maurice K.C.; Wong, Yung Hou
Regulation of Adenylyl Cyclase, ERK1/2, and CREB by G_z Following Acute and Chronic Activation of the δ-Opioid Receptor
Journal of Neurochemistry, v. 74, (4), April 2000, p. 1685-1693
Tso, Ha; Yung, Ying; Wong, Yung Hou
Regulation of C-jun N-terminal kinase by the ORL₁ receptor through multiple G proteins
Journal of Pharmacology and Experimental Therapeutics, v. 295, (3), December 2000, p. 11094-1100
Chan, Siu Lung Anthony; Wong, Yung Hou
The Amino Terminus of Gα_z is Required for Receptor Recognition, Whereas its α4/β6 Loop Is Essential for Inhibition of Adenylyl Cyclase
Molecular Pharmacology, v. 58, (5), November 2000, p. 993-1000
Ho, Maurice K.C.; Wong, Yung Hou
The Effect of Protein Kinase C Activation on G_z-Mediated Regulation of Type 2 and 6 Adenylyl Cyclases
Biological Signals and Receptors, v. 9, (1), January-February 2000, p. 21-28
Ho, Maurice K.C.; Chan, Joy S.C.; Yung, Ying; Wong, Yung Hou


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Article 7

Alanine-23 of transducin α subunit is involved in defining the affinity for βγ complex
NeuroReport, v. 10, (7), May 1999, p. 1561-1564
Ho, Maurice K C; Wong, Yung Hou
Alanine-23 of transducin α subunit is involved in defining the affinity for βγ complex
NeuroReport, v. 10, (9), June 1999, p. 1993-1996
Ho, Maurice Kwok Chung; Wong, Yung Hou
Chronic activation of ORL₁ receptor induces supersensitization of adenylyl cyclase
NeuroReport, v. 10, (14), September 1999, p. 2901-2905
Chan, Robbie; Wong, Yung Hou
Disruption of receptor-mediated activation of G protein by mutating a conserved arginine residue in the switch II region of the α subunit
Journal of Neurochemistry, v. 73, (5), November 1999, p. 2101-2109
Ho, Maurice K.C.; Yung, Ying; Wong, Yung Hou
G_L1 (Gα₁₄) couples the opioid receptor-like₁ receptor to stimulation of phospholipase C
Journal of Pharmacology and Experimental Therapeutics, v. 288, (1), January 1999, p. 232-238
Yung, Ying; Joshi, Sushma A.; Chan, Robbie Y.K.; Chan, Joy S.C.; Pei, Gang; Wong, Yung Hou
Mutational analysis of the structure and function of opioid receptors
Biopolymers - Peptide Science Section, v. 51, (6), 1999, p. 440-455
Law, Pingyee; Wong, Yung Hou; Loh, Horace
Stimulation of phospholipase C by the cloned μ, δ and κ opioid receptors via chimeric Gα_q mutants
European Journal of Neuroscience, v. 11, (2), January 1999, p. 383-388
Joshi, Sushma; Lee, Jonathan W.M.; Wong, Yung Hou


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Article 8

Chimeric Gα_q mutants harboring the last five carboxy-terminal residues of Gα_i2 or Gα_o are resistant to pertussis toxin-catalyzed ADP-ribosylation
FEBS Letters, v. 441, (1), December 1998, p. 67-70
Joshi, Sushma A.; Fan, Kenneth P.K.; Ho, Vannessa W.S.; Wong, Yung Hou
Differential coupling of μ-, δ-, and κ-opioid receptors to Gα₁₆- mediated stimulation of phospholipase C
Journal of Neurochemistry, v. 70, (5), May 1998, p. 2203-2211
Lee, Jonathan W.M.; Joshi, Sushma A.; Chan, Joy S.C.; Wong, Yung Hou
Evidence for heterotrimeric G proteins in sea anemones
Molecular Marine Biology and Biotechnology, v. 7, (1), March 1998, p. 31-38
New, David C.; Mcgaughey Nicola Jane; Wong, Yung Hou; Wong, Joseph T.Y.
Molecular and cellular analyses of melatonin receptor-mediated cAMP signaling in rat corpus epididymis
Journal of Pineal Research, v. 25, (4), December 1998, p. 219-228
Li, Lili; Xu, Jianning; Wong, Yung Hou; Wong, Joseph T.Y.; Pang, Shiufun; Shiu, Stephen Yuen Wing
Pertussis Toxin-Insensitive Signaling of the ORL₁ Receptor: Coupling to G_z and G₁₆ Proteins
Journal of Neurochemistry, v. 71, (5), November 1998, p. 2203-2210
Chan, Joy S.C.; Yung, Ying; Lee, Jonathan W.M.; Wu, Yalan; Pei, Gang; Wong, Yung Hou
Regulation of calcium influx and phospholipase C activity by indoleamines in dinoflagellate Crypthecodinium cohnii
Journal of Pineal Research, v. 24, (3), April 1998, p. 152-161
Tsim, Siu-Tai; Wong, Joseph T.Y.; Wong, Yung Hou
Structure and Function of the Pertussis-Toxin-Insensitive G_z Protein
Biological Signals and Receptors, v. 7, (2), March-April 1998, p. 80-89
Ho, Maurice K.C.; Wong, Yung Hou
The calcitonin gene-related peptide-induced acetylcholinesterase synthesis in cultured chick myotubes is mediated by cyclic AMP
Journal of Neurochemistry, v. 71, (1), July 1998, p. 152-160
Choi, Roy Chi Yan; Yung, Lisa Ying; Dong, Tina Ting Xia; Wan, David C.C.; Wong, Yung Hou; Tsim, Karl Wah Keung


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Article 5

Calcium ion dependency and the role of inositol phosphates in melatonin-induced encystment of dinoflagellates
Journal of Cell Science, v. 110, (12), June 1997, p. 1387-1393
Tsim, Siu Tai; Wong, Joseph T.Y.; Wong, Yung Hou
Functional Role of Amino-Terminal Serine¹⁶ and Serine²⁷ of Gα_z in Receptor and Effector Coupling
Journal of Neurochemistry, v. 68, (6), June 1997, p. 2514-2522
Ho, Maurice K.C.; Wong, Yung Hou
Melatonin and 5-methoxytryptamine induced muscular contraction in sea anemones
Journal of Experimental Zoology, v. 279, (3), October 1997, p. 201-207
Tsang, Wai Hung; Mcgaughey Nicola Jane; Wong, Yung Hou; Wong, Joseph T.Y.
Receptor-induced βγ release from fatty acylation-deficient mutants of Gα_z
NeuroReport, v. 8, (4), March 1997, p. 937-940
Beck, Helga I.; Chan, Joy S.C.; Wong, Yung Hou
Role of Amino- and Carboxyl-Terminal Regions of G_αz in the Recognition of G_i-Coupled Receptors
Molecular Pharmacology, v. 52, (1), July 1997, p. 38-45
Tsu Rachel Caroline; Ho, Maurice K.C.; Yung, Ying; Joshi, Sushma A.; Wong, Yung Hou


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Article 6

CGP 52608-induced cyst formation in dinoflagellates: Possible involvement of a nuclear receptor for melatonin
Journal of Pineal Research, v. 21, (2), September 1996, p. 101-107
Tsim, Siu Tai; Wong, Joseph T.Y.; Wong, Yung Hou
Effects of Dibutyryl cAMP and Bacterial Toxins on Indoleamine-Induced Encystment of Dinoflagellates
Biological Signals, v. 5, (1), January-February 1996, p. 22-29
Tsim, Siu Tai; Wong, Joseph T.Y.; Wong, Yung Hou
G_i-mediated stimulation of type II adenylyl cyclase is augmented by G_q-coupled receptor activation and phorbol ester treatment
Journal of Neuroscience, v. 16, (4), February 1996, p. 1317-1323
Tsu, Rachel Caroline; Wong, Yung Hou
Inverse agonistic effect of ICI-174,864 on the cloned delta-opioid receptor: Role of G protein and adenylyl cyclase activation
Molecular Pharmacology, v. 50, (6), December 1996, p. 1651-1657
Chiu, Tillie T.; Yung, Ying; Wong, Yung Hou
Possible involvement of G proteins in indoleamine-induced encystment in dinoflagellates
Molecular Marine Biology and Biotechnology, v. 5, (2), June 1996, p. 162-167
Tsim, Siu Tai; Yung, Ying; Wong, Joseph T.Y.; Wong, Yung Hou
The G Protein Linkage of Melatonin Receptors
Frontiers of Hormone Research, v. 21, 1996, p. 147-153
Wong, Yung Hou


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Article 7

Activation of Type II Adenylyl Cyclase by the Cloned μ‐Opioid Receptor: Coupling to Multiple G Proteins
Journal of Neurochemistry, v. 65, (6), December 1995, p. 2682-2689
Chan, Joy S.C.; Chiu, Tillie T.; Wong, Yung Hou
Differential coupling of the formyl peptide receptor to adenylate cyclase and phospholipase C by the pertussis toxin-insensitive G_z protein
Biochemical Journal, v. 309, (1), July 1995, p. 331-339
Tsu, Rachel Caroline; Lai, H.W.L.; Allen, Rodger A.; Wong, Yung Hou
GZ coupling to the rat κ-opioid receptor
FEBS Letters, v. 360, (1), February 1995, p. 97-99
Lai, Helen W.L.; Minami, Masabumi; Satoh, Masamichi; Wong, Yung Hou
Mutant α subunit of G(z) transforms Swiss 3T3 cells
Oncogene, v. 10, (10), May 1995, p. 1927-1933
Wong, Yung Hou; Chan, Joy S.C.; Yung, Ying; Bourne, Henry R.
Regulation of multiple effectors by the cloned δ-opioid receptor: Stimulation of phospholipase C and type II adenylyl cyclase
Journal of Neurochemistry, v. 64, (6), June 1995, p. 2700-2707
Tsu, Rachel Caroline; Chan, Joy S.C.; Wong, Yung Hou
Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through G_i and G_z proteins
FEBS Letters, v. 372, (1), September 1995, p. 99-102
Yung, Ying; Tsim, Siu Tai; Wong, Yung Hou
Stimulation of type II adenylyl cyclase by chemoattractant formyl peptide and C5a receptors
Molecular Pharmacology, v. 47, (4), April 1995, p. 835-841
Tsu, Rachel Caroline; Allen, Rodger A.; Wong, Yung Hou


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Article 2

G_i Assays in Transfected Cells
Methods in Enzymology, v. 238, (C), January 1994, p. 81-94
Wong, Yung Hou
Indolemine-induced encystment in dinoflagellates
J. Mar. Biol. Ass. U.K, v. 74, 1994, p. 467-469
Wong, J.T.Y.; Wong, Yung Hou


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Article 4

Detection of Coincident Signals by G Proteins and Adenylyl Cyclase
Cold Spring Harbor Symposia on Quantitative Biology, v. 57, 1992, p. 145-148
Bourne, H.R.; Lustig, K.; Wong, Yung Hou; Conklin, B.R.
Gz-mediated hormonal inhibition of cyclic AMP accumulation
Science, v. 255, (5042), January 1992, p. 339-342
Wong, Yung Hou; Conklin, B.R.; Bourne, H.R.
Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C
Journal of Biological Chemistry, v. 267, (1), January 1992, p. 31-34
Conklin, B.R.; Chabre, O.; Wong, Yung Hou; Federman, A.; Bourne, H.R.
The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase
Journal of Biological Chemisty, v. 267, (29), October 1992, p. 20831-20834
Hung, D.T.; Wong, Yung Hou; Vu, T.K.; Coughlin, S.R.


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Article 3

A mutant α subunit of G_i2 induces neoplastic transformation of rat-1 cells
Proceedings of the National Academy of Sciences of the United States of America, v. 88, (16), August 1991, p. 7031-7035
Pace, A.M.; Wong, Yung Hou; Barnard, E.A.
G protein oncogenes
In: Origins of Human Cancer: A Comprehensive Review, 1991, p. 327-333
Bourne, H.R.; Goretzki, P.; Landis, C.; Lyons, J.; McCormick, F.; Pace, A.; Wong, Yung Hou
Mutant α subunits of G_i2 inhibit cyclic AMP accumulation
Nature, v. 351, (6321), May 1991, p. 63-65
Wong, Yung Hou; Federman, Alex; Pace, Ann M.; Zachary, Ian; Evans, Tony; Pouysségur, Jacques; Bourne, Henry R.


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Article 1

Agonist-selective protection of the opioid receptor-coupled G protein from inactivation by 5'-p-fluorosulphonylbenzoyl guanosine
Journal of Neurochemistry, v. 54, (1), January 1990, p. 39-45
Wong, Yung Hou; Demoliou-mason, C.D.; Hanley, M.R.; Barnard, E.A.


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Article 3

Opioid receptor-G protein interactions: pertussis toxin, Li+ effects and reconstitution studies
Li+ effects and reconstitution studies. Adv. Biosci, v. 75, 1989, p. 153-156
Wong, Yung Hou; Demoliou-Mason, C.D.; Barnard, E.A.
Opioid Receptors in Magnesium-Digitonin-Solubilized Rat Brain Membranes Are Tightly Coupled to a Pertussis Toxin-Sensitive Guanine Nucleotide-Binding Protein
Journal of Neurochemistry, v. 52, (4), April 1989, p. 0999-1009
Wong, Yung Hou; Demoliou-mason, C.D.; Barnard, E.A.
Uncoupling of the opioid receptor-G protein complexes by 5'-p-fluorosulphonylbenzoyl guanosine
Adv. Biosci., v. 75, 1989, p. 133-136
Wong, Yung Hou; Demoliou-Mason, C.D.; Barnard, E.A.


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Article 2

A complex of opioid receptor with G protein, characterized in digitonin solution
In: Regulatory Roles of Opioid Peptides, Edited by Illes P and Farsang C. 1988, p. 131-144
Wong, Yung Hou; Demoliou-Mason, C.D.; Barnard, E.A.
ADP-ribosylation with pertussis toxin modulates the GTP-sensitive opioid ligand binding in digitonin-soluble extracts of rat brain membranes
Journal of Neurochemistry, v. 51, (1), July 1988, p. 114-121
Wong, Yung Hou; Demoliou-mason, C.D.; Barnard, E.A.


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Article 1

Bradykinin stimulation of inositol phosphate and calcium responses is insensitive to pertussis toxin in NG115-401L neuronal cells
Biochemical and Biophysical Research Communications, v. 148, (1), October 1987, p. 412-416
Jackson, Trevor R.; Patterson, Sean I.; Wong, Yung Hou; Hanley, Michael R.


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Article 1

Effects of hypoxaemia and hyperoxaemia on some cardiovascular responses of rats to adrenaline
Archives of Physiology and Biochemistry, v. 94, (5), 1986, p. 323-329
Dai, S.; Wong, Yung Hou; Ogle, C.W.


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Article 1

Effects of Hypoventilation on the Cardiovascular Responses of Rats to Adrenaline and Acetylcholine
Pharmacology, v. 30, (6), 1985, p. 314-319
Dai, S.; Wong, Yung Hou


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2016 9

Anxiety and Depression with Neurogenesis Defects in Exchange Protein Directly Activated by cAMP 2-Deficient Mice are Ameliorated by a Selective Serotonin Reuptake Inhibitor, Prozac
Translational Psychiatry, v. 6, (9), September 2016, article number e881
Zhou, L.; Ma, Sukling; Yeung, Patrick Ka Kit; Wong, Yung Hou; Tsim, Karl Wah Keung; So, K. F.; Lam, L.C.W.; Chung, S.K. Article
Differential Regulation of CXCL8 Production by Different G Protein Subunits with Synergistic Stimulation by G_i^- and G_q^-Regulated Pathways
Journal of Molecular Biology, v. 428, (19), September 2016, p. 3869-3884
Chan, Anthony Siu Lung; Lau, Wai In; Szeto, Aydan C.H.; Wang, Jiuling; Wong, Yunghou Article
Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling
Proceedings of the National Academy of Sciences of the United States of America, v. 113, (7), February 2016, p. 1937-1942
Li, Songshan; Yang, Chao; Zhang, Li; Gao, Xin; Wang, Xuejie; Liu, Wen; Wang, Yuqi; Jiang, Songshan; Wong, Yung Hou; Zhang, Yifeng; Liu, Kai Article
Quantitative Analysis of Nucleosides and Nucleobases in Deer Antler: Variation in Different Species
Pharmaceutica Analytica Acta, v. 7, (4), April 2016, article number 1000474
Bi, Dan; Zhang, L.M.L.; Tang, Wai Lun; Duan, Ran; Leung, Ka Wing; Dong, Tingxia; Wong, Yung Hou; Lin, Huangquan; Tsim, Karl Wah Keung Article
Regulator of G Protein Signaling 20 Enhances Cancer Cell Aggregation, Migration, Invasion and Adhesion
Cellular Signalling, v. 28, (11), November 2016, p. 1663-1672
Yang, Lei; Lee, Mei Ki; Leung, Man Hon Manton; Wong, Yung Hou Article
Cdk5 Activity is Required for EphB-mediated Synaptogenesis
The 46th Annual Meeting of the Society for Neuroscience, San Diego, USA, 12-16 November 2016
Chen, Yu; Wong, Yung Hou; Fu, Wing Yu; Fu, Kit Yu; Ip, Nancy Yuk-Yu Conference paper
Flavonoids Induce the Expression of Acetylcholinesterase in Cultured Osteoblasts
Chemico-Biological Interactions, v. 259, (B), 25 November 2016, p. 295-300
Xu, Miranda Li; Bi, Wenchuan; Kong, Yeung Yeung Ava; Dong, Ting Xia; Wong, Yung Hou; Tsim, Karl Wah Keung Conference paper
Functional assessment of MT2 melatonin receptor variants that are associated with type 2 diabetes
Neuroscience Symposium 2016 & Annual Scientific Conference of The Hong Kong Society of Neurosciences, Hong Kong, May, 2016
Wu, Y.; Chan, K.H.; Wong, Yung Hou Conference paper
The role of RGS20 in cell cycle regulation and angiogenesis
2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Science, Lee Shau Kee Building, The Chinese University of Hong Kong, Hong Kong, 11 June 2016
Leung, M.; Alim, A.S.; Xu, R.; Wong, Yung Hou Conference paper

2015 15

Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on Gα_i3
Molecular and Cellular Biochemistry, v. 401, (1-2), March 2015, p. 27-38
Tse, Man Kit; Morris, Christina Jane; Zhang, Mingjie; Wong, Yung Hou Article
An intact helical domain is required for Gα₁₄ to stimulate phospholipase Cβ
BMC Structural Biology, v. 15, (1), September 2015, article number 18
Kwan, Dawna HT; Wong, Ka Ming; Chan, Anthony Siu Lung; Yung, Lisa Ying; Wong, Yung Hou Article
Association of activated Gα_q to the tumor suppressor Fhit is enhanced by phospholipase Cβ
BMC Cancer, v. 15, (1), October 2015, article number 775
Zuo, Hao; Wong, Yung Hou Article
Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons
Neurobiology of Disease, v. 73, January 2015, p. 366-376
Li, Songshan; He, Qinghai; Wang, Hao; Tang, Xuming; Ho, Kam Wing; Gao, Xin; Zhang, Qian; Shen, Yang; Cheung, Annie; Wong, Francis; Wong, Yung Hou; Ip, Nancy Yuk-yu; Jiang, Liwen; Yung, Wing Ho; Liu, Kai Article
Metastasis suppressors Nm23H1 and Nm23H2 differentially regulate neoplastic transformation and tumorigenesis
Cancer Letters, v. 361, (2), June 2015, p. 207-217
Tong, Yao; Yung, Lisa Ying; Wong, Yung Hou Article
Regulatory functions of Nm23-H2 in tumorigenesis: insights from biochemical to clinical perspectives
Naunyn-Schmiedeberg's Archives of Pharmacology, v. 388, (2), February 2015, p. 243-256
Li, Yuanjun; Tong, Yao; Wong, Yung Hou Article
RAS Genes
Encyclopedia of Cancer: a Springer Live Reference / Manfred Schwab. Berlin, Heidelberg : Springer, 2015, p. 1-6
Wong, Yung Hou; Pellicer, Angel; Liu, Wen Book chapter
Activation Of Phospholipase Cβ By NonDissociable Gq Proteins
ASCEPT-BPS Joint Scientific Meeting 2015, University of Hong Kong, 19-21 May 2015
Wong, Yung Hou; Liu, W.; Chan, Siu Lung Anthony; Poon, Lydia See Wing; Wong, K.M. Conference paper
Functional characterization of type 2 diabetes associated MTNRIB variants
2015 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 23 May 2015
Wu, Y.; Chan, K.H.; Wong, Yung Hou Conference paper
Inhibition of oncogenic Ras-induced tumorigenesis by Nm23 metastasis suppressors
The 2nd Annual Meeting of the International Ovarian Cancer Consortium and the Symposium on Tumor Microenvironment and Therapy Resistance, University of Oklahoma Health Sciences Center, Oklahoma City, USA, 16-18 August 2015
Wong, Y.H.; Li, Y. Conference paper
Involvement of G proteins in asymmetric cell division during neurogenesis
2015 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 23 May 2015
Yip, J.L.K.; Lee, M.M.K.; Wong, Yung Hou Conference paper
Molecular determinants of selective ligand binding at the human melatonin receptor
ASCEPT-BPS Joint Scientific Meeting (ASCEPT-BPS 2015), The University of Hong Kong, 19-21 May 2015
Chan, King Hang; Wong, Yung Hou Conference paper
Non-dissociable Gβ-Gα Fusion Proteins Reveal Different Mechanisms Of G Protein Activation
ASCEPT-BPS Joint Scientific Meeting (ASCEPT-BPS 2015), The University of Hong Kong, 19-21 May 2015
Liu, Wen; Chan, Siu Lung Anthony; Wong, Ka Ming; Wong, Yung Hou Conference paper
Post-transcriptional regulation of the regulator of G protein signaling 19 (RGS19) and metastasis suppressor Nm23 in cancer by microRNAs
2015 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 23 May 2015
Wong, Ka Ming; Wong, Yung Hou Conference paper
Role of surface residues on defining the functional specificity of Nm23 metastasis suppressors
ASCEPT-BPS Joint Scientific Meeting (ASCEPT-BPS 2015), The University of Hong Kong, 19-21 May 2015
Li, Yuanjun; Wong, Yung Hou Conference paper

2014 11

Angiotensin-[1-12] interacts with angiotensin type I receptors
Neuropharmacology, v. 81, June 2014, p. 267-273
Chan, King Hang; Chen, Yi Hung; Zhang, Ying; Wong, Yung Hou; Dun, Nae J. Article
Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management
NeuroSignals, v. 22, (1), May 2014, p. 52-63
Ip, Fanny Chui Fun; Ng, Yu Pong; An, Hui Jin; Dai, Ying; Pang, Hai Hong; Hu, Yue Qing; Chin, Allison C.; Harley, Calvin B.; Wong, Yung Hou; Ip, Nancy Yuk-Yu Article
Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via Toll-like receptor-4 dependent pathways
Neuroscience, v. 267, May 2014, p. 241-251
Tse, Kai Hei; Chow, K.B.S.; Leung, W.K.; Wong, Yung Hou; Wise, H. Article
Primary Sensory Neurons Regulate Toll-like receptor-4-dependent Activity of Glial Cells in Dorsal Root Ganglia
Neuroscience, v. 279, October 2014, p. 10-22
Tse, Kai-Hei; Chow, K.B.S.; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen Article
Synthesis and Functional Characterization of Substituted Isoquinolinones as MT₂-Selective Melatoninergic Ligands
PLoS ONE, v. 9, (12), December 2014, article number 0113638
Hu, Yueqing; Chan, King Hang; He, Xixin; Ho, Maurice Kwok Chung; Wong, Yung Hou Article
Activation of Gq without Subunits Dissociation
2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The University of Hong Kong, Hong Kong, 14 June 2014
Liu, Wen; Wong, Yung Hou Conference paper
Activation of PLCβ by a Non-dissociable Gq Protein
Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, Hong Kong, The University of Hong Kong, Hong Kong, 12-14 June 2014
Liu, W.; Chan, Siu Lung Anthony; Wong, K.M.; Wong, Yung Hou Conference paper
ENStem - A Cells as a Model for Studying Neurogenesis
Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, The University of Hong Kong, Hong Kong, 12-14 June 2014
Yip, J.L.K.; Lee, M.M.K.; Wong, Yung Hou Conference paper
Multi-faceted Metastasis Suppressor Nm23 is Up-regulated by RGS19 via Activating Transcription Factors
The 2014 Physiology Symposium and Joint Scientific Meeting of The Hong Kong Society of Neurosciences and The Biophysical Society of Hong Kong (HKSN-BSHK), The University of Hong Kong, Hong Kong, 12-14 June 2014
Li, Y.; Wong, Yung Hou Conference paper
RGS19 Up-regulates Nm23-H1/2 Expression via Stimulating Multiple Transcriptional Factors
Hong Kong Inter-University Biochemistry Postgraduate Symposium 2014, The University of Hong Kong, 14 June 2014
Li, Yuanjun; Wong, Yung Hou Conference paper
RGS20 as a Modulator of Tumorigenesis and Angiogenesis
2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The University of Hong Kong, Hong Kong, 14 June 2014
Leung, Man Hon Manton; Yang, Lei; Wong, Yung Hou Conference paper

2013 17

A Molecular and Chemical Perspective in Defining Melatonin Receptor Subtype Selectivity
International Journal of Molecular Sciences, v. 14, (9), September 2013, p. 18385-18406
Chan, King Hang; Wong, Yung Hou Article
Activation of Gα_q subunits up-regulates the expression of the tumor suppressor Fhit
Cellular Signalling, v. 25, (12), December 2013, p. 2440-2452
Zuo, Hao; Chan, Anthony Siu Lung; Ammer, Hermann; Wong, Yung Hou Article
Activation state-dependent interaction between Gα_q subunits and the Fhit tumor suppressor
Cell Communication and Signaling, v. 11, (1), August 2013, article number 59
Zuo, Hao; Chan, Grace P.W.; Zhu, Jing; Yeung, Wendy Wing Shan; Chan, Anthony Siu Lung; Ammer, Hermann; Wong, Yung Hou Article
Characterization of Substituted Phenylpropylamides as Highly Selective Agonists at the Melatonin MT2 Receptor
Current Medicinal Chemistry, v. 20, (2), January 2013, p. 289-300
Chan, King Hang; Hu, Sharry Y.; Ho, Maurice K C; Wong, Yung Hou Article
Development of substituted N-[3-(3-methoxylphenyl)propyl] amides as MT₂-selective melatonin agonists: Improving metabolic stability
Bioorganic and Medicinal Chemistry, v. 21, (2), January 2013, p. 547-552
Hu, Yueqing; Zhu, Jing; Chan, King Hang; Wong, Yung Hou Article
Gβγ-mediated activation of protein kinase D exhibits subunit specificity and requires Gβγ-responsive phospholipase Cβ isoforms
Cell Communication and Signaling, v. 11, (1), April 2013, article number 22
Lau, Winnie Wai In; Chan, Anthony Siu Lung; Poon, Lydia See Wing; Zhu, Jing; Wong, Yung Hou Article
Isolated dorsal root ganglion neurones inhibit receptor-dependent adenylyl cyclase activity in associated glial cells
British Journal of Pharmacology, v. 168, (3), February 2013, p. 746-760
Ng, Kai Yu; Yeung, Barry Ho Sing; Wong, Yung Hou; Wise, Helen Article
Neuronal Functions of Activators of G Protein Signaling
NeuroSignals, v. 21, (3-4), May 2013, p. 259-271
Tse, Man Kit; Wong, Yung Hou Article
Regulator of G protein signaling 19 suppresses Ras-induced neoplastic transformation and tumorigenesis
Cancer Letters, v. 339, (1), October 2013, p. 33-41
Wang, Yingchun; Tong, Yao; Tso, Prudence H.; Wong, Yung Hou Article
RGS19 inhibits Ras signaling through Nm23H1/2-mediated phosphorylation of the kinase suppressor of Ras
Cellular Signalling, v. 25, (5), May 2013, p. 1064-1074
Tso, Ha Prudence; Wang, Yingchun; Yung, Ying Lisa; Tong, Yao; Lee, Mei Ki Maggie; Wong, Yung Hou Article
Development of novel melatoninergics as circadian rhythm sleep disorder therapeutics
New Developments in Melatonin Research / Editors: Dario Acuna-Castroviejo, Iryna Rusanova, Germaine Escames. Nova Science Publishers, Inc., 2013, p. 53-76
Chan, King Hang; Cheung, Annie Suet Ting; Ho, Maurice K.C.; Wong, Yung Hou Book chapter
High-throughput screening in traditional Chinese medicine-based drug discovery
Antitumor Potential and Other Emerging Medicinal Properties of Natural Compounds / Editors: Evandro Fei Fang, Tzi Bun Ng. Dordrecht : Springer Science+Business Media, 2013, p. 387-404
Wong, Catherine Chi Kit; Wong, Yung Hou Book chapter
Nm23 Mediates RGS19-induced Suppression of Ras Signaling
The 9th International Congress of the NDP Kinase/Nm23/awd Gene Family, Boston, USA, 31 July - 4 August 2013
Wong, Yung Hou Conference paper
Regulation of STAT3 by GPCRs Involves Interleukin-6 Autocrine Signaling
The 7th IDRC Symposium, Seoul, Korea, 26-27 August 2013
Wong, Yung Hou Conference paper
Sensory Neurons Regulate Toll-like Receptor 4 (TLR4) Signaling in Glia Derived from Dorsal Root Ganglia (DRG)
2013 Annual Meeting of Society for Neuroscience, San Diego, USA, 9-13 November 2013
Tse, Kai Hei; Chow, Kevin Bing Shui; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen Conference paper
Toll-like Receptor 4 (TLR4) Differentially Regulates Cox-1 and Cox-2 to Enhance Prostanoid Production by Primary Sensory Neurons
2013 Annual Meeting of Hong Kong Society for Immunology, Hong Kong, 25 May, 2013
Tse, Kai Hei; Chow, Kevin Bing Shui; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen Conference paper
Toll-like Receptor 4 (TLR4) Increases Expression of Inflammatory Mediators in Primary Sensory Neurons via Activation of a MyD88-dependent Signaling Pathway
Acta Pharmacologica Sinica, v. 34, July 2013, p. 116
Wise, Helen; Chow, Kevin Bing Shui; Tse, Kai Hei; Leung, Wai Keung; Wong, Yung Hou Conference paper

2012 11

Activation of ras-dependent signaling pathways by G_14^-coupled receptors requires the adaptor protein TPR1
Journal of Cellular Biochemistry, v. 113, (11), November 2012, p. 3486-3497
Kwan, Dawna H.T.; Yung, Lisa Y.; Ye, Richard D.; Wong, Yung Hou Article
Astragaloside IV and Cycloastragenol Stimulate the Phosphorylation of Extracellular Signal-Regulated Protein Kinase in Multiple Cell Types
Planta Medica, v. 78, (2), January 2012, p. 115-121
Yung, Ying Lisa; Lam, Wing See; Ho, Maurice K.C.; Hu, Sharry Y.; Ip, Fanny C.F.; Pang, Haihong; Chin, Allison; Harley, Calvin B.; Ip, Nancy Yuk-yu; Wong, Yung Hou Article
CCR1-Mediated STAT3 Tyrosine Phosphorylation and CXCL8 Expression in THP-1 Macrophage-like Cells Involve Pertussis Toxin-Insensitive Gα_14/16 Signaling and IL-6 Release
Journal of Immunology, v. 189, (11), December 2012, p. 5266-5276
Lee, Mei Ki; Chui, Ricky K.S.; Tam, Issan Y.S.; Lau, Alaster H.Y.; Wong, Yung Hou Article
Elevated expression of RGS19 impairs the responsiveness of stress-activated protein kinases to serum
Molecular and Cellular Biochemistry, v. 362, (1-2), March 2012, p. 159-168
Ip, Angel K.C.; Tso, Ha; Lee, Mei Ki; Wong, Yung Hou Article
Interleukin-6 autocrine signaling mediates melatonin MT_1/2 receptor-induced STAT3 Tyr⁷⁰⁵ phosphorylation
Journal of Pineal Research, v. 52, (4), May 2012, p. 477-489
Lau, Wai In; Ng, Johnson K.Y.; Lee, Mei Ki; Chan, Siu Lung Anthony; Wong, Yung Hou Article
Pharmacokinetics, oral bioavailability and metabolism of a novel isoquinolinone-based melatonin receptor agonist in rats
Xenobiotica, v. 42, (11), November 2012, p. 1138-1150
Zhu, Jing; Hu, Sharry Y.; Ho, Maurice K.C.; Wong, Yung Hou Article
Prostacyclin Receptor-Dependent Inhibition of Human Erythroleukemia Cell Differentiation is STAT3-Dependent
Prostaglandins Leukotrienes and Essential Fatty Acids, v. 86, (3), March 2012, p. 119-126
Lau, Alaster H.Y.; Lai, Henry K.H.; Yeung, Barry H.S.; Leung, Sze Lee; Tsang, Suk Ying; Wong, Yung Hou; Wise, Helen Article
Rapid Uptake and Degradation of CXCL12 Depend on CXCR7 Carboxyl-terminal Serine/Threonine Residues
Journal of Biological Chemistry, v. 287, (34), August 2012, p. 28362-28377
Hoffmann, Frauke; Mueller, Wiebke; Schuetz, Dagmar; Penfold, Mark E.; Wong, Yung Hou; Schulz, Stefan; Stumm, Ralf Article
Activated Gαq subunits interact with the tumor suppressor Fhit and increase its expression and phosphorylation
Stephenson Cancer Center Mini Conference on Tumor Microenvironment and Drug Discovery, 2-3 Dec 2012, Oklahoma, USA, Abstract T1
Wong, Yung Hou Conference paper
Expression of Toll-like receptor 4 signaling components in adult rat dorsal root ganglion cells
Hong Kong-Taiwan Physiology Symposium 2012 and Joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, June 2012, p. 40
Tse, Kai Hei; Chow, Kevin Bing Shui; Ng, K. Y.; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen Conference paper
Novel interaction between signal transducing G proteins and the Fhit tumor suppressor
8th Asia Pacific Multidisciplinary Meeting for Cancer Research, May 11 2012, Hong Kong, Abstract T4
Wong, Yung Hou Conference paper

2011 11

3-Methoxylphenylpropyl amides as novel receptor subtype-selective melatoninergic ligands: characterization of physicochemical and pharmacokinetic properties
Xenobiotica, v. 41, (1), January 2011, p. 35-45
Zhu, Jing; Hu, Yueqing; Ho, Maurice K.C.; Wong, Yung Hou Article
Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRα2 isoforms
Cellular Signalling, v. 23, (11), November 2011, p. 1727-1737
Wan, Guoqiang; Zhou, Lihan; Lim, Qing `En; Wong, Yung Hou; Too, Heng-Phon Article
Expression of Gα_z in C2C12 Cells Restrains Myogenic Differentiation
Cellular Signalling, v. 23, (2), February 2011, p. 389-397
Mei, Hua; Ho, Kwok Chung Maurice; Yung, Ying; Wu, Zhenguo; Ip, Nancy Yuk-yu; Wong, Yung Hou Article
Glial cells isolated from dorsal root ganglia express prostaglandin E₂ (EP₄) and prostacyclin (IP) receptors
European Journal of Pharmacology, v. 661, (1-3), July 2011, p. 42-48
Ng, Kai Yu; Wong, Yung Hou; Wise, Helen Article
Gα₁₆ interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling
BMC Structural Biology, v. 11, April 2011, article number 17
Liu, A.M.F.; Lo, Kin H.; Guo, Emily X.; Ho, Maurice K.C.; Ye, Richard D.; Wong, Yung Hou Article
RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signaling
Cancer Letters, v. 309, (2), October 2011, p. 199-208
Tso, Prudence H.; Yung, Lisa Y.; Wang, Yingchun; Wong, Yung Hou Article
Regulation of Chemotaxis by Heterotrimeric G proteins
Chemotaxis: Types, Clinical Significance, and Mathematical Models / Edited by Timothy C. Williams. Hauppauge, N.Y.: Nova Science Publishers, c2011, p.109-134
Lee, Maggie M.K.; Wong, Yung Hou Book chapter
Nm23-H1 inhibits oncogene-induced neoplastic transformation
Second Inter-University Biochemistry Postgraduate Symposium, 11 Jun 2011, Hong Kong, Abstract P-U005
Tong, Yao; Wong, Yung Hou Conference paper
Regulation of Fhit by Gq family proteins
Second Inter-University Biochemistry Postgraduate Symposium, 11 Jun 2011, Hong Kong, Abstract P-U011
Zuo, H.; Chan, Anthony S.L.; Wong, Yung Hou Conference paper
The expression of Toll-like receptor 4 in rat dorsal root ganglia
Annual Scientific Meeting of the Hong Kong Society of Immunology, Hong Kong, 7 May 2011
Chow, KB; Chu, TCH; Leung, WK; Wong, Yung Hou; Wise, Helen Conference paper
Understanding the role of RGS20 in tumorigenesis
Second Inter-University Biochemistry Postgraduate Symposium, 11 Jun 2011, Hong Kong, Abstract P-U004
Yang, L.; Wong, Yung Hou Conference paper

2010 17

Activation of STAT3 by specific Gα subunits and multiple Gβγ dimers
International Journal of Biochemistry and Cell Biology, v. 42, (6), June 2010, p. 1052-1059
Yuen, J.W.F.; Poon, Lydia See Wing; Chan, Siu Lung Anthony; Yu, Frances W.Y.; Lo, Kin H.; Wong, Yung Hou Article
Gα₁₆ activates Ras by forming a complex with tetratricopeptide repeat 1 (TPR1) and Son of Sevenless (SOS)
Cellular Signalling, v. 22, (10), October 2010, p. 1448-1458
Liu, A.M.F.; Lo, Kin H.; Lee, Mei Ki; Wang, Yingchun; Yeung, Wendy W.S.; Ho, Maurice K.C.; Su, Yan; Ye, Richard D.; Wong, Yung Hou Article
Gα₁₆ interacts with Class IA phosphatidylinositol 3-kinases and inhibits Akt signaling
Cellular Signalling, v. 22, (9), September 2010, p. 1379-1387
Yeung, Wing Shan; Wong, Yung Hou Article
In Search of Novel and Therapeutically Significant Melatoninergic Ligands
Frontiers in CNS Drug Discovery, v. 1, 2010, p. 600-610
Mody, Sejal M.; Hu, Sharry Y.; Ho, Maurice K.C.; Wong, Yung Hou Article
In vitro Intestinal Absorption and First-pass Intestinal and Hepatic Metabolism of Cycloastragenol, a Potent Small Molecule Telomerase Activator
Drug Metabolism and Pharmacokinetics, v. 25, (5), November 2010, p. 477-486
Zhu, Jing; Lee, Stephanie; Ho, Maurice K.C.; Hu, Yueqing; Pang, Haihong; Ip, Fanny C.F.; Chin, Allison C.; Harley, Calvin B.; Ip, Nancy Yuk-Yu; Wong, Yung Hou Article
Nerve Growth Factor-Induced Differentiation of PC12 Cells Is Accompanied by Elevated Adenylyl Cyclase Activity
NeuroSignals, v. 18, (1), September 2010, p. 32-42
Yung, H.S.; Lai, K.H.; Chow, Kevin B.S.; Ip, Nancy Yuk-Yu; Tsim, Karl Wah Keung; Wong, Yung Hou; Wu, Zhenguo; Wise, Helen Article
RGS19 enhances cell proliferation through its C-terminal PDZ motif
Cellular Signalling, v. 22, (11), November 2010, p. 1700-1707
Tso, Ha; Wang, Yingchun; Wong, Sivia Y.S.; Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou Article
Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT₂-selective melatonin ligands
Bioorganic and Medicinal Chemistry Letters, v. 20, (8), April 2010, p. 2582-2585
Hu, Yueqing; Ho, Kwok Chung Maurice; Chan, King Hang; New, David C.; Wong, Yung Hou Article
The role of glial cells in influencing neurite extension by dorsal root ganglion cells
Neuron Glia Biology, v. 6, (1), February 2010, p. 19-29
Ng, Kai-Yu; Wong, Yung Hou; Wise, Helen Article
Functional Impacts of Signal Integration: Regulation of Inflammation-related Transcription Factors by Heterotrimeric G Proteins
Molecular to Modular Tumor Therapy: Tumors are Reconstructible Communicatively Evolving Systems / Edited by Albrecht Reichle. Dordrecht: Springer Science+Business Media B.V., 2010, p.161-189
Yeung, Wing Shan; Ho, Maurice K.C.; Wong, Yung Hou Book chapter
An investigation into the role of AGS3 in opiate tolerance and dependency
28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract PS13
Tse, Man Kit; Morris, Christina J.; Wong, Yung Hou Conference paper
Characterization of subtype-selective melatoninergic ligands with novel non-indoleamine scaffolds
PepCon 2010, 20-22 March 2010, Beijing, China
Ho, Maurice K.C.; Hu, Sharry Y.; Chan, King Hang; Zhu, Jing; Wong, Yung Hou Conference paper
Characterization of subtype-selective melatoninergic ligands with novel non-indoleamine scaffolds
Hong Kong Biochemistry Postgraduate Student Conference, 15 May 2010, Hong Kong, Abstract BCH10-A45
Hu, Sharry Y.; Ho, Maurice K.C.; Chan, King Hang; New, David C.; Wong, Yung Hou Conference paper
Differential activation of G protein family members: GTPgammaS triggers subunit dissociation of Gi3 but not Gq.
28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract T6
Chan, Siu Lung Anthony; Poon, Lydia See Wing; Wong, Yung Hou Conference paper
Functional coupling of Melatonin receptors with G16 leads to independent phosphorylation of Tyr-705 and Ser-727 on STAT3
The 28th Hong Kong Society of Neuroscience (HKSN) Annual Meeting, 7-8 June 2010, Hong Kong, Abstract T6
Lau, Winnie W.I.; Chan, Anthony S.L.; Wong, Yung Hou Conference paper
Melatonin MT1 receptor induces Fhit phosphorylation through the pertussis toxin-insensitive G16 protein
28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract T6
Zuo, H.; Chan, Siu Lung Anthony; Wong, Yung Hou Conference paper
Structure-activity relationships of novel subtype-selective melatoninergic ligands with novel non-indoleamine scaffolds
28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract Y6
Chan, King Hang013378; Ho, Maurice K.C.; Hu, Sharry Y.; Wong, Yung Hou Conference paper

2009 31

A Hematopoietic Perspective on the Promiscuity and Specificity of Gα₁₆ Signaling
NeuroSignals, v. 17, (1), February 2009, p. 71-81
Su, Yan; Ho, Maurice K.C.; Wong, Yung Hou Article
CCR1-mediated activation of nuclear factor-κB in THP-1 monocytic cells involves pertussis toxin-insensitive Gα₁₄ and Gα₁₆ signaling cascades
Journal of Leukocyte Biology, v. 86, (6), December 2009, p. 1319-1329
Lee, Mei Ki; Wong, Yung Hou Article
Differential and Synergistic Effect of Nerve Growth Factor and cAMP on the Regulation of Early Response Genes during Neuronal Differentiation
NeuroSignals, v. 17, (2), May 2009, p. 111-120
Ng, Yu Pong; Wu, Zhenguo; Wise, Helen; Tsim, Karl Wah Keung; Wong, Yung Hou; Ip, Nancy Yuk-Yu Article
G Protein signaling controls the differentiation of multiple cell lineages
BioFactors, v. 35, (3), May 2009, p. 232-238
Wang, Kepeng; Wong, Yung Hou Article
Gβ₃ forms distinct dimers with specific Gγ subunits and preferentially activates the β₃ isoform of phospholipase C
Cellular Signalling, v. 21, (5), May 2009, p. 737-744
Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou Article
Multiple G_i Proteins Participate in Nerve Growth Factor-Induced Activation of c-Jun N-terminal Kinases in PC12 Cells
Neurochemical Research, v. 34, (6), June 2009, p. 1101-1112
Tso, Ha; Morris, Christina Jane; Yung, Ying; Ip, Nancy Yuk-Yu; Wong, Yung Hou Article
Multiplex fluorimetric assays for monitoring algal toxins
Journal of the Marine Biological Association of the United Kingdom, v. 89, (2), March 2009, p. 287-293
Mak, Carmen K.M.; Yeung, Patrick K.K.; Kwok, Chun Man; Wong, Yung Hou; Wong, Joseph T.Y. Article
Regulation of mTOR and p70 S6 kinase by the muscarinic M4 receptor in PC12 cells
Cell Biology International, v. 33, (2), February 2009, p. 230-238
Chan, Grace P.W.; Wu, Eddy H.T.; Wong, Yung Hou Article
Regulation of transcription factors by heterotrimeric G proteins
Current Molecular Pharmacology, v. 2, (1), 2009, p. 19-31
Ho, Maurice K.C.; Su, Yan; Yeung, Wing Shan; Wong, Yung Hou Article
Reporter Gene Assays
Methods in Molecular Biology (Clifton, N.J.), v. 486, 2009, p. 109-123
Liu, A.M.F.; New, David C.; Lo, Kin H.; Wong, Yung Hou Article
The RhoA-specific guanine nucleotide exchange factor p63RhoGEF binds to activated Gα₁₆ and inhibits the canonical phospholipase Cβ pathway
Cellular Signalling, v. 21, (8), August 2009, p. 1317-1325
Yeung, Wing Shan; Wong, Yung Hou Article
Effect of cicaprost on differentiation of human erythroleukemia (HEL) cells
12th Scientific Meeting of the Hong Kong Pharmacology Society, Hong Kong, Abstract P10, 12-15 June 2009
Lai, K.H.; Lau, H.Y.A.; Tsang, Shui Ying; Wong, Yung Hou; Wise, H. Conference paper
Effects of Activator of G-protein Signaling 3 upon K-Opioid Receptor Signaling
The 27th Annual Meeting of the Hong Kong Society of Neuroscience (HKSN), Hong Kong, China. January 11-15, 2009
Tse, Man Kit; Wong, Yung Hou; Morris, Christina J. Conference paper
GAIP inhibits Ras signaling and tumor formation
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-47, 11-15 January 2009
Wang, Y.; Tso, Ha; Wong, Yung Hou Conference paper
Galphaq subunits interact with the Fhit tumor suppressor
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-40, 11-15 January 2009
Chan, G.P.W.; Chan, W.W.I.; Wong, Yung Hou Conference paper
Galphaz-regulated myogenic and osteogenic differentiation of C2C12 cells
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-45, 11-15 January 2009
Wang, K.; Yung, Ying; Ho, Maurice K.C.; Wong, Yung Hou Conference paper
GPCR signaling: role in cell proliferation and differentiation
12th Scientific Meeting of the Hong Kong Pharmacology Society, Hong Kong, Abstract PL2, 12-15 June 2009
Wong, Yung Hou Conference paper
Identification of Novel Binding Partners of GAIP
The 27th Annual Meeting of the Hong Kong Society of Neuroscience (HKSN), Hong Kong, China. January 11-15, 2009
Leung, Sing; Morris, Christina J.; Wong, Yung Hou Conference paper
In vitro pharmacological characterizations of novel receptor subtype-spepcific melatoninergic ligands
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-39, 11-15 January 2009
Zhu, Jing; Ho, Maurice K.C.; Hu, Sharry Y.; Wong, Yung Hou Conference paper
Melatonin MT1 and MT2 knockout mice exhibit impaired circadian rhythm re-entrainment
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-48, 11-15 January 2009
Xu, Y.; Ho, Maurice K.C.; Wong, Yung Hou Conference paper
Melatonin MT1 Receptor-mediated PKD Activation
Gordon Research Conferences on Mechanisms Of Cell Signalling - Towards Understanding Signalling Networks, 23-28 August, Oxford, UK
Chan, Siu Lung Anthony; Lau, Wai In; Wong, Yung Hou Conference paper
Melatonin MT2 receptor activates STAT3 through the pertussis toxin-insensitive G16 protein
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-39, 11-15 January 2009
Chan, Siu Lung Anthony; Lau, Wai In; Wong, Yung Hou Conference paper
Molecular determinants for G betagamma-induced activation of phospholipase C-beta isoforms
The 6th Asian Biophysics Association Symposium & 27th Hong Kong Society of Neuroscience Annual Meeting
Poon, See Wing; Chan, Anthony S.L.; Wong, Yung Hou Conference paper
Molecular determinants for Gbetagamma-induced activation of phospholipase C isoforms
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-46, 11-15 January 2009
Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou Conference paper
Prostanoid-stimulated cAMP production in rat dorsal root ganglion cells: role of non-neuronal cells
12th Scientific Meeting of the Hong Kong Pharmacology Society, Hong Kong, Abstract P6, 12-15 June 2009
Ng, K.Y.; Wong, Yung Hou; Wise, Helen Conference paper
RhoA-specific guanine nucleotide exchange factor p63RhoGEF modulates Galpha16 signaling
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-52, 11-15 January 2009
Yeung, Wing Shan; Wong, Yung Hou Conference paper
Role of non-neuronal cells on influencing neurite extension by rat dorsal root ganglion cell neurons
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-23, 11-15 January 2009
Ng, K.Y.; Wong, Yung Hou; Wise, Helen Conference paper
Role of PKC in melatonin receptor-mediated STAT3 activation
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract S16-7, 11-15 January 2009
Lau, Wai In; Chan, Siu Lung Anthony; Wong, Yung Hou Conference paper
Structure-activity relationships of novel melatonin MT2 subtype-selective ligands with non-indoleamine scaffolds
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-44, 11-15 January 2009
Chan, S.K.H.; Ho, Maurice K.C.; Wong, Yung Hou Conference paper
Targeting RGS proteins for the modulation of GPCR signaling
12th SCBA International Symposium, Taiwan, Abstract 7B-4, 14-18 June 2009
Wong, Yung Hou Conference paper
TPR1 is required for Galphaq-mediated Ras signaling
27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-38, 11-15 January 2009
Kwan, D.H.T.; Liu, A.M.F.; Wong, Yung Hou Conference paper

2008 14

Activation of the human FPRL-1 receptor promotes Ca²⁺ mobilization in U87 astrocytoma cells
Neurochemical Research, v. 33, (1), January 2008, p. 125-133
Kwan, Dawna H.T.; Kam, Angel Y.F.; Wong, Yung Hou Article
Differential involvement of Gα₁₆ in CC chemokine-induced stimulation of phospholipase Cβ, ERK, and chemotaxis
Cellular Signalling, v. 20, (6), June 2008, p. 1179-1189
Tian, Yaji; Lee, Maggie M.K.; Yung, Lisa Y.; Allen, Rodger A.; Slocombe, Patrick M.; Twomey, Breda M.; Wong, Yung Hou Article
Mutations on the switch III region and the alpha3 helix of Galpha₁₆ differentially affect receptor coupling and regulation of downstream effectors
Journal of Molecular Signaling, v. 3, November 2008, article number 17
Yu, May Y.M.; Ho, Maurice K.C.; Liu, A.M.F.; Wong, Yung Hou Article
Naturally Occurring Phenylethanoid Glycosides: Potential Leads for New Therapeutics
Current Medicinal Chemistry, v. 15, (25), October 2008, p. 2592-2613
Fu, Guangmiao; Pang, Haihong; Wong, Yung Hou Article
Nerve growth factor-induced stimulation of p38 mitogen-activated protein kinase in PC12 cells is partially mediated via G_i/o proteins
Cellular Signalling, v. 20, (8), August 2008, p. 1538-1544
Yung, Ying; Tso, Ha; Wu, Eddy H.T.; Yu, Jowie C.H.; Ip, Nancy Yuk-Yu; Wong, Yung Hou Article
Prostacyclin receptor-induced STAT3 phosphorylation in human erythroleukemia cells is mediated via Gα_s and Gα₁₆ hybrid signaling
Cellular Signalling, v. 20, (11), November 2008, p. 2095-2106
Lo, Kin H.; Liu, A.M.F.; Wise, Helen; Wong, Yung Hou Article
AGS3 modulation of ERK phosphorylation by the kappa-opioid receptor
9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS21, 25-26 March 2008
Morris, Christina Jane; Wong, Yung Hou Conference paper
AGS3 Modulation of ERK Phosphorylation by the Kappa-Opioid Receptor
The 39th Annual International Narcotics Research Conference (INRC), Charleston, SC. USA. July 13-18, 2008
Morris, Christina J.; Tse, Man Kit; Wong, Yung Hou Conference paper
Formation of specific G protein Betagamma-dimers and their corresponding activation of phospholipase C isoforms
9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS24, 25-26 March 2008
Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou Conference paper
Galpha14 signaling through TPR1: a structural and functional perspective
9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS22, 25-26 March 2008
Kwan, D.H.T.; Wong, Yung Hou Conference paper
GAlphaz Inhibits Myogenic Differentiation of C2C12 Cells
The 9th AEARU Workshop on Molecular Biology and Biotechnology, Hong Kong, 25 - 26 March 2008
Ho, Kwok Chung Maurice; Mei, Hua; Yung, Ying; Wu, Zhenguo; Ip, Nancy Yuk-Yu; Wong, Yung Hou Conference paper
Influence of glial cells on stress-induced neurite retraction in rat dorsal root ganglion cells
APSN 2008, Shanghai, China, Abstract, 24-26 June 2008
Ng, K.Y.; Wong, Yung Hou; Wise, Helen Conference paper
Melatonin MT1 receptor-mediated STAT3 activation through Galpha16
9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS25, 25-26 March 2008
Lau, Wai In; Chan, Siu Lung Anthony; Wong, Yung Hou Conference paper
Nerve growth factor-induced differentiation of rat pheochromocytoma (PC12) cells leads to changes in adenylyl cyclase activity
APSN 2008, Shanghai, China, Abstract, 24-26 June 2008
Lai, K.H.; Yung, H.S.; Wong, Yung Hou; Wise, Helen Conference paper

2007 12

Dopaminergic and adrenergic toxicities on SK-N-MC human neuroblastoma cells are mediated through G protein signaling and oxidative stress
Apoptosis, v. 12, (1), January 2007, p. 167-179
Chan, Siu Lung Anthony; Ng, Linda W.C.; Poon, Lydia See Wing; Chan, Winnie W.Y.; Wong, Yung Hou Article
Expression of G protein beta subunits in rat skeletal muscle after nerve injury: Implication in the regulation of neuregulin signaling
Neuroscience, v. 146, (2), May 2007, p. 594-603
Lok, Ka Chun; Fu, Amy Kit Yu; Ip, Fanny Chun Fun; Wong, Yung Hou; Ip, Nancy Yuk-Yu Article
Formyl peptide receptor like 1 differentially requires mitogen-activated protein kinases for the induction of glial fibrillary acidic protein and interleukin-1α in human U87 astrocytoma cells
Cellular Signalling, v. 19, (10), October 2007, p. 2106-2117
Kam, Angel Y.F.; Tse, Timothy T.M.; Kwan, Dawna H.T.; Wong, Yung Hou Article
Formyl peptide-receptor like-1 requires lipid raft and extracellular signal-regulated protein kinase to activate inhibitor-κB kinase in human U87 astrocytoma cells
Journal of Neurochemistry, v. 103, (4), November 2007, p. 1553-1566
Kam, Angel Y.F.; Liu, Andrew M.F.; Wong, Yung Hou Article
G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis
FEBS Journal, v. 274, (23), December 2007, p. 6025-6036
New, David C.; Wu, Kelvin; Kwok, Alice W.S.; Wong, Yung Hou Article
In search of novel and therapeutically significant melatoninergic ligands
Recent Patents on CNS Drug Discovery, v. 2, (3), November 2007, p. 241-245
Mody, Sejal M.; Hu, Sharry Y.; Ho, Maurice K.C.; Wong, Yung Hou Article
Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression
Journal of Molecular Signaling, v. 2, February 2007, article number 2
New, David C.; Wong, Yung Hou Article
NRG induces membrane targeting of Gαz in muscle: implication in myogenesis
NeuroReport, v. 18, (14), September 2007, p. 1433-1436
Lok, Ka Chun; Fu, Kit Yu; Ip, Fanny C.F.; Wong, Yung Hou; Ip, Nancy Yuk-Yu Article
Adenylyl cyclase activity during NGF-induced differentiation of rat pheochromocytoma (PC12) cells
Croucher Advanced Study Institute on Movement Disorders: Basic and Clinical Sciences, Hong Kong., 27 November - 1 December 2007
Yung, H.S.; Lai, K.H.; Wong, Yung Hou; Wise, Helen Conference paper
Drug Development Candidate TAT2 Activates Telomerase in Primary Neuronal Cultures
Abstract P052
An, Hui Jin; Ip, Fanny C.F.; Hu, Sharry Y; Ho, Maurice K C; Chin, A.C.; Harley, C.B.; Wong, Yung Hou; Ip, Nancy Yuk-Yu Conference paper
Identification of subtype-selective melatonin receptor ligands from traditional Chinese medicine
MGH-HKU-Nature Forum. Molecular Medicine and Biopharma Opportunities, Hong Kong, 5-6 March 2007. Abstract P042.
Ho, Maurice K.C.; New, David C.; Hu, Sharry Y.; Pang, Haihong; Wong, Yung Hou Conference paper
Knowledge-Based Drug Discovery: Identification of Novel Leads From Traditional Chinese Medicine
MGH-HKU-Nature Forum. Molecular Medicine and Biopharma Opportunities, Hong Kong, 5 - 6 March 2007
Pang, Haihong; Hu, Sharry Y.; Ho, Maurice K C; Ip, Fanny C.F.; An, Hui Jin; Ip, Nancy Yuk-Yu; Wong, Yung Hou Conference paper

2006 28

Activation of muscarinic M₄ receptor augments NGF-induced pro-survival Akt signaling in PC12 cells
Cellular Signalling, v. 18, (3), March 2006, p. 258-293
Wu, Eddy H.T.; Wong, Yung Hou Article
Activation of STAT3 by Gα_s Distinctively Requires Protein Kinase A, JNK, and Phosphatidylinositol 3-Kinase
Journal of Biological Chemistry, v. 281, (47), November 2006, p. 35812-35825
Liu, A.M.F.; Lo, Kin H.; Wong, Cecilia S.S.; Morris, Christina; Wise, Helen; Wong, Yung Hou Article
CKBM stimulates MAPKs but inhibits LPS-induced IFN-γ in lymphocytes
Phytotherapy Research, v. 20, (9), September 2006, p. 725-731
Chan, Siu Lung Anthony; Yip, Eric C.H.; Yung, Ying; Pang, Haihong; Luk, Sharon C.W.; Pang, Shin F.; Wong, Yung Hou Article
Constitutively active α subunits of G_q/11 and G_2/13 families inhibit activation of the pro-survival Akt signaling cascade
FEBS Journal, v. 273, (11), June 2006, p. 2388-2398
Wu, Eddy H.T.; Tam, Becky H.L.; Wong, Yung Hou Article
GABA_B heterodimeric receptors promote Ca²⁺ influx via store-operated channels in rat cortical neurons and transfected chinese hamster ovary cells
Neuroscience, v. 137, (4), 2006, p. 1347-1358
New, David C.; An, Hui Jin; Ip, Nancy Yuk-Yu; Wong, Yung Hou Article
Involvement of calcium mobilization from caffeine-sensitive stores in mechanically induced cell cycle arrest in the dinoflagellate Crypthecodinium cohnii
Cell Calcium, v. 39, (3), March 2006, p. 259-274
Yeung, Patrick Ka Kit; Lam, Connie Mo Ching; Ma, Zhiyi; Wong, Yung Hou; Wong, Joseph T.Y. Article
Opioid receptor-like (ORL1) receptor utilizes both G(0A) and G(0B) for signal transduction
Protein & Peptide Letters, v. 13, (5), May 2006, p. 437-441
Tso, Ha; Wong, Yung Hou Article
Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: A mechanism requiring PTX-insensitive G proteins, ERK and JNK
Cellular Signalling, v. 18, (3), March 2006, p. 307-317
Lo, Kin H.; Wise, Helen; Wong, Yung Hou Article
Protocatechuic acid induces cell death in HepG2 hepatocellular carcinoma cells through a c-Jun N-terminal kinase-dependent mechanism
Cell Biology and Toxicology, v. 22, (4), July 2006, p. 293-302
Yip, E.C.H.; Chan, Siu Lung Anthony; Pang, Haihong; Tam, Y.K.; Wong, Yung Hou Article
The aqueous extract of Radix Glycyrrhizae stimulates mitogen-activated protein kinases and nuclear factor-kappa B in Jurkat T-cells and THP-1 monocytic cells
American Journal of Chinese Medicine, v. 34, (2), 2006, p. 263-278
Chan, Siu Lung Anthony; Pang, Haihong; Yip, Eric Chun Hung; Tam, Yunkau; Wong, Yung Hou Article
Transcriptional activation of c-Fos by constitutively active Gα₁₆QL through a STAT1-dependent pathway
Cellular Signalling, v. 18, (12), December 2006, p. 2143-2153
Lo, Kin H.; Wong, Yung Hou Article
Tuberin: A Stimulus-Regulated Tumor Suppressor Protein Controlled by a Diverse Array of Receptor Tyrosine Kinases and G Protein-Coupled Receptors
NeuroSignals, v. 15, (5), July 2006, p. 217-227
Wu, Eddy H.T.; Wu, Kelvin K.H.; Wong, Yung Hou Article
G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity [Book review]
ChemMedChem, v. 1, (7), July 2006, p. 741-742
Wong, Yung Hou Book review
A time-dependent loss of prostaglandin EP3 receptors in PC12 cells during neuroal differentiation
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Yung, H.S.; Wong, Yung Hou; Wise, Helen Conference paper
Apoptosis of human neuroblastoma SK-N-MC cells induced by dopamine and norepinephrine
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Chan, Siu Lung Anthony; Ng, L.W.C.; Poon, Lydia See Wing; Chan, W.W.Y.; Wong, Yung Hou Conference paper
Axin Is Involved in Nerve Growth Factor-Induced Differentiation of PC12 Cells
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies & Annual Meeting of Hong Kong Society of Neurosciences, Hong Kong, 30 November - 2 December 2006
Ng, Yu Pong; Lin, Shengcai; Fu, Kit Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu Conference paper
Cell-based Fluorimetric assays for monitoring Gembierddiscus toxins
Proceedings of the Third International Conference on the Prevention and Management of Harmful Algal blooms in the South China Sea, p1-5. June, 2006. The Association on Harmful Algal Blooms in the South China Sea
Mak, Carmen K.M.; Yeung, Patrick K.K.; Wong, Yung Hou; Wong, Joseph T.Y. Conference paper
Co-stimulation of Galphas alters Galpha16-mediated STAT3 activation.
Croucher Advanced Study Institute on Signaling in Cell Growth and Differentiation, Hong Kong, Abstract., 2006
Wong, Yung Hou Conference paper
Ga sub(16) Binds to RhoA-Specific Guanine Nucleotide Exchange Factor p63RhoGEF and Competes with the Canonical PLC/PKC Pathway
46th Annual Meeting of the American Society for Cell Biology, San Diego Convention center, San Diego, California (USA), 9-13 Dec 2006
Yeung, W.W.S.; Wong, Yung Hou Conference paper
Ga sub(s) Mediates b sub(2)-Adrenergic Receptor-Induced Stat3 Phosphorylation
4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS 2006), Cheung Kung Hai Conference Centre, Hong Kong City (Hong Kong-S.A.R of China), 30 Nov-2 Dec 2006
Liu, A.M.F.; Lo, Kin H.; Wong, C.S.S.; Morris, Christina Jane; Wise, Helen; Wong, Yung Hou Conference paper
Galpha14 interacts with tetratricopeptide repeat 1 for Ras signaling
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, Nov ember 30 - December 2, 2006. Abstract.
Kwan, D.H.T.; Wong, Yung Hou Conference paper
Galpha16 binds to RhoA-specific guanine nucleotide exchange factor p63RhoGEF and competes with the canonical PLC/PKC pathway
45th Annual Meeting of the American Society for Cell Biology, San Diego, USA, 13-17 December 2006. Abstract 67.
Yeung, Wing Shan; Wong, Yung Hou Conference paper
Modulation of kappa-opioid signaling by RGS proteins
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Tso, Ha; Wong, Yung Hou Conference paper
Opioid-induced pro-survival signals and the Akt/Tuberin pathway
Intl Narcotics Res Conf, Minnesota, USA, 9-14 July 2006, Abstract S II-5
Wong, Yung Hou Conference paper
p63RhoGEF, a membrane-bound guanine nucleotide exchange factor, modulates signaling by heterotrimeric G proteins
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, Nov 30 - Dec 2, 2006, Abstract
Yeung, Wing Shan; Wong, Yung Hou Conference paper
Regulatory mechanism of mTOR and p70 S6 kinase by muscarinic M4 receptors in PC12 cells
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Chan, G.P.W.; Wu, Eddy H.T.; Wong, Yung Hou Conference paper
Role of Axin in Nerve Growth Factor-Induced Differentiation of PC12 Cells
The 5th Gordon Research Conference on 'Molecular and Cellular Neurobiology', Hong Kong, 11 - 16 June 2006
Ng, Yu Pong; Lin, Shengcai; Fu, Kit Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu Conference paper
The down-regulation of prostaglandin EP3 receptor subtype during neuronal differentiation
IUPHAR 2006, Beijing, China, Abstract
Yung, H.S.; Wong, Yung Hou; Wise, Helen Conference paper

2005 33

Activation of nuclear factor κB by somatostatin type 2 receptor in pancreatic acinar AR42J cells involves Gα₁₄ and multiple signaling components: A mechanism requiring protein kinase C, calmodulin-dependent kinase II, ERK, and c-Src
Journal of Biological Chemistry, v. 280, (41), October 2005, p. 34617-34625
Liu, A.M.F.; Wong, Yung Hou Article
Activation of δ-, κ-, and μ-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells
Biochemical and Biophysical Research Communications, v. 334, (3), September 2005, p. 838-844
Wu, Eddy H.T.; Wong, Yung Hou Article
An aqueous extract of the popular Chinese nutraceutical Kwei Ling Ko (Tortoise shell-Rhizome Jelly) activates the PPARγ pathway and down-regulates the NFκB activity
Phytomedicine, v. 12, (10), November 2005, p. 748-759
Yip, Eric Chun Hung; Liu, A.M.F; Wong, Joseph T.Y.; Wong, Yung Hou Article
Carvacrol and eugenol differentially stimulate intracellular Ca²⁺ mobilization and mitogen-activated protein kinases in Jurkat T-cells and monocytic THP-1 cells
Planta medica, v. 71, (7), July 2005, p. 634-639
Chan, Siu Lung Anthony; Pang, Haihong; Yip, Eric Chun Hung; Tam, Yunkau; Wong, Yung Hou Article
Chimeric and Promiscuous G Proteins in Drug Discovery and the Deorphanization of GPCRs
Drug Design Reviews Online, v. 2, (1), February 2005, p. 66-79
New, David C.; Wong, Yung Hou Article
G_q-Mediated Activation of c-Jun N-Terminal Kinase by the Gastrin-Releasing Peptide-Preferring Bombesin Receptor Is Inhibited upon Costimulation of the G_s-Coupled Dopamine D₁ Receptor in COS-7 Cells
Molecular Pharmacology, v. 68, (5), November 2005, p. 1354-1364
Chan, Siu Lung Anthony; Wong, Yung Hou Article
Immuno-regulatory effects of CKBM on the activities of mitogen-activated protein kinases and the release of cytokines in THP-1 monocytic cells
Biological and Pharmaceutical Bulletin, v. 28, (9), September 2005, p. 1645-1650
Chan, Siu Lung Anthony; Yip, Eric Chun Hung; Yung, Ying; Pang, Haihong; Luk, Sharon; Pang, Shiufun; Wong, Yung Hou Article
Integration of G protein signals by extracellular signal-regulated protein kinases in SK-N-MC neuroepithelioma cells
Journal of Neurochemistry, v. 94, (5), August 2005, p. 1457-1470
Chan, Siu Lung Anthony; Yeung, Wendy W.S.; Wong, Yung Hou Article
Involvement of G_i/o Proteins in Nerve Growth Factor-Stimulated Phosphorylation and Degradation of Tuberin in PC-12 Cells and Cortical Neurons
Molecular Pharmacology, v. 67, (4), April 2005, p. 1195-1205
Wu, Eddy H.T.; Wong, Yung Hou Article
Mu-Opioid Receptor-Mediated Phosphorylation of IκB Kinase in Human Neuroblastoma SH-SY5Y Cells
NeuroSignals, v. 14, (3), July 2005, p. 136-142
Liu, A.M.F.; Wong, Yung Hou Article
Pertussis toxin-sensitive G_i/o proteins are involved in nerve growth factor-induced pro-survival Akt signaling cascade in PC12 cells
Cellular Signalling, v. 17, (7), July 2005, p. 881-890
Wu, Eddy H.T.; Wong, Yung Hou Article
Molecular Basis of Opioid Actions: Regulation of Mitogen-activated Protein Kinases
Recent Developments in Pain Research, 2005 / Edited by Anna Capasso. Research Signpost Publishers, 2005, p. 41-58
Chan, Siu Lung Anthony; New, David C.; Wong, Yung Hou Book chapter
Activated Galpha11, Galpha12, and Galpha13 inhibit activation of the pro-survival AKT signaling cascade
24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract P-25.
Tam, H.L.; Wu, Eddy H.T.; Wong, Yung Hou Conference paper
Activation of muscarinic M4 receptor augments NGF-induced pro-survival Akt signaling in PC12 cells
24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract O-12.
Wu, Eddy H.T.; Wong, Yung Hou Conference paper
Activation of the human FPRL-1 receptor promotes Ca2+ mobilization and stimulates mitogen-activated protein kinases in U87 astrocytoma cells.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P-9., 2005
Kwan, Dawna H.T.; Kam, Angel Y.F.; Wong, Yung Hou Conference paper
Differential regulation of signal transducers and activators of transcription by G protein subunits
24th Scientific Meeting of the Kong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract P-37.
Yuen, J.W.F.; Wong, Yung Hou Conference paper
Expression profiling of Galphaz-regulated genes
24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., 13-14 January 2005, Abstract P-23.
Mei, H.; Ho, Maurice K.C.; Yung, Ying; Wong, Yung Hou Conference paper
Function of Galphaz in muscle differentiation
HKU/HKUST/Cambridge University Joint Research Retreat, Hong Kong., 10-12 March 2005
Mei, H.; Ho, Maurice K.C.; Yung, Ying; Wong, Yung Hou Conference paper
G14-mediated stimulation of NFkappaB by the type 2 somatostatin receptor
24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract P-29
Liu, A.M.L.; Wong, Yung Hou Conference paper
Identification of Critical Early Genes Involved in Nerve Growth Factor-Induced PC12 Differentiation
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5 - 6 December 2005
Xiao, Fang; Ng, Yu Pong; Tsim, Karl Wah Keung; Wise, Helen; Wong, Yung Hou; Ip, Nancy Yuk-Yu; Wu, Zhenguo Conference paper
Involvement of Gi/o proteins in nerve growth factor-stimulated phosphorylation and degradation of tuberin in PC12 cells
HKU/HKUST/Cambridge University Joint Research Retreat, Hong Kong, 10-12 March 2005
Wu, Eddy H.T.; Wong, Yung Hou Conference paper
New perspectives in G protein signaling: regulation of protein kinases and transcription factors.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Plenary Lecture I., 2005
Wong, Yung Hou Conference paper
NGF-Induced Neuronal Differentiation of PC12 Cells: Delineation of Signaling Molecules and Mapping of Pathways.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5 - 6 December 2005
Leung, W.K.W.; Choi, Chi Yan; Ip, Nancy Yuk-Yu; Wu, Zhenguo; Wong, Yung Hou; Cheung, P.T.; Tsim, Karl Wah Keung Conference paper
Overexpression of Galphaz Inhibits Muscle Differentiation
Abstract P-14
Mei, Hua; Wu, Zhenguo; Ip, Nancy Yuk-Yu; Wong, Yung Hou Conference paper
Regulation of STAT3 phosphorylation by Galphas.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong. Abstract P3., 2005
Lo, Kin H.; Liu, A.M.F.; Wise, Helen; Wong, Yung Hou Conference paper
Role of Axin in Nerve Growth Factor-Stimulated Neurite Outgrowth
Abstract O-2.
Ng, Yu Pong; Lin, Shengcai; Fu, Wing Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu Conference paper
Role of Calmodulin-Dependent Kinase II in Nerve Growth Factor-Induced Differentiation of PC12 Cells.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5-6 December 2005
Kam, Yuet Fong; Yung, Ying; Wu, Eddy H.T.; Ng, Yu Pong; Wu, Zhenguo; Tsim, Karl Wah Keung; Wise, Helen; Ip, Nancy Yuk-Yu; Wong, Yung Hou Conference paper
Screening for NMDA Receptor Antagonists Using Traditional Chinese Medicine
Abstract P-7
Ip, Fanny C.F.; An, Hui Jin; Chan, Agnes Wing Sze; Tong, Pui Sze; Hu, Sharry Y.; Wong, Yung Hou; Ip, Nancy Yuk-Yu Conference paper
Stimulation of mitogen-activated protein kinases by the human FPRL-1 receptor
24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., 13-14 January 2005, Abstract P-27.
Kam, Angel Y.F.; Tse, T.T.M.; New, David C.; Wong, Yung Hou Conference paper
Synergistic activation of extracellular signal-regulated kinase by Gi- and Gq-coupled receptors in SK-N-MC neuroepithelioma cells
HKU/HKUST/Cambridge University Joint Research Retreat, Hong Kong, 10-12 March 2005
Yeung, Wing Shan; Wong, Yung Hou Conference paper
Synergistic activation of extracellular signal-regulated kinase by Gi- and Gq-coupled receptors in SK-N-MC neuroepithelioma cells
24th Scientific Meeting of the Hong Kong Society of Neurosciences Hong Kong, 13-14 January 2005, Abstract P-33
Yeung, Wing Shan; Chan, Siu Lung Anthony; Wong, Yung Hou Conference paper
The effect of NGF-induced differentiation on the expression of prostanoid receptors in PC12 cells.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P-19., 2005
Yung, H.S.; Wong, Yung Hou; Wise, Helen Conference paper
Unraveling chemokine signaling for drug discovery.
Pacifichem 2005, Hawaii, USA., 15-20 December 2005
Wong, Yung Hou Conference paper

2004 18

Characterization of CHO cells stably expressing a Gα_16/z Chimera for high throughput screening of GPCRs
Assay and Drug Development Technologies, v. 2, (3), June 2004, p. 269-280
New, David C.; Wong, Yung Hou Article
Differential chemokine activation of CC chemokine receptor 1-regulated pathways: ligand selective activation of Gα₁₄-coupled pathways
European Journal of Immunology, v. 34, (3), March 2004, p. 785-795
Tian, Yaji; New, David C.; Yung, Ying; Allen, Rodger A.; Slocombe, Patrick M.; Twomey, Breda M.; Lee, Mei Ki; Wong, Yung Hou Article
Epidermal growth factor differentially augments G_i-mediated stimulation of c-Jun N-terminal kinase activity
British Journal of Pharmacology, v. 142, (4), June 2004, p. 635-646
Chan, Siu Lung Anthony; Wong, Yung Hou Article
G₁₆-mediated Activation of Nuclear Factor κB by the Adenosine A₁ Receptor Involves c-Src, Protein Kinase C, and ERK Signaling
Journal of Biological Chemistry, v. 279, (51), December 2004, p. 53196-53204
Liu, A.M.F.; Wong, Yung Hou Article
Gβγ signaling and Ca²⁺ mobilization co-operate synergistically in a Sos and Rac-dependent manner in the activation of JNK by G_q-coupled receptors
Cellular Signalling, v. 16, (7), July 2004, p. 823-836
Chan, Siu Lung Anthony; Wong, Yung Hou Article
Identification of a stretch of six divergent amino acids on the α5 helix of Gα₁₆ as a major determinant of the promiscuity and efficiency of receptor coupling
Biochemical Journal, v. 380, (2), June 2004, p. 361-369
Ho, Maurice K.C.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Wong, Yung Hou Article
Phosphatidylinositol-3 kinase is distinctively required for μ-, but not κ-opioid receptor-induced activation of c-Jun N-terminal kinase
Journal of Neurochemistry, v. 89, (2), April 2004, p. 391-402
Kam, Angel Y.F.; Chan, Siu Lung Anthony; Wong, Yung Hou Article
Prostacyclin receptor-mediated activation of extracellular signal-regulated kinases 1 and 2
Cellular Signalling, v. 16, (4), April 2004, p. 477-486
Chu, Kit-Man; Chow, Kevin B.S.; Wong, Yung Hou; Wise, Helen Article
Regulation of STAT3 by μ-opioid receptors in human neuroblastoma SH-SY5Ycells
NeuroReport, v. 15, (9), June 2004, p. 1431-1435
Yuen, Jessie W.F.; So, Ivy Y.W.; Kam, Angel Y.F.; Wong, Yung Hou Article
Replacement of the α5 helix of Gα₁₆ with Gα_s-specific sequences enhances promiscuity of Gα₁₆ toward G_s-coupled receptors
Cellular Signalling, v. 16, (1), January 2004, p. 51-62
Hazari Anjali Ajaykumar; Lowes, Vicki L.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Ho, Maurice K.C.; Wong, Yung Hou Article
Signal Transducer and Activator of Transcription 3 Activation by the δ-Opioid Receptor via Gα₁₄ Involves Multiple Intermediates
Molecular Pharmacology, v. 65, (6), June 2004, p. 1487-1439
Lo, Kin H.; Wong, Yung Hou Article
κ-Opioid Receptor Signals through Src and Focal Adhesion Kinase to Stimulate c-Jun N-Terminal Kinases in Transfected COS-7 Cells and Human Monocytic THP-1 Cells
Journal of Pharmacology and Experimental Therapeutics, v. 310, (1), July 2004, p. 301-310
Kam, Angel Y.F.; Chan, Siu Lung Anthony; Wong, Yung Hou Article
Atypical regulation of calcium signals in astrocytoma 1321N1 cells expressing the purinergic P2Y12 receptor.
The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Hong Kong, Abstract B-P33-15, 4-7 February
Ho, Maurice K.C.; Simon, J.; Barnard, E.A.; Wong, Yung Hou Conference paper
Gi family members participate in nerve growth factor-mediated translational control in PC12 cells
Gordon Research Conference on Molecular & Cellular Neurobiology, Hong Kong, P65, 6-11 June
Wu, Eddy H.T.; Wong, Yung Hou Conference paper
Opioid-mediated regulation of protein kinases and transcription factors
The 3rd Meeting of Asian Pacific Opioid Symposium on Molecular Basis of Opioid Tolerance and Dependence, Kyoto, Japan, 18 July 2004, Abstract
Wong, Yung Hou Conference paper
Purinergic regulations of mitogen-activated protein kinases and calcium mobilization in rat brain capillary endothelial B10 cells
The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Hong Kong, Abstract B-P33-12, 4-7 February
Wong, Yung Hou; Ho, Maurice K.C.; Leung, E.H.Y.; Simon, J.; Barnard, E.A. Conference paper
Regulation of nuclear factor kappaB and STAT3 by mu-opioid receptors in human neuroblastoma SH-SY5Y cells
Intl Narcotics Res Conf, Kyoto, Japan, 18-23 July 2004, Abstract P-52
Wong, Yung Hou; Liu, A.M.F.; Yuen, J.W.F.; Kam, A.Y.F. Conference paper
Requirement of Gi/o proteins and phosphatidylinositol-3-kinase in nerve growth factor-induced tuberin phosphorylation and degradation
The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Hong Kong, Abstract B-P33-4, 4-7 February
Wu, Eddy H.T.; Wong, Yung Hou Conference paper

2003 17

BML-190 and AM251 act as inverse agonists at the human cannabinoid CB₂ receptor: signalling via cAMP and inositol phosphates
FEBS Letters, v. 536, (1-3), February 2003, p. 157-160
New, David C.; Wong, Yung Hou Article
CC chemokine receptor-coupled signalling pathways
生物化学与生物物理学报=Acta Biochimica et Biophysica Sinica, v. 2003, (09), 2003, p. 779-788
New, David C.; Wong, Yung Hou Article
Constitutively Active Gα₁₆ Stimulates STAT3 via a c-Src/JAK- and ERK-dependent Mechanism
Journal of Biological Chemistry, v. 278, (52), December 2003, p. 52154-52165
Lo, Kin H.; Cheung, Helen; Wong, Yung Hou Article
G Protein-Linked Effector and Second Messenger Systems Involved in Melatonin Signal Transduction
NeuroSignals, v. 12, (2), March 2003, p. 59-70
New, David C.; Tsim, Siu T.; Wong, Yung Hou Article
Gα_16/z chimeras efficiently link a wide range of G protein-coupled receptors to calcium mobilization
Journal of Biomolecular Screening, v. 8, (1), February 2003, p. 39-49
Liu, A.M.F.; Ho, Maurice K.C.; Wong, Cecilia S.S.; Chan, Jasmine H.P.; Pau, Anson H.M.; Wong, Yung Hou Article
Molecular basis of opioid dependence: Role of signal regulation by G-proteins
Clinical and Experimental Pharmacology and Physiology, v. 30, (5-6), May-June 2003, p. 307-316
Tso, Ha; Wong, Yung Hou Article
Rac and Cdc42-dependent regulation of c-Jun N-terminal kinases by the delta-opioid receptor
Journal of Neurochemistry, v. 84, (3), February 2003, p. 503-513
Kam, Angel Y.F.; Chan, Siu Lung Anthony; Wong, Yung Hou Article
Regulation of STAT3 activity by G₁₆-coupled receptors
Biochemical and Biophysical Research Communications, v. 303, (3), April 2003, p. 920-925
Wu, Eddy H.T.; Lo, Kin H.; Wong, Yung Hou Article
Reporter gene assays and their applications to bioassays of natural products
Phytotherapy Research, v. 17, (5), May 2003, p. 439-448
New, David C.; Miller-martini, David M.; Wong, Yung Hou Article
The first and third intracellular loops together with the carboxy terminal tail of the delta-opioid receptor contribute toward functional interaction with G₁₆
Journal of Neurochemistry, v. 87, (3), November 2003, p. 697-708
Chan, Anthony S.L.; Law, Ping Y.; Loh, Horace H.; Ho, Peter N.N.; Wu, Wai-Man; Chan, Joy S.C.; Wong, Yung Hou Article
The β6/α5 regions of Gα_i2 and Gα_oA increase the promiscuity of Gα₁₆ but are insufficient for pertussis toxin-catalyzed ADP-ribosylation
European Journal of Pharmacology, v. 473, (2-3), July 2003, p. 105-115
Wong, Cecilia S.S.; Ho, Maurice K.C.; Wong, Yung Hou Article
Activation of STAT3 by hematopoietic-specific G proteins
10th Congress of Federation of Asian & Oceanian Biochemists and Molecular Biologists, India, Abstract S27, 7-11 December
Wong, Yung Hou; Lo, Kin H. Conference paper
Constitutively active Galpha16 stimulates STAT1 via a c-Src/JAK- and ERK-dependent mechanism
43rd Annual Meeting of the American Society for Cell Biology, San Francisco, USA, Abstract 1573, 13-17 December
Lo, Kin H.; Wong, Yung Hou Conference paper
Pertussis toxin-sensitive Gi/o proteins are involved in nerve growth factor-induced Akt signaling cascade in PC12 cells
23rd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract OP3, 9-10 December
Wu, E.H.T.; Wong, Yung Hou Conference paper
Pertussis toxin-sensitive Gi/o proteins participate in nerve growth factor-induced activation of survival Akt kinase and nuclear factor kappaB
43rd Annual Meeting of the American Society for Cell Biology, San Francisco, USA, Abstract 67, 13-17 December
Wu, E.H.T.; Wong, Yung Hou Conference paper
STAT3 activation by the delta-opioid receptor via Galpha14 involves c-Src/JAK- and ERK-dependent pathways
23rd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PP9, 9-10 December
Lo, Kin H.; Wong, Yung Hou Conference paper
The Roles of G-Proteins in the Formation of Neuromuscular Junction and Myogenesis
The 23rd Annual Scientific Conference of the Hong Kong Society of Neuroscience, Hong Kong, 9 - 10 December 2003
Lok, Ka Chun; Fu, Wing Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu Conference paper

2002 19

Characterization and Channel Coupling of the P2Y₁₂Nucleotide Receptor of Brain Capillary Endothelial Cells
Journal of Biological Chemistry, v. 277, (35), August 2002, p. 37390-31400
Simon, Joseph; Filippov, Alexander K.; G?ransson, Sara A.; Wong, Yung Hou; Frelin, Christian; Michel, Anton D.; Brown, David A.; Barnard, Eric A. Article
Co-Expressions of Different Opioid Receptor Types Differentially Modulate Their Signaling via G₁₆
NeuroSignals, v. 11, (2), March-April 2002, p. 115-122
Ho, Maurice K.C.; New, David C.; Wong, Yung Hou Article
Constitutive activation of the opioid receptor-like (ORL₁) receptor by mutation of Asn133 to tryptophan in the third transmembrane region
Journal of Neurochemistry, v. 83, (6), December 2002, p. 1461-1470
Kam, Kenneth Wan Lung; New, David C.; Wong, Yung Hou Article
Integration of Signals from Receptor Tyrosine Kinases and G Protein-Coupled Receptors
NeuroSignals, v. 11, (1), January-February 2002, p. 5-19
Lowes, Vicki L.; Ip, Nancy Yuk-Yu; Wong, Ying Hou Article
Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins
Cellular Signalling, v. 14, (3), March 2002, p. 249-257
Chan, Siu Lung Anthony; Lai, Frank; Lo, Kin H.; Voyno-yasenetskaya, Tatyana A.; Stanbridge, Eric John; Wong, Yung Hou Article
Molecular determinants for the differential coupling of Gα₁₆ to the melatonin MT1, MT2 and Xenopus Mel1c receptors
Journal of Neurochemistry, v. 80, (5), March 2002, p. 436-745
Lai, Frank; Mody, Sejal M.; Yung, Ying; Kam, Jason Y.M.; Pang, Celia Sook Fun; Pang, Shiufun; Wong, Yung Hou Article
Prostanoid Signal Integration and Cross Talk
NeuroSignals, v. 11, (1), January-February 2002, p. 20-28
Wise, Helen; Wong, Yung Hou; Jones, Robert Leslie Article
Signal Diversification by the Neuronal-Specific Gz Protein.
Neuro-Signals, 11: 170-171
Wong, Yung Hou Article
The ORL₁ Receptor: Molecular Pharmacology and Signalling Mechanisms
NeuroSignals, v. 11, (4), July 2002, p. 197-212
New, David C.; Wong, Yung Hou Article
G protein structure diversity
Structure and Function of GPCRs in the Nervous System / 63-86
Ho, Maurice K.C.; Wong, Yung Hou Book chapter
Atypical G protein signaling: The path to kinases
Croucher Advanced Study Institute on Cell Signaling and Gene Transcription, Croucher Foundation, Hong Kong, S2
Wong, Yung Hou Conference paper
BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor
22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P10
New, David C.; Wong, Yung Hou Conference paper
Expressions of regulators of G protein signaling RGSZ1 and GAIP augment neuronal differentiation of PC12 cells
22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P12
Ho, Maurice K.C.; Wu, Eddy H.T.; Wong, Yung Hou Conference paper
Involvement of G Protein Signaling Pathway at the Neuromuscular Junctions
Abstract P11
Lok, Ka C.; Fu, Wing Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu Conference paper
mu-Opioid receptor-mediated activation of c-Jun N-terminal kinase requires phosphatidylinositol 3-kinase
22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P13
Kam, Yuet Fong; Wong, Yung Hou Conference paper
Nerve Growth Factor-Dependent Activation of C-Jun N-Terminal Kinase in PC12 Cells Is Mediated via Pertussis Toxin-Sensitive G Proteins
Abstract O19
Tso, Ha; Yung, Ying; Yu, Jowie C.H.; Ip, Nancy Yuk-Yu; Wong, Yung Hou Conference paper
Regulation of STAT3 activity by ORL1 receptor through Galpha16
22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract O6
Wu, Eddy H.T.; Lo, Kin H.; Wong, Yung Hou Conference paper
Signal diversification by the neuronal-specific Gz protein
Croucher Advanced Study Institute on Molecular Neuroscience Hong Kong University of Science and Technology
Wong, Yung Hou Conference paper
The application of Galpha16/Z chimeras in high-throughput drug screening
Third International Symposium for Chinese Medicinal Chemists, Hong Kong, December
New, David C.; Ho, Maurice K.C.; Dai, Wei M.; Wong, Yung Hou Conference paper

2001 19

A reporter gene assay for the detection of phytoestrogens in traditional Chinese medicine
Phytotherapy Research, v. 15, (6), September 2001, p. 487-492
Miller-martini, David M; Chan, Robbie Y.K.; Ip, Nancy Yuk-Yu; Sheu, S.J.; Wong, Yung Hou Article
Bacterial formyl peptide mediated chemotaxis and extracellular acidification in shrimp haemocytes
Developmental and Comparative Immunology, v. 25, (4), May 2001, p. 269-277
Yip, Eric Chun Hung; Wong, Yung Hou; Wong, Joseph T.Y. Article
Chimeric Gα_q subunits can distinguish the long form of the Xenopus Mel1c melatonin receptor from the mammalian mt1 and MT2 melatonin receptors
Journal of Pineal Research, v. 30, (3), April 2001, p. 171-179
Lai, Frank P.L.; Mody, Sejal M.; Yung, Ying; Pang, Celia Sook Fun; Pang, Shiufun; Wong, Yung Hou Article
G_z signaling: Emerging divergence from G_i signaling
Oncogene, v. 20, (13 REV. ISS. 1), March 2001, p. 1615-1625
Ho, Maurice K.C.; Wong, Yung Hou Article
Gα₁₄ links a variety of G_i- and G_s-coupled receptors to the stimulation of phospholipase C
British Journal of Pharmacology, v. 132, (7), April 2001, p. 1431-1440
Ho, Maurice K.C.; Yung, Ying; Chan, Joy S.C.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Wong, Yung Hou Article
Opioid-induced adenylyl cyclase supersensitization in human embryonic kidney 293 cells requires pertussis toxin-sensitive G proteins other than G_i1 and G_i3
Neuroscience Letters, v. 299, (1-2), February 2001, p. 25-28
Tso, Ha; Wong, Yung Hou Article
Prostacyclin receptor-independent inhibition of phospholipase C activity by non-prostanoid prostacyclin mimetics
British Journal of Pharmacology, v. 134, (7), December 2001, p. 1375-1384
Chow, Kevin B.S.; Wong, Yung Hou; Wise, Helen Article
Role of extracellular signal-regulated kinases in opioid-induced adenylyl cyclase superactivation in human embryonic kidney 293 cells
Neuroscience Letters, v. 316, (1), December 2001, p. 13-16
Tso, Ha; Wong, Yung Hou Article
The Cyclic AMP-Mediated Expression of Acetylcholinesterase in Myotubes Shows Contrasting Activation and Repression between Avian and Mammalian Enzymes
Molecular and Cellular Neuroscience, v. 17, (4), April 2001, p. 732-745
Choi, Roy Chi Yan; Siow, Nina Lam; Zhu, Shangquan; Wan, David Chi Cheong; Wong, Yung Hou; Tsim, Karl Wah Keung Article
Applications of chimeric and mutant Ga16 subunits in ligand screening for orphan G protein-coupled receptors.
7th Annual Conference of the Society for Biomolecular Screening, Baltimore, USA., Abstract 10012
Wong, Yung Hou; Ho, Maurice K.C. Conference paper
Neuronal Gz protein differentially regulates mitogen-activated protein kinases and signal transducers and activators of transcription
21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P38
Ho, Maurice K.C.; Lo, Kin H.; Chan, Siu Lung Anthony; Tso, Ha; Wong, Yung Hou Conference paper
Rac and Cdc42-dependent regulation of c-Jun N-terminal kinase by the opioid receptors.
International Symposium on Cell Signaling - from diseases to drug discovery, Hong Kong.
Kam, Angel Y.F.; Wong, Yung Hou Conference paper
Regulation of STAT3 activity by heterotrimeric G proteins of the Gq subfamily.
21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., Abstract P26
Wong, Yung Hou; Lo, Kin H.; Ho, Maurice K.C. Conference paper
Replacement of the C-terminal residues of Ga16 with Gai2 or Gao1 residues enhances its promiscuity for receptor recognition.
21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., Abstract P25
Wong, Cecilia S.S.; Pau, Anson H.M.; Wong, Yung Hou Conference paper
Selected mutations in the a5 helix of Ga16 increase its promiscuity for receptors
21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract 37
Chan, Jasmine H.P.; Ho, Maurice K.C.; Wong, Yung Hou Conference paper
Selected mutations of the a5 helix of Ga16 improves the coupling of Gi-linked receptor
International Symposium on Cell Signaling - from diseases to drug discovery, Hong Kong
Ho, Maurice K.C.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Wong, Yung Hou Conference paper
Signaling from opioid receptors to c-Jun N-terminal kinase requires the small GTP-binding proteins Rac and Cdc42.
41st Annual Meeting of the American Society for Cell Biology, Washington, USA., Abstract 1233
Kam, Angel Y.F.; Wong, Yung Hou Conference paper
Suppression of prostacyclin receptor-mediated phospholipase C stimulation by Ga14.
21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., Abstract P39
Lee, Mei Ki; Joshi, Sushma A.; Wise, Helen; Wong, Yung Hou Conference paper
The regulation of c-Jun N-terminal kinase by opioid receptors involves Rac and Cdc42
21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract 24
Kam, Angel Y.F.; Wong, Yung Hou Conference paper

2000 13

Activation of B-Raf and Regulation of the Mitogen-activated Protein Kinase Pathway by the G_o α chain
Molecular Biology of the Cell, v. 11, (4), April 2000, p. 1129-1142
Antonelli, Valeria; Bernasconi, Francesca; Wong, Yung Hou; Vallar, Lucia Article
Cloning of a novel G-protein-coupled receptor from the sea anemone nervous system
Biochemical and Biophysical Research Communications, v. 271, (3), May 2000, p. 761-769
New, David C.; Wong, Yung Hou; Wong, Joseph T.Y. Article
Deciphering the role of G_i2 in opioid-induced adenylyl cyclase supersensitization
NeuroReport, v. 11, (14), September 2000, p. 3213-3217
Tso, Ha; Wong, Yung Hou Article
Evidence for transduction of mu but not kappa opioid modulation of extracellular signal-regulated kinase activity by G_z and G₁₂ proteins
Cellular Signalling, v. 12, (7), July 2000, p. 481-489
Belcheva, Mariana M.; Wong, Yung Hou; Coscia, Carmine J. Article
G_z Can Mediate the Acute Actions of μ- and κ-Opioids but Is Not Involved in Opioid-Induced Adenylyl Cyclase Supersensitization
Journal of Pharmacology and Experimental Therapeutics, v. 295, (1), October 2000, p. 168-176
Tso, Ha; Wong, Yung Hou Article
Immunoglobulin G1 Fc Fragment-Tagged Human Opioid Receptor-Like Receptor Retains the Ability to Inhibit cAMP Accumulation
Biological Signals and Receptors, v. 9, (5), September-October 2000, p. 240-247
Yung, Ying; Tsim, Karl Wah Keung; Pei, Gang; Wong, Yung Hou Article
Incorporation of Gα_z-specific sequence at the carboxyl terminus increases the promiscuity of Gα₁₆ toward G_i-coupled receptors
Molecular Pharmacology, v. 57, (1), January 2000, p. 13-23
Mody, Sejal M.; Ho, Maurice K.C.; Joshi, Sushma A.; Wong, Yung Hou Article
Molecular mechanisms and regulation of opioid receptor signaling
Annual Review of Pharmacology and Toxicology, v. 40, April 2000, p. 389-430
Law, Pingyee; Wong, Yung Hou; Loh, Horace Article
Preactivation Permits Subsequent Stimulation of Phospholipase C by G,sub>i-Coupled Receptors
Molecular Pharmacology, v. 57, (4), April 2000, p. 700-708
Chan, Joy S.C.; Lee, Jonathan W.M.; Ho, Maurice K.C.; Wong, Yung Hou Article
Regulation of Adenylyl Cyclase, ERK1/2, and CREB by G_z Following Acute and Chronic Activation of the δ-Opioid Receptor
Journal of Neurochemistry, v. 74, (4), April 2000, p. 1685-1693
Tso, Ha; Yung, Ying; Wong, Yung Hou Article
Regulation of C-jun N-terminal kinase by the ORL₁ receptor through multiple G proteins
Journal of Pharmacology and Experimental Therapeutics, v. 295, (3), December 2000, p. 11094-1100
Chan, Siu Lung Anthony; Wong, Yung Hou Article
The Amino Terminus of Gα_z is Required for Receptor Recognition, Whereas its α4/β6 Loop Is Essential for Inhibition of Adenylyl Cyclase
Molecular Pharmacology, v. 58, (5), November 2000, p. 993-1000
Ho, Maurice K.C.; Wong, Yung Hou Article
The Effect of Protein Kinase C Activation on G_z-Mediated Regulation of Type 2 and 6 Adenylyl Cyclases
Biological Signals and Receptors, v. 9, (1), January-February 2000, p. 21-28
Ho, Maurice K.C.; Chan, Joy S.C.; Yung, Ying; Wong, Yung Hou Article

1999 7

Alanine-23 of transducin α subunit is involved in defining the affinity for βγ complex
NeuroReport, v. 10, (7), May 1999, p. 1561-1564
Ho, Maurice K C; Wong, Yung Hou Article
Alanine-23 of transducin α subunit is involved in defining the affinity for βγ complex
NeuroReport, v. 10, (9), June 1999, p. 1993-1996
Ho, Maurice Kwok Chung; Wong, Yung Hou Article
Chronic activation of ORL₁ receptor induces supersensitization of adenylyl cyclase
NeuroReport, v. 10, (14), September 1999, p. 2901-2905
Chan, Robbie; Wong, Yung Hou Article
Disruption of receptor-mediated activation of G protein by mutating a conserved arginine residue in the switch II region of the α subunit
Journal of Neurochemistry, v. 73, (5), November 1999, p. 2101-2109
Ho, Maurice K.C.; Yung, Ying; Wong, Yung Hou Article
G_L1 (Gα₁₄) couples the opioid receptor-like₁ receptor to stimulation of phospholipase C
Journal of Pharmacology and Experimental Therapeutics, v. 288, (1), January 1999, p. 232-238
Yung, Ying; Joshi, Sushma A.; Chan, Robbie Y.K.; Chan, Joy S.C.; Pei, Gang; Wong, Yung Hou Article
Mutational analysis of the structure and function of opioid receptors
Biopolymers - Peptide Science Section, v. 51, (6), 1999, p. 440-455
Law, Pingyee; Wong, Yung Hou; Loh, Horace Article
Stimulation of phospholipase C by the cloned μ, δ and κ opioid receptors via chimeric Gα_q mutants
European Journal of Neuroscience, v. 11, (2), January 1999, p. 383-388
Joshi, Sushma; Lee, Jonathan W.M.; Wong, Yung Hou Article

1998 8

Chimeric Gα_q mutants harboring the last five carboxy-terminal residues of Gα_i2 or Gα_o are resistant to pertussis toxin-catalyzed ADP-ribosylation
FEBS Letters, v. 441, (1), December 1998, p. 67-70
Joshi, Sushma A.; Fan, Kenneth P.K.; Ho, Vannessa W.S.; Wong, Yung Hou Article
Differential coupling of μ-, δ-, and κ-opioid receptors to Gα₁₆- mediated stimulation of phospholipase C
Journal of Neurochemistry, v. 70, (5), May 1998, p. 2203-2211
Lee, Jonathan W.M.; Joshi, Sushma A.; Chan, Joy S.C.; Wong, Yung Hou Article
Evidence for heterotrimeric G proteins in sea anemones
Molecular Marine Biology and Biotechnology, v. 7, (1), March 1998, p. 31-38
New, David C.; Mcgaughey Nicola Jane; Wong, Yung Hou; Wong, Joseph T.Y. Article
Molecular and cellular analyses of melatonin receptor-mediated cAMP signaling in rat corpus epididymis
Journal of Pineal Research, v. 25, (4), December 1998, p. 219-228
Li, Lili; Xu, Jianning; Wong, Yung Hou; Wong, Joseph T.Y.; Pang, Shiufun; Shiu, Stephen Yuen Wing Article
Pertussis Toxin-Insensitive Signaling of the ORL₁ Receptor: Coupling to G_z and G₁₆ Proteins
Journal of Neurochemistry, v. 71, (5), November 1998, p. 2203-2210
Chan, Joy S.C.; Yung, Ying; Lee, Jonathan W.M.; Wu, Yalan; Pei, Gang; Wong, Yung Hou Article
Regulation of calcium influx and phospholipase C activity by indoleamines in dinoflagellate Crypthecodinium cohnii
Journal of Pineal Research, v. 24, (3), April 1998, p. 152-161
Tsim, Siu-Tai; Wong, Joseph T.Y.; Wong, Yung Hou Article
Structure and Function of the Pertussis-Toxin-Insensitive G_z Protein
Biological Signals and Receptors, v. 7, (2), March-April 1998, p. 80-89
Ho, Maurice K.C.; Wong, Yung Hou Article
The calcitonin gene-related peptide-induced acetylcholinesterase synthesis in cultured chick myotubes is mediated by cyclic AMP
Journal of Neurochemistry, v. 71, (1), July 1998, p. 152-160
Choi, Roy Chi Yan; Yung, Lisa Ying; Dong, Tina Ting Xia; Wan, David C.C.; Wong, Yung Hou; Tsim, Karl Wah Keung Article

1997 5

Calcium ion dependency and the role of inositol phosphates in melatonin-induced encystment of dinoflagellates
Journal of Cell Science, v. 110, (12), June 1997, p. 1387-1393
Tsim, Siu Tai; Wong, Joseph T.Y.; Wong, Yung Hou Article
Functional Role of Amino-Terminal Serine¹⁶ and Serine²⁷ of Gα_z in Receptor and Effector Coupling
Journal of Neurochemistry, v. 68, (6), June 1997, p. 2514-2522
Ho, Maurice K.C.; Wong, Yung Hou Article
Melatonin and 5-methoxytryptamine induced muscular contraction in sea anemones
Journal of Experimental Zoology, v. 279, (3), October 1997, p. 201-207
Tsang, Wai Hung; Mcgaughey Nicola Jane; Wong, Yung Hou; Wong, Joseph T.Y. Article
Receptor-induced βγ release from fatty acylation-deficient mutants of Gα_z
NeuroReport, v. 8, (4), March 1997, p. 937-940
Beck, Helga I.; Chan, Joy S.C.; Wong, Yung Hou Article
Role of Amino- and Carboxyl-Terminal Regions of G_αz in the Recognition of G_i-Coupled Receptors
Molecular Pharmacology, v. 52, (1), July 1997, p. 38-45
Tsu Rachel Caroline; Ho, Maurice K.C.; Yung, Ying; Joshi, Sushma A.; Wong, Yung Hou Article

1996 6

CGP 52608-induced cyst formation in dinoflagellates: Possible involvement of a nuclear receptor for melatonin
Journal of Pineal Research, v. 21, (2), September 1996, p. 101-107
Tsim, Siu Tai; Wong, Joseph T.Y.; Wong, Yung Hou Article
Effects of Dibutyryl cAMP and Bacterial Toxins on Indoleamine-Induced Encystment of Dinoflagellates
Biological Signals, v. 5, (1), January-February 1996, p. 22-29
Tsim, Siu Tai; Wong, Joseph T.Y.; Wong, Yung Hou Article
G_i-mediated stimulation of type II adenylyl cyclase is augmented by G_q-coupled receptor activation and phorbol ester treatment
Journal of Neuroscience, v. 16, (4), February 1996, p. 1317-1323
Tsu, Rachel Caroline; Wong, Yung Hou Article
Inverse agonistic effect of ICI-174,864 on the cloned delta-opioid receptor: Role of G protein and adenylyl cyclase activation
Molecular Pharmacology, v. 50, (6), December 1996, p. 1651-1657
Chiu, Tillie T.; Yung, Ying; Wong, Yung Hou Article
Possible involvement of G proteins in indoleamine-induced encystment in dinoflagellates
Molecular Marine Biology and Biotechnology, v. 5, (2), June 1996, p. 162-167
Tsim, Siu Tai; Yung, Ying; Wong, Joseph T.Y.; Wong, Yung Hou Article
The G Protein Linkage of Melatonin Receptors
Frontiers of Hormone Research, v. 21, 1996, p. 147-153
Wong, Yung Hou Article

1995 7

Activation of Type II Adenylyl Cyclase by the Cloned μ‐Opioid Receptor: Coupling to Multiple G Proteins
Journal of Neurochemistry, v. 65, (6), December 1995, p. 2682-2689
Chan, Joy S.C.; Chiu, Tillie T.; Wong, Yung Hou Article
Differential coupling of the formyl peptide receptor to adenylate cyclase and phospholipase C by the pertussis toxin-insensitive G_z protein
Biochemical Journal, v. 309, (1), July 1995, p. 331-339
Tsu, Rachel Caroline; Lai, H.W.L.; Allen, Rodger A.; Wong, Yung Hou Article
GZ coupling to the rat κ-opioid receptor
FEBS Letters, v. 360, (1), February 1995, p. 97-99
Lai, Helen W.L.; Minami, Masabumi; Satoh, Masamichi; Wong, Yung Hou Article
Mutant α subunit of G(z) transforms Swiss 3T3 cells
Oncogene, v. 10, (10), May 1995, p. 1927-1933
Wong, Yung Hou; Chan, Joy S.C.; Yung, Ying; Bourne, Henry R. Article
Regulation of multiple effectors by the cloned δ-opioid receptor: Stimulation of phospholipase C and type II adenylyl cyclase
Journal of Neurochemistry, v. 64, (6), June 1995, p. 2700-2707
Tsu, Rachel Caroline; Chan, Joy S.C.; Wong, Yung Hou Article
Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through G_i and G_z proteins
FEBS Letters, v. 372, (1), September 1995, p. 99-102
Yung, Ying; Tsim, Siu Tai; Wong, Yung Hou Article
Stimulation of type II adenylyl cyclase by chemoattractant formyl peptide and C5a receptors
Molecular Pharmacology, v. 47, (4), April 1995, p. 835-841
Tsu, Rachel Caroline; Allen, Rodger A.; Wong, Yung Hou Article

1994 2

G_i Assays in Transfected Cells
Methods in Enzymology, v. 238, (C), January 1994, p. 81-94
Wong, Yung Hou Article
Indolemine-induced encystment in dinoflagellates
J. Mar. Biol. Ass. U.K, v. 74, 1994, p. 467-469
Wong, J.T.Y.; Wong, Yung Hou Article

1992 4

Detection of Coincident Signals by G Proteins and Adenylyl Cyclase
Cold Spring Harbor Symposia on Quantitative Biology, v. 57, 1992, p. 145-148
Bourne, H.R.; Lustig, K.; Wong, Yung Hou; Conklin, B.R. Article
Gz-mediated hormonal inhibition of cyclic AMP accumulation
Science, v. 255, (5042), January 1992, p. 339-342
Wong, Yung Hou; Conklin, B.R.; Bourne, H.R. Article
Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C
Journal of Biological Chemistry, v. 267, (1), January 1992, p. 31-34
Conklin, B.R.; Chabre, O.; Wong, Yung Hou; Federman, A.; Bourne, H.R. Article
The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase
Journal of Biological Chemisty, v. 267, (29), October 1992, p. 20831-20834
Hung, D.T.; Wong, Yung Hou; Vu, T.K.; Coughlin, S.R. Article

1991 3

A mutant α subunit of G_i2 induces neoplastic transformation of rat-1 cells
Proceedings of the National Academy of Sciences of the United States of America, v. 88, (16), August 1991, p. 7031-7035
Pace, A.M.; Wong, Yung Hou; Barnard, E.A. Article
G protein oncogenes
In: Origins of Human Cancer: A Comprehensive Review, 1991, p. 327-333
Bourne, H.R.; Goretzki, P.; Landis, C.; Lyons, J.; McCormick, F.; Pace, A.; Wong, Yung Hou Article
Mutant α subunits of G_i2 inhibit cyclic AMP accumulation
Nature, v. 351, (6321), May 1991, p. 63-65
Wong, Yung Hou; Federman, Alex; Pace, Ann M.; Zachary, Ian; Evans, Tony; Pouysségur, Jacques; Bourne, Henry R. Article

1990 1

Agonist-selective protection of the opioid receptor-coupled G protein from inactivation by 5'-p-fluorosulphonylbenzoyl guanosine
Journal of Neurochemistry, v. 54, (1), January 1990, p. 39-45
Wong, Yung Hou; Demoliou-mason, C.D.; Hanley, M.R.; Barnard, E.A. Article

1989 3

Opioid receptor-G protein interactions: pertussis toxin, Li+ effects and reconstitution studies
Li+ effects and reconstitution studies. Adv. Biosci, v. 75, 1989, p. 153-156
Wong, Yung Hou; Demoliou-Mason, C.D.; Barnard, E.A. Article
Opioid Receptors in Magnesium-Digitonin-Solubilized Rat Brain Membranes Are Tightly Coupled to a Pertussis Toxin-Sensitive Guanine Nucleotide-Binding Protein
Journal of Neurochemistry, v. 52, (4), April 1989, p. 0999-1009
Wong, Yung Hou; Demoliou-mason, C.D.; Barnard, E.A. Article
Uncoupling of the opioid receptor-G protein complexes by 5'-p-fluorosulphonylbenzoyl guanosine
Adv. Biosci., v. 75, 1989, p. 133-136
Wong, Yung Hou; Demoliou-Mason, C.D.; Barnard, E.A. Article

1988 2

A complex of opioid receptor with G protein, characterized in digitonin solution
In: Regulatory Roles of Opioid Peptides, Edited by Illes P and Farsang C. 1988, p. 131-144
Wong, Yung Hou; Demoliou-Mason, C.D.; Barnard, E.A. Article
ADP-ribosylation with pertussis toxin modulates the GTP-sensitive opioid ligand binding in digitonin-soluble extracts of rat brain membranes
Journal of Neurochemistry, v. 51, (1), July 1988, p. 114-121
Wong, Yung Hou; Demoliou-mason, C.D.; Barnard, E.A. Article

1987 1

Bradykinin stimulation of inositol phosphate and calcium responses is insensitive to pertussis toxin in NG115-401L neuronal cells
Biochemical and Biophysical Research Communications, v. 148, (1), October 1987, p. 412-416
Jackson, Trevor R.; Patterson, Sean I.; Wong, Yung Hou; Hanley, Michael R. Article

1986 1

Effects of hypoxaemia and hyperoxaemia on some cardiovascular responses of rats to adrenaline
Archives of Physiology and Biochemistry, v. 94, (5), 1986, p. 323-329
Dai, S.; Wong, Yung Hou; Ogle, C.W. Article

1985 1

Effects of Hypoventilation on the Cardiovascular Responses of Rats to Adrenaline and Acetylcholine
Pharmacology, v. 30, (6), 1985, p. 314-319
Dai, S.; Wong, Yung Hou Article


No Publications






Teaching Assignment

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2021-22 Winter 0 2021-22 Fall 5 2020-21 Summer 1 2020-21 Spring 7 2020-21 Winter 0 2020-21 Fall 7

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LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS4971 Biochemistry and Cell Biology Project Research I
LIFS6170 Special Topics in Molecular, Cell and Developmental Biology
UROP1100E Undergraduate Research Opportunities Series 1
UROP2100E Undergraduate Research Opportunities Series 2


UROP1100D Undergraduate Research Opportunities Series 1


BIBU4850 Biotechnology and Business Project Research
BTEC5380 Drug Discovery and Development
LIFS3510 Junior Research Project I
LIFS4380 Pharmacology and Toxicology
LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS4981 Biochemistry and Cell Biology Project Research II
LIFS6117D Current Topics in Cell Biology


BIBU4820 Biotechnology Entrepreneurship and Business Operations
BIBU4850 Biotechnology and Business Project Research
LIFS4960 Biological Science Capstone Project
LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS4963 Biotechnology Capstone Project
LIFS4971 Biochemistry and Cell Biology Project Research I
LIFS6170 Special Topics in Molecular, Cell and Developmental Biology


No Teaching Assignments


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)

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All Supervisions Current RPGs Graduated RPGs

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Current RPGs

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Doctor of Philosophy TANG, Qing
Life Science( 2021 - )

TSE, Lap Hang
Life Science( 2017 - )

GU, Yishan
Life Science( 2016 - )

SONG, Jiaxing
Life Science( 2016 - )

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Master of Philosophy DO, Yelim
Life Science( 2021 - )

KIM, Eunah
Life Science( 2021 - )

LEE, Seayoung
Life Science( 2021 - )

CHAN, Ho Yung
Life Science( 2020 - )

LAW, Ka Yin
Life Science( 2020 - )

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Graduated RPGs

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Doctor of Philosophy SAINI, Vasu
Life Science( Completed in 2021 )

WONG, Ka Ming
Life Science( Completed in 2020 )

LIU, Wen
Life Science( Completed in 2019 )

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Master of Philosophy CHUNG, Yin Kwan
Life Science( Completed in 2020 )









ProjectsFrom January 2020 to December 2022

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All Projects 9 Leading Projects 3 Participating Projects 6

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The Center for Neurodegenerative Diseases


N/A Participating


Innovation and Technology Fund


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
FU Amy Kit Yu
LEUNG Danny Chi Yeu
LIU Kai
WANG Jiguang
WONG Yung Hou
WU Zhenguo


2020 -




A Stem Cell Approach to Dissect the Molecular Basis of Neurodegenerative Diseases


以干细胞方法解析神经退行性疾病的分子基础 Participating


RGC - Theme-based Research Scheme


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
CHUNG Kenny K
FU Amy Kit Yu
QI Robert Zhong
QU Jianan
TSIM Karl Wah Keung
WEN Zilong
WONG Yung Hou
WU Zhenguo
XIA Jun


2019 -




Development of Next-Generation Anti-inflammatory and Anti-tussive Herbal Products


研发新一代抗炎和止咳草药产品 Leading


Innovation and Technology Fund


Project Team (HKUST)
WONG Yung Hou (Lead)


2019 -




Evaluation of the effectiveness of a traditional Chinese herbal formula (Yang Xin Tang) in the treatment of Alzheimer's disease Leading


Health and Medical Research Fund


Project Team (HKUST)
WONG Yung Hou (Lead)
FU Amy Kit Yu


2019 -




Regulation of leukemia inhibitory factor (LIF) by G protein-coupled receptors (GPCRs) for intercellular communication between neurons and astrocytes


通过G蛋白偶联受体（GPCR）对白血病抑制因子（LIF）的调控来在神经元和星形胶质细胞之间传递讯息 Leading


RGC - General Research Fund


Project Team (HKUST)
WONG Yung Hou (Lead)


2019 - 2021




The Research on diagnosis and treatment of Alzheimer's disease


阿尔茨海默症的诊治方法研究 Participating


Department of Science and Technology of Guangdong Province


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
FU Amy Kit Yu
LIU Kai
WONG Yung Hou
WU Zhenguo
ZHOU Fred Xiaopu


2018 -




Cellular mechanisms of synaptic functions and plasticity in health and neurodegenerative diseases


健康及神经退行性病变过程中突触功能和可塑性调控的细胞机制 Participating


RGC - Areas of Excellence Scheme


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
FU Amy Kit Yu
LIU Kai
WONG Yung Hou
WU Zhenguo
XIA Jun


2017 -




Open Operation System of Guangdong Provincial Key Laboratory of Brain Science, Disease, and Drug Development (Inspection Qualified in 2017)


广东省脑科学及疾病与药物研究重点实验室开放运行（2017年度考评合格） Participating


Department of Science and Technology of Guangdong Province


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
FU Amy Kit Yu
LIU Kai
QI Robert Zhong
WONG Yung Hou
WU Zhenguo
XIA Jun


2017 - 2020




State Key Laboratory of Molecular Neuroscience (The Hong Kong University of Science and Technology)


分子神经科学国家重点实验室（香港科技大学） Participating


Innovation and Technology Fund


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHOW King Lau
CHUNG Kenny K
DAI Wei Min
GUO Zhihong
HUANG Pingbo
LIANG Chun
MILLER Andrew Leitch
POON Randy Yat Choi
QI Robert Zhong
TSIM Karl Wah Keung
WEN Zilong
WONG Joseph Tin Yum
WONG Yung Hou
WU Zhenguo
ZHU Guang


2011 -