Zhenguo WU
邬振国
PhD in Biochemistry
The University of Western Ontario, 1995

Professor
Division of Life Science

Director of Laboratory Animal Facility

Director of Center for Stem Cell Research

Director of HKUST-SIAT Joint Lab for Brain Science

Associate Director of Biotechnology Research Institute



(852) 2358 8704
bczgwu@ust.hk
Room 5527
Personal Web

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ORCID
0000-0003-3049-8324

ResearcherID
B-8144-2013

Scopus ID
8218909600




Research Interest Publications Projects Teaching Assignment RPG Supervision Space used




Research Interest

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Stem cell biology
Cell signaling
Muscle stem cells
Transcriptional regulation
Muscle differentiation and regeneration



Publications

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All Years 84 2022 0 2021 2 2020 1 2019 3 2018 5 2017 2 2016 71

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2021 2

Paxbp1 controls a key checkpoint for cell growth and survival during early activation of quiescent muscle satellite cells
Proceedings of the National Academy of Sciences of the United States of America, v. 118, (13), March 2021, article number e2021093118
Zhou, Shaopu; Han, Lifang; Weng, Mingxi; Zhu, Han; Heng, Youshan; Wang, Gang; Shen, Zeyu; Chen, Xianwei; Fu, Xinrong; Zhang, Mingjie; Wu, Zhenguo Article
Type 2 Diabetic Mice Enter A State Of Spontaneous Hibernation- Like Suspended Animation Following Accumulation Of Uric Acid
Journal of Biological Chemistry, v. 297, (4), October 2021, article number 101166
Zhao, Yang; Cheng, Rui; Zhao, Yue; Ge, Wenhao; Yang, Yunxia; Ding, Zhao; Xu, Xi; Wang, Zhongqiu; Wu, Zhenguo; Zhang, Jianfa Article

2020 1

A long noncoding RNA, LncMyoD, modulates chromatin accessibility to regulate muscle stem cell myogenic lineage progression
Proceedings of the National Academy of Sciences of the United States of America, v. 117, (51), December 2020, p. 32464-32475
Dong, Anqi; Preusch, Christopher Brandon; So, Wai Kin; Lin, Kangning; Luan, Shaoyuan; Yi, Ran; Wong, Wing Chiu; Wu, Zhenguo; Cheung, Hiu Tung Article

2019 3

In vivo study of metabolic dynamics and heterogeneity in brown and beige fat by label‐free multiphoton redox and fluorescence lifetime microscopy
Journal of Biophotonics, 18 October 2019, article number e201960057
He, Sicong; Wei, Xiuqing; Qin, Zhongya; Chen, Congping; Wu, Zhenguo; Qu, Jianan Article
Structure of BAl1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds
Nature Communications, v. 10, (1), December 2019, article number 51
Weng, Zhuangfeng; Situ, Chenghao; Lin, Lin; Wu, Zhenguo; Zhu, Jinwei; Zhang, Rongguang Article
YY1 Regulates Skeletal Muscle Regeneration Through Controlling Metabolic Reprogramming of Satellite Cells
EMBO Journal, v. 38, (10), May 2019, article number e99727
Chen, Fengyuan; Zhou, Jiajian; Li, Yuying; Zhao, Yu; Yuan, Jie; Cao, Yang; Wang, Lijun; Zhang, Zongkang; Zhang, Baoting; Wang, Chi Chiu; Cheung, Tom H.; Wu, Zhenguo; Wong, Carmen Chak‐Lui; Sun, Hao; Wang, Huating Article

2018 5

In Vivo Imaging-guided Microsurgery Based on Femtosecond Laser Produced New Fluorescent Compounds in Biological Tissues
Biomedical Optics Express, v. 9, (2), February 2018, p. 581-590
Sun, Qiqi; Qin, Zhongya; Wu, Wanjie; Lin, Yue; Chen, Congping; He, Sicong; Li, Xuesong; Wu, Zhenguo; Luo, Yi; Qu, Jianan Y. Article
In vivo metabolic imaging and monitoring of brown and beige fat
Journal of Biophotonics, v. 11, (8), August 2018, article number e201800019
He, Sicong; An, yitai; Li, Xuesong; Wei, Xiuqing; Sun, qiqi; Wu, Zhenguo; Qu, Jianan Article
p110α of PI3K is Necessary and Sufficient for Quiescence Exit in Adult Muscle Satellite Cells
EMBO journal, v. 37, (8), April 2018, article number e98239
Wang, Gang; Zhu, Han; Situ, Chenghao; Han, Lifang; Yu, Youqian; Cheung, Tom H.; Liu, Kai; Wu, Zhenguo Article
In vivo two-photon imaging of macrophage activities in skeletal muscle regeneration
Proceedings of SPIE: Progress in Biomedical Optics and Imaging, v. 10497, 2018, article number 1049704
Qin, Zhongya; Long, Yanyang; Sun, Qiqi; He, Sicong; Li, Xuesong; Chen, Congping; Wu, Zhenguo; Qu, Jianan Conference paper
Integrated SRS And Fluorescence Imaging For Study Of Thermogenesis And Lipid Metabolism In Vivo
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, v. 10498, 2018, article number 104981I
He, Sicong; An, Yitai; Li, Xuesong; Wu, Zhenguo; Qu, Jianan Conference paper

2017 2

A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes
Developmental Cell, v. 41, (4), May 2017, p. 382-391.e5
An, Yitai; Wang, Gang; Diao, Yarui; Long, Yanyang; Fu, Xinrong; Weng, Mingxi; Zhou, Liang; Sun, Kun; Cheung, Tom H.; Ip, Nancy Yuk-yu; Sun, Hao; Wang, Huating; Wu, Zhenguo Article
Malat1 Regulates Myogenic Differentiation and Muscle Regeneration Through Modulating MyoD Transcriptional Activity
Cell Discovery, v. 3, March 2017, article number 17002
Chen, Xiaona; He, Liangqiang; Zhao, Yu; Li, Yuying; Zhang, Suyang; Sun, Kun; So, Karl; Chen, Fengyuan; Zhou, Liang; Lu, Leina; Wang, Lijun; Zhu, Xihua; Bao, Xichen; Esteban, Miguel A.; Nakagawa, Shinichi; Prasanth, Kannanganattu V.; Wu, Zhenguo; Sun, Hao; Wang, Huating Article

2016 2

Cyclin G2 Inhibits Epithelial-to-Mesenchymal Transition by Disrupting Wnt/β-Catenin Signaling
Oncogene, v. 35, (36), September 2016, p. 4816-4827
Bernaudo, Stefanie; Salem, Mohamed; Qi, X.; Zhou, W.; Zhang, C.; Yang, W.; Rosman, D.; Deng, Z.; Ye, G.; Yang, Burton; Vanderhyden, Barbara C.; Wu, Zhenguo; Peng, C. Article
STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration
Cell Reports, v. 16, (8), 23 August 2016, p. 2102-2115
Zhu, Han; Xiao, Fang; Wang, Gang; Wei, Xiuqing; Jiang, Lei; Chen, Yan; Zhu, Lin; Wang, Haixia; Diao, Yarui; Wang, Huating; Ip, Nancy Y Y; Cheung, Tom H.; Wu, Zhenguo Article

2015 2

A Universal and Facile Approach for the Formation of a Protein Hydrogel for 3D Cell Encapsulation
Advanced Functional Materials, v. 25, (39), October 2015, p. 6189-6198
Chen, Yin; Dai, Xin; Huang, Lu; Sun, Yang; Chan, Ho Nam; Shen, Bo; Zeng, Xiaoqian; Wu, Zhenguo; Hsing, I-Ming; Guo, Zhihong; Wu, Hongkai Article
MicroRNAs 99b-5p/100-5p Regulated by Endoplasmic Reticulum Stress are Involved in Abeta-Induced Pathologies
Frontiers in Aging Neuroscience, v. 7, November 2015, article number 210
Ye, Xiaoyang; Luo, Hongxue; Chen, Yan; Wu, Qi; Xiong, Yi; Zhu, Yinyong; Diao, Yarui; Wu, Zhenguo; Miao, Jianting; Wan, Jun Article

2014 4

Cdk5-dependent Mst3 phosphorylation and activity regulate neuronal migration through RhoA inhibition
The Journal of neuroscience, v. 34, (22), May 2014, p. 7425-7436
Tang, Jing; Ip, Pak Kan; Ye, Tao; Ng, Yu Pong; Yung, Wing-Ho; Wu, Zhenguo; Fang, Weiqun; Fu, Kit Yu; Ip, Nancy Y Y Article
Label-free multimodal nonlinear optical microscopy reveals fundamental insights of skeletal muscle development
Biomedical Optics Express, v. 5, (1), January 2014, p. 158-166
Sun, Qiqi; Li, Yanfeng; He, Sicong; Situ, Chenghao; Wu, Zhenguo; Qu, Jianan Article
miR-203, a Tumor Suppressor Frequently Down-regulated by Promoter Hypermethylation in Rhabdomyosarcoma
Journal of Biological Chemistry, v. 289, (1), January 2014, p. 529-539
Diao, Yarui; Guo, Xing; Jiang, Lei; Wang, Gang; Zhang, Chao; Wan, Jun; Jin, Yan; Wu, Zhenguo Article
Advanced nonlinear optical microscopy for imaging of development of skeletal muscle
Biomedical Optics (BIOMED), Miami, Florida, USA, 26-30 April 2014
Sun, Qiqi; Li, Yanfeng; He, Sicong; Situ, Chenghao; Wu, Zhenguo; Qu, Jianan Conference paper

2013 1

Cdk5-dependent Phosphorylation of Mst3 Regulates Radial Migration through Modulating RhoA Activity
2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The Chinese University of Hong Kong, Hong Kong, 15 June 2013
Tang, Jing; Ip, Jacque Pak Kan; Fang, Weiqun; Zhong, Wanting; Ng, Yu Pong; Wu, Zhenguo; Shi, Lei; Fu, Kit Yu; Ip, Nancy Yuk-Yu Conference paper

2012 9

A continuous spectrophotometric assay for mitogen-activated protein kinase kinases
Analytical biochemistry, v. 421, (1), 2012, p. 191-197
Zheng, Lisha; Zhang, Yuanyuan; Wu, Jiawei; Wu, Zhenguo; Zhang, Zhongyin; Wang, Zhixin Article
A novel mechanism of control of NF kappa B activation and inflammation involving A(2B) adenosine receptors
Journal of cell science, v. 125, (19), 2012, p. 4507-4517
Sun, Ying; Duan, Yuanyuan; Eisenstein, Anna S.; Hu, Wenbao; Quintana, Adrien; Lam, Wai Kwan; Wang, Yan; Wu, Zhenguo; Ravid, Katya; Huang, Pingbo Article
Impact of SARS-coronavirus-encoded proteins on cellular signalling pathways and cytokine/chemokine gene expression
Hong Kong medical journal, v. 18, (4), 2012, p. 16-19
Chan, Jonathan K.L.; Cheung, Po Yan; He, Mingliang; Wu, Zhenguo Article
Keratin K18 Increases Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Surface Expression by Binding to Its C-terminal Hydrophobic Patch
Journal of Biological Chemistry, v. 287, (48), 2012, Nov, p. 40547-40559
Duan, Yuanyuan; Sun, Ying; Zhang, Fan; Zhang, Wei; Wang, Dong; Wang, Yan; Cao, Xu; Hu, Wenbao; Xie, Changyan; Cuppoletti, John; Magin, Thomas Michael; Wang, Haixia; Wu, Zhenguo; Li, Ning; Huang, Pingbo Article
Loss of STAT1 in bone marrow-derived cells accelerates skeletal muscle regeneration
PLoS ONE, v. 7, (5), 2012, Article number e37656
Gao, Yan; Li, Yanfeng; Guo, Xing; Wu, Zhenguo; Zhang, Wei Article
Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism
Cell stem cell, v. 11, (2), 2012, Aug, p. 231-241
Diao, Yarui; Guo, Xing; Li, Yanfeng; Sun, Kun; Lu, Leina; Jiang, Lei; Fu, Xinrong; Zhu, Han; Sun, Hao; Wang, Huating; Wu, Zhenguo Article
Signal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex
EMBO journal, v. 31, (2), 2012, p. 301-316
Forcales, Sonia Vanina; Albini, Sonia; Giordani, Lorenzo; Malecová, Barbora; Cignolo, Luca; Chernov, Andrei V.; Coutinho, Paula; Saccone, Valentina; Consalvi, Silvia; Williams, Roy Steve; Wang, Kepeng; Wu, Zhenguo; Baranovskaya, Svetlana S.; Miller, Andrew M.; Dilworth, F. Jeffrey; Puri, Pier Lorenzo Orenzo Article
TRAF6 promotes myogenic differentiation via the TAK1/p38 mitogen-activated protein kinase and akt pathways
PLoS ONE, v. 7, (4), 2012, Apr, Article number e34081
Xiao, Fang; Wang, Haixia; Fu, Xinrong; Li, Yanfeng; Wu, Zhenguo Article
Functional Roles of Mst3 in Radial Migration During the Development of Mouse Cerebral Cortex
The 42nd Annual Meeting of the Society for Neuroscience, New Orleans, USA, 13–17 October 2012
Tang, Jing; Ip, Pak Kan; Fang, Weiqun; Zhong, Weiting; Ng, Yu Pong; Wu, Zhenguo; Shi, Lei; Fu, Kit Yu; Ip, Nancy Yuk-Yu Conference paper

2011 2

Expression of Gα_z in C2C12 Cells Restrains Myogenic Differentiation
Cellular Signalling, v. 23, (2), February 2011, p. 389-397
Mei, Hua; Ho, Kwok Chung Maurice; Yung, Ying; Wu, Zhenguo; Ip, Nancy Yuk-yu; Wong, Yung Hou Article
Oncostatin M inhibits myoblast differentiation and regulates muscle regeneration
Cell Research, v. 21, (2), 2011, p. 350-364
Xiao, Fang; Wang, Haixia; Fu, Xinrong; Li, Yanfeng; Ma, Kewei; Sun, Luguo; Gao, Xiang; Wu, Zhenguo Article

2010 4

Nerve Growth Factor-Induced Differentiation of PC12 Cells Is Accompanied by Elevated Adenylyl Cyclase Activity
NeuroSignals, v. 18, (1), September 2010, p. 32-42
Yung, H.S.; Lai, K.H.; Chow, Kevin B.S.; Ip, Nancy Yuk-Yu; Tsim, Karl Wah Keung; Wong, Yung Hou; Wu, Zhenguo; Wise, Helen Article
Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding
Proceedings of the National Academy of Sciences of the United States of America, v. 107, (49), December 2010, p. 20974-20979
Diao, Yarui; Liu, Wei; Wong, Catherine C.L.; Wang, Xi; Lee, Ka Man; Cheung, Po Yan; Pan, Lifeng; Xu, Tao; Han, Jiahuai; Yates, John Robert R.; Zhang, Mingjie; Wu, Zhenguo Article
Role of mitogen-activated protein kinase in Zn-BC-AM PDT-induced apoptosis in nasopharyngeal carcinoma cells
Cell biochemistry and function, v. 28, (3), 2010, APR, p. 239-248
Koon, Ho Kee; Chan, Pui Shan; Wu, Zhenguo; Wong, Ricky Ngok Shun; Lung, Maria; Chang, Chi Kwong; Mak, Nai Ki Article
Tyk2/STAT3 Signaling Mediates beta-Amyloid-Induced Neuronal Cell Death: Implications in Alzheimer's Disease
Journal of Neuroscience, v. 30, (20), May 2010, p. 6873-6881
Wan, Jun; Fu, Kit Yu; Ip, Fanny Chui Fun; Ng, Ho Keung; Hugon, Jacques; Page, Guylène K.; Wang, Jerry Hsueh-ching; Lai, Kwok On; Wu, Zhenguo; Ip, Nancy Yuk-yu Article

2009 3

Differential and Synergistic Effect of Nerve Growth Factor and cAMP on the Regulation of Early Response Genes during Neuronal Differentiation
NeuroSignals, v. 17, (2), May 2009, p. 111-120
Ng, Yu Pong; Wu, Zhenguo; Wise, Helen; Tsim, Karl Wah Keung; Wong, Yung Hou; Ip, Nancy Yuk-Yu Article
SOCS1, SOCS3, and PIAS1 Promote Myogenic Differentiation by Inhibiting the Leukemia Inhibitory Factor-Induced JAK1/STAT1/STAT3 Pathway
Molecular and cellular biology, v. 29, (18), 2009, SEP, p. 5084-5093
Diao, Yarui; Wang, Xi; Wu, Zhenguo Article
Screening of Essential Kinases for Neuronal Differentiation
The 6th Asian Biophysics Association Symposium, Hong Kong, 11 - 15 January 2009
Ng, Yu Pong; Lai, Kwok On; An, Hui Jin; Wu, Zhenguo; Ip, Nancy Yuk-Yu Conference paper

2008 6

Involvement of the p38 mitogen-activated protein kinase alpha, beta, and gamma isoforms in myogenic differentiation
Molecular biology of the cell, v. 19, (4), 2008, APR, p. 1519-1528
Wang, Haixia; Xu, Qing; Xiao, Fang; Jiang, Yong; Wu, Zhenguo Article
Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma
Hepatology, v. 47, (2), 2008, FEB, p. 503-510
Ma, Ningfang; Hu, Liang; Fung, Jackie Mei Wah; Xie, Dan; Zheng, Bojian; Chen, Leilei; Tang, Dongjiang; Fu, Li; Wu, Zhenguo; Chen, Muhan; Fang, Yan; Guan, Xinyuan Article
JAK2/STAT2/STAT3 Are Required for Myogenic Differentiation
Journal of biological chemistry, v. 283, (49), 2008, DEC, p. 34029-34036
Wang, Kepeng; Wang, Chihao; Xiao, Fang; Wang, Haixia; Wu, Zhenguo Article
GAlphaz Inhibits Myogenic Differentiation of C2C12 Cells
The 9th AEARU Workshop on Molecular Biology and Biotechnology, Hong Kong, 25 - 26 March 2008
Ho, Kwok Chung Maurice; Mei, Hua; Yung, Ying; Wu, Zhenguo; Ip, Nancy Yuk-Yu; Wong, Yung Hou Conference paper
Mechanistic study of the LMP1-mediated non-canonical NF-kappaB pathway
The 13th Biennial Conference of the International Association for Research on Epstein-Barr virus and associated diseases, Guangzhou, China, November 7-10, 2008, p. 69
Cheung, Po Yan; Wu, Zhenguo Conference paper
The role of the suppressor of cytokine signaling (SOCS) proteins in skeletal muscle differentiation
First EMBO Conference on teh molecular and cellular mechanisms regulating skeletal muscle development and regeneration, Sant Feliu de Guixols, Spain, Sept 24-29, 2008
Wang, Xi; Diao, Yarui; Wu, Zhenguo Conference paper

2007 6

BS69 is involved in cellular senescence through the p53-p21Cip1 pathway
EMBO reports, v. 8, (10), 2007, October, p. 952-958
Zhang, Wei; Chan, Homan; Gao, Yan; Poon, Randy Yat Choi; Wu, Zhenguo Article
Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins
FEBS letters, v. 581, (2), 2007, JAN, p. 196-202
Zou, Haiying; Li, Qinxi; Lin, Shengcai; Wu, Zhenguo; Han, Jiahuai; Ye, Zhiyun Article
JAK1-STAT1-STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts
Journal of Cell Biology, v. 179, (1), October 2007, p. 129-138
Sun, Luguo; Ma, Kewei; Wang, Haixia; Xiao, Fang; Gao, Yan; Zhang, Wei; Wang, Kepeng; Gao, Xiang; Ip, Nancy Yuk-Yu; Wu, Zhenguo Article
Latent membrane protein 1 suppresses RASSF1A expression, disrupts microtubule structures and induces chromosomal aberrations in human epithelial cells
Oncogene, v. 26, (21), 2007, p. 3069-3080
Man, Cornelia; Rosa, Jack; Lee, Leo Tsz On; Lee, Vien H.Y.; Chow, Billy K.C.; Lo, Kwok Wai; Doxsey, Stephen John; Wu, Zhenguo; Kwong, Yok Lam; Jin, Dong Yan; Cheung, Annie Lai Man; Tsao, George Sai Wah Article
Myostatin induces cyclin D1 degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/AKT/GSK-3β pathway and is antagonized by insulin-like growth factor
Journal of biological chemistry, v. 282, (6), 2007, p. 3799-3808
Yang, Wei; Zhang, Yong; Li, Yanfeng; Wu, Zhenguo; Zhu, Dahai Article
Sequential recruitment of PCAF and BRG1 contributes to myogenin activation in 12-O-tetradecanoylphorbol-13-acetate-induced early differentiation of rhabdomyosarcoma-derived cells
Journal of biological chemistry, v. 282, (26), 2007, JUN, p. 18872-18878
Li, Zhaoyong; Yang, Jun; Gao, Xin; Lu, Jianyi; Zhang, Yi; Wang, Kepeng; Cheng, Mobin; Wu, Ninghua; Zhang, Ye; Wu, Zhenguo; Shen, Yufei Article

2006 4

BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway
Molecular and cellular biology, v. 26, (2), 2006, JAN, p. 448-456
Wan, Jun; Zhang, Wei; Wu, Liming; Bai, Ting; Zhang, Mingjie; Lo, Kwok Wai; Chui, Yiuloon; Cui, Yan; Tao, Qian; Yamamoto, Masahiro; Akira, Shizuo; Wu, Zhenguo Article
Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation
Journal of biological chemistry, v. 281, (7), 2006, FEB, p. 4423-4433
Grégoire, Serge; Tremblay, Annie M.; Xiao, Lin; Yang, Qian; Ma, Kewei; Nie, Jianyun; Mao, Zixu; Wu, Zhenguo; Giguère, Vincent; Yang, Xiangjiao Article
Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase
International journal of cancer, v. 119, (7), 2006, OCT, p. 1567-1576
Li, Hoiming; Man, Cornelia; Jin, Yuesheng; Deng, Wen; Yip, Yimling; Feng, Huichen; Cheung, Yukchun; Lo, Kwok Wai; Meltzer, Paul S.; Wu, Zhenguo; Kwong, Yok Lam; Yuen, Anthony Po Wing; Tsao, George Sai Wah Article
The C-terminal activating region 2 of the Epstein-Barr virus-encoded latent membrane protein 1 activates NF-kappa B through TRAF6 and TAK1
Journal of biological chemistry, v. 281, (4), 2006, JAN, p. 2162-2169
Wu, Liming; Nakano, Hiroyasu; Wu, Zhenguo Article

2005 7

Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome
American journal of respiratory and critical care medicine, v. 171, (8), 2005, APR, p. 850-857
Jiang, Yong; Xu, Jun; Zhou, Chengzhi; Wu, Zhenguo; Zhong, Shuqing; Liu, Jinghua; Luo, Wei; Chen, Tao; Qin, Qinghe; Deng, Peng Article
Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation
Molecular and cellular biology, v. 25, (9), 2005, MAY, p. 3575-3582
Ma, Kewei; Chan, Jonathan K.L.; Zhu, Guang; Wu, Zhenguo Article
The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation
Journal of biological chemistry, v. 280, (9), 2005, MAR, p. 8172-8179
Lo, Kevin W.H.; Kan, Homan; Chan, Ling Nga; Xu, Weiguang; Wang, Kepeng; Wu, Zhenguo; Sheng, Morgan; Zhang, Mingjie Article
Identification of Critical Early Genes Involved in Nerve Growth Factor-Induced PC12 Differentiation
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5 - 6 December 2005
Xiao, Fang; Ng, Yu Pong; Tsim, Karl Wah Keung; Wise, Helen; Wong, Yung Hou; Ip, Nancy Yuk-Yu; Wu, Zhenguo Conference paper
NGF-Induced Neuronal Differentiation of PC12 Cells: Delineation of Signaling Molecules and Mapping of Pathways.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5 - 6 December 2005
Leung, W.K.W.; Choi, Chi Yan; Ip, Nancy Yuk-Yu; Wu, Zhenguo; Wong, Yung Hou; Cheung, P.T.; Tsim, Karl Wah Keung Conference paper
Overexpression of Galphaz Inhibits Muscle Differentiation
Abstract P-14
Mei, Hua; Wu, Zhenguo; Ip, Nancy Yuk-Yu; Wong, Yung Hou Conference paper
Role of Calmodulin-Dependent Kinase II in Nerve Growth Factor-Induced Differentiation of PC12 Cells.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5-6 December 2005
Kam, Yuet Fong; Yung, Ying; Wu, Eddy H.T.; Ng, Yu Pong; Wu, Zhenguo; Tsim, Karl Wah Keung; Wise, Helen; Ip, Nancy Yuk-Yu; Wong, Yung Hou Conference paper

2004 4

Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation
Journal of cell science, v. 117, (14), 2004, JUN, p. 3021-3029
Sun, Luguo; Liu, Lanying; Yang, Xiangjiao; Wu, Zhenguo Article
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation
EMBO journal, v. 23, (23), 2004, NOV, p. 4583-4594
Rui, Yanning; Xu, Zhen; Lin, Shuyong; Li, Qinxi; Rui, Hongliang; Luo, Wen; Zhou, Haimeng; Cheung, Po Yan; Wu, Zhenguo; Ye, Zhiyun; Li, Peng; Han, Jiahuai; Lin, Shengcai Article
Elucidation of the c-Jun N-terminal kinase pathway mediated by Epstein-Barr virus-encoded latent membrane protein
Molecular and cellular biology, v. 24, (1), 2004, JAN, p. 192-199
Wan, Jun; Sun, Luguo; Mendoza, Jennifer Woo; Chui, Yiuloon; Huang, Dolly; Chen, Zhijian; Suzuki, Nobutaka; Suzuki, Shinobu; Yeh, Wenchen; Akira, Shizuo; Matsumoto, Kunihiro; Liu, Zhenggang; Wu, Zhenguo Article
p150(Glued), dynein, and microtubules are specifically required for activation of MKK3/6 and p38 MAPKs
Journal of biological chemistry, v. 279, (44), 2004, OCT, p. 45308-45311
Cheung, Po Yan; Zhang, Yi; Long, Jiafu; Lin, Shengcai; Zhang, Mingjie; Jiang, Yong; Wu, Zhenguo Article

2003 2

Functional characterization of an amino-terminal region of HDAC4 that possesses MEF2 binding and transcriptional repressive activity
Journal of biological chemistry, v. 278, (26), 2003, JUN, p. 23515-23521
Chan, Jonathan K.L.; Sun, Luguo; Yang, Xiangjiao; Zhu, Guang; Wu, Zhenguo Article
The involvement of calcineurin in acetylcholine receptor redistribution in muscle
Molecular and Cellular Neuroscience, v. 23, (4), 2003, AUG, p. 587-599
Madhavan, Raghavan; Zhao, Xiaotao; Chan, Frances; Wu, Zhenguo; Peng, Benjamin Hsiao Ming Article

2002 3

p38 mitogen-activated protein kinase-, calcium-calmodulin-dependent protein kinase-, and calcineurin-mediated signaling pathways transcriptionally regulate myogenin expression
Molecular biology of the cell, v. 13, (6), 2002, p. 1940-1952
Xu, Qing; Yu, Lu; Liu, Lanying; Cheung, Ching Fung; Li, Xue; Yee, Siupok; Yang, Xiangjiao; Wu, Zhenguo Article
Positive feedback regulation between Akt2 and MyoD during muscle differentiation - Cloning of Akt2 promoter
Journal of biological chemistry, v. 277, (26), 2002, JUN, p. 23230-23235
Kaneko, Satoshi; Feldman, Richard I.; Yu, Lu; Wu, Zhenguo; Gritsko, Tatiana M.; Shelley, Sue A.; Nicosia, Santo Valeric; Nobori, Tsutomu; Cheng, Jinquan Article
Involvement of the ser/thr phosphatase calcineurin in acetylcholine receptor dispersal and clustering
Gordon Research Conference, HKUST, Hong Kong
Madhavan, Raghavan; Chan, Frances; Wu, Zhenguo; Peng, Benjamin Hsiao Ming Conference paper

2001 1

p38 Mitogen-activated Protein Kinase-, Calcium-Calmodulin-dependent Protein Kinase-, and Calcineurin-mediated Signaling Pathways Transcriptionally Regulate Myogenin Expression
The 9th SCBA International Symposium, Taipai, 5-10 August 2001, p. 218
Xu, Qing; Cheung, Ching Fung; Liu, Lanying; Li, Xue; Yee, Siupok; Yang, Xiangjiao; Wu, Zhenguo Conference paper

2000 3

Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells
Genes and Development, v. 14, (5), March 2000, p. 574-584
Puri, Pier Lorenzo Orenzo; Wu, Zhenguo; Zhang, Peilin; Wood, Lauren D.; Bhakta, Kunjan S.; Han, Jiahuai; Feramisco, James R.; Karin, Michael; Wang, Jean Y.J. Article
p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps
Molecular and Cellular Biology, v. 20, (11), 2000, p. 3951-3964
Wu, Zhenguo; Woodring, Pamela J.; Bhakta, Kunjan S.; Tamura, Kumiko; Wen, Fang; Feramisco, James R.; Karin, Michael; Wang, Jean Y.J.; Puri, Pier Lorenzo Orenzo Article
The insulin-like growth factor-phosphatidylinositol 3-kinase-Akt signaling pathway regulates myogenin expression in normal myogenic cells but not in Rhabdomyosarcoma-derived RD cells
Journal of biological chemistry, v. 275, (47), 2000, NOV, p. 36750-36757
Xu, Qing; Wu, Zhenguo Article

1998 3

JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension
Genes and Development, v. 12, (21), Nov 1998, p. 3369-3381
Xia, Ying; Wu, Zhenguo; Su, Bing; Murray, Brion William; Karin, Michael Article
Mutations in domain IIIα of the Mu transposase: Evidence suggesting an active site component which interacts with the Mu-host junction
Journal of Molecular Biology, v. 282, (2), 1998, p. 265-274
Naigamwalla, Darius Z.; Coros, Colin Joseph; Wu, Zhenguo; Chaconas, George Article
Stabilisation of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway
Science, v. 280, (5371), 1998, Jun, p. 1945-1949
Chen, Chingyi; Del Gatto-Konczak, Fabienne; Wu, Zhenguo; Karin, Michael Article

1997 2

Molecular cloning and Characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase
Molecular and Cellular Biology, v. 17, (12), 1997, p. 7407-7416
Wu, Zhenguo; Wu, Jun; Jacinto, Estela; Karin, Michael Article
The Mu transposase tetramer is inactive in unassisted strand transfer: an auto-allosteric effect of Mu A promotes the reaction in the absence of Mu B
Journal of Molecular Biology, v. 267, (1), 1997, p. 132-141
Wu, Zhenguo; Chaconas, George Article

1995 1

A novel DNA binding and nuclease activity in Mu transposase: localization of a catalytic region involved in donor cleavage
The EMBO Journal, v. 14, (15), 1995, p. 3835-3843
Wu, Zhenguo; Chaconas, George Article

1994 1

Characterization of a region in Mu transposase that is involved in interaction with Mu B protein
Journal of biological chemistry, v. 269, (46), Nov 1994, p. 28829-28833
Wu, Zhenguo; Chaconas, George Article

1992 1

Flanking host sequences can exert an inhibitory effect on the cleavage step of the in vitro Mu DNA strand transfer reaction
Journal of Biological Chemistry, v. 267, (14), May 1992, p. 9552-9558
Wu, Zhenguo; Chaconas, George Article


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Article 2

Paxbp1 controls a key checkpoint for cell growth and survival during early activation of quiescent muscle satellite cells
Proceedings of the National Academy of Sciences of the United States of America, v. 118, (13), March 2021, article number e2021093118
Zhou, Shaopu; Han, Lifang; Weng, Mingxi; Zhu, Han; Heng, Youshan; Wang, Gang; Shen, Zeyu; Chen, Xianwei; Fu, Xinrong; Zhang, Mingjie; Wu, Zhenguo
Type 2 Diabetic Mice Enter A State Of Spontaneous Hibernation- Like Suspended Animation Following Accumulation Of Uric Acid
Journal of Biological Chemistry, v. 297, (4), October 2021, article number 101166
Zhao, Yang; Cheng, Rui; Zhao, Yue; Ge, Wenhao; Yang, Yunxia; Ding, Zhao; Xu, Xi; Wang, Zhongqiu; Wu, Zhenguo; Zhang, Jianfa


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Article 1

A long noncoding RNA, LncMyoD, modulates chromatin accessibility to regulate muscle stem cell myogenic lineage progression
Proceedings of the National Academy of Sciences of the United States of America, v. 117, (51), December 2020, p. 32464-32475
Dong, Anqi; Preusch, Christopher Brandon; So, Wai Kin; Lin, Kangning; Luan, Shaoyuan; Yi, Ran; Wong, Wing Chiu; Wu, Zhenguo; Cheung, Hiu Tung


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Article 3

In vivo study of metabolic dynamics and heterogeneity in brown and beige fat by label‐free multiphoton redox and fluorescence lifetime microscopy
Journal of Biophotonics, 18 October 2019, article number e201960057
He, Sicong; Wei, Xiuqing; Qin, Zhongya; Chen, Congping; Wu, Zhenguo; Qu, Jianan
Structure of BAl1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds
Nature Communications, v. 10, (1), December 2019, article number 51
Weng, Zhuangfeng; Situ, Chenghao; Lin, Lin; Wu, Zhenguo; Zhu, Jinwei; Zhang, Rongguang
YY1 Regulates Skeletal Muscle Regeneration Through Controlling Metabolic Reprogramming of Satellite Cells
EMBO Journal, v. 38, (10), May 2019, article number e99727
Chen, Fengyuan; Zhou, Jiajian; Li, Yuying; Zhao, Yu; Yuan, Jie; Cao, Yang; Wang, Lijun; Zhang, Zongkang; Zhang, Baoting; Wang, Chi Chiu; Cheung, Tom H.; Wu, Zhenguo; Wong, Carmen Chak‐Lui; Sun, Hao; Wang, Huating


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Article 3

In Vivo Imaging-guided Microsurgery Based on Femtosecond Laser Produced New Fluorescent Compounds in Biological Tissues
Biomedical Optics Express, v. 9, (2), February 2018, p. 581-590
Sun, Qiqi; Qin, Zhongya; Wu, Wanjie; Lin, Yue; Chen, Congping; He, Sicong; Li, Xuesong; Wu, Zhenguo; Luo, Yi; Qu, Jianan Y.
In vivo metabolic imaging and monitoring of brown and beige fat
Journal of Biophotonics, v. 11, (8), August 2018, article number e201800019
He, Sicong; An, yitai; Li, Xuesong; Wei, Xiuqing; Sun, qiqi; Wu, Zhenguo; Qu, Jianan
p110α of PI3K is Necessary and Sufficient for Quiescence Exit in Adult Muscle Satellite Cells
EMBO journal, v. 37, (8), April 2018, article number e98239
Wang, Gang; Zhu, Han; Situ, Chenghao; Han, Lifang; Yu, Youqian; Cheung, Tom H.; Liu, Kai; Wu, Zhenguo

Conference paper 2

In vivo two-photon imaging of macrophage activities in skeletal muscle regeneration
Proceedings of SPIE: Progress in Biomedical Optics and Imaging, v. 10497, 2018, article number 1049704
Qin, Zhongya; Long, Yanyang; Sun, Qiqi; He, Sicong; Li, Xuesong; Chen, Congping; Wu, Zhenguo; Qu, Jianan
Integrated SRS And Fluorescence Imaging For Study Of Thermogenesis And Lipid Metabolism In Vivo
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, v. 10498, 2018, article number 104981I
He, Sicong; An, Yitai; Li, Xuesong; Wu, Zhenguo; Qu, Jianan


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Article 2

A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes
Developmental Cell, v. 41, (4), May 2017, p. 382-391.e5
An, Yitai; Wang, Gang; Diao, Yarui; Long, Yanyang; Fu, Xinrong; Weng, Mingxi; Zhou, Liang; Sun, Kun; Cheung, Tom H.; Ip, Nancy Yuk-yu; Sun, Hao; Wang, Huating; Wu, Zhenguo
Malat1 Regulates Myogenic Differentiation and Muscle Regeneration Through Modulating MyoD Transcriptional Activity
Cell Discovery, v. 3, March 2017, article number 17002
Chen, Xiaona; He, Liangqiang; Zhao, Yu; Li, Yuying; Zhang, Suyang; Sun, Kun; So, Karl; Chen, Fengyuan; Zhou, Liang; Lu, Leina; Wang, Lijun; Zhu, Xihua; Bao, Xichen; Esteban, Miguel A.; Nakagawa, Shinichi; Prasanth, Kannanganattu V.; Wu, Zhenguo; Sun, Hao; Wang, Huating


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Article 2

Cyclin G2 Inhibits Epithelial-to-Mesenchymal Transition by Disrupting Wnt/β-Catenin Signaling
Oncogene, v. 35, (36), September 2016, p. 4816-4827
Bernaudo, Stefanie; Salem, Mohamed; Qi, X.; Zhou, W.; Zhang, C.; Yang, W.; Rosman, D.; Deng, Z.; Ye, G.; Yang, Burton; Vanderhyden, Barbara C.; Wu, Zhenguo; Peng, C.
STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration
Cell Reports, v. 16, (8), 23 August 2016, p. 2102-2115
Zhu, Han; Xiao, Fang; Wang, Gang; Wei, Xiuqing; Jiang, Lei; Chen, Yan; Zhu, Lin; Wang, Haixia; Diao, Yarui; Wang, Huating; Ip, Nancy Y Y; Cheung, Tom H.; Wu, Zhenguo


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Article 2

A Universal and Facile Approach for the Formation of a Protein Hydrogel for 3D Cell Encapsulation
Advanced Functional Materials, v. 25, (39), October 2015, p. 6189-6198
Chen, Yin; Dai, Xin; Huang, Lu; Sun, Yang; Chan, Ho Nam; Shen, Bo; Zeng, Xiaoqian; Wu, Zhenguo; Hsing, I-Ming; Guo, Zhihong; Wu, Hongkai
MicroRNAs 99b-5p/100-5p Regulated by Endoplasmic Reticulum Stress are Involved in Abeta-Induced Pathologies
Frontiers in Aging Neuroscience, v. 7, November 2015, article number 210
Ye, Xiaoyang; Luo, Hongxue; Chen, Yan; Wu, Qi; Xiong, Yi; Zhu, Yinyong; Diao, Yarui; Wu, Zhenguo; Miao, Jianting; Wan, Jun


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Article 3

Cdk5-dependent Mst3 phosphorylation and activity regulate neuronal migration through RhoA inhibition
The Journal of neuroscience, v. 34, (22), May 2014, p. 7425-7436
Tang, Jing; Ip, Pak Kan; Ye, Tao; Ng, Yu Pong; Yung, Wing-Ho; Wu, Zhenguo; Fang, Weiqun; Fu, Kit Yu; Ip, Nancy Y Y
Label-free multimodal nonlinear optical microscopy reveals fundamental insights of skeletal muscle development
Biomedical Optics Express, v. 5, (1), January 2014, p. 158-166
Sun, Qiqi; Li, Yanfeng; He, Sicong; Situ, Chenghao; Wu, Zhenguo; Qu, Jianan
miR-203, a Tumor Suppressor Frequently Down-regulated by Promoter Hypermethylation in Rhabdomyosarcoma
Journal of Biological Chemistry, v. 289, (1), January 2014, p. 529-539
Diao, Yarui; Guo, Xing; Jiang, Lei; Wang, Gang; Zhang, Chao; Wan, Jun; Jin, Yan; Wu, Zhenguo

Conference paper 1

Advanced nonlinear optical microscopy for imaging of development of skeletal muscle
Biomedical Optics (BIOMED), Miami, Florida, USA, 26-30 April 2014
Sun, Qiqi; Li, Yanfeng; He, Sicong; Situ, Chenghao; Wu, Zhenguo; Qu, Jianan


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Conference paper 1

Cdk5-dependent Phosphorylation of Mst3 Regulates Radial Migration through Modulating RhoA Activity
2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The Chinese University of Hong Kong, Hong Kong, 15 June 2013
Tang, Jing; Ip, Jacque Pak Kan; Fang, Weiqun; Zhong, Wanting; Ng, Yu Pong; Wu, Zhenguo; Shi, Lei; Fu, Kit Yu; Ip, Nancy Yuk-Yu


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Article 8

A continuous spectrophotometric assay for mitogen-activated protein kinase kinases
Analytical biochemistry, v. 421, (1), 2012, p. 191-197
Zheng, Lisha; Zhang, Yuanyuan; Wu, Jiawei; Wu, Zhenguo; Zhang, Zhongyin; Wang, Zhixin
A novel mechanism of control of NF kappa B activation and inflammation involving A(2B) adenosine receptors
Journal of cell science, v. 125, (19), 2012, p. 4507-4517
Sun, Ying; Duan, Yuanyuan; Eisenstein, Anna S.; Hu, Wenbao; Quintana, Adrien; Lam, Wai Kwan; Wang, Yan; Wu, Zhenguo; Ravid, Katya; Huang, Pingbo
Impact of SARS-coronavirus-encoded proteins on cellular signalling pathways and cytokine/chemokine gene expression
Hong Kong medical journal, v. 18, (4), 2012, p. 16-19
Chan, Jonathan K.L.; Cheung, Po Yan; He, Mingliang; Wu, Zhenguo
Keratin K18 Increases Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Surface Expression by Binding to Its C-terminal Hydrophobic Patch
Journal of Biological Chemistry, v. 287, (48), 2012, Nov, p. 40547-40559
Duan, Yuanyuan; Sun, Ying; Zhang, Fan; Zhang, Wei; Wang, Dong; Wang, Yan; Cao, Xu; Hu, Wenbao; Xie, Changyan; Cuppoletti, John; Magin, Thomas Michael; Wang, Haixia; Wu, Zhenguo; Li, Ning; Huang, Pingbo
Loss of STAT1 in bone marrow-derived cells accelerates skeletal muscle regeneration
PLoS ONE, v. 7, (5), 2012, Article number e37656
Gao, Yan; Li, Yanfeng; Guo, Xing; Wu, Zhenguo; Zhang, Wei
Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism
Cell stem cell, v. 11, (2), 2012, Aug, p. 231-241
Diao, Yarui; Guo, Xing; Li, Yanfeng; Sun, Kun; Lu, Leina; Jiang, Lei; Fu, Xinrong; Zhu, Han; Sun, Hao; Wang, Huating; Wu, Zhenguo
Signal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex
EMBO journal, v. 31, (2), 2012, p. 301-316
Forcales, Sonia Vanina; Albini, Sonia; Giordani, Lorenzo; Malecová, Barbora; Cignolo, Luca; Chernov, Andrei V.; Coutinho, Paula; Saccone, Valentina; Consalvi, Silvia; Williams, Roy Steve; Wang, Kepeng; Wu, Zhenguo; Baranovskaya, Svetlana S.; Miller, Andrew M.; Dilworth, F. Jeffrey; Puri, Pier Lorenzo Orenzo
TRAF6 promotes myogenic differentiation via the TAK1/p38 mitogen-activated protein kinase and akt pathways
PLoS ONE, v. 7, (4), 2012, Apr, Article number e34081
Xiao, Fang; Wang, Haixia; Fu, Xinrong; Li, Yanfeng; Wu, Zhenguo

Conference paper 1

Functional Roles of Mst3 in Radial Migration During the Development of Mouse Cerebral Cortex
The 42nd Annual Meeting of the Society for Neuroscience, New Orleans, USA, 13–17 October 2012
Tang, Jing; Ip, Pak Kan; Fang, Weiqun; Zhong, Weiting; Ng, Yu Pong; Wu, Zhenguo; Shi, Lei; Fu, Kit Yu; Ip, Nancy Yuk-Yu


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Article 2

Expression of Gα_z in C2C12 Cells Restrains Myogenic Differentiation
Cellular Signalling, v. 23, (2), February 2011, p. 389-397
Mei, Hua; Ho, Kwok Chung Maurice; Yung, Ying; Wu, Zhenguo; Ip, Nancy Yuk-yu; Wong, Yung Hou
Oncostatin M inhibits myoblast differentiation and regulates muscle regeneration
Cell Research, v. 21, (2), 2011, p. 350-364
Xiao, Fang; Wang, Haixia; Fu, Xinrong; Li, Yanfeng; Ma, Kewei; Sun, Luguo; Gao, Xiang; Wu, Zhenguo


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Article 4

Nerve Growth Factor-Induced Differentiation of PC12 Cells Is Accompanied by Elevated Adenylyl Cyclase Activity
NeuroSignals, v. 18, (1), September 2010, p. 32-42
Yung, H.S.; Lai, K.H.; Chow, Kevin B.S.; Ip, Nancy Yuk-Yu; Tsim, Karl Wah Keung; Wong, Yung Hou; Wu, Zhenguo; Wise, Helen
Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding
Proceedings of the National Academy of Sciences of the United States of America, v. 107, (49), December 2010, p. 20974-20979
Diao, Yarui; Liu, Wei; Wong, Catherine C.L.; Wang, Xi; Lee, Ka Man; Cheung, Po Yan; Pan, Lifeng; Xu, Tao; Han, Jiahuai; Yates, John Robert R.; Zhang, Mingjie; Wu, Zhenguo
Role of mitogen-activated protein kinase in Zn-BC-AM PDT-induced apoptosis in nasopharyngeal carcinoma cells
Cell biochemistry and function, v. 28, (3), 2010, APR, p. 239-248
Koon, Ho Kee; Chan, Pui Shan; Wu, Zhenguo; Wong, Ricky Ngok Shun; Lung, Maria; Chang, Chi Kwong; Mak, Nai Ki
Tyk2/STAT3 Signaling Mediates beta-Amyloid-Induced Neuronal Cell Death: Implications in Alzheimer's Disease
Journal of Neuroscience, v. 30, (20), May 2010, p. 6873-6881
Wan, Jun; Fu, Kit Yu; Ip, Fanny Chui Fun; Ng, Ho Keung; Hugon, Jacques; Page, Guylène K.; Wang, Jerry Hsueh-ching; Lai, Kwok On; Wu, Zhenguo; Ip, Nancy Yuk-yu


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Article 2

Differential and Synergistic Effect of Nerve Growth Factor and cAMP on the Regulation of Early Response Genes during Neuronal Differentiation
NeuroSignals, v. 17, (2), May 2009, p. 111-120
Ng, Yu Pong; Wu, Zhenguo; Wise, Helen; Tsim, Karl Wah Keung; Wong, Yung Hou; Ip, Nancy Yuk-Yu
SOCS1, SOCS3, and PIAS1 Promote Myogenic Differentiation by Inhibiting the Leukemia Inhibitory Factor-Induced JAK1/STAT1/STAT3 Pathway
Molecular and cellular biology, v. 29, (18), 2009, SEP, p. 5084-5093
Diao, Yarui; Wang, Xi; Wu, Zhenguo

Conference paper 1

Screening of Essential Kinases for Neuronal Differentiation
The 6th Asian Biophysics Association Symposium, Hong Kong, 11 - 15 January 2009
Ng, Yu Pong; Lai, Kwok On; An, Hui Jin; Wu, Zhenguo; Ip, Nancy Yuk-Yu


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Article 3

Involvement of the p38 mitogen-activated protein kinase alpha, beta, and gamma isoforms in myogenic differentiation
Molecular biology of the cell, v. 19, (4), 2008, APR, p. 1519-1528
Wang, Haixia; Xu, Qing; Xiao, Fang; Jiang, Yong; Wu, Zhenguo
Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma
Hepatology, v. 47, (2), 2008, FEB, p. 503-510
Ma, Ningfang; Hu, Liang; Fung, Jackie Mei Wah; Xie, Dan; Zheng, Bojian; Chen, Leilei; Tang, Dongjiang; Fu, Li; Wu, Zhenguo; Chen, Muhan; Fang, Yan; Guan, Xinyuan
JAK2/STAT2/STAT3 Are Required for Myogenic Differentiation
Journal of biological chemistry, v. 283, (49), 2008, DEC, p. 34029-34036
Wang, Kepeng; Wang, Chihao; Xiao, Fang; Wang, Haixia; Wu, Zhenguo

Conference paper 3

GAlphaz Inhibits Myogenic Differentiation of C2C12 Cells
The 9th AEARU Workshop on Molecular Biology and Biotechnology, Hong Kong, 25 - 26 March 2008
Ho, Kwok Chung Maurice; Mei, Hua; Yung, Ying; Wu, Zhenguo; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Mechanistic study of the LMP1-mediated non-canonical NF-kappaB pathway
The 13th Biennial Conference of the International Association for Research on Epstein-Barr virus and associated diseases, Guangzhou, China, November 7-10, 2008, p. 69
Cheung, Po Yan; Wu, Zhenguo
The role of the suppressor of cytokine signaling (SOCS) proteins in skeletal muscle differentiation
First EMBO Conference on teh molecular and cellular mechanisms regulating skeletal muscle development and regeneration, Sant Feliu de Guixols, Spain, Sept 24-29, 2008
Wang, Xi; Diao, Yarui; Wu, Zhenguo


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Article 6

BS69 is involved in cellular senescence through the p53-p21Cip1 pathway
EMBO reports, v. 8, (10), 2007, October, p. 952-958
Zhang, Wei; Chan, Homan; Gao, Yan; Poon, Randy Yat Choi; Wu, Zhenguo
Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins
FEBS letters, v. 581, (2), 2007, JAN, p. 196-202
Zou, Haiying; Li, Qinxi; Lin, Shengcai; Wu, Zhenguo; Han, Jiahuai; Ye, Zhiyun
JAK1-STAT1-STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts
Journal of Cell Biology, v. 179, (1), October 2007, p. 129-138
Sun, Luguo; Ma, Kewei; Wang, Haixia; Xiao, Fang; Gao, Yan; Zhang, Wei; Wang, Kepeng; Gao, Xiang; Ip, Nancy Yuk-Yu; Wu, Zhenguo
Latent membrane protein 1 suppresses RASSF1A expression, disrupts microtubule structures and induces chromosomal aberrations in human epithelial cells
Oncogene, v. 26, (21), 2007, p. 3069-3080
Man, Cornelia; Rosa, Jack; Lee, Leo Tsz On; Lee, Vien H.Y.; Chow, Billy K.C.; Lo, Kwok Wai; Doxsey, Stephen John; Wu, Zhenguo; Kwong, Yok Lam; Jin, Dong Yan; Cheung, Annie Lai Man; Tsao, George Sai Wah
Myostatin induces cyclin D1 degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/AKT/GSK-3β pathway and is antagonized by insulin-like growth factor
Journal of biological chemistry, v. 282, (6), 2007, p. 3799-3808
Yang, Wei; Zhang, Yong; Li, Yanfeng; Wu, Zhenguo; Zhu, Dahai
Sequential recruitment of PCAF and BRG1 contributes to myogenin activation in 12-O-tetradecanoylphorbol-13-acetate-induced early differentiation of rhabdomyosarcoma-derived cells
Journal of biological chemistry, v. 282, (26), 2007, JUN, p. 18872-18878
Li, Zhaoyong; Yang, Jun; Gao, Xin; Lu, Jianyi; Zhang, Yi; Wang, Kepeng; Cheng, Mobin; Wu, Ninghua; Zhang, Ye; Wu, Zhenguo; Shen, Yufei


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Article 4

BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway
Molecular and cellular biology, v. 26, (2), 2006, JAN, p. 448-456
Wan, Jun; Zhang, Wei; Wu, Liming; Bai, Ting; Zhang, Mingjie; Lo, Kwok Wai; Chui, Yiuloon; Cui, Yan; Tao, Qian; Yamamoto, Masahiro; Akira, Shizuo; Wu, Zhenguo
Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation
Journal of biological chemistry, v. 281, (7), 2006, FEB, p. 4423-4433
Grégoire, Serge; Tremblay, Annie M.; Xiao, Lin; Yang, Qian; Ma, Kewei; Nie, Jianyun; Mao, Zixu; Wu, Zhenguo; Giguère, Vincent; Yang, Xiangjiao
Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase
International journal of cancer, v. 119, (7), 2006, OCT, p. 1567-1576
Li, Hoiming; Man, Cornelia; Jin, Yuesheng; Deng, Wen; Yip, Yimling; Feng, Huichen; Cheung, Yukchun; Lo, Kwok Wai; Meltzer, Paul S.; Wu, Zhenguo; Kwong, Yok Lam; Yuen, Anthony Po Wing; Tsao, George Sai Wah
The C-terminal activating region 2 of the Epstein-Barr virus-encoded latent membrane protein 1 activates NF-kappa B through TRAF6 and TAK1
Journal of biological chemistry, v. 281, (4), 2006, JAN, p. 2162-2169
Wu, Liming; Nakano, Hiroyasu; Wu, Zhenguo


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Article 3

Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome
American journal of respiratory and critical care medicine, v. 171, (8), 2005, APR, p. 850-857
Jiang, Yong; Xu, Jun; Zhou, Chengzhi; Wu, Zhenguo; Zhong, Shuqing; Liu, Jinghua; Luo, Wei; Chen, Tao; Qin, Qinghe; Deng, Peng
Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation
Molecular and cellular biology, v. 25, (9), 2005, MAY, p. 3575-3582
Ma, Kewei; Chan, Jonathan K.L.; Zhu, Guang; Wu, Zhenguo
The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation
Journal of biological chemistry, v. 280, (9), 2005, MAR, p. 8172-8179
Lo, Kevin W.H.; Kan, Homan; Chan, Ling Nga; Xu, Weiguang; Wang, Kepeng; Wu, Zhenguo; Sheng, Morgan; Zhang, Mingjie

Conference paper 4

Identification of Critical Early Genes Involved in Nerve Growth Factor-Induced PC12 Differentiation
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5 - 6 December 2005
Xiao, Fang; Ng, Yu Pong; Tsim, Karl Wah Keung; Wise, Helen; Wong, Yung Hou; Ip, Nancy Yuk-Yu; Wu, Zhenguo
NGF-Induced Neuronal Differentiation of PC12 Cells: Delineation of Signaling Molecules and Mapping of Pathways.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5 - 6 December 2005
Leung, W.K.W.; Choi, Chi Yan; Ip, Nancy Yuk-Yu; Wu, Zhenguo; Wong, Yung Hou; Cheung, P.T.; Tsim, Karl Wah Keung
Overexpression of Galphaz Inhibits Muscle Differentiation
Abstract P-14
Mei, Hua; Wu, Zhenguo; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Role of Calmodulin-Dependent Kinase II in Nerve Growth Factor-Induced Differentiation of PC12 Cells.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5-6 December 2005
Kam, Yuet Fong; Yung, Ying; Wu, Eddy H.T.; Ng, Yu Pong; Wu, Zhenguo; Tsim, Karl Wah Keung; Wise, Helen; Ip, Nancy Yuk-Yu; Wong, Yung Hou


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Article 4

Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation
Journal of cell science, v. 117, (14), 2004, JUN, p. 3021-3029
Sun, Luguo; Liu, Lanying; Yang, Xiangjiao; Wu, Zhenguo
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation
EMBO journal, v. 23, (23), 2004, NOV, p. 4583-4594
Rui, Yanning; Xu, Zhen; Lin, Shuyong; Li, Qinxi; Rui, Hongliang; Luo, Wen; Zhou, Haimeng; Cheung, Po Yan; Wu, Zhenguo; Ye, Zhiyun; Li, Peng; Han, Jiahuai; Lin, Shengcai
Elucidation of the c-Jun N-terminal kinase pathway mediated by Epstein-Barr virus-encoded latent membrane protein
Molecular and cellular biology, v. 24, (1), 2004, JAN, p. 192-199
Wan, Jun; Sun, Luguo; Mendoza, Jennifer Woo; Chui, Yiuloon; Huang, Dolly; Chen, Zhijian; Suzuki, Nobutaka; Suzuki, Shinobu; Yeh, Wenchen; Akira, Shizuo; Matsumoto, Kunihiro; Liu, Zhenggang; Wu, Zhenguo
p150(Glued), dynein, and microtubules are specifically required for activation of MKK3/6 and p38 MAPKs
Journal of biological chemistry, v. 279, (44), 2004, OCT, p. 45308-45311
Cheung, Po Yan; Zhang, Yi; Long, Jiafu; Lin, Shengcai; Zhang, Mingjie; Jiang, Yong; Wu, Zhenguo


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Article 2

Functional characterization of an amino-terminal region of HDAC4 that possesses MEF2 binding and transcriptional repressive activity
Journal of biological chemistry, v. 278, (26), 2003, JUN, p. 23515-23521
Chan, Jonathan K.L.; Sun, Luguo; Yang, Xiangjiao; Zhu, Guang; Wu, Zhenguo
The involvement of calcineurin in acetylcholine receptor redistribution in muscle
Molecular and Cellular Neuroscience, v. 23, (4), 2003, AUG, p. 587-599
Madhavan, Raghavan; Zhao, Xiaotao; Chan, Frances; Wu, Zhenguo; Peng, Benjamin Hsiao Ming


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Article 2

p38 mitogen-activated protein kinase-, calcium-calmodulin-dependent protein kinase-, and calcineurin-mediated signaling pathways transcriptionally regulate myogenin expression
Molecular biology of the cell, v. 13, (6), 2002, p. 1940-1952
Xu, Qing; Yu, Lu; Liu, Lanying; Cheung, Ching Fung; Li, Xue; Yee, Siupok; Yang, Xiangjiao; Wu, Zhenguo
Positive feedback regulation between Akt2 and MyoD during muscle differentiation - Cloning of Akt2 promoter
Journal of biological chemistry, v. 277, (26), 2002, JUN, p. 23230-23235
Kaneko, Satoshi; Feldman, Richard I.; Yu, Lu; Wu, Zhenguo; Gritsko, Tatiana M.; Shelley, Sue A.; Nicosia, Santo Valeric; Nobori, Tsutomu; Cheng, Jinquan

Conference paper 1

Involvement of the ser/thr phosphatase calcineurin in acetylcholine receptor dispersal and clustering
Gordon Research Conference, HKUST, Hong Kong
Madhavan, Raghavan; Chan, Frances; Wu, Zhenguo; Peng, Benjamin Hsiao Ming


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Conference paper 1

p38 Mitogen-activated Protein Kinase-, Calcium-Calmodulin-dependent Protein Kinase-, and Calcineurin-mediated Signaling Pathways Transcriptionally Regulate Myogenin Expression
The 9th SCBA International Symposium, Taipai, 5-10 August 2001, p. 218
Xu, Qing; Cheung, Ching Fung; Liu, Lanying; Li, Xue; Yee, Siupok; Yang, Xiangjiao; Wu, Zhenguo


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Article 3

Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells
Genes and Development, v. 14, (5), March 2000, p. 574-584
Puri, Pier Lorenzo Orenzo; Wu, Zhenguo; Zhang, Peilin; Wood, Lauren D.; Bhakta, Kunjan S.; Han, Jiahuai; Feramisco, James R.; Karin, Michael; Wang, Jean Y.J.
p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps
Molecular and Cellular Biology, v. 20, (11), 2000, p. 3951-3964
Wu, Zhenguo; Woodring, Pamela J.; Bhakta, Kunjan S.; Tamura, Kumiko; Wen, Fang; Feramisco, James R.; Karin, Michael; Wang, Jean Y.J.; Puri, Pier Lorenzo Orenzo
The insulin-like growth factor-phosphatidylinositol 3-kinase-Akt signaling pathway regulates myogenin expression in normal myogenic cells but not in Rhabdomyosarcoma-derived RD cells
Journal of biological chemistry, v. 275, (47), 2000, NOV, p. 36750-36757
Xu, Qing; Wu, Zhenguo


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Article 3

JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension
Genes and Development, v. 12, (21), Nov 1998, p. 3369-3381
Xia, Ying; Wu, Zhenguo; Su, Bing; Murray, Brion William; Karin, Michael
Mutations in domain IIIα of the Mu transposase: Evidence suggesting an active site component which interacts with the Mu-host junction
Journal of Molecular Biology, v. 282, (2), 1998, p. 265-274
Naigamwalla, Darius Z.; Coros, Colin Joseph; Wu, Zhenguo; Chaconas, George
Stabilisation of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway
Science, v. 280, (5371), 1998, Jun, p. 1945-1949
Chen, Chingyi; Del Gatto-Konczak, Fabienne; Wu, Zhenguo; Karin, Michael


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Article 2

Molecular cloning and Characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase
Molecular and Cellular Biology, v. 17, (12), 1997, p. 7407-7416
Wu, Zhenguo; Wu, Jun; Jacinto, Estela; Karin, Michael
The Mu transposase tetramer is inactive in unassisted strand transfer: an auto-allosteric effect of Mu A promotes the reaction in the absence of Mu B
Journal of Molecular Biology, v. 267, (1), 1997, p. 132-141
Wu, Zhenguo; Chaconas, George


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Article 1

A novel DNA binding and nuclease activity in Mu transposase: localization of a catalytic region involved in donor cleavage
The EMBO Journal, v. 14, (15), 1995, p. 3835-3843
Wu, Zhenguo; Chaconas, George


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Article 1

Characterization of a region in Mu transposase that is involved in interaction with Mu B protein
Journal of biological chemistry, v. 269, (46), Nov 1994, p. 28829-28833
Wu, Zhenguo; Chaconas, George


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Article 1

Flanking host sequences can exert an inhibitory effect on the cleavage step of the in vitro Mu DNA strand transfer reaction
Journal of Biological Chemistry, v. 267, (14), May 1992, p. 9552-9558
Wu, Zhenguo; Chaconas, George


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2016 2

Cyclin G2 Inhibits Epithelial-to-Mesenchymal Transition by Disrupting Wnt/β-Catenin Signaling
Oncogene, v. 35, (36), September 2016, p. 4816-4827
Bernaudo, Stefanie; Salem, Mohamed; Qi, X.; Zhou, W.; Zhang, C.; Yang, W.; Rosman, D.; Deng, Z.; Ye, G.; Yang, Burton; Vanderhyden, Barbara C.; Wu, Zhenguo; Peng, C. Article
STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration
Cell Reports, v. 16, (8), 23 August 2016, p. 2102-2115
Zhu, Han; Xiao, Fang; Wang, Gang; Wei, Xiuqing; Jiang, Lei; Chen, Yan; Zhu, Lin; Wang, Haixia; Diao, Yarui; Wang, Huating; Ip, Nancy Y Y; Cheung, Tom H.; Wu, Zhenguo Article

2015 2

A Universal and Facile Approach for the Formation of a Protein Hydrogel for 3D Cell Encapsulation
Advanced Functional Materials, v. 25, (39), October 2015, p. 6189-6198
Chen, Yin; Dai, Xin; Huang, Lu; Sun, Yang; Chan, Ho Nam; Shen, Bo; Zeng, Xiaoqian; Wu, Zhenguo; Hsing, I-Ming; Guo, Zhihong; Wu, Hongkai Article
MicroRNAs 99b-5p/100-5p Regulated by Endoplasmic Reticulum Stress are Involved in Abeta-Induced Pathologies
Frontiers in Aging Neuroscience, v. 7, November 2015, article number 210
Ye, Xiaoyang; Luo, Hongxue; Chen, Yan; Wu, Qi; Xiong, Yi; Zhu, Yinyong; Diao, Yarui; Wu, Zhenguo; Miao, Jianting; Wan, Jun Article

2014 4

Cdk5-dependent Mst3 phosphorylation and activity regulate neuronal migration through RhoA inhibition
The Journal of neuroscience, v. 34, (22), May 2014, p. 7425-7436
Tang, Jing; Ip, Pak Kan; Ye, Tao; Ng, Yu Pong; Yung, Wing-Ho; Wu, Zhenguo; Fang, Weiqun; Fu, Kit Yu; Ip, Nancy Y Y Article
Label-free multimodal nonlinear optical microscopy reveals fundamental insights of skeletal muscle development
Biomedical Optics Express, v. 5, (1), January 2014, p. 158-166
Sun, Qiqi; Li, Yanfeng; He, Sicong; Situ, Chenghao; Wu, Zhenguo; Qu, Jianan Article
miR-203, a Tumor Suppressor Frequently Down-regulated by Promoter Hypermethylation in Rhabdomyosarcoma
Journal of Biological Chemistry, v. 289, (1), January 2014, p. 529-539
Diao, Yarui; Guo, Xing; Jiang, Lei; Wang, Gang; Zhang, Chao; Wan, Jun; Jin, Yan; Wu, Zhenguo Article
Advanced nonlinear optical microscopy for imaging of development of skeletal muscle
Biomedical Optics (BIOMED), Miami, Florida, USA, 26-30 April 2014
Sun, Qiqi; Li, Yanfeng; He, Sicong; Situ, Chenghao; Wu, Zhenguo; Qu, Jianan Conference paper

2013 1

Cdk5-dependent Phosphorylation of Mst3 Regulates Radial Migration through Modulating RhoA Activity
2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, The Chinese University of Hong Kong, Hong Kong, 15 June 2013
Tang, Jing; Ip, Jacque Pak Kan; Fang, Weiqun; Zhong, Wanting; Ng, Yu Pong; Wu, Zhenguo; Shi, Lei; Fu, Kit Yu; Ip, Nancy Yuk-Yu Conference paper

2012 9

A continuous spectrophotometric assay for mitogen-activated protein kinase kinases
Analytical biochemistry, v. 421, (1), 2012, p. 191-197
Zheng, Lisha; Zhang, Yuanyuan; Wu, Jiawei; Wu, Zhenguo; Zhang, Zhongyin; Wang, Zhixin Article
A novel mechanism of control of NF kappa B activation and inflammation involving A(2B) adenosine receptors
Journal of cell science, v. 125, (19), 2012, p. 4507-4517
Sun, Ying; Duan, Yuanyuan; Eisenstein, Anna S.; Hu, Wenbao; Quintana, Adrien; Lam, Wai Kwan; Wang, Yan; Wu, Zhenguo; Ravid, Katya; Huang, Pingbo Article
Impact of SARS-coronavirus-encoded proteins on cellular signalling pathways and cytokine/chemokine gene expression
Hong Kong medical journal, v. 18, (4), 2012, p. 16-19
Chan, Jonathan K.L.; Cheung, Po Yan; He, Mingliang; Wu, Zhenguo Article
Keratin K18 Increases Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Surface Expression by Binding to Its C-terminal Hydrophobic Patch
Journal of Biological Chemistry, v. 287, (48), 2012, Nov, p. 40547-40559
Duan, Yuanyuan; Sun, Ying; Zhang, Fan; Zhang, Wei; Wang, Dong; Wang, Yan; Cao, Xu; Hu, Wenbao; Xie, Changyan; Cuppoletti, John; Magin, Thomas Michael; Wang, Haixia; Wu, Zhenguo; Li, Ning; Huang, Pingbo Article
Loss of STAT1 in bone marrow-derived cells accelerates skeletal muscle regeneration
PLoS ONE, v. 7, (5), 2012, Article number e37656
Gao, Yan; Li, Yanfeng; Guo, Xing; Wu, Zhenguo; Zhang, Wei Article
Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism
Cell stem cell, v. 11, (2), 2012, Aug, p. 231-241
Diao, Yarui; Guo, Xing; Li, Yanfeng; Sun, Kun; Lu, Leina; Jiang, Lei; Fu, Xinrong; Zhu, Han; Sun, Hao; Wang, Huating; Wu, Zhenguo Article
Signal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex
EMBO journal, v. 31, (2), 2012, p. 301-316
Forcales, Sonia Vanina; Albini, Sonia; Giordani, Lorenzo; Malecová, Barbora; Cignolo, Luca; Chernov, Andrei V.; Coutinho, Paula; Saccone, Valentina; Consalvi, Silvia; Williams, Roy Steve; Wang, Kepeng; Wu, Zhenguo; Baranovskaya, Svetlana S.; Miller, Andrew M.; Dilworth, F. Jeffrey; Puri, Pier Lorenzo Orenzo Article
TRAF6 promotes myogenic differentiation via the TAK1/p38 mitogen-activated protein kinase and akt pathways
PLoS ONE, v. 7, (4), 2012, Apr, Article number e34081
Xiao, Fang; Wang, Haixia; Fu, Xinrong; Li, Yanfeng; Wu, Zhenguo Article
Functional Roles of Mst3 in Radial Migration During the Development of Mouse Cerebral Cortex
The 42nd Annual Meeting of the Society for Neuroscience, New Orleans, USA, 13–17 October 2012
Tang, Jing; Ip, Pak Kan; Fang, Weiqun; Zhong, Weiting; Ng, Yu Pong; Wu, Zhenguo; Shi, Lei; Fu, Kit Yu; Ip, Nancy Yuk-Yu Conference paper

2011 2

Expression of Gα_z in C2C12 Cells Restrains Myogenic Differentiation
Cellular Signalling, v. 23, (2), February 2011, p. 389-397
Mei, Hua; Ho, Kwok Chung Maurice; Yung, Ying; Wu, Zhenguo; Ip, Nancy Yuk-yu; Wong, Yung Hou Article
Oncostatin M inhibits myoblast differentiation and regulates muscle regeneration
Cell Research, v. 21, (2), 2011, p. 350-364
Xiao, Fang; Wang, Haixia; Fu, Xinrong; Li, Yanfeng; Ma, Kewei; Sun, Luguo; Gao, Xiang; Wu, Zhenguo Article

2010 4

Nerve Growth Factor-Induced Differentiation of PC12 Cells Is Accompanied by Elevated Adenylyl Cyclase Activity
NeuroSignals, v. 18, (1), September 2010, p. 32-42
Yung, H.S.; Lai, K.H.; Chow, Kevin B.S.; Ip, Nancy Yuk-Yu; Tsim, Karl Wah Keung; Wong, Yung Hou; Wu, Zhenguo; Wise, Helen Article
Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding
Proceedings of the National Academy of Sciences of the United States of America, v. 107, (49), December 2010, p. 20974-20979
Diao, Yarui; Liu, Wei; Wong, Catherine C.L.; Wang, Xi; Lee, Ka Man; Cheung, Po Yan; Pan, Lifeng; Xu, Tao; Han, Jiahuai; Yates, John Robert R.; Zhang, Mingjie; Wu, Zhenguo Article
Role of mitogen-activated protein kinase in Zn-BC-AM PDT-induced apoptosis in nasopharyngeal carcinoma cells
Cell biochemistry and function, v. 28, (3), 2010, APR, p. 239-248
Koon, Ho Kee; Chan, Pui Shan; Wu, Zhenguo; Wong, Ricky Ngok Shun; Lung, Maria; Chang, Chi Kwong; Mak, Nai Ki Article
Tyk2/STAT3 Signaling Mediates beta-Amyloid-Induced Neuronal Cell Death: Implications in Alzheimer's Disease
Journal of Neuroscience, v. 30, (20), May 2010, p. 6873-6881
Wan, Jun; Fu, Kit Yu; Ip, Fanny Chui Fun; Ng, Ho Keung; Hugon, Jacques; Page, Guylène K.; Wang, Jerry Hsueh-ching; Lai, Kwok On; Wu, Zhenguo; Ip, Nancy Yuk-yu Article

2009 3

Differential and Synergistic Effect of Nerve Growth Factor and cAMP on the Regulation of Early Response Genes during Neuronal Differentiation
NeuroSignals, v. 17, (2), May 2009, p. 111-120
Ng, Yu Pong; Wu, Zhenguo; Wise, Helen; Tsim, Karl Wah Keung; Wong, Yung Hou; Ip, Nancy Yuk-Yu Article
SOCS1, SOCS3, and PIAS1 Promote Myogenic Differentiation by Inhibiting the Leukemia Inhibitory Factor-Induced JAK1/STAT1/STAT3 Pathway
Molecular and cellular biology, v. 29, (18), 2009, SEP, p. 5084-5093
Diao, Yarui; Wang, Xi; Wu, Zhenguo Article
Screening of Essential Kinases for Neuronal Differentiation
The 6th Asian Biophysics Association Symposium, Hong Kong, 11 - 15 January 2009
Ng, Yu Pong; Lai, Kwok On; An, Hui Jin; Wu, Zhenguo; Ip, Nancy Yuk-Yu Conference paper

2008 6

Involvement of the p38 mitogen-activated protein kinase alpha, beta, and gamma isoforms in myogenic differentiation
Molecular biology of the cell, v. 19, (4), 2008, APR, p. 1519-1528
Wang, Haixia; Xu, Qing; Xiao, Fang; Jiang, Yong; Wu, Zhenguo Article
Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma
Hepatology, v. 47, (2), 2008, FEB, p. 503-510
Ma, Ningfang; Hu, Liang; Fung, Jackie Mei Wah; Xie, Dan; Zheng, Bojian; Chen, Leilei; Tang, Dongjiang; Fu, Li; Wu, Zhenguo; Chen, Muhan; Fang, Yan; Guan, Xinyuan Article
JAK2/STAT2/STAT3 Are Required for Myogenic Differentiation
Journal of biological chemistry, v. 283, (49), 2008, DEC, p. 34029-34036
Wang, Kepeng; Wang, Chihao; Xiao, Fang; Wang, Haixia; Wu, Zhenguo Article
GAlphaz Inhibits Myogenic Differentiation of C2C12 Cells
The 9th AEARU Workshop on Molecular Biology and Biotechnology, Hong Kong, 25 - 26 March 2008
Ho, Kwok Chung Maurice; Mei, Hua; Yung, Ying; Wu, Zhenguo; Ip, Nancy Yuk-Yu; Wong, Yung Hou Conference paper
Mechanistic study of the LMP1-mediated non-canonical NF-kappaB pathway
The 13th Biennial Conference of the International Association for Research on Epstein-Barr virus and associated diseases, Guangzhou, China, November 7-10, 2008, p. 69
Cheung, Po Yan; Wu, Zhenguo Conference paper
The role of the suppressor of cytokine signaling (SOCS) proteins in skeletal muscle differentiation
First EMBO Conference on teh molecular and cellular mechanisms regulating skeletal muscle development and regeneration, Sant Feliu de Guixols, Spain, Sept 24-29, 2008
Wang, Xi; Diao, Yarui; Wu, Zhenguo Conference paper

2007 6

BS69 is involved in cellular senescence through the p53-p21Cip1 pathway
EMBO reports, v. 8, (10), 2007, October, p. 952-958
Zhang, Wei; Chan, Homan; Gao, Yan; Poon, Randy Yat Choi; Wu, Zhenguo Article
Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins
FEBS letters, v. 581, (2), 2007, JAN, p. 196-202
Zou, Haiying; Li, Qinxi; Lin, Shengcai; Wu, Zhenguo; Han, Jiahuai; Ye, Zhiyun Article
JAK1-STAT1-STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts
Journal of Cell Biology, v. 179, (1), October 2007, p. 129-138
Sun, Luguo; Ma, Kewei; Wang, Haixia; Xiao, Fang; Gao, Yan; Zhang, Wei; Wang, Kepeng; Gao, Xiang; Ip, Nancy Yuk-Yu; Wu, Zhenguo Article
Latent membrane protein 1 suppresses RASSF1A expression, disrupts microtubule structures and induces chromosomal aberrations in human epithelial cells
Oncogene, v. 26, (21), 2007, p. 3069-3080
Man, Cornelia; Rosa, Jack; Lee, Leo Tsz On; Lee, Vien H.Y.; Chow, Billy K.C.; Lo, Kwok Wai; Doxsey, Stephen John; Wu, Zhenguo; Kwong, Yok Lam; Jin, Dong Yan; Cheung, Annie Lai Man; Tsao, George Sai Wah Article
Myostatin induces cyclin D1 degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/AKT/GSK-3β pathway and is antagonized by insulin-like growth factor
Journal of biological chemistry, v. 282, (6), 2007, p. 3799-3808
Yang, Wei; Zhang, Yong; Li, Yanfeng; Wu, Zhenguo; Zhu, Dahai Article
Sequential recruitment of PCAF and BRG1 contributes to myogenin activation in 12-O-tetradecanoylphorbol-13-acetate-induced early differentiation of rhabdomyosarcoma-derived cells
Journal of biological chemistry, v. 282, (26), 2007, JUN, p. 18872-18878
Li, Zhaoyong; Yang, Jun; Gao, Xin; Lu, Jianyi; Zhang, Yi; Wang, Kepeng; Cheng, Mobin; Wu, Ninghua; Zhang, Ye; Wu, Zhenguo; Shen, Yufei Article

2006 4

BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway
Molecular and cellular biology, v. 26, (2), 2006, JAN, p. 448-456
Wan, Jun; Zhang, Wei; Wu, Liming; Bai, Ting; Zhang, Mingjie; Lo, Kwok Wai; Chui, Yiuloon; Cui, Yan; Tao, Qian; Yamamoto, Masahiro; Akira, Shizuo; Wu, Zhenguo Article
Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation
Journal of biological chemistry, v. 281, (7), 2006, FEB, p. 4423-4433
Grégoire, Serge; Tremblay, Annie M.; Xiao, Lin; Yang, Qian; Ma, Kewei; Nie, Jianyun; Mao, Zixu; Wu, Zhenguo; Giguère, Vincent; Yang, Xiangjiao Article
Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase
International journal of cancer, v. 119, (7), 2006, OCT, p. 1567-1576
Li, Hoiming; Man, Cornelia; Jin, Yuesheng; Deng, Wen; Yip, Yimling; Feng, Huichen; Cheung, Yukchun; Lo, Kwok Wai; Meltzer, Paul S.; Wu, Zhenguo; Kwong, Yok Lam; Yuen, Anthony Po Wing; Tsao, George Sai Wah Article
The C-terminal activating region 2 of the Epstein-Barr virus-encoded latent membrane protein 1 activates NF-kappa B through TRAF6 and TAK1
Journal of biological chemistry, v. 281, (4), 2006, JAN, p. 2162-2169
Wu, Liming; Nakano, Hiroyasu; Wu, Zhenguo Article

2005 7

Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome
American journal of respiratory and critical care medicine, v. 171, (8), 2005, APR, p. 850-857
Jiang, Yong; Xu, Jun; Zhou, Chengzhi; Wu, Zhenguo; Zhong, Shuqing; Liu, Jinghua; Luo, Wei; Chen, Tao; Qin, Qinghe; Deng, Peng Article
Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation
Molecular and cellular biology, v. 25, (9), 2005, MAY, p. 3575-3582
Ma, Kewei; Chan, Jonathan K.L.; Zhu, Guang; Wu, Zhenguo Article
The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation
Journal of biological chemistry, v. 280, (9), 2005, MAR, p. 8172-8179
Lo, Kevin W.H.; Kan, Homan; Chan, Ling Nga; Xu, Weiguang; Wang, Kepeng; Wu, Zhenguo; Sheng, Morgan; Zhang, Mingjie Article
Identification of Critical Early Genes Involved in Nerve Growth Factor-Induced PC12 Differentiation
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5 - 6 December 2005
Xiao, Fang; Ng, Yu Pong; Tsim, Karl Wah Keung; Wise, Helen; Wong, Yung Hou; Ip, Nancy Yuk-Yu; Wu, Zhenguo Conference paper
NGF-Induced Neuronal Differentiation of PC12 Cells: Delineation of Signaling Molecules and Mapping of Pathways.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5 - 6 December 2005
Leung, W.K.W.; Choi, Chi Yan; Ip, Nancy Yuk-Yu; Wu, Zhenguo; Wong, Yung Hou; Cheung, P.T.; Tsim, Karl Wah Keung Conference paper
Overexpression of Galphaz Inhibits Muscle Differentiation
Abstract P-14
Mei, Hua; Wu, Zhenguo; Ip, Nancy Yuk-Yu; Wong, Yung Hou Conference paper
Role of Calmodulin-Dependent Kinase II in Nerve Growth Factor-Induced Differentiation of PC12 Cells.
25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5-6 December 2005
Kam, Yuet Fong; Yung, Ying; Wu, Eddy H.T.; Ng, Yu Pong; Wu, Zhenguo; Tsim, Karl Wah Keung; Wise, Helen; Ip, Nancy Yuk-Yu; Wong, Yung Hou Conference paper

2004 4

Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation
Journal of cell science, v. 117, (14), 2004, JUN, p. 3021-3029
Sun, Luguo; Liu, Lanying; Yang, Xiangjiao; Wu, Zhenguo Article
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation
EMBO journal, v. 23, (23), 2004, NOV, p. 4583-4594
Rui, Yanning; Xu, Zhen; Lin, Shuyong; Li, Qinxi; Rui, Hongliang; Luo, Wen; Zhou, Haimeng; Cheung, Po Yan; Wu, Zhenguo; Ye, Zhiyun; Li, Peng; Han, Jiahuai; Lin, Shengcai Article
Elucidation of the c-Jun N-terminal kinase pathway mediated by Epstein-Barr virus-encoded latent membrane protein
Molecular and cellular biology, v. 24, (1), 2004, JAN, p. 192-199
Wan, Jun; Sun, Luguo; Mendoza, Jennifer Woo; Chui, Yiuloon; Huang, Dolly; Chen, Zhijian; Suzuki, Nobutaka; Suzuki, Shinobu; Yeh, Wenchen; Akira, Shizuo; Matsumoto, Kunihiro; Liu, Zhenggang; Wu, Zhenguo Article
p150(Glued), dynein, and microtubules are specifically required for activation of MKK3/6 and p38 MAPKs
Journal of biological chemistry, v. 279, (44), 2004, OCT, p. 45308-45311
Cheung, Po Yan; Zhang, Yi; Long, Jiafu; Lin, Shengcai; Zhang, Mingjie; Jiang, Yong; Wu, Zhenguo Article

2003 2

Functional characterization of an amino-terminal region of HDAC4 that possesses MEF2 binding and transcriptional repressive activity
Journal of biological chemistry, v. 278, (26), 2003, JUN, p. 23515-23521
Chan, Jonathan K.L.; Sun, Luguo; Yang, Xiangjiao; Zhu, Guang; Wu, Zhenguo Article
The involvement of calcineurin in acetylcholine receptor redistribution in muscle
Molecular and Cellular Neuroscience, v. 23, (4), 2003, AUG, p. 587-599
Madhavan, Raghavan; Zhao, Xiaotao; Chan, Frances; Wu, Zhenguo; Peng, Benjamin Hsiao Ming Article

2002 3

p38 mitogen-activated protein kinase-, calcium-calmodulin-dependent protein kinase-, and calcineurin-mediated signaling pathways transcriptionally regulate myogenin expression
Molecular biology of the cell, v. 13, (6), 2002, p. 1940-1952
Xu, Qing; Yu, Lu; Liu, Lanying; Cheung, Ching Fung; Li, Xue; Yee, Siupok; Yang, Xiangjiao; Wu, Zhenguo Article
Positive feedback regulation between Akt2 and MyoD during muscle differentiation - Cloning of Akt2 promoter
Journal of biological chemistry, v. 277, (26), 2002, JUN, p. 23230-23235
Kaneko, Satoshi; Feldman, Richard I.; Yu, Lu; Wu, Zhenguo; Gritsko, Tatiana M.; Shelley, Sue A.; Nicosia, Santo Valeric; Nobori, Tsutomu; Cheng, Jinquan Article
Involvement of the ser/thr phosphatase calcineurin in acetylcholine receptor dispersal and clustering
Gordon Research Conference, HKUST, Hong Kong
Madhavan, Raghavan; Chan, Frances; Wu, Zhenguo; Peng, Benjamin Hsiao Ming Conference paper

2001 1

p38 Mitogen-activated Protein Kinase-, Calcium-Calmodulin-dependent Protein Kinase-, and Calcineurin-mediated Signaling Pathways Transcriptionally Regulate Myogenin Expression
The 9th SCBA International Symposium, Taipai, 5-10 August 2001, p. 218
Xu, Qing; Cheung, Ching Fung; Liu, Lanying; Li, Xue; Yee, Siupok; Yang, Xiangjiao; Wu, Zhenguo Conference paper

2000 3

Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells
Genes and Development, v. 14, (5), March 2000, p. 574-584
Puri, Pier Lorenzo Orenzo; Wu, Zhenguo; Zhang, Peilin; Wood, Lauren D.; Bhakta, Kunjan S.; Han, Jiahuai; Feramisco, James R.; Karin, Michael; Wang, Jean Y.J. Article
p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps
Molecular and Cellular Biology, v. 20, (11), 2000, p. 3951-3964
Wu, Zhenguo; Woodring, Pamela J.; Bhakta, Kunjan S.; Tamura, Kumiko; Wen, Fang; Feramisco, James R.; Karin, Michael; Wang, Jean Y.J.; Puri, Pier Lorenzo Orenzo Article
The insulin-like growth factor-phosphatidylinositol 3-kinase-Akt signaling pathway regulates myogenin expression in normal myogenic cells but not in Rhabdomyosarcoma-derived RD cells
Journal of biological chemistry, v. 275, (47), 2000, NOV, p. 36750-36757
Xu, Qing; Wu, Zhenguo Article

1998 3

JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension
Genes and Development, v. 12, (21), Nov 1998, p. 3369-3381
Xia, Ying; Wu, Zhenguo; Su, Bing; Murray, Brion William; Karin, Michael Article
Mutations in domain IIIα of the Mu transposase: Evidence suggesting an active site component which interacts with the Mu-host junction
Journal of Molecular Biology, v. 282, (2), 1998, p. 265-274
Naigamwalla, Darius Z.; Coros, Colin Joseph; Wu, Zhenguo; Chaconas, George Article
Stabilisation of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway
Science, v. 280, (5371), 1998, Jun, p. 1945-1949
Chen, Chingyi; Del Gatto-Konczak, Fabienne; Wu, Zhenguo; Karin, Michael Article

1997 2

Molecular cloning and Characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase
Molecular and Cellular Biology, v. 17, (12), 1997, p. 7407-7416
Wu, Zhenguo; Wu, Jun; Jacinto, Estela; Karin, Michael Article
The Mu transposase tetramer is inactive in unassisted strand transfer: an auto-allosteric effect of Mu A promotes the reaction in the absence of Mu B
Journal of Molecular Biology, v. 267, (1), 1997, p. 132-141
Wu, Zhenguo; Chaconas, George Article

1995 1

A novel DNA binding and nuclease activity in Mu transposase: localization of a catalytic region involved in donor cleavage
The EMBO Journal, v. 14, (15), 1995, p. 3835-3843
Wu, Zhenguo; Chaconas, George Article

1994 1

Characterization of a region in Mu transposase that is involved in interaction with Mu B protein
Journal of biological chemistry, v. 269, (46), Nov 1994, p. 28829-28833
Wu, Zhenguo; Chaconas, George Article

1992 1

Flanking host sequences can exert an inhibitory effect on the cleavage step of the in vitro Mu DNA strand transfer reaction
Journal of Biological Chemistry, v. 267, (14), May 1992, p. 9552-9558
Wu, Zhenguo; Chaconas, George Article


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Teaching Assignment

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2021-22 Winter 0 2021-22 Fall 5 2020-21 Summer 1 2020-21 Spring 5 2020-21 Winter 0 2020-21 Fall 7

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LIFS1010 Appreciation of Biological Sciences
LIFS3010 Molecular and Cellular Biology I
LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS4971 Biochemistry and Cell Biology Project Research I
LIFS5710 Cellular Regulation


BTEC5210 Principles and Application in Biotechnology


LIFS4963 Biotechnology Capstone Project
LIFS4981 Biochemistry and Cell Biology Project Research II
LIFS6115D Current Topics in Development and Systems Biology
SCIE1500 Guided Study on Research I
SCIE2500 Guided Study on Research II


LIFS1010 Appreciation of Biological Sciences
LIFS3010 Molecular and Cellular Biology I
LIFS4960 Biological Science Capstone Project
LIFS4963 Biotechnology Capstone Project
LIFS5710 Cellular Regulation
LIFS6111M Life Science Postgraduate Student Seminar
SCIE4500 IRE Research Project II


No Teaching Assignments


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)

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All Supervisions Current RPGs Graduated RPGs

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Current RPGs

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Doctor of Philosophy ALFONSI, Maria Vittoria
Life Science( 2021 - )

CHEN, Shiwen
Life Science( 2021 - )

DING, Zhanbo
Life Science( 2021 - )

GAO, Chuan
Life Science( 2021 - )

JIAN, Tao
Life Science( 2021 - )

QIU, Hua
Life Science( 2021 - )

REN, Xiaokun
Life Science( 2021 - )

SHEN, Zeyu
Life Science( 2021 - )

SUN, Yuexiang (co-supervision)
Advanced Materials( 2021 - )

XU, Yang
Life Science( 2021 - )

ZHANG, Bonan
Life Science( 2021 - )

ZHAO, Yipeng
Life Science( 2021 - )

ZHOU, Nan
Life Science( 2021 - )

ZHU, Shihan
Life Science( 2021 - )

LIN, Lirong
Life Science( 2020 - )

XU, Jingyan
Life Science( 2020 - )

HAN, Lifang
Life Science( 2018 - )

HENG, Youshan
Life Science( 2017 - )

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Master of Philosophy QIU, Yudan
Life Science( 2020 - )

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Graduated RPGs

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Doctor of Philosophy CHEN, Xianwei
Life Science( Completed in 2021 )

ZHOU, Shaopu
Life Science( Completed in 2021 )

WEI, Xiuqing
Life Science( Completed in 2020 )

YU, Youqian
Life Science( Completed in 2019 )

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Master of Philosophy ALFONSI, Maria Vittoria
Life Science( Completed in 2021 )

HENG, Youshan
Life Science( Completed in 2019 )

VO, Thi Hoai Thuong
Life Science( Completed in 2019 )

WANG, Ruirong
Life Science( Completed in 2019 )









ProjectsFrom January 2020 to December 2022

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All Projects 19 Leading Projects 8 Participating Projects 11

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Stem cell-niche interactions in tissue maintenance and engineering


干细胞与微环境互作在组织维持和组织工程中的应用 Participating


RGC - Theme-based Research Scheme


Project Team (HKUST)
XIE Ting (Lead)
CHEUNG Tom
GUO Yusong
LEUNG Danny Chi Yeu
LIU Kai
MAK Ho Yi
SUN Fei
WEN Zilong
WU Angela Ruohao
WU Zhenguo
YAN Yan


2022 -




The Center for Neurodegenerative Diseases


N/A Participating


Innovation and Technology Fund


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
FU Amy Kit Yu
LEUNG Danny Chi Yeu
LIU Kai
WANG Jiguang
WONG Yung Hou
WU Zhenguo


2020 -




Mechanistic study of aggravated muscle fibrosis in a Stat3/Dystrophin (Dmd) double knockout mouse model for human Duchenne muscular dystrophy


对杜氏肌肉营养缺陷症导致的严重肌肉纤维化的机理研究 Leading


RGC - General Research Fund


Project Team (HKUST)
WU Zhenguo (Lead)


2020 -




Modulation of postsynaptic density complex formation by IRSp53


IRSp53蛋白对突触后膜致密区构建的调控 Leading


RGC - General Research Fund


Project Team (HKUST)
WU Zhenguo (Lead)


2020 -




Molecular regulation of quiescence and early activation in muscle stem cells


骨骼肌干细胞静息态及早期活化的分子调控 Leading


RGC - Collaborative Research Fund


Project Team (HKUST)
WU Zhenguo (Lead)
CHEUNG Tom
LEUNG Danny Chi Yeu


2020 -




The Role of IL-33 in Synaptic Dysfunctions and Pathogenesis of Alzheimer's Disease


白介素-33在阿兹海默氏症突触功能失调及发病过程中的作用 Participating


RGC - Collaborative Research Fund


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
FU Amy Kit Yu
WU Zhenguo
XIA Jun


2020 -




The Research on diagnosis and treatment of Alzheimer's disease


阿尔茨海默症的诊治方法研究 Participating


Department of Science and Technology of Guangdong Province, Shenzhen Science and Technology Innovation Committee


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
FU Amy Kit Yu
LIU Kai
WONG Yung Hou
WU Zhenguo
ZHOU Fred Xiaopu


2018 - , 2020 -




A Stem Cell Approach to Dissect the Molecular Basis of Neurodegenerative Diseases


以干细胞方法解析神经退行性疾病的分子基础 Participating


RGC - Theme-based Research Scheme


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
CHUNG Kenny K
FU Amy Kit Yu
QI Robert Zhong
QU Jianan
TSIM Karl Wah Keung
WEN Zilong
WONG Yung Hou
WU Zhenguo
XIA Jun


2019 -




Functional Characterization of Muscle Satllite Cells in a Progeria Mouse Model


对一早衰小鼠模型中肌肉干细胞的功能研究 Leading


RGC - General Research Fund


Project Team (HKUST)
WU Zhenguo (Lead)


2019 -




Mechanistic studies of the obesity-induced abnormal purine nucleotides in muscle repair and regeneration


肥胖诱导的异常嘌呤核苷酸信号影响骨骼肌再生与修复的机制 Leading


National Natural Science Foundation of China / Research Grants Council Joint Research Scheme


Project Team (HKUST)
WU Zhenguo (Lead)


2019 -




Introduction of new Microplate Spectrophotometer technique in LIFS 2720 Leading


Central Reserve Fund - School-based Initiatives


Project Team (HKUST)
WU Zhenguo (Lead)


2019 - 2020




Investigating the regulation mechanisms of myogenic/adipogenic lineage commitment and differentiation using single-cell transcriptomics


用单细胞转录组学研究肌源及脂肪细胞系定型与分化的调控机制 Participating


RGC - General Research Fund


Project Team (HKUST)
WU Angela Ruohao (Lead)
WU Zhenguo


2018 -




The role of E2F4 in the development of brown and beige fat in vivo


研究E2F4在体内棕色及米色脂肪发育中的作用 Leading


RGC - General Research Fund


Project Team (HKUST)
WU Zhenguo (Lead)


2018 - 2021




Cellular mechanisms of synaptic functions and plasticity in health and neurodegenerative diseases


健康及神经退行性病变过程中突触功能和可塑性调控的细胞机制 Participating


RGC - Areas of Excellence Scheme


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
FU Amy Kit Yu
LIU Kai
WONG Yung Hou
WU Zhenguo
XIA Jun


2017 -




Investigation of the role of PaxBP1 in adult muscle satellite cells


研究蛋白质PaxBP1在成体肌肉干细胞中的作用 Leading


RGC - General Research Fund


Project Team (HKUST)
WU Zhenguo (Lead)


2017 - 2020




Open Operation System of Guangdong Provincial Key Laboratory of Brain Science, Disease, and Drug Development (Inspection Qualified in 2017)


广东省脑科学及疾病与药物研究重点实验室开放运行（2017年度考评合格） Participating


Department of Science and Technology of Guangdong Province


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
FU Amy Kit Yu
LIU Kai
QI Robert Zhong
WONG Yung Hou
WU Zhenguo
XIA Jun


2017 - 2020




Hong Kong Branch of National Engineering Research Center for Tissue Restoration & Reconstruction


国家人体组织功能重建工程技术研究中心香港分中心 Participating


Innovation and Technology Fund


Project Team (HKUST)
SUN Jianwei (Lead)
CHAU Ying
GUO Zhihong
HSING I-ming
IP Nancy Yuk-Yu
JIA Guocheng
KO Robert Kam Ming
KWOK Ryan Tsz Kin
LAM Wing Yip
LIANG Chun
LIN Nian
LUO Zhengtang
MI Yongli
TSIM Karl Wah Keung
WILLIAMS Ian Duncan
WU Hongkai
WU Zhenguo
YAN Henry He
YAN Yan
YANG Jinglei
YAO Shuhuai


2015 -




Mechanistic basis of synaptic development, signalling and neuro-disorders


神经突触的发育,信号转导及经神疾病的分子机理 Participating


RGC - Areas of Excellence Scheme


Project Team (HKUST)
WEN Zilong (Lead)
LIU Kai
QU Jianan
WU Zhenguo
YAN Yan


2013 -




State Key Laboratory of Molecular Neuroscience (The Hong Kong University of Science and Technology)


分子神经科学国家重点实验室（香港科技大学） Participating


Innovation and Technology Fund


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHOW King Lau
CHUNG Kenny K
DAI Wei Min
GUO Zhihong
HUANG Pingbo
LIANG Chun
MILLER Andrew Leitch
POON Randy Yat Choi
QI Robert Zhong
TSIM Karl Wah Keung
WEN Zilong
WONG Joseph Tin Yum
WONG Yung Hou
WU Zhenguo
ZHU Guang


2011 -