Kenward VONG
黄敬皓
PhD in Biological Chemistry
McGill University, 2013

Assistant Professor
Department of Chemistry



(852) 3469 2551
kvong@ust.hk
Room 4522
Personal Web

---

Google Scholar
i5KvVQYAAAAJ

ORCID
0000-0002-8850-5163

ResearcherID
ABH-2717-2020

Scopus ID
24802735200




Research Interest Publications




Research Interest

---

Chemical biology
Bioinorganic chemistry
Bioorganic chemistry
Protein engineering



Publications

---

All Years 26 2022 1 2021 3 2020 6 2019 3 2018 4 2017 2 2016 7

---

Expand All Collapse All


2022 1

Synthetic prodrug design enables biocatalytic activation in mice to elicit tumor growth suppression
Nature Communications, v. 13, (1), January 2022, article number 39
Nasibullin, Igor; Smirnov, Ivan; Ahmadi, Peni; Vong, Kenward; Kurbangalieva, Almira; Tanaka, Katsunori Article

2021 3

Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy
Science Advances, v. 7, (17), April 2021, article number eabg4038
Vong, Kenward; Tahara, Tsuyoshi; Urano, Sayaka; Nasibullin, Igor; Tsubokura, Kazuki; Nakao, Yoichi; Kurbangalieva, Almira; Onoe, Hirotaka; Watanabe, Yasuyoshi; Tanaka, Katsunori Article
Exploring and adapting the molecular selectivity of artificial metalloenzymes
Bulletin of the Chemical Society of Japan, v. 94, (2), February 2021, p. 382-396
Vong, Kenward; Nasibullin, Igor; Tanaka, Katsunori Article
Prodrug Activation by Gold Artificial Metalloenzyme-Catalyzed Synthesis of Phenanthridinium Derivatives via Hydroamination
Angewandte Chemie - International Edition, v. 60, (22), May 2021, p. 12446-12454
Chang, Tsung-Che; Vong, Kenward; Yamamoto, Tomoya; Tanaka, Katsunori Article

2020 6

Artificial Glycoproteins as a Scaffold for Targeted Drug Therapy
Small, v. 16, (27), July 2020, article number 1906890
Vong, Kenward; Yamamoto, Tomoya; Tanaka, Katsunori Article
Bioorthogonal release of anticancer drugs via gold-triggered 2-alkynylbenzamide cyclization
Chemical Science, v. 11, (40), October 2020, p. 10933-10938
Vong, Kenward; Yamamoto, Tomoya; Chang, Tsung-Che; Tanaka, Katsunori Article
The journey to in vivo synthetic chemistry: From azaelectrocyclization to artificial metalloenzymes
Bulletin of the Chemical Society of Japan, v. 93, (11), November 2020, p. 1275-1286
Tanaka, Katsunori; Vong, Kenward Article
Unlocking the therapeutic potential of artificial metalloenzymes
Proceedings of the Japan Academy, Series B, v. 96, (3), March 2020, p. 79-94
Tanaka, Katsunori; Vong, Kenward Article
Glycan-Mediated Targeting Methods
Handbook of in vivo chemistry in mice: From lab to living system / Edited by Katsunori Tanaka and Kenward Vong. Germany : Wiley, 2020, p. 489-530
Vong, Kenward; Tanaka, Katsunori; Fukase, Koichi Book chapter
In vivo metal catalysis in living biological systems
Handbook of in vivo chemistry in mice: From lab to living system / Edited by Katsunori Tanaka and Kenward Vong. Germany : Wiley, 2020, p. 309-354
Vong, Kenward; Tanaka, Katsunori Book chapter

2019 3

An artificial metalloenzyme biosensor can detect ethylene gas in fruits and Arabidopsis leaves
Nature Communications, v. 10, (1), December 2019, article number 5746
Vong, Kenward; Eda, Shohei; Kadota, Yasuhiro; Nasibullin, Igor; Wakatake, Takanori; Yokoshima, Satoshi; Shirasu, Ken; Tanaka, Katsunori Article
Biocompatibility and therapeutic potential of glycosylated albumin artificial metalloenzymes
Nature Catalysis, v. 2, (9), September 2019, p. 780-792
Eda, Shohei; Nasibullin, Igor; Vong, Kenward; Kudo, Norio; Yoshida, Minoru; Kurbangalieva, Almira; Tanaka, Katsunori Article
Influence of glycosylation pattern on protein biodistribution and kinetics in vivo within mice
Kinetic Control in Synthesis and Self-Assembly / Edited by Munenori Numata, Shiki Yagai and Toshiyuki Hamura. UK : Elsevier, 2019, p. 127-161
Vong, Kenward; Tanaka, Katsunori Book chapter

2018 4

2-Benzoylpyridine ligand complexation with gold critical for propargyl ester-based protein labeling
Chemistry - A European Journal, v. 24, (42), July 2018, p. 10595-10600
Lin, Yixuan; Vong, Kenward; Matsuoka, Koji; Tanaka, Katsunori Article
A viable strategy for screening the effects of glycan heterogeneity on target organ adhesion and biodistribution in live mice
Chemical Communications, v. 54, (63), August 2018, p. 8693-8696
Ogura, Akihiro; Urano, Sayaka; Tahara, Tsuyoshi; Nozaki, Satoshi; Sibgatullina, Regina; Vong, Kenward; Suzuki, Takehiro; Dohmae, Naoshi; Kurbangalieva, Almira; Watanabe, Yasuyoshi; Tanaka, Katsunori Article
Cellular Studies of an Aminoglycoside Potentiator Reveal a New Inhibitor of Aminoglycoside Resistance
ChemBioChem, v. 19, (19), October 2018, p. 2107-2113
Guan, Jinming; Vong, Kenward; Wee, Kathleen; Fakhoury, Johans; Dullaghan, Edie; Auclair, Karine Article
Therapeutic in vivo synthetic chemistry: exploring on opportunity to activate drugs at specific sites in the body
European Journal of Clinical Investigation, v. 48, (Suppl 1), p. 219-220
Tsubokura, Kazuki; Vong, Kenward; Sibgatullina, Regina; Kurbangalieva, Almira; Tanaka, Katsunori Article

2017 2

Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters
Chemical Communications, v. 53, (60), August 2017, p. 8403-8406
Vong, Kenward; Tsubokura, Kazuki; Nakao, Yoichi; Tanei, Tomonori; Noguchi, Shinzaburo; Kitazume, Shinobu; Taniguchi, Naoyuki; Tanaka, Katsunori Article
In vivo gold complex catalysis within live mice
Angewandte Chemie - International Edition, v. 56, (13), March 2017, p. 3579-3584
Tsubokura, Kazuki; Vong, Kenward; Pradipta, Ambara R; Ogura, Akihiro; Urano, Sayaka; Tahara, Tsuyoshi; Nozaki, Satoshi; Onoe, Hirotaka; Nakao, Yoichi; Sibgatullina, Regina; Kurbangalieva, Almira; Watanabe, Yasuyoshi; Tanaka, Katsunori Article

2016 1

Propargyl-assisted selective amidation applied in C-terminal glycine peptide conjugation
Chemistry - A European Journal, v. 22, (52), December 2016, p. 18865-18872
Vong, Kenward King Ho; Maeda, Satoshi; Tanaka, Katsunori Article

2015 1

Cell surface and in vivo interaction of dendrimeric N-glycoclusters
Glycoconjugate Journal, v. 32, (7), October 2015, p. 497-503
Taichi, Misako; Kitazume, Shinobu; Vong, Kenward; Imamaki, Rie; Kurbangalieva, Almira; Taniguchi, Naoyuki; Tanaka, Katsunori Article

2014 1

Exploring structural motifs necessary for substrate binding in the active site of Escherichia coli pantothenate kinase
Bioorganic and Medicinal Chemistry, v. 22, (12), June 2014, p. 3083-3090
Awuah, Emelia; Ma, Eric; Hoegl, Annabelle; Vong, Kenward; Habib, Eric; Auclair, Karine Article

2012 2

Inhibitors of aminoglycoside resistance activated in cells
ACS Chemical Biology, v. 7, (3), March 2012, p. 470-475
Vong, Kenward King Ho; Tam, Ingrid S.; Yan, Xuxu; Auclair, Karine Article
Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase
MedChemComm, v. 3, (4), April 2021, p. 397-407
Vong, Kenward King Ho; Auclair, Karine Article

2011 1

Geminal dialkyl derivatives of N-substituted pantothenamides: synthesis and antibacterial activity
Bioorganic & Medicinal Chemistry, v. 19, (8), April 2011, p. 2696-2706
Akinnusi, T Olukayode; Vong, Kenward King Ho; Auclair, Karine Article

2008 1

Synthesis and use of sulfonamide-, sulfoxide-, or sulfone-containing aminoglycoside-CoA bisubstrates as mechanistic probes for aminoglycoside N-6'-acetyltransferase
Bioorganic and Medicinal Chemistry Letters, v. 18, (20), October 2008, p. 5518-5522
Gao, Feng; Yan, Xuxu; Zahr, Omar; Larsen, Aaron; Vong, Kenward King Ho; Auclair, Karine Article


Expand All Collapse All


Article 1

Synthetic prodrug design enables biocatalytic activation in mice to elicit tumor growth suppression
Nature Communications, v. 13, (1), January 2022, article number 39
Nasibullin, Igor; Smirnov, Ivan; Ahmadi, Peni; Vong, Kenward; Kurbangalieva, Almira; Tanaka, Katsunori


Expand All Collapse All


Article 3

Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy
Science Advances, v. 7, (17), April 2021, article number eabg4038
Vong, Kenward; Tahara, Tsuyoshi; Urano, Sayaka; Nasibullin, Igor; Tsubokura, Kazuki; Nakao, Yoichi; Kurbangalieva, Almira; Onoe, Hirotaka; Watanabe, Yasuyoshi; Tanaka, Katsunori
Exploring and adapting the molecular selectivity of artificial metalloenzymes
Bulletin of the Chemical Society of Japan, v. 94, (2), February 2021, p. 382-396
Vong, Kenward; Nasibullin, Igor; Tanaka, Katsunori
Prodrug Activation by Gold Artificial Metalloenzyme-Catalyzed Synthesis of Phenanthridinium Derivatives via Hydroamination
Angewandte Chemie - International Edition, v. 60, (22), May 2021, p. 12446-12454
Chang, Tsung-Che; Vong, Kenward; Yamamoto, Tomoya; Tanaka, Katsunori


Expand All Collapse All


Article 4

Artificial Glycoproteins as a Scaffold for Targeted Drug Therapy
Small, v. 16, (27), July 2020, article number 1906890
Vong, Kenward; Yamamoto, Tomoya; Tanaka, Katsunori
Bioorthogonal release of anticancer drugs via gold-triggered 2-alkynylbenzamide cyclization
Chemical Science, v. 11, (40), October 2020, p. 10933-10938
Vong, Kenward; Yamamoto, Tomoya; Chang, Tsung-Che; Tanaka, Katsunori
The journey to in vivo synthetic chemistry: From azaelectrocyclization to artificial metalloenzymes
Bulletin of the Chemical Society of Japan, v. 93, (11), November 2020, p. 1275-1286
Tanaka, Katsunori; Vong, Kenward
Unlocking the therapeutic potential of artificial metalloenzymes
Proceedings of the Japan Academy, Series B, v. 96, (3), March 2020, p. 79-94
Tanaka, Katsunori; Vong, Kenward

Book chapter 2

Glycan-Mediated Targeting Methods
Handbook of in vivo chemistry in mice: From lab to living system / Edited by Katsunori Tanaka and Kenward Vong. Germany : Wiley, 2020, p. 489-530
Vong, Kenward; Tanaka, Katsunori; Fukase, Koichi
In vivo metal catalysis in living biological systems
Handbook of in vivo chemistry in mice: From lab to living system / Edited by Katsunori Tanaka and Kenward Vong. Germany : Wiley, 2020, p. 309-354
Vong, Kenward; Tanaka, Katsunori


Expand All Collapse All


Article 2

An artificial metalloenzyme biosensor can detect ethylene gas in fruits and Arabidopsis leaves
Nature Communications, v. 10, (1), December 2019, article number 5746
Vong, Kenward; Eda, Shohei; Kadota, Yasuhiro; Nasibullin, Igor; Wakatake, Takanori; Yokoshima, Satoshi; Shirasu, Ken; Tanaka, Katsunori
Biocompatibility and therapeutic potential of glycosylated albumin artificial metalloenzymes
Nature Catalysis, v. 2, (9), September 2019, p. 780-792
Eda, Shohei; Nasibullin, Igor; Vong, Kenward; Kudo, Norio; Yoshida, Minoru; Kurbangalieva, Almira; Tanaka, Katsunori

Book chapter 1

Influence of glycosylation pattern on protein biodistribution and kinetics in vivo within mice
Kinetic Control in Synthesis and Self-Assembly / Edited by Munenori Numata, Shiki Yagai and Toshiyuki Hamura. UK : Elsevier, 2019, p. 127-161
Vong, Kenward; Tanaka, Katsunori


Expand All Collapse All


Article 4

2-Benzoylpyridine ligand complexation with gold critical for propargyl ester-based protein labeling
Chemistry - A European Journal, v. 24, (42), July 2018, p. 10595-10600
Lin, Yixuan; Vong, Kenward; Matsuoka, Koji; Tanaka, Katsunori
A viable strategy for screening the effects of glycan heterogeneity on target organ adhesion and biodistribution in live mice
Chemical Communications, v. 54, (63), August 2018, p. 8693-8696
Ogura, Akihiro; Urano, Sayaka; Tahara, Tsuyoshi; Nozaki, Satoshi; Sibgatullina, Regina; Vong, Kenward; Suzuki, Takehiro; Dohmae, Naoshi; Kurbangalieva, Almira; Watanabe, Yasuyoshi; Tanaka, Katsunori
Cellular Studies of an Aminoglycoside Potentiator Reveal a New Inhibitor of Aminoglycoside Resistance
ChemBioChem, v. 19, (19), October 2018, p. 2107-2113
Guan, Jinming; Vong, Kenward; Wee, Kathleen; Fakhoury, Johans; Dullaghan, Edie; Auclair, Karine
Therapeutic in vivo synthetic chemistry: exploring on opportunity to activate drugs at specific sites in the body
European Journal of Clinical Investigation, v. 48, (Suppl 1), p. 219-220
Tsubokura, Kazuki; Vong, Kenward; Sibgatullina, Regina; Kurbangalieva, Almira; Tanaka, Katsunori


Expand All Collapse All


Article 2

Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters
Chemical Communications, v. 53, (60), August 2017, p. 8403-8406
Vong, Kenward; Tsubokura, Kazuki; Nakao, Yoichi; Tanei, Tomonori; Noguchi, Shinzaburo; Kitazume, Shinobu; Taniguchi, Naoyuki; Tanaka, Katsunori
In vivo gold complex catalysis within live mice
Angewandte Chemie - International Edition, v. 56, (13), March 2017, p. 3579-3584
Tsubokura, Kazuki; Vong, Kenward; Pradipta, Ambara R; Ogura, Akihiro; Urano, Sayaka; Tahara, Tsuyoshi; Nozaki, Satoshi; Onoe, Hirotaka; Nakao, Yoichi; Sibgatullina, Regina; Kurbangalieva, Almira; Watanabe, Yasuyoshi; Tanaka, Katsunori


Expand All Collapse All


Article 1

Propargyl-assisted selective amidation applied in C-terminal glycine peptide conjugation
Chemistry - A European Journal, v. 22, (52), December 2016, p. 18865-18872
Vong, Kenward King Ho; Maeda, Satoshi; Tanaka, Katsunori


Expand All Collapse All


Article 1

Cell surface and in vivo interaction of dendrimeric N-glycoclusters
Glycoconjugate Journal, v. 32, (7), October 2015, p. 497-503
Taichi, Misako; Kitazume, Shinobu; Vong, Kenward; Imamaki, Rie; Kurbangalieva, Almira; Taniguchi, Naoyuki; Tanaka, Katsunori


Expand All Collapse All


Article 1

Exploring structural motifs necessary for substrate binding in the active site of Escherichia coli pantothenate kinase
Bioorganic and Medicinal Chemistry, v. 22, (12), June 2014, p. 3083-3090
Awuah, Emelia; Ma, Eric; Hoegl, Annabelle; Vong, Kenward; Habib, Eric; Auclair, Karine


Expand All Collapse All


Article 2

Inhibitors of aminoglycoside resistance activated in cells
ACS Chemical Biology, v. 7, (3), March 2012, p. 470-475
Vong, Kenward King Ho; Tam, Ingrid S.; Yan, Xuxu; Auclair, Karine
Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase
MedChemComm, v. 3, (4), April 2021, p. 397-407
Vong, Kenward King Ho; Auclair, Karine


Expand All Collapse All


Article 1

Geminal dialkyl derivatives of N-substituted pantothenamides: synthesis and antibacterial activity
Bioorganic & Medicinal Chemistry, v. 19, (8), April 2011, p. 2696-2706
Akinnusi, T Olukayode; Vong, Kenward King Ho; Auclair, Karine


Expand All Collapse All


Article 1

Synthesis and use of sulfonamide-, sulfoxide-, or sulfone-containing aminoglycoside-CoA bisubstrates as mechanistic probes for aminoglycoside N-6'-acetyltransferase
Bioorganic and Medicinal Chemistry Letters, v. 18, (20), October 2008, p. 5518-5522
Gao, Feng; Yan, Xuxu; Zahr, Omar; Larsen, Aaron; Vong, Kenward King Ho; Auclair, Karine


Expand All Collapse All


2016 1

Propargyl-assisted selective amidation applied in C-terminal glycine peptide conjugation
Chemistry - A European Journal, v. 22, (52), December 2016, p. 18865-18872
Vong, Kenward King Ho; Maeda, Satoshi; Tanaka, Katsunori Article

2015 1

Cell surface and in vivo interaction of dendrimeric N-glycoclusters
Glycoconjugate Journal, v. 32, (7), October 2015, p. 497-503
Taichi, Misako; Kitazume, Shinobu; Vong, Kenward; Imamaki, Rie; Kurbangalieva, Almira; Taniguchi, Naoyuki; Tanaka, Katsunori Article

2014 1

Exploring structural motifs necessary for substrate binding in the active site of Escherichia coli pantothenate kinase
Bioorganic and Medicinal Chemistry, v. 22, (12), June 2014, p. 3083-3090
Awuah, Emelia; Ma, Eric; Hoegl, Annabelle; Vong, Kenward; Habib, Eric; Auclair, Karine Article

2012 2

Inhibitors of aminoglycoside resistance activated in cells
ACS Chemical Biology, v. 7, (3), March 2012, p. 470-475
Vong, Kenward King Ho; Tam, Ingrid S.; Yan, Xuxu; Auclair, Karine Article
Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase
MedChemComm, v. 3, (4), April 2021, p. 397-407
Vong, Kenward King Ho; Auclair, Karine Article

2011 1

Geminal dialkyl derivatives of N-substituted pantothenamides: synthesis and antibacterial activity
Bioorganic & Medicinal Chemistry, v. 19, (8), April 2011, p. 2696-2706
Akinnusi, T Olukayode; Vong, Kenward King Ho; Auclair, Karine Article

2008 1

Synthesis and use of sulfonamide-, sulfoxide-, or sulfone-containing aminoglycoside-CoA bisubstrates as mechanistic probes for aminoglycoside N-6'-acetyltransferase
Bioorganic and Medicinal Chemistry Letters, v. 18, (20), October 2008, p. 5518-5522
Gao, Feng; Yan, Xuxu; Zahr, Omar; Larsen, Aaron; Vong, Kenward King Ho; Auclair, Karine Article









ProjectsFrom January 2020 to December 2022

---