Zilong WEN
温子龙
PhD in Molecular Cell Biology
The Rockefeller University, 1997

Professor
Division of Life Science

PG Programs Coordinator (Life Science)



(852) 2358 7294
zilong@ust.hk
Room 5449
Personal Web

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Google Scholar
1h4-21YAAAAJ

ORCID
0000-0002-4260-7682

Scopus ID
55630978700




Research Interest Publications Projects Teaching Assignment RPG Supervision Space used




Research Interest

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Developmental biology
Immunology
Genetics
Cell development
Cell signaling



Publications

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All Years 89 2022 0 2021 3 2020 5 2019 4 2018 3 2017 4 2016 70

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2021 3

De Novo Germline and Somatic Variants Convergently Promote Endothelial-to-Mesenchymal Transition in Simplex Brain Arteriovenous Malformation
Circulation Research, v. 129, (9), October 2021, p. 825-839
Li, Hao; Nam, Yoonhee; Huo, Ran; Fu, Weilun; Jiang, Biaobin; Zhou, Qiuxia; Song, Dong; Yang, Yingxi; Jiao, Yuming; Weng, Jiancong; Yan, Zihan; Di, Lin; Li, Jie; Wang, Jie; Xu, Hongyuan; Wang, Shuo; Zhao, Jizong; Wen, Zilong; Wang, Jiguang; Cao, Yong Article
Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish
Science China Life Sciences, 16 March 2021
Chen, Jiakui; Li, Gaofei; Lian, Junwei; Ma, Ning; Huang, Zhibin; Li, Jianchao; Wen, Zilong; Zhang, Wenqing; Zhang, Yiyue Article
The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway
Cell Death & Disease, v. 12, (10), October 2021, article number 906
Zhao, Yan; Wu, Mei; Li, Jing; Meng, Ping; Chen, Jiakui; Huang, Zhibin; Xu, Jin; Wen, Zilong; Zhang, Wenqing; Zhang, Yiyue Article

2020 5

Endoderm-Derived Myeloid-like Metaphocytes in Zebrafish Gill Mediate Soluble Antigen-Induced Immunity
Cell Reports, v. 33, (1), 6 October 2020, article number 108227
Lin, Xi; Zhou, Qiuxia; Lin, Guanzhen; Zhao, Changlong; Wen, Zilong Article
In vivo single-cell lineage tracing in zebrafish using high-resolution infrared laser-mediated gene induction microscopy
eLife, v. 9, January 2020, article number e52024
He, Sicong; Tian, Ye; Feng, Shachuan; Wu, Yi; Shen, Xinwei; Chen, Kani; He, Yingzhu; Sun, Qiqi; Li, Xuesong; Xu, Jin; Wen, Zilong; Qu, Jianan Article
Lightening the Way of Hematopoiesis: Infrared Laser-Mediated Lineage Tracing With High Spatial-Temporal Resolution
Experimental Hematology, v. 85, May 2020, p. 3-7
He, Sicong; Xu, Jin; Qu, Jianan; Wen, Zilong Article
Tripartite-Motif Family Protein 35-28 Regulates Microglia Development by Preventing Necrotic Death of Microglial Precursors in Zebrafish
The Journal of Biological Chemistry, v. 295, (26), June 2020, p. 8846-8856
Yu, Tao; Kuang, Haoyue; Chen, Jiahao; Lin, Xi; Wu, Yi; Chen, Keyu; Zhang, Mingjie; Zhang, Wenqing; Wen, Zilong Article
Two phenotypically and functionally distinct microglial populations in adult zebrafish
Science Advances, v. 6, (47), November 2020, article number eabd1160
Wu, Shuting; Nguyen, Linh T. M.; Pan, Hongru; Hassan, Shaoli; Dai, Yimei; Xu, Jin; Wen, Zilong Article

2019 4

An Ectoderm-Derived Myeloid-like Cell Population Functions as Antigen Transporters for Langerhans Cells in Zebrafish Epidermis
Developmental Cell, v. 49, (4), May 2019, p. 605-617.e5
Lin, Xi; Zhou, Qiuxia; Lin, Guanzhen; Xu, Jin; Wen, Zilong Article
Dysregulation of Microglial Function Contributes to Neuronal Impairment in Mcoln1a-Deficient Zebrafish
iScience, v. 13, March 2019, p. 391-401
Jin, Wan; Dai, Yimei; Li, Funing; Zhu, Lu; Huang, Zhibin; Liu, Wei; Li, Jianchao; Zhang, Mingjie; Du, Jiulin; Zhang, Wenqing; Wen, Zilong Article
Nlrc3-like is required for microglia maintenance in zebrafish
Journal of Genetics and Genomics, v. 46, (6), June 2019, p. 291-299
Wang, Tienan; Yan, Bo; Lou, Liang; Lin, X.; Yu, T.; Wu, Shuting; Lu, Qing; Liu, Wei; Huang, Zhibin; Zhang, Mingjie; Zhang, Wenqing; Wen, Zilong Article
Tissue-resident macrophages: from zebrafish to mouse
Blood Science, v. 1, (1), August 2019, article number 13, p. 57-60
Lin, Xi; Wen, Zilong; Xu, Jin Article

2018 3

Adult Zebrafish Langerhans Cells Arise from Hematopoietic Stem/Progenitor Cells
eLIFE, v. 7, June 2018, article number e36131
He, Sicong; Chen, Jiahao; Jiang, Yunyun; Wu, Yi; Zhu, Lu; Jin, Wan; Zhao, Changlong; Yu, Tao; Wang, Tienan; Wu, Shuting; Lin, Xi; Qu, Jianan; Zhang, Wenqing; Wen, Zilong; Xu, Jin Article
Il34-Csf1r Pathway Regulates the Migration and Colonization of Microglial Precursors
Developmental Cell, v. 46, (5), September 2018, p. 552-563.e4
Wu, Shuting; Xue, Rongtao; Hassan, Shaoli; Nguyen, Thi My Linh; Wang, Tienan; Pan, Hongru; Xu, Jin; Liu, Qifa; Zhang, Wenqing; Wen, Zilong Article
Labeling single cell for in-vivo study of cell fate mapping and lineage tracing
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, v. 10497, 2018, article number 104970J
He, Sicong; Xu, Jin; Wu yi; Tian, Ye; Sun, Qiqi; Wen, Zilong; Qu, Jianan Conference paper

2017 4

C-Myb Hyperactivity Leads to Myeloid and Lymphoid Malignancies in Zebrafish
Leukemia, v. 31, (1), January 2017, p. 222-233
Liu, Wei; Wu, M.; Huang, Z.; Lian, J.; Chen, J.; Wang, Tienan; Leung, A.Y.H.; Liao, Y.; Zhang, Zhang Jin; Liu, Qifa; Yen, K.; Lin, S.; Zon, Leonard I.; Wen, Zilong; Zhang, Yunfan; Zhang, Wenqing Article
Distinct Regulatory Networks Control the Development of Macrophages of Different Origins in Zebrafish
Blood, v. 129, (4), January 2017, p. 509-519
Yu, Tao; Guo, Weilin; Tian, Ye; Xu, Jin; Chen, Jiahao; Li, Li; Wen, Zilong Article
The First Wave of T Lymphopoiesis in Zebrafish Arises from Aorta Endothelium Independent of Hematopoietic Stem Cells
Journal of Experimental Medicine, v. 214, (11), November 2017, p. 3347-3360
Tian, Ye; Xu, Jin; Feng, Shachuan; He, Sicong; Zhao, Shizheng; Zhu, Lu; Jin, Wan; Dai, Yimei; Luo, Lingfei; Qu, Jianan Y.; Wen, Zilong Article
NME7 Functions in ciliogenesis and left-right asymmetry development
EMBO Conference–Centrosomes and Spindle Pole Bodies, EMBL Heidelberg, Germany, 24-27 September 2017
Liu, Pengfei; Yu, Tao; Wen, Zilong; Qi, Robert Zhong Conference paper

2016 6

Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish
Journal of Genetics and Genomics, v. 43, (10), October 2016, p. 593-600
Dai, Yimei; Zhu, Lu; Huang, Zhibin; Zhou, Minyu; Jin, Wan; Liu, Wei; Xu, Mengchang; Yu, Tao; Zhang, Yiyue; Wen, Zilong; Liao, Wangjun; Zhang, Wenqing Article
c-Myb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish
Blood, v. 128, (3), July 2016, p. 415-426
Jin, Hao; Huang, Zhibin; Chi, Yali; Wu, Mei; Zhou, Riyang; Zhao, Lingfeng; Xu, Jin; Zhen, Fenghua; Lan, Yahui; Li, Li; Zhang, Wenqing; Wen, Zilong; Zhang, Yiyue Article
Microglia Colonization of Developing Zebrafish Midbrain Is Promoted by Apoptotic Neuron and Lysophosphatidylcholine
Developmental Cell, v. 38, (2), July 2016, p. 214-222
Xu, Jin; Wang, Tienan; Wu, Yi; Jin, Wan; Wen, Zilong Article
Real-Time Imaging of Cell Behaviors in Living Organisms by a Mitochondria-Targeting AIE Fluorogen
Advanced Functional Materials, v. 26, (39), October 2016, p. 7132-7138
Situ, Bo; Chen, Sijie; Zhao, Engui; Leung, Wai Tung; Chen, Yilong; Hong, Yuning; Lam, Wing Yip; Wen, Zilong; Liu, Wei; Zhang, Wenqing; Zheng, Lei; Tang, Benzhong Article
RNA Polymerase III Component Rpc9 Regulates Hematopoietic Stem and Progenitor Cell Maintenance in Zebrafish
Development (Cambridge), v. 143, (12), June 2016, p. 2103-2110
Wei, Yonglong; Xu, Jin; Zhang, Wenqing; Wen, Zilong; Liu, Feng Article
Origin of Microglia in Brain: A Study in Zebrafish Model
Biomedical Optics Congress 2016, Florida United States : Optical Society of America, 2016
He, Sicong; Xu, Jin; Wen, Zilong; Qu, Jianan Conference paper

2015 3

Functions of Idh1 and Its Mutation in the Regulation of Developmental Hematopoiesis in Zebrafish
Blood, v. 125, (19), May 2015, p. 2974-2984
Shi, Xiangguo; He, Bai-Liang; Ma, Alvin C.H.; Guo, Yuhan; Chi, Yali; Man, Cheuk Him; Zhang, Wenqing; Zhang, Yiyue; Wen, Zilong; Cheng, Tao; Leung, Anskar Y.H. Article
Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish
Scientific Reports, v. 5, March 2015, article number 9011
Yuan, Hao; Zhang, Tao; Liu, Xiaohui; Deng, Min; Zhang, Wenqing; Wen, Zilong; Chen, Saijuan; Chen, Zhu; De The, Hugues; Zhou, Jun; Zhu, Jun Article
Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish
Developmental Cell, v. 34, (6), September 2015, p. 632-641
Xu, Jin; Zhu, Lu; He, Sicong; Wu, Yi; Jin, Wan; Yu, Tao; Qu, Jianan Y.; Wen, Zilong Article

2014 4

IL-1β and reactive oxygen species differentially regulate neutrophil directional migration and basal random motility in a zebrafish injury-induced inflammation model
Journal of Immunology, v. 192, (12), June 2014, p. 5998-6008
Yan, Bo; Han, Peidong; Pan, Lifeng; Lu, Wei; Xiong, Jingwei; Zhang, Mingjie; Zhang, Wenqing; Li, Li; Wen, Zilong Article
In Vivo Micro-Vascular Imaging and Flow Cytometry in Zebrafish Using Two-photon Excited Endogenous Fluorescence
Biomedical Optics Express, v. 5, (3), 2014, p. 653-663
Zeng, Yan; Yan, Bo; Sun, Qiqi; He, Sicong; Jiang, Jun; Wen, Zilong; Qu, Jianan Article
In Vivo Nonlinear Optical Imaging of Immune Responses: Tissue Injury and Infection
Biophysical Journal, v. 107, (10), 2014, p. 2436-2443
Zeng, Yan; Yan, Bo; Xu, Jin; Sun, Qiqi; He, Sicong; Jiang, Jun; Wen, Zilong; Qu, Jianan Article
Nonlinear Optical Microscopy for in Vivo Imaging Microvasculature and Blood Flow
Conference Proceedings: Biomedical Optics, 2014
Zeng, Yan; Yan, Bo; Sun, Qiqi; He, Sicong; Jiang, Jun; Wen, Zilong; Qu, Jianan Conference paper

2013 4

Hemogenic Endothelium Specification and Hematopoietic Stem Cell Maintenance Employ Distinct Scl Isoforms
Development (Cambridge), v. 140, (19), October 2013, p. 3977-3985
Zhen, Fenghua; Lan, Yahui; Yan, Bo; Zhang, Wenqing; Wen, Zilong Article
Label-Free in Vivo Imaging of Human Leukocytes Using Two-photon Excited Endogenous Fluorescence
Journal of Biomedical Optics, v. 18, (4), 2013, article number 040504
Zeng, Yan; Yan, Bo; Sun, Qiqi; Teh, Seng Khoon; Zhang, Wei; Wen, Zilong; Qu, Jianan Article
Suppression of Pu.1 Function Results in Expanded Myelopoiesis in Zebrafish
Leukemia, v. 27, (9), September 2013, p. 1913-1917
Sun, Jiping; Liu, Wei; Li, Li; Chen, Jiahao; Wu, Mei; Zhang, Yiyue; Leung, Anskar; Zhang, Wenqing; Wen, Zilong; Liao, Wangjun Article
Two-Photon Excited Endogenous Fluorescence for Label-Free in Vivo Imaging Ingestion of Disease-Causing Bacteria by Human Leukocytes
SPIE Proceedings, v. 8588, February 2013
Zeng, Yan; Yan, Bo; Sun, Qiqi; Teh, Seng Khoon; Zhang, Wei; Wen, Zilong; Qu, Jianan Conference paper

2012 8

Antiparallel Coiled-coil-mediated Dimerization of Myosin X
Proceedings of the National Academy of Sciences of the United States of America, v. 109, (43), 2012, Oct, p. 17388-17393
Lu, Qing; Ye, Fei; Wei, Zhiyi; Wen, Zilong; Zhang, Mingjie Article
Label-free in Vivo Flow Cytometry in Zebrafish Using Two-photon Autofluorescence Imaging
Optics Letters, v. 37, (13), 2012, Jul, p. 2490-2492
Zeng, Yan; Xu, Jin; Li, Dong; Li, Li; Wen, Zilong; Qu, Jianan Article
Live Imaging Reveals Differing Roles of Macrophages and Neutrophils during Zebrafish Tail Fin Regeneration
Journal of Biological Chemistry, v. 287, (30), 2012, Jul, p. 25353-25360
Li, Li; Yan, Bo; Shi, Yu-Qian; Zhang, Wen-Qing; Wen, Zi-Long Article
Myelopoiesis during Zebrafish Early Development
Journal of Genetics and Genomics, v. 39, (9), 2012, Sep, p. 435-442
Xu, Jin; Du, Linsen; Wen, Zilong Article
Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo
Developmental cell, v. 23, (6), December 2012, p. 1189-1202
Li, Ying; Du, Xu-fei; Liu, Chang-sheng; Wen, Zi-long; Du, Jiu-lin Article
Runx1 Regulates Embryonic Myeloid Fate Choice in Zebrafish Through a Negative Feedback Loop Inhibiting Pu.1 Expression
Blood, v. 119, (22), 2012, Jun, p. 5239-5249
Jin, Hao; Li, Li; Xu, Jin; Zhen, Fenghua; Zhu, Lu; Liu, Pu Paul; Zhang, Mingjie; Zhang, Wenqing; Wen, Zilong Article
SUMO1-activating Enzyme Subunit 1 Is Essential for the Survival of Hematopoietic Stem/Progenitor Cells in Zebrafish
Development (Cambridge), v. 139, (23), 2012, Dec, p. 4321-4329
Li, Xiuling; Lan, Yahui; Xu, Jin; Zhang, Wenqing; Wen, Zilong Article
In vivo cytometry using two-photon autofluorescence microscopy
Biomedical Optics and 3-D Imaging, OSA Technical Digest (Optical Society of America), Miami, Florida, United States, 28 Apr - 2 May, 2012
Zeng, Yan; Xu, Jin; Li, Dong; Li, Li; Wen, Zilong; Qu, Jianan Conference paper

2011 4

CMyb Regulates Hematopoietic Stem/Progenitor Cell Mobilization during Zebrafish Hematopoiesis
Blood, v. 118, (15), 2011, Oct, p. 4093-4101
Zhang, Yiyue; Jin, H.; Li, L.; Qin, F.X.F.; Wen, Z. Article
Erythrocytes in the trunk of zebrafish embryos
Development, v. 138, (18), September 2011, p. 3862-3863
Jin, Hao; Wen, Zilong Article
Irf8 Regulates Macrophage Versus Neutrophil Fate During Zebrafish Primitive Myelopoiesis
Blood, v. 117, (4), 2011, p. 1359-1369
Li, Li; Jin, Hao; Xu, Jin; Shi, Yuqian; Wen, Zilong Article
Rumba and Haus3 are essential factors for the maintenance of hematopoietic stem/progenitor cells during zebrafish hematopoiesis
Development, v. 138, (4), 2011, Jan, p. 619-629
Du, Linsen; Xu, J.; Li, Xiuling; Ma, Ning; Liu, Yanmei; Peng, Jinrong; Osato, Motomi; Zhang, Wenqing; Wen, Zilong Article

2010 3

A Runx1 intronic enhancer marks hemogenic endothelial cells and hematopoietic stem cells
Stem Cells, v. 28, (10), 2010, p. 1869-1881
Ng, Cherry Ee Lin; Yokomizo, Tomomasa; Yamashita, Namiko; Cirovic, Branko; Jin, Hao; Wen, Zilong; Ito, Yoshiaki; Osato, Motomi Article
Development of Multilineage Adult Hematopoiesis in the Zebrafish with a Runx1 Truncation Mutation
Blood, v. 115, (14), 2010, APR 8, p. 2806-2809
Sood, Raman; English, Milton A.; Belele, Christiane L.; Jin, Hao; Bishop, Kevin; Haskins, Rebecca; McKinney, Mary Cathleen; Chahal, Jagman; Weinstein, Brant M.; Wen, Zilong; Liu, P. Paul Article
Regulation of Gene Expression by FSP27 in White and Brown Adipose Tissue
BMC Genomics, v. 11, (1), 2010, JUL 22, Article number 446
Li, De; Zhang, Yinxin; Xu, Li; Zhou, Linkang; Wang, Yue; Xue, Bofu; Wen, Zilong; Li, Peng; Sang, Jianli Article

2009 2

Autoinhibition of UNC5b Revealed by the Cytoplasmic Domain Structure of the Receptor
Molecular Cell, v. 33, (6), 2009, MAR 27, p. 692-703
Wang, Rui; Wei, Zhiyi; Jin, Hao; Wu, Hao; Yu, Cong; Wen, Wenyu; Chan, Ling Nga; Wen, Zilong; Zhang, Mingjie Article
Definitive Hematopoietic Stem/progenitor Cells Manifest Distinct Differentiation Output in the Zebrafish VDA and PBI
Development, v. 136, (4), 2009, FEB 15, p. 647-654
Jin, Hao; Sood, Raman; Xu, Jin; Zhen, Fenghua; English, Milton A.; Liu, Pu Paul; Wen, Zilong Article

2008 2

Mypt1-mediated Spatial Positioning of Bmp2-producing Cells is Essential for Liver Organogenesis
Development, v. 135, (19), 2008, p. 3209-3218
Huang, Honghui; Ruan, Hua; Aw, Meng Yuan; Hussain, Alamgir; Guo, Lin; Gao, Chuan; Qian, Feng; Leung, Thomas; Song, Haiwei; Kimelman, David; Wen, Zilong; Peng, Jinrong Article
Up-Regulation of Mitochondrial Activity and Acquirement of Brown Adipose Tissue-Like Property in the White Adipose Tissue of Fsp27 Deficient Mice
PloS One, v. 3, (8), 2008, AUG 6
Toh, Shen Yon; Gong, Jingyi; Du, Guoli; Li, John Zhong; Yang, Shuqun; Ye, Jing; Yao, Huilan; Zhang, Yinxin; Xue, Bofu; Li, Qing; Yang, Hongyuan; Wen, Zilong; Li, Peng Article

2007 5

Amotl2 is Essential for Cell Movements in Zebrafish Embryo and Regulates C-Src Translocation
Development, v. 134, (5), March 2007, p. 979-988
Huang, Huizhe; Lu, Fu-I; Jia, Shunji; Meng, Shu; Cao, Ying; Wang, Yeqi; Ma, Weiping; Yin, Kun; Wen, Zilong; Peng, Jingrong; Thisse, Christine; Thisse, Bernard; Meng, Anming Article
Cideb Regulates Diet-induced Obesity, Liver Steatosis, and Insulin Sensitivity by Controlling Lipogenesis and Fatty Acid Oxidation
Diabetes, v. 56, (10), 2007, OCT, p. 2523-2532
Li, John Zhong; Ye, Jing; Xue, Bofu; Qi, Jingzhong; Zhang, Jing; Zhou, Zhihong; Li, Qing; Wen, Zilong; Li, Peng Article
Distinct Functions for Different Scl Isoforms in Zebrafish Primitive and Definitive Hematopoiesis
PLoS Biology, v. 5, (5), May 2007, p. 1110-1119
Qian, Feng; Zhen, Fenghua; Xu, Jin; Huang, Mei; Li, Wanyu; Wen, Zilong Article
Migratory Path of Definitive Hematopoietic Stem/progenitor Cells During Zebrafish Development
Blood, v. 109, (12), 2007, p. 5208-5214
Jin, Hao; Xu, Jin; Wen, Zilong Article
The Zebrafish Udu Gene Encodes a Novel Nuclear Factor and is Essential for Primitive Erythroid Cell Development
Blood, v. 110, (1), 1 July 2007, p. 99-106
Liu, Yanmei; Du, Linsen; Osato, Motomi; Teo, Eng Hui; Qian, Feng; Jin, Hao; Zhen, Fenghua; Xu, Jin; Guo, Lin; Huang, Honghui; Chen, J.; Geisler, Robert; Jiang, Yun-Jin; Peng, Jinrong; Wen, Zilong Article

2006 1

The 5′ zebrafish scl promoter targets transcription to the brain, spinal cord, and hematopoietic and endothelial progenitors
Developmental Dynamics, v. 235, (1), January 2006, p. 60-67
Jin, Hao; Xu, Jin; Qian, Feng; Du, Linsen; Tan, Chee Yong; Lin, Zhixin; Peng, Jinrong; Wen, Zilong Article

2005 4

Genome-wide identification of female-enriched genes in zebrafish
Developmental Dynamics, v. 232, (1), January 2005, p. 171-179
Wen, Chaoming; Zhang, Zhenhai; Ma, Weiping; Xu, Min; Wen, Zilong; Peng, Jinrong Article
Identification of the Conserved Serine/threonine Residues Important for Gibberellin-sensitivity of Arabidopsis RGL2 Protein
Plant Journal, v. 44, (1), October 2005, p. 88-99
Hussain, Alamgir; Cao, Dongni; Cheng, Hui; Wen, Zilong; Peng, Jinrong Article
Loss of Function of Def Selectively Up-regulates Δ113p53 Expression to Arrest Expansion Growth of Digestive Organs in Zebrafish
Genes and Development, v. 19, (23), 1 December 2005, p. 2900-2911
Chen, Jun; Ruan, Hua; Ng, Sok Meng; Gao, Chuan; Soo, Hui Meng; Wu, Wei; Zhang, Zhenhai; Wen, Zilong; Lane, David P.; Peng, Jinrong Article
Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes
Developmental Dynamics, v. 233, (3), July 2005, p. 1163-1172
Qian, Feng; Zhen, Fenghua; Ong, Chinthing; Jin, Suk-Won; Soo, Hui Meng; Stainier, Didier Y.R.; Lin, Shuo; Peng, Jinrong; Wen, Zilong Article

2003 2

15000 Unique Zebrafish EST Clusters and Their Future Use in Microarray for Profiling Gene Expression Patterns During Embryogenesis
Genome Research, v. 13, (3), 2003, p. 455-466
Lo, Jane; Lee, Sorcheng; Xu, Min; Liu, Feng; Ruan, Hua; Eun, Alvin; He, Yawen; Ma, Weiping; Wang, Weefuen; Wen, Zilong; Peng, Jinrong Article
Emergence of a coronavirus infectious bronchitis virus mutant with a truncated 3b gene: Functional characterization of the 3b protein in pathogenesis and replication
Virology, v. 311, (1), 20 June 2003, p. 16-27
Shen, Shuo; Wen, Zilong; Liu, Dingxiang Article

2002 3

Cloning and Expression Pattern of the lysozyme C Gene in Zebrafish
Mechanisms of Development, v. 113, (1), 2002, p. 69-72
Liu, Feng; Wen, Zilong Article
Morphologic transformation of the thymus in developing zebrafish
Developmental Dynamics, v. 225, (1), September 2002, p. 87-94
Lam, Siewhong; Chua, H. L.; Gong, Zhiyuan; Wen, Zilong; LAM, Toongjin; SIN, Yokemin Article
The chromatin-remodelling factor BRG1 selectively activates a subset of interferon α-inducible genes
Nature Cell BIiology, v. 4, (10), Oct 2002, p. 774-781
Huang, Mei; Qian, Feng; Hu, Yuanyu; Ang, Chengeng; Li, Zhong; Wen, Zilong Article

1999 1

The Linker Domain of Stat1 is Required for Gamma Interferon-driven Transcription
Molecular and Cellular Biology, v. 19, (7), 1999, p. 5016-5112
Yang, Edward; Wen, Zilong; Haspel, Richard L.; Zhang, Jue J.; Darnell, James E. Article

1997 3

Mapping of Stat3 Serine Phosphorylation to a Single Residue (727) and Evidence that Serine Phosphorylation has no Influence on DNA Binding of Stat1 and Stat3
Nucleic Acids Research, v. 25, (11), 1997, p. 2062-2067
Wen, Zilong; Darnell, James E. Article
STAT signaling is active during early mammalian development
Developmental Dynamics, v. 208, (2), 1997, February, p. 190-198
Duncan, Stephen A.; Zhong, Zhong; Wen, Zilong; Darnell, James E. Article
Stat1 Serine Phosphorylation Occurs Independently of Tyrosine Phosphorylation and Requires an Activated Jak2 Kinase
Molecular and Cellular Biology, v. 17, (11), 1997, November, p. 6618-6623
Wen, Zilong; Xu, Liangzhong; Darnell, James E.; Zhu, Xuejun Article

1996 1

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon α and interferon γ
Proceedings of the National Academy of Sciences of the United States of America, v. 93, (15), 1996, July, p. 7673-7678
Bromberg, Jacqueline F.; Horvath, Curt M.; Wen, Zilong; Schreiber, Robert D.; Darnell, James E. Article

1995 6

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain
Genes and Development, v. 9, (8), 1995, p. 984-994
Horvath, Curt M.; Wen, Zilong; Darnell, James E. Article
Distribution of the mammalian Stat gene family in mouse chromosomes
Genomics, v. 29, (1), 1995, p. 225-228
Zhong, Zhong; Wen, Zilong; Darnell, James E.; Mui, Alice; Miyajima, Atsushi; Gilbert, Debra J.; Schindler, Christian W.; Quelle, Frederick W.; Ihle, James N.; Jenkins, Nancy A B G; Copeland, Neal G L F Article
In Vivo Growth Hormone Treatment Rapidly Stimulates the Tyrosine Phosphorylation and Activation of Stat3
Molecular Endocrinology, v. 9, (2), 1995, p.171-177
Gronowski, Ann M.; Zhong, Zhong; Wen, Zilong; Thomas, Michael J.; Rotwein, Peter S.; Darnell, James E. Article
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phopshorylation
Cell, v. 82, (2), 1995, July, p. 241-250
Wen, Zilong; Zhong, Zhong; Darnell, James E. Article
Stat3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase
Proceedings of the National Academy of Sciences of the United States of America, v. 92, (15), 1995, July, p. 6915-6919
Boulton, Teri G.; Zhong, Zhong; Wen, Zilong; Darnell, James E.; Stahl, Neil; Yancopoulo?, George D. Article
The Genomic Structure of the STAT Genes-multiple Exons in Coincident Sites in STAT1 and STAT2
Nucleic Acids Research, v. 23, (3), 1995, February, p. 459-463
Qureshi, Sajjad A.; Yan, Riqiang; Zhong, Zhong; Wen, Zilong; Darnell, James E. Article

1994 3

Epidermal Growth Factor and Lipopolysaccharide Activate Stat3 Transcription Factor in Mouse Liver
Journal of Biological Chemistry, v. 269, (35), 1994, Septermber, p. 21933-21935
Ruff-Jamison, Susan; Zhong, Zhong; Wen, Zilong; Chen, Katherine; Darnell, James E.; Cohen, Stanley W. Article
Stat3 and Stat4: members of the family of signal transducers and activators of transcription
Proceedings of the National Academy of Sciences of the United States of America, v. 91, (11), 1994, May, p. 4806-4810
Zhong, Zhong; Wen, Zilong; Darnell, James E. Article
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
Science, v, 264, (5155), 1994, p. 95-98
Wen, Zilong; Zhong, Zhong; Darnell, James E. Article

1993 1

Binding of peptides lacking consensus anchor residue alters H-2Ld serologic recognition
Immunology, v. 151, (10) 15 November 1993, p. 5387-5397
Solheim, Joyce C.; Carre?o, Beatriz M.; Smith, Joseph D.; Gorka, John; Myers, Nancy B.; Wen, Zilong; Martinko, John M.; Lee, David R.; Hansen, Ted H. Article

1992 2

Interaction of an α-melanocyte-stimulating hormone-diphtheria toxin fusion protein with melanotropin receptors in human melanoma metastases
Cancer Research, v. 52, (9), 1992, p. 2545-2548
Tatro,Jeffrey B.; Wen, Zilong; Entwistle, Margaret L.; Atkin, Michael B.; Smith, Thomas J.; Reichlin, Seymour; Murphy, John R. Article
Phe496 and Leu497 are Essential for Receptor Binding and Cytotoxic Action of Murine Interleukin-4 Receptor Targeted Fusion Toxin DAB389-mIL-4
Protein Engineering, Design and Selecitionv. 5, (3), 1992, p. 241-248
Lakkis, Fadi G.; Landgraf, Bryan E.; Wen, Zilong; Strom, Terry B.; Murphy, John R. Article

1991 1

Diphtheria toxin-related α-melanocyte-stimulating hormone Fusion Toxin: Internal in-frame Deletion from Thr387 to His485 Results in the Formation of a Highly Potent Fusion Toxin which is Resistant to Proteolytic Degradation
Journal of Biological Chemistry, v. 266, (19), 1991, p. 12289-12293
Wen, Zilong; Tao, Xu; Lakkis, Fadi G.; Kiyokawa, Tetsuyuki; Murphy, John R. Article

1990 1

Cellular Processing of the Interleukin-2 Fusion Toxin DAB486-IL-2 and Efficient Delivery of Diphtheria Fragment A to the Cytosol of Target Cells Requires Arg194
Journal of Biological Chemistry, v. 265, (33), 1990, p. 20673-20677
Williams, Diane P.; Wen, Zilong; Watson, Rose Scott; Boyd, Jessica M.; Strom, Terry B.; Murphy, John R. Article


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Article 3

De Novo Germline and Somatic Variants Convergently Promote Endothelial-to-Mesenchymal Transition in Simplex Brain Arteriovenous Malformation
Circulation Research, v. 129, (9), October 2021, p. 825-839
Li, Hao; Nam, Yoonhee; Huo, Ran; Fu, Weilun; Jiang, Biaobin; Zhou, Qiuxia; Song, Dong; Yang, Yingxi; Jiao, Yuming; Weng, Jiancong; Yan, Zihan; Di, Lin; Li, Jie; Wang, Jie; Xu, Hongyuan; Wang, Shuo; Zhao, Jizong; Wen, Zilong; Wang, Jiguang; Cao, Yong
Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish
Science China Life Sciences, 16 March 2021
Chen, Jiakui; Li, Gaofei; Lian, Junwei; Ma, Ning; Huang, Zhibin; Li, Jianchao; Wen, Zilong; Zhang, Wenqing; Zhang, Yiyue
The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway
Cell Death & Disease, v. 12, (10), October 2021, article number 906
Zhao, Yan; Wu, Mei; Li, Jing; Meng, Ping; Chen, Jiakui; Huang, Zhibin; Xu, Jin; Wen, Zilong; Zhang, Wenqing; Zhang, Yiyue


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Article 5

Endoderm-Derived Myeloid-like Metaphocytes in Zebrafish Gill Mediate Soluble Antigen-Induced Immunity
Cell Reports, v. 33, (1), 6 October 2020, article number 108227
Lin, Xi; Zhou, Qiuxia; Lin, Guanzhen; Zhao, Changlong; Wen, Zilong
In vivo single-cell lineage tracing in zebrafish using high-resolution infrared laser-mediated gene induction microscopy
eLife, v. 9, January 2020, article number e52024
He, Sicong; Tian, Ye; Feng, Shachuan; Wu, Yi; Shen, Xinwei; Chen, Kani; He, Yingzhu; Sun, Qiqi; Li, Xuesong; Xu, Jin; Wen, Zilong; Qu, Jianan
Lightening the Way of Hematopoiesis: Infrared Laser-Mediated Lineage Tracing With High Spatial-Temporal Resolution
Experimental Hematology, v. 85, May 2020, p. 3-7
He, Sicong; Xu, Jin; Qu, Jianan; Wen, Zilong
Tripartite-Motif Family Protein 35-28 Regulates Microglia Development by Preventing Necrotic Death of Microglial Precursors in Zebrafish
The Journal of Biological Chemistry, v. 295, (26), June 2020, p. 8846-8856
Yu, Tao; Kuang, Haoyue; Chen, Jiahao; Lin, Xi; Wu, Yi; Chen, Keyu; Zhang, Mingjie; Zhang, Wenqing; Wen, Zilong
Two phenotypically and functionally distinct microglial populations in adult zebrafish
Science Advances, v. 6, (47), November 2020, article number eabd1160
Wu, Shuting; Nguyen, Linh T. M.; Pan, Hongru; Hassan, Shaoli; Dai, Yimei; Xu, Jin; Wen, Zilong


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Article 4

An Ectoderm-Derived Myeloid-like Cell Population Functions as Antigen Transporters for Langerhans Cells in Zebrafish Epidermis
Developmental Cell, v. 49, (4), May 2019, p. 605-617.e5
Lin, Xi; Zhou, Qiuxia; Lin, Guanzhen; Xu, Jin; Wen, Zilong
Dysregulation of Microglial Function Contributes to Neuronal Impairment in Mcoln1a-Deficient Zebrafish
iScience, v. 13, March 2019, p. 391-401
Jin, Wan; Dai, Yimei; Li, Funing; Zhu, Lu; Huang, Zhibin; Liu, Wei; Li, Jianchao; Zhang, Mingjie; Du, Jiulin; Zhang, Wenqing; Wen, Zilong
Nlrc3-like is required for microglia maintenance in zebrafish
Journal of Genetics and Genomics, v. 46, (6), June 2019, p. 291-299
Wang, Tienan; Yan, Bo; Lou, Liang; Lin, X.; Yu, T.; Wu, Shuting; Lu, Qing; Liu, Wei; Huang, Zhibin; Zhang, Mingjie; Zhang, Wenqing; Wen, Zilong
Tissue-resident macrophages: from zebrafish to mouse
Blood Science, v. 1, (1), August 2019, article number 13, p. 57-60
Lin, Xi; Wen, Zilong; Xu, Jin


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Article 2

Adult Zebrafish Langerhans Cells Arise from Hematopoietic Stem/Progenitor Cells
eLIFE, v. 7, June 2018, article number e36131
He, Sicong; Chen, Jiahao; Jiang, Yunyun; Wu, Yi; Zhu, Lu; Jin, Wan; Zhao, Changlong; Yu, Tao; Wang, Tienan; Wu, Shuting; Lin, Xi; Qu, Jianan; Zhang, Wenqing; Wen, Zilong; Xu, Jin
Il34-Csf1r Pathway Regulates the Migration and Colonization of Microglial Precursors
Developmental Cell, v. 46, (5), September 2018, p. 552-563.e4
Wu, Shuting; Xue, Rongtao; Hassan, Shaoli; Nguyen, Thi My Linh; Wang, Tienan; Pan, Hongru; Xu, Jin; Liu, Qifa; Zhang, Wenqing; Wen, Zilong

Conference paper 1

Labeling single cell for in-vivo study of cell fate mapping and lineage tracing
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, v. 10497, 2018, article number 104970J
He, Sicong; Xu, Jin; Wu yi; Tian, Ye; Sun, Qiqi; Wen, Zilong; Qu, Jianan


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Article 3

C-Myb Hyperactivity Leads to Myeloid and Lymphoid Malignancies in Zebrafish
Leukemia, v. 31, (1), January 2017, p. 222-233
Liu, Wei; Wu, M.; Huang, Z.; Lian, J.; Chen, J.; Wang, Tienan; Leung, A.Y.H.; Liao, Y.; Zhang, Zhang Jin; Liu, Qifa; Yen, K.; Lin, S.; Zon, Leonard I.; Wen, Zilong; Zhang, Yunfan; Zhang, Wenqing
Distinct Regulatory Networks Control the Development of Macrophages of Different Origins in Zebrafish
Blood, v. 129, (4), January 2017, p. 509-519
Yu, Tao; Guo, Weilin; Tian, Ye; Xu, Jin; Chen, Jiahao; Li, Li; Wen, Zilong
The First Wave of T Lymphopoiesis in Zebrafish Arises from Aorta Endothelium Independent of Hematopoietic Stem Cells
Journal of Experimental Medicine, v. 214, (11), November 2017, p. 3347-3360
Tian, Ye; Xu, Jin; Feng, Shachuan; He, Sicong; Zhao, Shizheng; Zhu, Lu; Jin, Wan; Dai, Yimei; Luo, Lingfei; Qu, Jianan Y.; Wen, Zilong

Conference paper 1

NME7 Functions in ciliogenesis and left-right asymmetry development
EMBO Conference–Centrosomes and Spindle Pole Bodies, EMBL Heidelberg, Germany, 24-27 September 2017
Liu, Pengfei; Yu, Tao; Wen, Zilong; Qi, Robert Zhong


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Article 5

Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish
Journal of Genetics and Genomics, v. 43, (10), October 2016, p. 593-600
Dai, Yimei; Zhu, Lu; Huang, Zhibin; Zhou, Minyu; Jin, Wan; Liu, Wei; Xu, Mengchang; Yu, Tao; Zhang, Yiyue; Wen, Zilong; Liao, Wangjun; Zhang, Wenqing
c-Myb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish
Blood, v. 128, (3), July 2016, p. 415-426
Jin, Hao; Huang, Zhibin; Chi, Yali; Wu, Mei; Zhou, Riyang; Zhao, Lingfeng; Xu, Jin; Zhen, Fenghua; Lan, Yahui; Li, Li; Zhang, Wenqing; Wen, Zilong; Zhang, Yiyue
Microglia Colonization of Developing Zebrafish Midbrain Is Promoted by Apoptotic Neuron and Lysophosphatidylcholine
Developmental Cell, v. 38, (2), July 2016, p. 214-222
Xu, Jin; Wang, Tienan; Wu, Yi; Jin, Wan; Wen, Zilong
Real-Time Imaging of Cell Behaviors in Living Organisms by a Mitochondria-Targeting AIE Fluorogen
Advanced Functional Materials, v. 26, (39), October 2016, p. 7132-7138
Situ, Bo; Chen, Sijie; Zhao, Engui; Leung, Wai Tung; Chen, Yilong; Hong, Yuning; Lam, Wing Yip; Wen, Zilong; Liu, Wei; Zhang, Wenqing; Zheng, Lei; Tang, Benzhong
RNA Polymerase III Component Rpc9 Regulates Hematopoietic Stem and Progenitor Cell Maintenance in Zebrafish
Development (Cambridge), v. 143, (12), June 2016, p. 2103-2110
Wei, Yonglong; Xu, Jin; Zhang, Wenqing; Wen, Zilong; Liu, Feng

Conference paper 1

Origin of Microglia in Brain: A Study in Zebrafish Model
Biomedical Optics Congress 2016, Florida United States : Optical Society of America, 2016
He, Sicong; Xu, Jin; Wen, Zilong; Qu, Jianan


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Article 3

Functions of Idh1 and Its Mutation in the Regulation of Developmental Hematopoiesis in Zebrafish
Blood, v. 125, (19), May 2015, p. 2974-2984
Shi, Xiangguo; He, Bai-Liang; Ma, Alvin C.H.; Guo, Yuhan; Chi, Yali; Man, Cheuk Him; Zhang, Wenqing; Zhang, Yiyue; Wen, Zilong; Cheng, Tao; Leung, Anskar Y.H.
Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish
Scientific Reports, v. 5, March 2015, article number 9011
Yuan, Hao; Zhang, Tao; Liu, Xiaohui; Deng, Min; Zhang, Wenqing; Wen, Zilong; Chen, Saijuan; Chen, Zhu; De The, Hugues; Zhou, Jun; Zhu, Jun
Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish
Developmental Cell, v. 34, (6), September 2015, p. 632-641
Xu, Jin; Zhu, Lu; He, Sicong; Wu, Yi; Jin, Wan; Yu, Tao; Qu, Jianan Y.; Wen, Zilong


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Article 3

IL-1β and reactive oxygen species differentially regulate neutrophil directional migration and basal random motility in a zebrafish injury-induced inflammation model
Journal of Immunology, v. 192, (12), June 2014, p. 5998-6008
Yan, Bo; Han, Peidong; Pan, Lifeng; Lu, Wei; Xiong, Jingwei; Zhang, Mingjie; Zhang, Wenqing; Li, Li; Wen, Zilong
In Vivo Micro-Vascular Imaging and Flow Cytometry in Zebrafish Using Two-photon Excited Endogenous Fluorescence
Biomedical Optics Express, v. 5, (3), 2014, p. 653-663
Zeng, Yan; Yan, Bo; Sun, Qiqi; He, Sicong; Jiang, Jun; Wen, Zilong; Qu, Jianan
In Vivo Nonlinear Optical Imaging of Immune Responses: Tissue Injury and Infection
Biophysical Journal, v. 107, (10), 2014, p. 2436-2443
Zeng, Yan; Yan, Bo; Xu, Jin; Sun, Qiqi; He, Sicong; Jiang, Jun; Wen, Zilong; Qu, Jianan

Conference paper 1

Nonlinear Optical Microscopy for in Vivo Imaging Microvasculature and Blood Flow
Conference Proceedings: Biomedical Optics, 2014
Zeng, Yan; Yan, Bo; Sun, Qiqi; He, Sicong; Jiang, Jun; Wen, Zilong; Qu, Jianan


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Article 3

Hemogenic Endothelium Specification and Hematopoietic Stem Cell Maintenance Employ Distinct Scl Isoforms
Development (Cambridge), v. 140, (19), October 2013, p. 3977-3985
Zhen, Fenghua; Lan, Yahui; Yan, Bo; Zhang, Wenqing; Wen, Zilong
Label-Free in Vivo Imaging of Human Leukocytes Using Two-photon Excited Endogenous Fluorescence
Journal of Biomedical Optics, v. 18, (4), 2013, article number 040504
Zeng, Yan; Yan, Bo; Sun, Qiqi; Teh, Seng Khoon; Zhang, Wei; Wen, Zilong; Qu, Jianan
Suppression of Pu.1 Function Results in Expanded Myelopoiesis in Zebrafish
Leukemia, v. 27, (9), September 2013, p. 1913-1917
Sun, Jiping; Liu, Wei; Li, Li; Chen, Jiahao; Wu, Mei; Zhang, Yiyue; Leung, Anskar; Zhang, Wenqing; Wen, Zilong; Liao, Wangjun

Conference paper 1

Two-Photon Excited Endogenous Fluorescence for Label-Free in Vivo Imaging Ingestion of Disease-Causing Bacteria by Human Leukocytes
SPIE Proceedings, v. 8588, February 2013
Zeng, Yan; Yan, Bo; Sun, Qiqi; Teh, Seng Khoon; Zhang, Wei; Wen, Zilong; Qu, Jianan


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Article 7

Antiparallel Coiled-coil-mediated Dimerization of Myosin X
Proceedings of the National Academy of Sciences of the United States of America, v. 109, (43), 2012, Oct, p. 17388-17393
Lu, Qing; Ye, Fei; Wei, Zhiyi; Wen, Zilong; Zhang, Mingjie
Label-free in Vivo Flow Cytometry in Zebrafish Using Two-photon Autofluorescence Imaging
Optics Letters, v. 37, (13), 2012, Jul, p. 2490-2492
Zeng, Yan; Xu, Jin; Li, Dong; Li, Li; Wen, Zilong; Qu, Jianan
Live Imaging Reveals Differing Roles of Macrophages and Neutrophils during Zebrafish Tail Fin Regeneration
Journal of Biological Chemistry, v. 287, (30), 2012, Jul, p. 25353-25360
Li, Li; Yan, Bo; Shi, Yu-Qian; Zhang, Wen-Qing; Wen, Zi-Long
Myelopoiesis during Zebrafish Early Development
Journal of Genetics and Genomics, v. 39, (9), 2012, Sep, p. 435-442
Xu, Jin; Du, Linsen; Wen, Zilong
Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo
Developmental cell, v. 23, (6), December 2012, p. 1189-1202
Li, Ying; Du, Xu-fei; Liu, Chang-sheng; Wen, Zi-long; Du, Jiu-lin
Runx1 Regulates Embryonic Myeloid Fate Choice in Zebrafish Through a Negative Feedback Loop Inhibiting Pu.1 Expression
Blood, v. 119, (22), 2012, Jun, p. 5239-5249
Jin, Hao; Li, Li; Xu, Jin; Zhen, Fenghua; Zhu, Lu; Liu, Pu Paul; Zhang, Mingjie; Zhang, Wenqing; Wen, Zilong
SUMO1-activating Enzyme Subunit 1 Is Essential for the Survival of Hematopoietic Stem/Progenitor Cells in Zebrafish
Development (Cambridge), v. 139, (23), 2012, Dec, p. 4321-4329
Li, Xiuling; Lan, Yahui; Xu, Jin; Zhang, Wenqing; Wen, Zilong

Conference paper 1

In vivo cytometry using two-photon autofluorescence microscopy
Biomedical Optics and 3-D Imaging, OSA Technical Digest (Optical Society of America), Miami, Florida, United States, 28 Apr - 2 May, 2012
Zeng, Yan; Xu, Jin; Li, Dong; Li, Li; Wen, Zilong; Qu, Jianan


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Article 4

CMyb Regulates Hematopoietic Stem/Progenitor Cell Mobilization during Zebrafish Hematopoiesis
Blood, v. 118, (15), 2011, Oct, p. 4093-4101
Zhang, Yiyue; Jin, H.; Li, L.; Qin, F.X.F.; Wen, Z.
Erythrocytes in the trunk of zebrafish embryos
Development, v. 138, (18), September 2011, p. 3862-3863
Jin, Hao; Wen, Zilong
Irf8 Regulates Macrophage Versus Neutrophil Fate During Zebrafish Primitive Myelopoiesis
Blood, v. 117, (4), 2011, p. 1359-1369
Li, Li; Jin, Hao; Xu, Jin; Shi, Yuqian; Wen, Zilong
Rumba and Haus3 are essential factors for the maintenance of hematopoietic stem/progenitor cells during zebrafish hematopoiesis
Development, v. 138, (4), 2011, Jan, p. 619-629
Du, Linsen; Xu, J.; Li, Xiuling; Ma, Ning; Liu, Yanmei; Peng, Jinrong; Osato, Motomi; Zhang, Wenqing; Wen, Zilong


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Article 3

A Runx1 intronic enhancer marks hemogenic endothelial cells and hematopoietic stem cells
Stem Cells, v. 28, (10), 2010, p. 1869-1881
Ng, Cherry Ee Lin; Yokomizo, Tomomasa; Yamashita, Namiko; Cirovic, Branko; Jin, Hao; Wen, Zilong; Ito, Yoshiaki; Osato, Motomi
Development of Multilineage Adult Hematopoiesis in the Zebrafish with a Runx1 Truncation Mutation
Blood, v. 115, (14), 2010, APR 8, p. 2806-2809
Sood, Raman; English, Milton A.; Belele, Christiane L.; Jin, Hao; Bishop, Kevin; Haskins, Rebecca; McKinney, Mary Cathleen; Chahal, Jagman; Weinstein, Brant M.; Wen, Zilong; Liu, P. Paul
Regulation of Gene Expression by FSP27 in White and Brown Adipose Tissue
BMC Genomics, v. 11, (1), 2010, JUL 22, Article number 446
Li, De; Zhang, Yinxin; Xu, Li; Zhou, Linkang; Wang, Yue; Xue, Bofu; Wen, Zilong; Li, Peng; Sang, Jianli


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Article 2

Autoinhibition of UNC5b Revealed by the Cytoplasmic Domain Structure of the Receptor
Molecular Cell, v. 33, (6), 2009, MAR 27, p. 692-703
Wang, Rui; Wei, Zhiyi; Jin, Hao; Wu, Hao; Yu, Cong; Wen, Wenyu; Chan, Ling Nga; Wen, Zilong; Zhang, Mingjie
Definitive Hematopoietic Stem/progenitor Cells Manifest Distinct Differentiation Output in the Zebrafish VDA and PBI
Development, v. 136, (4), 2009, FEB 15, p. 647-654
Jin, Hao; Sood, Raman; Xu, Jin; Zhen, Fenghua; English, Milton A.; Liu, Pu Paul; Wen, Zilong


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Article 2

Mypt1-mediated Spatial Positioning of Bmp2-producing Cells is Essential for Liver Organogenesis
Development, v. 135, (19), 2008, p. 3209-3218
Huang, Honghui; Ruan, Hua; Aw, Meng Yuan; Hussain, Alamgir; Guo, Lin; Gao, Chuan; Qian, Feng; Leung, Thomas; Song, Haiwei; Kimelman, David; Wen, Zilong; Peng, Jinrong
Up-Regulation of Mitochondrial Activity and Acquirement of Brown Adipose Tissue-Like Property in the White Adipose Tissue of Fsp27 Deficient Mice
PloS One, v. 3, (8), 2008, AUG 6
Toh, Shen Yon; Gong, Jingyi; Du, Guoli; Li, John Zhong; Yang, Shuqun; Ye, Jing; Yao, Huilan; Zhang, Yinxin; Xue, Bofu; Li, Qing; Yang, Hongyuan; Wen, Zilong; Li, Peng


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Article 5

Amotl2 is Essential for Cell Movements in Zebrafish Embryo and Regulates C-Src Translocation
Development, v. 134, (5), March 2007, p. 979-988
Huang, Huizhe; Lu, Fu-I; Jia, Shunji; Meng, Shu; Cao, Ying; Wang, Yeqi; Ma, Weiping; Yin, Kun; Wen, Zilong; Peng, Jingrong; Thisse, Christine; Thisse, Bernard; Meng, Anming
Cideb Regulates Diet-induced Obesity, Liver Steatosis, and Insulin Sensitivity by Controlling Lipogenesis and Fatty Acid Oxidation
Diabetes, v. 56, (10), 2007, OCT, p. 2523-2532
Li, John Zhong; Ye, Jing; Xue, Bofu; Qi, Jingzhong; Zhang, Jing; Zhou, Zhihong; Li, Qing; Wen, Zilong; Li, Peng
Distinct Functions for Different Scl Isoforms in Zebrafish Primitive and Definitive Hematopoiesis
PLoS Biology, v. 5, (5), May 2007, p. 1110-1119
Qian, Feng; Zhen, Fenghua; Xu, Jin; Huang, Mei; Li, Wanyu; Wen, Zilong
Migratory Path of Definitive Hematopoietic Stem/progenitor Cells During Zebrafish Development
Blood, v. 109, (12), 2007, p. 5208-5214
Jin, Hao; Xu, Jin; Wen, Zilong
The Zebrafish Udu Gene Encodes a Novel Nuclear Factor and is Essential for Primitive Erythroid Cell Development
Blood, v. 110, (1), 1 July 2007, p. 99-106
Liu, Yanmei; Du, Linsen; Osato, Motomi; Teo, Eng Hui; Qian, Feng; Jin, Hao; Zhen, Fenghua; Xu, Jin; Guo, Lin; Huang, Honghui; Chen, J.; Geisler, Robert; Jiang, Yun-Jin; Peng, Jinrong; Wen, Zilong


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Article 1

The 5′ zebrafish scl promoter targets transcription to the brain, spinal cord, and hematopoietic and endothelial progenitors
Developmental Dynamics, v. 235, (1), January 2006, p. 60-67
Jin, Hao; Xu, Jin; Qian, Feng; Du, Linsen; Tan, Chee Yong; Lin, Zhixin; Peng, Jinrong; Wen, Zilong


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Article 4

Genome-wide identification of female-enriched genes in zebrafish
Developmental Dynamics, v. 232, (1), January 2005, p. 171-179
Wen, Chaoming; Zhang, Zhenhai; Ma, Weiping; Xu, Min; Wen, Zilong; Peng, Jinrong
Identification of the Conserved Serine/threonine Residues Important for Gibberellin-sensitivity of Arabidopsis RGL2 Protein
Plant Journal, v. 44, (1), October 2005, p. 88-99
Hussain, Alamgir; Cao, Dongni; Cheng, Hui; Wen, Zilong; Peng, Jinrong
Loss of Function of Def Selectively Up-regulates Δ113p53 Expression to Arrest Expansion Growth of Digestive Organs in Zebrafish
Genes and Development, v. 19, (23), 1 December 2005, p. 2900-2911
Chen, Jun; Ruan, Hua; Ng, Sok Meng; Gao, Chuan; Soo, Hui Meng; Wu, Wei; Zhang, Zhenhai; Wen, Zilong; Lane, David P.; Peng, Jinrong
Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes
Developmental Dynamics, v. 233, (3), July 2005, p. 1163-1172
Qian, Feng; Zhen, Fenghua; Ong, Chinthing; Jin, Suk-Won; Soo, Hui Meng; Stainier, Didier Y.R.; Lin, Shuo; Peng, Jinrong; Wen, Zilong


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Article 2

15000 Unique Zebrafish EST Clusters and Their Future Use in Microarray for Profiling Gene Expression Patterns During Embryogenesis
Genome Research, v. 13, (3), 2003, p. 455-466
Lo, Jane; Lee, Sorcheng; Xu, Min; Liu, Feng; Ruan, Hua; Eun, Alvin; He, Yawen; Ma, Weiping; Wang, Weefuen; Wen, Zilong; Peng, Jinrong
Emergence of a coronavirus infectious bronchitis virus mutant with a truncated 3b gene: Functional characterization of the 3b protein in pathogenesis and replication
Virology, v. 311, (1), 20 June 2003, p. 16-27
Shen, Shuo; Wen, Zilong; Liu, Dingxiang


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Article 3

Cloning and Expression Pattern of the lysozyme C Gene in Zebrafish
Mechanisms of Development, v. 113, (1), 2002, p. 69-72
Liu, Feng; Wen, Zilong
Morphologic transformation of the thymus in developing zebrafish
Developmental Dynamics, v. 225, (1), September 2002, p. 87-94
Lam, Siewhong; Chua, H. L.; Gong, Zhiyuan; Wen, Zilong; LAM, Toongjin; SIN, Yokemin
The chromatin-remodelling factor BRG1 selectively activates a subset of interferon α-inducible genes
Nature Cell BIiology, v. 4, (10), Oct 2002, p. 774-781
Huang, Mei; Qian, Feng; Hu, Yuanyu; Ang, Chengeng; Li, Zhong; Wen, Zilong


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Article 1

The Linker Domain of Stat1 is Required for Gamma Interferon-driven Transcription
Molecular and Cellular Biology, v. 19, (7), 1999, p. 5016-5112
Yang, Edward; Wen, Zilong; Haspel, Richard L.; Zhang, Jue J.; Darnell, James E.


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Article 3

Mapping of Stat3 Serine Phosphorylation to a Single Residue (727) and Evidence that Serine Phosphorylation has no Influence on DNA Binding of Stat1 and Stat3
Nucleic Acids Research, v. 25, (11), 1997, p. 2062-2067
Wen, Zilong; Darnell, James E.
STAT signaling is active during early mammalian development
Developmental Dynamics, v. 208, (2), 1997, February, p. 190-198
Duncan, Stephen A.; Zhong, Zhong; Wen, Zilong; Darnell, James E.
Stat1 Serine Phosphorylation Occurs Independently of Tyrosine Phosphorylation and Requires an Activated Jak2 Kinase
Molecular and Cellular Biology, v. 17, (11), 1997, November, p. 6618-6623
Wen, Zilong; Xu, Liangzhong; Darnell, James E.; Zhu, Xuejun


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Article 1

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon α and interferon γ
Proceedings of the National Academy of Sciences of the United States of America, v. 93, (15), 1996, July, p. 7673-7678
Bromberg, Jacqueline F.; Horvath, Curt M.; Wen, Zilong; Schreiber, Robert D.; Darnell, James E.


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Article 6

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain
Genes and Development, v. 9, (8), 1995, p. 984-994
Horvath, Curt M.; Wen, Zilong; Darnell, James E.
Distribution of the mammalian Stat gene family in mouse chromosomes
Genomics, v. 29, (1), 1995, p. 225-228
Zhong, Zhong; Wen, Zilong; Darnell, James E.; Mui, Alice; Miyajima, Atsushi; Gilbert, Debra J.; Schindler, Christian W.; Quelle, Frederick W.; Ihle, James N.; Jenkins, Nancy A B G; Copeland, Neal G L F
In Vivo Growth Hormone Treatment Rapidly Stimulates the Tyrosine Phosphorylation and Activation of Stat3
Molecular Endocrinology, v. 9, (2), 1995, p.171-177
Gronowski, Ann M.; Zhong, Zhong; Wen, Zilong; Thomas, Michael J.; Rotwein, Peter S.; Darnell, James E.
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phopshorylation
Cell, v. 82, (2), 1995, July, p. 241-250
Wen, Zilong; Zhong, Zhong; Darnell, James E.
Stat3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase
Proceedings of the National Academy of Sciences of the United States of America, v. 92, (15), 1995, July, p. 6915-6919
Boulton, Teri G.; Zhong, Zhong; Wen, Zilong; Darnell, James E.; Stahl, Neil; Yancopoulo?, George D.
The Genomic Structure of the STAT Genes-multiple Exons in Coincident Sites in STAT1 and STAT2
Nucleic Acids Research, v. 23, (3), 1995, February, p. 459-463
Qureshi, Sajjad A.; Yan, Riqiang; Zhong, Zhong; Wen, Zilong; Darnell, James E.


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Article 3

Epidermal Growth Factor and Lipopolysaccharide Activate Stat3 Transcription Factor in Mouse Liver
Journal of Biological Chemistry, v. 269, (35), 1994, Septermber, p. 21933-21935
Ruff-Jamison, Susan; Zhong, Zhong; Wen, Zilong; Chen, Katherine; Darnell, James E.; Cohen, Stanley W.
Stat3 and Stat4: members of the family of signal transducers and activators of transcription
Proceedings of the National Academy of Sciences of the United States of America, v. 91, (11), 1994, May, p. 4806-4810
Zhong, Zhong; Wen, Zilong; Darnell, James E.
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
Science, v, 264, (5155), 1994, p. 95-98
Wen, Zilong; Zhong, Zhong; Darnell, James E.


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Article 1

Binding of peptides lacking consensus anchor residue alters H-2Ld serologic recognition
Immunology, v. 151, (10) 15 November 1993, p. 5387-5397
Solheim, Joyce C.; Carre?o, Beatriz M.; Smith, Joseph D.; Gorka, John; Myers, Nancy B.; Wen, Zilong; Martinko, John M.; Lee, David R.; Hansen, Ted H.


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Article 2

Interaction of an α-melanocyte-stimulating hormone-diphtheria toxin fusion protein with melanotropin receptors in human melanoma metastases
Cancer Research, v. 52, (9), 1992, p. 2545-2548
Tatro,Jeffrey B.; Wen, Zilong; Entwistle, Margaret L.; Atkin, Michael B.; Smith, Thomas J.; Reichlin, Seymour; Murphy, John R.
Phe496 and Leu497 are Essential for Receptor Binding and Cytotoxic Action of Murine Interleukin-4 Receptor Targeted Fusion Toxin DAB389-mIL-4
Protein Engineering, Design and Selecitionv. 5, (3), 1992, p. 241-248
Lakkis, Fadi G.; Landgraf, Bryan E.; Wen, Zilong; Strom, Terry B.; Murphy, John R.


Expand All Collapse All


Article 1

Diphtheria toxin-related α-melanocyte-stimulating hormone Fusion Toxin: Internal in-frame Deletion from Thr387 to His485 Results in the Formation of a Highly Potent Fusion Toxin which is Resistant to Proteolytic Degradation
Journal of Biological Chemistry, v. 266, (19), 1991, p. 12289-12293
Wen, Zilong; Tao, Xu; Lakkis, Fadi G.; Kiyokawa, Tetsuyuki; Murphy, John R.


Expand All Collapse All


Article 1

Cellular Processing of the Interleukin-2 Fusion Toxin DAB486-IL-2 and Efficient Delivery of Diphtheria Fragment A to the Cytosol of Target Cells Requires Arg194
Journal of Biological Chemistry, v. 265, (33), 1990, p. 20673-20677
Williams, Diane P.; Wen, Zilong; Watson, Rose Scott; Boyd, Jessica M.; Strom, Terry B.; Murphy, John R.


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2016 6

Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish
Journal of Genetics and Genomics, v. 43, (10), October 2016, p. 593-600
Dai, Yimei; Zhu, Lu; Huang, Zhibin; Zhou, Minyu; Jin, Wan; Liu, Wei; Xu, Mengchang; Yu, Tao; Zhang, Yiyue; Wen, Zilong; Liao, Wangjun; Zhang, Wenqing Article
c-Myb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish
Blood, v. 128, (3), July 2016, p. 415-426
Jin, Hao; Huang, Zhibin; Chi, Yali; Wu, Mei; Zhou, Riyang; Zhao, Lingfeng; Xu, Jin; Zhen, Fenghua; Lan, Yahui; Li, Li; Zhang, Wenqing; Wen, Zilong; Zhang, Yiyue Article
Microglia Colonization of Developing Zebrafish Midbrain Is Promoted by Apoptotic Neuron and Lysophosphatidylcholine
Developmental Cell, v. 38, (2), July 2016, p. 214-222
Xu, Jin; Wang, Tienan; Wu, Yi; Jin, Wan; Wen, Zilong Article
Real-Time Imaging of Cell Behaviors in Living Organisms by a Mitochondria-Targeting AIE Fluorogen
Advanced Functional Materials, v. 26, (39), October 2016, p. 7132-7138
Situ, Bo; Chen, Sijie; Zhao, Engui; Leung, Wai Tung; Chen, Yilong; Hong, Yuning; Lam, Wing Yip; Wen, Zilong; Liu, Wei; Zhang, Wenqing; Zheng, Lei; Tang, Benzhong Article
RNA Polymerase III Component Rpc9 Regulates Hematopoietic Stem and Progenitor Cell Maintenance in Zebrafish
Development (Cambridge), v. 143, (12), June 2016, p. 2103-2110
Wei, Yonglong; Xu, Jin; Zhang, Wenqing; Wen, Zilong; Liu, Feng Article
Origin of Microglia in Brain: A Study in Zebrafish Model
Biomedical Optics Congress 2016, Florida United States : Optical Society of America, 2016
He, Sicong; Xu, Jin; Wen, Zilong; Qu, Jianan Conference paper

2015 3

Functions of Idh1 and Its Mutation in the Regulation of Developmental Hematopoiesis in Zebrafish
Blood, v. 125, (19), May 2015, p. 2974-2984
Shi, Xiangguo; He, Bai-Liang; Ma, Alvin C.H.; Guo, Yuhan; Chi, Yali; Man, Cheuk Him; Zhang, Wenqing; Zhang, Yiyue; Wen, Zilong; Cheng, Tao; Leung, Anskar Y.H. Article
Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish
Scientific Reports, v. 5, March 2015, article number 9011
Yuan, Hao; Zhang, Tao; Liu, Xiaohui; Deng, Min; Zhang, Wenqing; Wen, Zilong; Chen, Saijuan; Chen, Zhu; De The, Hugues; Zhou, Jun; Zhu, Jun Article
Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish
Developmental Cell, v. 34, (6), September 2015, p. 632-641
Xu, Jin; Zhu, Lu; He, Sicong; Wu, Yi; Jin, Wan; Yu, Tao; Qu, Jianan Y.; Wen, Zilong Article

2014 4

IL-1β and reactive oxygen species differentially regulate neutrophil directional migration and basal random motility in a zebrafish injury-induced inflammation model
Journal of Immunology, v. 192, (12), June 2014, p. 5998-6008
Yan, Bo; Han, Peidong; Pan, Lifeng; Lu, Wei; Xiong, Jingwei; Zhang, Mingjie; Zhang, Wenqing; Li, Li; Wen, Zilong Article
In Vivo Micro-Vascular Imaging and Flow Cytometry in Zebrafish Using Two-photon Excited Endogenous Fluorescence
Biomedical Optics Express, v. 5, (3), 2014, p. 653-663
Zeng, Yan; Yan, Bo; Sun, Qiqi; He, Sicong; Jiang, Jun; Wen, Zilong; Qu, Jianan Article
In Vivo Nonlinear Optical Imaging of Immune Responses: Tissue Injury and Infection
Biophysical Journal, v. 107, (10), 2014, p. 2436-2443
Zeng, Yan; Yan, Bo; Xu, Jin; Sun, Qiqi; He, Sicong; Jiang, Jun; Wen, Zilong; Qu, Jianan Article
Nonlinear Optical Microscopy for in Vivo Imaging Microvasculature and Blood Flow
Conference Proceedings: Biomedical Optics, 2014
Zeng, Yan; Yan, Bo; Sun, Qiqi; He, Sicong; Jiang, Jun; Wen, Zilong; Qu, Jianan Conference paper

2013 4

Hemogenic Endothelium Specification and Hematopoietic Stem Cell Maintenance Employ Distinct Scl Isoforms
Development (Cambridge), v. 140, (19), October 2013, p. 3977-3985
Zhen, Fenghua; Lan, Yahui; Yan, Bo; Zhang, Wenqing; Wen, Zilong Article
Label-Free in Vivo Imaging of Human Leukocytes Using Two-photon Excited Endogenous Fluorescence
Journal of Biomedical Optics, v. 18, (4), 2013, article number 040504
Zeng, Yan; Yan, Bo; Sun, Qiqi; Teh, Seng Khoon; Zhang, Wei; Wen, Zilong; Qu, Jianan Article
Suppression of Pu.1 Function Results in Expanded Myelopoiesis in Zebrafish
Leukemia, v. 27, (9), September 2013, p. 1913-1917
Sun, Jiping; Liu, Wei; Li, Li; Chen, Jiahao; Wu, Mei; Zhang, Yiyue; Leung, Anskar; Zhang, Wenqing; Wen, Zilong; Liao, Wangjun Article
Two-Photon Excited Endogenous Fluorescence for Label-Free in Vivo Imaging Ingestion of Disease-Causing Bacteria by Human Leukocytes
SPIE Proceedings, v. 8588, February 2013
Zeng, Yan; Yan, Bo; Sun, Qiqi; Teh, Seng Khoon; Zhang, Wei; Wen, Zilong; Qu, Jianan Conference paper

2012 8

Antiparallel Coiled-coil-mediated Dimerization of Myosin X
Proceedings of the National Academy of Sciences of the United States of America, v. 109, (43), 2012, Oct, p. 17388-17393
Lu, Qing; Ye, Fei; Wei, Zhiyi; Wen, Zilong; Zhang, Mingjie Article
Label-free in Vivo Flow Cytometry in Zebrafish Using Two-photon Autofluorescence Imaging
Optics Letters, v. 37, (13), 2012, Jul, p. 2490-2492
Zeng, Yan; Xu, Jin; Li, Dong; Li, Li; Wen, Zilong; Qu, Jianan Article
Live Imaging Reveals Differing Roles of Macrophages and Neutrophils during Zebrafish Tail Fin Regeneration
Journal of Biological Chemistry, v. 287, (30), 2012, Jul, p. 25353-25360
Li, Li; Yan, Bo; Shi, Yu-Qian; Zhang, Wen-Qing; Wen, Zi-Long Article
Myelopoiesis during Zebrafish Early Development
Journal of Genetics and Genomics, v. 39, (9), 2012, Sep, p. 435-442
Xu, Jin; Du, Linsen; Wen, Zilong Article
Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo
Developmental cell, v. 23, (6), December 2012, p. 1189-1202
Li, Ying; Du, Xu-fei; Liu, Chang-sheng; Wen, Zi-long; Du, Jiu-lin Article
Runx1 Regulates Embryonic Myeloid Fate Choice in Zebrafish Through a Negative Feedback Loop Inhibiting Pu.1 Expression
Blood, v. 119, (22), 2012, Jun, p. 5239-5249
Jin, Hao; Li, Li; Xu, Jin; Zhen, Fenghua; Zhu, Lu; Liu, Pu Paul; Zhang, Mingjie; Zhang, Wenqing; Wen, Zilong Article
SUMO1-activating Enzyme Subunit 1 Is Essential for the Survival of Hematopoietic Stem/Progenitor Cells in Zebrafish
Development (Cambridge), v. 139, (23), 2012, Dec, p. 4321-4329
Li, Xiuling; Lan, Yahui; Xu, Jin; Zhang, Wenqing; Wen, Zilong Article
In vivo cytometry using two-photon autofluorescence microscopy
Biomedical Optics and 3-D Imaging, OSA Technical Digest (Optical Society of America), Miami, Florida, United States, 28 Apr - 2 May, 2012
Zeng, Yan; Xu, Jin; Li, Dong; Li, Li; Wen, Zilong; Qu, Jianan Conference paper

2011 4

CMyb Regulates Hematopoietic Stem/Progenitor Cell Mobilization during Zebrafish Hematopoiesis
Blood, v. 118, (15), 2011, Oct, p. 4093-4101
Zhang, Yiyue; Jin, H.; Li, L.; Qin, F.X.F.; Wen, Z. Article
Erythrocytes in the trunk of zebrafish embryos
Development, v. 138, (18), September 2011, p. 3862-3863
Jin, Hao; Wen, Zilong Article
Irf8 Regulates Macrophage Versus Neutrophil Fate During Zebrafish Primitive Myelopoiesis
Blood, v. 117, (4), 2011, p. 1359-1369
Li, Li; Jin, Hao; Xu, Jin; Shi, Yuqian; Wen, Zilong Article
Rumba and Haus3 are essential factors for the maintenance of hematopoietic stem/progenitor cells during zebrafish hematopoiesis
Development, v. 138, (4), 2011, Jan, p. 619-629
Du, Linsen; Xu, J.; Li, Xiuling; Ma, Ning; Liu, Yanmei; Peng, Jinrong; Osato, Motomi; Zhang, Wenqing; Wen, Zilong Article

2010 3

A Runx1 intronic enhancer marks hemogenic endothelial cells and hematopoietic stem cells
Stem Cells, v. 28, (10), 2010, p. 1869-1881
Ng, Cherry Ee Lin; Yokomizo, Tomomasa; Yamashita, Namiko; Cirovic, Branko; Jin, Hao; Wen, Zilong; Ito, Yoshiaki; Osato, Motomi Article
Development of Multilineage Adult Hematopoiesis in the Zebrafish with a Runx1 Truncation Mutation
Blood, v. 115, (14), 2010, APR 8, p. 2806-2809
Sood, Raman; English, Milton A.; Belele, Christiane L.; Jin, Hao; Bishop, Kevin; Haskins, Rebecca; McKinney, Mary Cathleen; Chahal, Jagman; Weinstein, Brant M.; Wen, Zilong; Liu, P. Paul Article
Regulation of Gene Expression by FSP27 in White and Brown Adipose Tissue
BMC Genomics, v. 11, (1), 2010, JUL 22, Article number 446
Li, De; Zhang, Yinxin; Xu, Li; Zhou, Linkang; Wang, Yue; Xue, Bofu; Wen, Zilong; Li, Peng; Sang, Jianli Article

2009 2

Autoinhibition of UNC5b Revealed by the Cytoplasmic Domain Structure of the Receptor
Molecular Cell, v. 33, (6), 2009, MAR 27, p. 692-703
Wang, Rui; Wei, Zhiyi; Jin, Hao; Wu, Hao; Yu, Cong; Wen, Wenyu; Chan, Ling Nga; Wen, Zilong; Zhang, Mingjie Article
Definitive Hematopoietic Stem/progenitor Cells Manifest Distinct Differentiation Output in the Zebrafish VDA and PBI
Development, v. 136, (4), 2009, FEB 15, p. 647-654
Jin, Hao; Sood, Raman; Xu, Jin; Zhen, Fenghua; English, Milton A.; Liu, Pu Paul; Wen, Zilong Article

2008 2

Mypt1-mediated Spatial Positioning of Bmp2-producing Cells is Essential for Liver Organogenesis
Development, v. 135, (19), 2008, p. 3209-3218
Huang, Honghui; Ruan, Hua; Aw, Meng Yuan; Hussain, Alamgir; Guo, Lin; Gao, Chuan; Qian, Feng; Leung, Thomas; Song, Haiwei; Kimelman, David; Wen, Zilong; Peng, Jinrong Article
Up-Regulation of Mitochondrial Activity and Acquirement of Brown Adipose Tissue-Like Property in the White Adipose Tissue of Fsp27 Deficient Mice
PloS One, v. 3, (8), 2008, AUG 6
Toh, Shen Yon; Gong, Jingyi; Du, Guoli; Li, John Zhong; Yang, Shuqun; Ye, Jing; Yao, Huilan; Zhang, Yinxin; Xue, Bofu; Li, Qing; Yang, Hongyuan; Wen, Zilong; Li, Peng Article

2007 5

Amotl2 is Essential for Cell Movements in Zebrafish Embryo and Regulates C-Src Translocation
Development, v. 134, (5), March 2007, p. 979-988
Huang, Huizhe; Lu, Fu-I; Jia, Shunji; Meng, Shu; Cao, Ying; Wang, Yeqi; Ma, Weiping; Yin, Kun; Wen, Zilong; Peng, Jingrong; Thisse, Christine; Thisse, Bernard; Meng, Anming Article
Cideb Regulates Diet-induced Obesity, Liver Steatosis, and Insulin Sensitivity by Controlling Lipogenesis and Fatty Acid Oxidation
Diabetes, v. 56, (10), 2007, OCT, p. 2523-2532
Li, John Zhong; Ye, Jing; Xue, Bofu; Qi, Jingzhong; Zhang, Jing; Zhou, Zhihong; Li, Qing; Wen, Zilong; Li, Peng Article
Distinct Functions for Different Scl Isoforms in Zebrafish Primitive and Definitive Hematopoiesis
PLoS Biology, v. 5, (5), May 2007, p. 1110-1119
Qian, Feng; Zhen, Fenghua; Xu, Jin; Huang, Mei; Li, Wanyu; Wen, Zilong Article
Migratory Path of Definitive Hematopoietic Stem/progenitor Cells During Zebrafish Development
Blood, v. 109, (12), 2007, p. 5208-5214
Jin, Hao; Xu, Jin; Wen, Zilong Article
The Zebrafish Udu Gene Encodes a Novel Nuclear Factor and is Essential for Primitive Erythroid Cell Development
Blood, v. 110, (1), 1 July 2007, p. 99-106
Liu, Yanmei; Du, Linsen; Osato, Motomi; Teo, Eng Hui; Qian, Feng; Jin, Hao; Zhen, Fenghua; Xu, Jin; Guo, Lin; Huang, Honghui; Chen, J.; Geisler, Robert; Jiang, Yun-Jin; Peng, Jinrong; Wen, Zilong Article

2006 1

The 5′ zebrafish scl promoter targets transcription to the brain, spinal cord, and hematopoietic and endothelial progenitors
Developmental Dynamics, v. 235, (1), January 2006, p. 60-67
Jin, Hao; Xu, Jin; Qian, Feng; Du, Linsen; Tan, Chee Yong; Lin, Zhixin; Peng, Jinrong; Wen, Zilong Article

2005 4

Genome-wide identification of female-enriched genes in zebrafish
Developmental Dynamics, v. 232, (1), January 2005, p. 171-179
Wen, Chaoming; Zhang, Zhenhai; Ma, Weiping; Xu, Min; Wen, Zilong; Peng, Jinrong Article
Identification of the Conserved Serine/threonine Residues Important for Gibberellin-sensitivity of Arabidopsis RGL2 Protein
Plant Journal, v. 44, (1), October 2005, p. 88-99
Hussain, Alamgir; Cao, Dongni; Cheng, Hui; Wen, Zilong; Peng, Jinrong Article
Loss of Function of Def Selectively Up-regulates Δ113p53 Expression to Arrest Expansion Growth of Digestive Organs in Zebrafish
Genes and Development, v. 19, (23), 1 December 2005, p. 2900-2911
Chen, Jun; Ruan, Hua; Ng, Sok Meng; Gao, Chuan; Soo, Hui Meng; Wu, Wei; Zhang, Zhenhai; Wen, Zilong; Lane, David P.; Peng, Jinrong Article
Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes
Developmental Dynamics, v. 233, (3), July 2005, p. 1163-1172
Qian, Feng; Zhen, Fenghua; Ong, Chinthing; Jin, Suk-Won; Soo, Hui Meng; Stainier, Didier Y.R.; Lin, Shuo; Peng, Jinrong; Wen, Zilong Article

2003 2

15000 Unique Zebrafish EST Clusters and Their Future Use in Microarray for Profiling Gene Expression Patterns During Embryogenesis
Genome Research, v. 13, (3), 2003, p. 455-466
Lo, Jane; Lee, Sorcheng; Xu, Min; Liu, Feng; Ruan, Hua; Eun, Alvin; He, Yawen; Ma, Weiping; Wang, Weefuen; Wen, Zilong; Peng, Jinrong Article
Emergence of a coronavirus infectious bronchitis virus mutant with a truncated 3b gene: Functional characterization of the 3b protein in pathogenesis and replication
Virology, v. 311, (1), 20 June 2003, p. 16-27
Shen, Shuo; Wen, Zilong; Liu, Dingxiang Article

2002 3

Cloning and Expression Pattern of the lysozyme C Gene in Zebrafish
Mechanisms of Development, v. 113, (1), 2002, p. 69-72
Liu, Feng; Wen, Zilong Article
Morphologic transformation of the thymus in developing zebrafish
Developmental Dynamics, v. 225, (1), September 2002, p. 87-94
Lam, Siewhong; Chua, H. L.; Gong, Zhiyuan; Wen, Zilong; LAM, Toongjin; SIN, Yokemin Article
The chromatin-remodelling factor BRG1 selectively activates a subset of interferon α-inducible genes
Nature Cell BIiology, v. 4, (10), Oct 2002, p. 774-781
Huang, Mei; Qian, Feng; Hu, Yuanyu; Ang, Chengeng; Li, Zhong; Wen, Zilong Article

1999 1

The Linker Domain of Stat1 is Required for Gamma Interferon-driven Transcription
Molecular and Cellular Biology, v. 19, (7), 1999, p. 5016-5112
Yang, Edward; Wen, Zilong; Haspel, Richard L.; Zhang, Jue J.; Darnell, James E. Article

1997 3

Mapping of Stat3 Serine Phosphorylation to a Single Residue (727) and Evidence that Serine Phosphorylation has no Influence on DNA Binding of Stat1 and Stat3
Nucleic Acids Research, v. 25, (11), 1997, p. 2062-2067
Wen, Zilong; Darnell, James E. Article
STAT signaling is active during early mammalian development
Developmental Dynamics, v. 208, (2), 1997, February, p. 190-198
Duncan, Stephen A.; Zhong, Zhong; Wen, Zilong; Darnell, James E. Article
Stat1 Serine Phosphorylation Occurs Independently of Tyrosine Phosphorylation and Requires an Activated Jak2 Kinase
Molecular and Cellular Biology, v. 17, (11), 1997, November, p. 6618-6623
Wen, Zilong; Xu, Liangzhong; Darnell, James E.; Zhu, Xuejun Article

1996 1

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon α and interferon γ
Proceedings of the National Academy of Sciences of the United States of America, v. 93, (15), 1996, July, p. 7673-7678
Bromberg, Jacqueline F.; Horvath, Curt M.; Wen, Zilong; Schreiber, Robert D.; Darnell, James E. Article

1995 6

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain
Genes and Development, v. 9, (8), 1995, p. 984-994
Horvath, Curt M.; Wen, Zilong; Darnell, James E. Article
Distribution of the mammalian Stat gene family in mouse chromosomes
Genomics, v. 29, (1), 1995, p. 225-228
Zhong, Zhong; Wen, Zilong; Darnell, James E.; Mui, Alice; Miyajima, Atsushi; Gilbert, Debra J.; Schindler, Christian W.; Quelle, Frederick W.; Ihle, James N.; Jenkins, Nancy A B G; Copeland, Neal G L F Article
In Vivo Growth Hormone Treatment Rapidly Stimulates the Tyrosine Phosphorylation and Activation of Stat3
Molecular Endocrinology, v. 9, (2), 1995, p.171-177
Gronowski, Ann M.; Zhong, Zhong; Wen, Zilong; Thomas, Michael J.; Rotwein, Peter S.; Darnell, James E. Article
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phopshorylation
Cell, v. 82, (2), 1995, July, p. 241-250
Wen, Zilong; Zhong, Zhong; Darnell, James E. Article
Stat3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase
Proceedings of the National Academy of Sciences of the United States of America, v. 92, (15), 1995, July, p. 6915-6919
Boulton, Teri G.; Zhong, Zhong; Wen, Zilong; Darnell, James E.; Stahl, Neil; Yancopoulo?, George D. Article
The Genomic Structure of the STAT Genes-multiple Exons in Coincident Sites in STAT1 and STAT2
Nucleic Acids Research, v. 23, (3), 1995, February, p. 459-463
Qureshi, Sajjad A.; Yan, Riqiang; Zhong, Zhong; Wen, Zilong; Darnell, James E. Article

1994 3

Epidermal Growth Factor and Lipopolysaccharide Activate Stat3 Transcription Factor in Mouse Liver
Journal of Biological Chemistry, v. 269, (35), 1994, Septermber, p. 21933-21935
Ruff-Jamison, Susan; Zhong, Zhong; Wen, Zilong; Chen, Katherine; Darnell, James E.; Cohen, Stanley W. Article
Stat3 and Stat4: members of the family of signal transducers and activators of transcription
Proceedings of the National Academy of Sciences of the United States of America, v. 91, (11), 1994, May, p. 4806-4810
Zhong, Zhong; Wen, Zilong; Darnell, James E. Article
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
Science, v, 264, (5155), 1994, p. 95-98
Wen, Zilong; Zhong, Zhong; Darnell, James E. Article

1993 1

Binding of peptides lacking consensus anchor residue alters H-2Ld serologic recognition
Immunology, v. 151, (10) 15 November 1993, p. 5387-5397
Solheim, Joyce C.; Carre?o, Beatriz M.; Smith, Joseph D.; Gorka, John; Myers, Nancy B.; Wen, Zilong; Martinko, John M.; Lee, David R.; Hansen, Ted H. Article

1992 2

Interaction of an α-melanocyte-stimulating hormone-diphtheria toxin fusion protein with melanotropin receptors in human melanoma metastases
Cancer Research, v. 52, (9), 1992, p. 2545-2548
Tatro,Jeffrey B.; Wen, Zilong; Entwistle, Margaret L.; Atkin, Michael B.; Smith, Thomas J.; Reichlin, Seymour; Murphy, John R. Article
Phe496 and Leu497 are Essential for Receptor Binding and Cytotoxic Action of Murine Interleukin-4 Receptor Targeted Fusion Toxin DAB389-mIL-4
Protein Engineering, Design and Selecitionv. 5, (3), 1992, p. 241-248
Lakkis, Fadi G.; Landgraf, Bryan E.; Wen, Zilong; Strom, Terry B.; Murphy, John R. Article

1991 1

Diphtheria toxin-related α-melanocyte-stimulating hormone Fusion Toxin: Internal in-frame Deletion from Thr387 to His485 Results in the Formation of a Highly Potent Fusion Toxin which is Resistant to Proteolytic Degradation
Journal of Biological Chemistry, v. 266, (19), 1991, p. 12289-12293
Wen, Zilong; Tao, Xu; Lakkis, Fadi G.; Kiyokawa, Tetsuyuki; Murphy, John R. Article

1990 1

Cellular Processing of the Interleukin-2 Fusion Toxin DAB486-IL-2 and Efficient Delivery of Diphtheria Fragment A to the Cytosol of Target Cells Requires Arg194
Journal of Biological Chemistry, v. 265, (33), 1990, p. 20673-20677
Williams, Diane P.; Wen, Zilong; Watson, Rose Scott; Boyd, Jessica M.; Strom, Terry B.; Murphy, John R. Article


No Publications






Teaching Assignment

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2021-22 Winter 0 2021-22 Fall 7 2020-21 Summer 1 2020-21 Spring 4 2020-21 Winter 0 2020-21 Fall 4

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LIFS4910A Independent Study
LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS4971 Biochemistry and Cell Biology Project Research I
LIFS6111O Life Science Postgraduate Student Seminar
LIFS6170 Special Topics in Molecular, Cell and Developmental Biology
UROP2100E Undergraduate Research Opportunities Series 2
UROP3100E Undergraduate Research Opportunities Series 3


UROP1100D Undergraduate Research Opportunities Series 1


LIFS4060 Immunobiology
LIFS5260 Biochemical and Molecular Basis of Diseases
LIFS6115D Current Topics in Development and Systems Biology
SCIE1500 Guided Study on Research I


LIFS4960 Biological Science Capstone Project
LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS4963 Biotechnology Capstone Project
LIFS6170 Special Topics in Molecular, Cell and Developmental Biology


No Teaching Assignments


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)

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All Supervisions Current RPGs Graduated RPGs

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Current RPGs

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Doctor of Philosophy CHENG, Kefan
Life Science( 2021 - )

HUANG, Ying
Life Science( 2021 - )

LI, Si
Life Science( 2021 - )

PHAM, Thi Giang
Life Science( 2021 - )

WU, Haowei
Life Science( 2021 - )

ZHU, Hao
Life Science( 2021 - )

TANG, Jinlin
Life Science( 2020 - )

HASSAN, Shaoli
Life Science( 2019 - )

NGUYEN, Thi My Linh
Life Science( 2019 - )

TRINH, Thi Huong
Life Science( 2019 - )

ZHOU, Qiuxia
Life Science( 2019 - )

LIN, Guanzhen
Life Science( 2018 - )

LOU, Liang
Life Science( 2018 - )

PAN, Hongru
Life Science( 2018 - )

ZHAO, Shizheng
Life Science( 2018 - )

ZHAO, Changlong
Life Science( 2017 - )

FENG, Shachuan
Life Science( 2015 - )

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Graduated RPGs

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Doctor of Philosophy DAI, Yimei
Life Science( Completed in 2020 )

GUO, Weilin
Life Science( Completed in 2020 )

LIN, Xi
Life Science( Completed in 2020 )

TIAN, Ye
Life Science( Completed in 2019 )

WU, Shuting
Life Science( Completed in 2019 )

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Master of Philosophy CHENG, Kefan (co-supervision)
Life Science( Completed in 2021 )

FU, Yiming (co-supervision)
Electronic and Computer Engineering( Completed in 2021 )

NGUYEN, Thi My Linh
Life Science( Completed in 2019 )

ZHOU, Qiuxia
Life Science( Completed in 2019 )









ProjectsFrom January 2020 to December 2022

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All Projects 12 Leading Projects 8 Participating Projects 4

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Stem cell-niche interactions in tissue maintenance and engineering


干细胞与微环境互作在组织维持和组织工程中的应用 Participating


RGC - Theme-based Research Scheme


Project Team (HKUST)
XIE Ting (Lead)
CHEUNG Tom
GUO Yusong
LEUNG Danny Chi Yeu
LIU Kai
MAK Ho Yi
SUN Fei
WEN Zilong
WU Angela Ruohao
WU Zhenguo
YAN Yan


2022 -




The development and immune function of metaphocytes in zebrafish barrier tissues


斑马鱼屏障组织中介递细胞的发育和免疫功能研究 Leading


RGC - General Research Fund


Project Team (HKUST)
WEN Zilong (Lead)


2022 -




The molecular control of microglia maintenance


小胶质细胞群体维持的分子机制 Leading


RGC - General Research Fund


Project Team (HKUST)
WEN Zilong (Lead)


2021 -




Molecular Mechanisms of Cell Lineage Transition and Hematopoietic Tissue Formation subtopic 2: Blood cell progressive differentiation and programming mechanism


细胞谱系转变与造血组织形成的编程机制项目之课题二血细胞逐级分化与编程机制 Participating


Ministry of Science and Technology of the People's Republic of China


Project Team (HKUST)
WEN Zilong


2019 -




A Stem Cell Approach to Dissect the Molecular Basis of Neurodegenerative Diseases


以干细胞方法解析神经退行性疾病的分子基础 Participating


RGC - Theme-based Research Scheme


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
CHUNG Kenny K
FU Amy Kit Yu
QI Robert Zhong
QU Jianan
TSIM Karl Wah Keung
WEN Zilong
WONG Yung Hou
WU Zhenguo
XIA Jun


2019 -




Hematopoietic Cell Development Leading


Croucher Foundation


Project Team (HKUST)
WEN Zilong (Lead)


2019 -




The migratory path and regulation of hematopoietic stem cell migration during development


探究造血干细胞在斑马鱼发育过程中的迁移路径及相关调控机制 Leading


RGC - General Research Fund


Project Team (HKUST)
WEN Zilong (Lead)


2019 - 2021




Development of infrared-mediated single cell-labeling and study of non-HSC-derived T cells in zebrafish


研发红外光介导的单细胞标记技术以及研究斑马鱼中非造血干细胞来源的T淋巴细胞 Leading


RGC - Collaborative Research Fund


Project Team (HKUST)
WEN Zilong (Lead)
QU Jianan
WANG Jiguang
WU Angela Ruohao


2018 - 2021




The role of phospholipid signaling in microglia colonization and small chemical compound screening in zebrafish


溶血磷脂酸信号途径调控斑马鱼小胶质细胞神经组织定植作用及小分子化合物筛选 Leading


National Natural Science Foundation of China / Research Grants Council Joint Research Scheme


Project Team (HKUST)
WEN Zilong (Lead)


2018 - 2021




Unraveling the roles of Csf1r and their ligands in zebrafish hematopoiesis


探究斑马鱼中Csf1r受体以及其配体在造血发育中的作用 Leading


RGC - General Research Fund


Project Team (HKUST)
WEN Zilong (Lead)


2018 - 2020




Mechanistic basis of synaptic development, signalling and neuro-disorders


神经突触的发育,信号转导及经神疾病的分子机理 Leading


RGC - Areas of Excellence Scheme


Project Team (HKUST)
WEN Zilong (Lead)
LIU Kai
QU Jianan
WU Zhenguo
YAN Yan


2013 -




State Key Laboratory of Molecular Neuroscience (The Hong Kong University of Science and Technology)


分子神经科学国家重点实验室（香港科技大学） Participating


Innovation and Technology Fund


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHOW King Lau
CHUNG Kenny K
DAI Wei Min
GUO Zhihong
HUANG Pingbo
LIANG Chun
MILLER Andrew Leitch
POON Randy Yat Choi
QI Robert Zhong
TSIM Karl Wah Keung
WEN Zilong
WONG Joseph Tin Yum
WONG Yung Hou
WU Zhenguo
ZHU Guang


2011 -