Tuan Anh NGUYEN

PhD in Biochemistry
Korea Advanced Institute of Science and Technology, 2012

Assistant Professor
Division of Life Science



(852) 3469 2679
tuananh@ust.hk
Room 5513
Personal Web

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ORCID
0000-0001-7793-2699

Scopus ID
57202141736




Research Interest Publications Projects Teaching Assignment RPG Supervision Space used




Research Interest

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RNA interacting proteins and enzymes lab (RIPE Lab)
Chemical biology
Molecular biology
Structural biology



Publications

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All Years 21 2022 0 2021 1 2020 4 2019 1 2018 2 2017 0 2016 13

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2021 1

Bulges control pri-miRNA processing in a position and strand-dependent manner
RNA biology, 31 December 2020
Li, Shaohua; Le, Thi Nhu Y; Nguyen, Trung Duc; Trinh, Tam Anh; Nguyen, Tuan Anh Article

2020 4

Human disease-associated single nucleotide polymorphism changes the orientation of DROSHA on pri-mir-146a
RNA, v. 26, (12), December 2020, p. 1777-1786
Le, Cong Truc; Nguyen, Thuy Linh; Nguyen, Trung Duc; Nguyen, Tuan Anh Article
Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor
Nature Communications, v. 11, (1), December 2020, article number 1926
Li, Shaohua; Nguyen, Trung Duc; Nguyen, Thuy Linh; Nguyen, Tuan Anh Article
Select Amino Acids in DGCR8 Are Essential for the UGU-pri-miRNA Interaction and Processing
Communications Biology, v. 3, July 2020, article number 244
Dang, Thi Lieu; Le, Cong Truc; Le, Minh Ngoc; Nguyen, Trung Duc; Nguyen, Thuy Linh; Bao, Sheng; Li, Shaohua; Nguyen, Tuan Anh Article
The Internal Loops in the Lower Stem of Primary MicroRNA Transcripts Facilitate Single Cleavage of Human Microprocessor
Nucleic Acids Research, v. 48, (5), March 2020, p. 2579-2593
Nguyen, Thuy Linh; Nguyen, Trung Duc; Bao, Sheng; Li, Shaohua; Nguyen, Tuan Anh Article

2019 1

Orientation of Human Microprocessor on Primary MicroRNAs
Biochemistry, v. 58, (4), January 2019, p. 189-198
Nguyen, Huong Minh; Nguyen, Trung Duc; Nguyen, Thuy Linh; Nguyen, Tuan Anh Article

2018 2

Microprocessor Depends on Hemin to Recognize the Apical Loop of Primary MicroRNA
Nucleic Acids Research, v. 46, (11), June 2018, p. 5726-5736
Nguyen, Tuan Anh; Park, Joha; Dang, Thi Lieu; Choi, Yeon-Gil; Kim, Narry Article
SRSF₃ recruits DROSHA to the basal junction of primary microRNAs
RNA, v. 24, (7), July 2018, p. 892-898
Kim, Kijun; Nguyen, Trung Duc; Li, Shaohua; Nguyen, Tuan Anh Article

2016 1

Structure of Human DROSHA
Cell, v. 164, (1-2), January 2016, p. 81-90
Kwon, S. Chul; Nguyen, Tuan Anh; Choi, Yeongil; Jo, Myunghyun; Hohng, Sungchul C.; Kim, V. Narry; Woo, Jae-Sung Article

2015 3

A Physiological Significance Of The Functional Interaction Between Mus81 And Rad27 In Homologous Recombination Repair
Nucleic Acids Research, v. 43, (3), 2015, p. 1684-1699
Thu, Huong Phung Thi; Nguyen, Tuan Anh; Munashingha, Palinda Ruvan; Kwon, Buki; Van, Quydao; Seo, Yeonsoo Article
Functional Anatomy of the Human Microprocessor
Cell, v. 161, (6), June 2015, p. 1374-1387
Nguyen, Tuan Anh; Jo, Myunghyun; Choi, Yeongil; Park, Joha; Kwon, S. Chul; Hohng, Sungchul C.; Kim, V. Narry; Woo, Jae-Sung Article
How Human Microprocessor Recognizes Primary MicroRNAs and Finds the Correct Cleavage Sites
Biodesign, v. 3, (2), June 2015, p. 77-87
Nguyen, Tuan Anh; Kwon, S. Chul; Woo, Jae-Sung Article

2014 1

Adenylation of Maternally Inherited MicroRNAs by Wispy
Molecular Cell, v. 56, (5), December 2014, p. 696-707
Lee, Mihye; Choi, Yeon; Kim, Kijun; Jin, Hua; Lim, Jaechul; Nguyen, Tuan Anh; Yang, Jihye; Jeong, Minsun; Giráldez, Antonio J.; Yang, Hui; Patel, Dinshaw J.; Kim, V. Narry Article

2012 3

Biochemical Studies Of The Saccharomyces Cerevisiae Mph1 Helicase On Junction-Containing DNA Structures
Nucleic Acids Research, v. 40, (5), March 2012, p. 2089-2106
Kang, Young-Hoon; Munashingha, Palinda Ruvan; Lee, Chul-Hwan; Nguyen, Tuan Anh; Seo, Yeon-Soo Article
Human Mus81 Complexes Stimulate Flap Endonuclease 1
FEBS Journal, v. 279, (13), July 2012, p. 2412-2430
Shin, Yong-keol; Amangyeld, Tamir; Nguyen, Tuan Anh; Munashingha, Palinda Ruvan; Seo, Yeon-soo Article
The Trans-autostimulatory Activity of Rad27 Suppresses DNA2 Defects in Okazaki Fragment Processing
Journal of Biological Chemistry, v. 287, (12), March 2012, p. 8675-8687
Munashingha, Palinda Ruvan; Lee, Chul-Hwan; Kang, Young-Hoon; Shin, Yongkeol; Nguyen, Tuan Anh; Seo, Yeon-soo Article

2011 2

Analysis of Subunit Assembly and Function of the Saccharomyces Cerevisiae RNase H2 Complex
The FEBS Journal, v. 278, (24), December 2011, p. 4927-4942
Nguyen, Tuan Anh; Tak, Yon-Soo; Lee, Chul-Hwan; Kang, Young-Hoon; Cho, Il-Taeg; Seo, Yeon-Soo Article
Lagging Strand Synthesis and Genomic Stability
DNA Repair - On the Pathways to Fixing DNA Damage and Errors /Francesca Storici. Croatia: InTech, September 9, 2011 , chapter 1, p.1-24
Nguyen, Tuan Anh; Lee, Chul-Hwan; Seo, Yeonsoo Book chapter

2010 1

Genetic and Functional Interactions Between Mus81-Mms4 and Rad27
Nucleic Acids Research, v. 38, (21), November 2010, p. 7611-7625
Kang, Min-Jung; Lee, Chul-Hwan; Kang, Young-Hoon; Cho, Ii-Taeg; Nguyen, Tuan Anh; Seo, Yeonsoo Article

2009 2

Human Replication Factor C Stimulates Flap Endonuclease 1
Journal of Biological Chemistry, v. 284, (16), April 2009, p. 10387-10399
Cho, Ii-Taeg; Kim, Do-Hyung; Kang, Young-Hoon; Lee, Chul-Hwan; Amangyeld, Tamir; Nguyen, Tuan Anh; Hurwitz, Jerard; Seo, Yeonsoo Article
Involvement of Vts1, a Structure-specific RNA-binding Protein, in Okazaki Fragment Processing in Yeast
Nucleic Acids Research, v. 38, (5), December 2009, article number gkp1135, p. 1583-1595
Lee, Chul-Hwan; Shin, Yongkeol; Phung, Thi Thu Huong; Bae, Jae Seok; Kang, Young-Hoon; Nguyen, Tuan Anh; Kim, Jeong-Hoon; Kim, Do-Hyung; Kang, Min-Jung; Bae, Sung-Ho; Seo, Yeonsoo Article


Expand All Collapse All


Article 1

Bulges control pri-miRNA processing in a position and strand-dependent manner
RNA biology, 31 December 2020
Li, Shaohua; Le, Thi Nhu Y; Nguyen, Trung Duc; Trinh, Tam Anh; Nguyen, Tuan Anh


Expand All Collapse All


Article 4

Human disease-associated single nucleotide polymorphism changes the orientation of DROSHA on pri-mir-146a
RNA, v. 26, (12), December 2020, p. 1777-1786
Le, Cong Truc; Nguyen, Thuy Linh; Nguyen, Trung Duc; Nguyen, Tuan Anh
Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor
Nature Communications, v. 11, (1), December 2020, article number 1926
Li, Shaohua; Nguyen, Trung Duc; Nguyen, Thuy Linh; Nguyen, Tuan Anh
Select Amino Acids in DGCR8 Are Essential for the UGU-pri-miRNA Interaction and Processing
Communications Biology, v. 3, July 2020, article number 244
Dang, Thi Lieu; Le, Cong Truc; Le, Minh Ngoc; Nguyen, Trung Duc; Nguyen, Thuy Linh; Bao, Sheng; Li, Shaohua; Nguyen, Tuan Anh
The Internal Loops in the Lower Stem of Primary MicroRNA Transcripts Facilitate Single Cleavage of Human Microprocessor
Nucleic Acids Research, v. 48, (5), March 2020, p. 2579-2593
Nguyen, Thuy Linh; Nguyen, Trung Duc; Bao, Sheng; Li, Shaohua; Nguyen, Tuan Anh


Expand All Collapse All


Article 1

Orientation of Human Microprocessor on Primary MicroRNAs
Biochemistry, v. 58, (4), January 2019, p. 189-198
Nguyen, Huong Minh; Nguyen, Trung Duc; Nguyen, Thuy Linh; Nguyen, Tuan Anh


Expand All Collapse All


Article 2

Microprocessor Depends on Hemin to Recognize the Apical Loop of Primary MicroRNA
Nucleic Acids Research, v. 46, (11), June 2018, p. 5726-5736
Nguyen, Tuan Anh; Park, Joha; Dang, Thi Lieu; Choi, Yeon-Gil; Kim, Narry
SRSF₃ recruits DROSHA to the basal junction of primary microRNAs
RNA, v. 24, (7), July 2018, p. 892-898
Kim, Kijun; Nguyen, Trung Duc; Li, Shaohua; Nguyen, Tuan Anh


Expand All Collapse All


Article 1

Structure of Human DROSHA
Cell, v. 164, (1-2), January 2016, p. 81-90
Kwon, S. Chul; Nguyen, Tuan Anh; Choi, Yeongil; Jo, Myunghyun; Hohng, Sungchul C.; Kim, V. Narry; Woo, Jae-Sung


Expand All Collapse All


Article 3

A Physiological Significance Of The Functional Interaction Between Mus81 And Rad27 In Homologous Recombination Repair
Nucleic Acids Research, v. 43, (3), 2015, p. 1684-1699
Thu, Huong Phung Thi; Nguyen, Tuan Anh; Munashingha, Palinda Ruvan; Kwon, Buki; Van, Quydao; Seo, Yeonsoo
Functional Anatomy of the Human Microprocessor
Cell, v. 161, (6), June 2015, p. 1374-1387
Nguyen, Tuan Anh; Jo, Myunghyun; Choi, Yeongil; Park, Joha; Kwon, S. Chul; Hohng, Sungchul C.; Kim, V. Narry; Woo, Jae-Sung
How Human Microprocessor Recognizes Primary MicroRNAs and Finds the Correct Cleavage Sites
Biodesign, v. 3, (2), June 2015, p. 77-87
Nguyen, Tuan Anh; Kwon, S. Chul; Woo, Jae-Sung


Expand All Collapse All


Article 1

Adenylation of Maternally Inherited MicroRNAs by Wispy
Molecular Cell, v. 56, (5), December 2014, p. 696-707
Lee, Mihye; Choi, Yeon; Kim, Kijun; Jin, Hua; Lim, Jaechul; Nguyen, Tuan Anh; Yang, Jihye; Jeong, Minsun; Giráldez, Antonio J.; Yang, Hui; Patel, Dinshaw J.; Kim, V. Narry


Expand All Collapse All


Article 3

Biochemical Studies Of The Saccharomyces Cerevisiae Mph1 Helicase On Junction-Containing DNA Structures
Nucleic Acids Research, v. 40, (5), March 2012, p. 2089-2106
Kang, Young-Hoon; Munashingha, Palinda Ruvan; Lee, Chul-Hwan; Nguyen, Tuan Anh; Seo, Yeon-Soo
Human Mus81 Complexes Stimulate Flap Endonuclease 1
FEBS Journal, v. 279, (13), July 2012, p. 2412-2430
Shin, Yong-keol; Amangyeld, Tamir; Nguyen, Tuan Anh; Munashingha, Palinda Ruvan; Seo, Yeon-soo
The Trans-autostimulatory Activity of Rad27 Suppresses DNA2 Defects in Okazaki Fragment Processing
Journal of Biological Chemistry, v. 287, (12), March 2012, p. 8675-8687
Munashingha, Palinda Ruvan; Lee, Chul-Hwan; Kang, Young-Hoon; Shin, Yongkeol; Nguyen, Tuan Anh; Seo, Yeon-soo


Expand All Collapse All


Article 1

Analysis of Subunit Assembly and Function of the Saccharomyces Cerevisiae RNase H2 Complex
The FEBS Journal, v. 278, (24), December 2011, p. 4927-4942
Nguyen, Tuan Anh; Tak, Yon-Soo; Lee, Chul-Hwan; Kang, Young-Hoon; Cho, Il-Taeg; Seo, Yeon-Soo

Book chapter 1

Lagging Strand Synthesis and Genomic Stability
DNA Repair - On the Pathways to Fixing DNA Damage and Errors /Francesca Storici. Croatia: InTech, September 9, 2011 , chapter 1, p.1-24
Nguyen, Tuan Anh; Lee, Chul-Hwan; Seo, Yeonsoo


Expand All Collapse All


Article 1

Genetic and Functional Interactions Between Mus81-Mms4 and Rad27
Nucleic Acids Research, v. 38, (21), November 2010, p. 7611-7625
Kang, Min-Jung; Lee, Chul-Hwan; Kang, Young-Hoon; Cho, Ii-Taeg; Nguyen, Tuan Anh; Seo, Yeonsoo


Expand All Collapse All


Article 2

Human Replication Factor C Stimulates Flap Endonuclease 1
Journal of Biological Chemistry, v. 284, (16), April 2009, p. 10387-10399
Cho, Ii-Taeg; Kim, Do-Hyung; Kang, Young-Hoon; Lee, Chul-Hwan; Amangyeld, Tamir; Nguyen, Tuan Anh; Hurwitz, Jerard; Seo, Yeonsoo
Involvement of Vts1, a Structure-specific RNA-binding Protein, in Okazaki Fragment Processing in Yeast
Nucleic Acids Research, v. 38, (5), December 2009, article number gkp1135, p. 1583-1595
Lee, Chul-Hwan; Shin, Yongkeol; Phung, Thi Thu Huong; Bae, Jae Seok; Kang, Young-Hoon; Nguyen, Tuan Anh; Kim, Jeong-Hoon; Kim, Do-Hyung; Kang, Min-Jung; Bae, Sung-Ho; Seo, Yeonsoo


Expand All Collapse All


2016 1

Structure of Human DROSHA
Cell, v. 164, (1-2), January 2016, p. 81-90
Kwon, S. Chul; Nguyen, Tuan Anh; Choi, Yeongil; Jo, Myunghyun; Hohng, Sungchul C.; Kim, V. Narry; Woo, Jae-Sung Article

2015 3

A Physiological Significance Of The Functional Interaction Between Mus81 And Rad27 In Homologous Recombination Repair
Nucleic Acids Research, v. 43, (3), 2015, p. 1684-1699
Thu, Huong Phung Thi; Nguyen, Tuan Anh; Munashingha, Palinda Ruvan; Kwon, Buki; Van, Quydao; Seo, Yeonsoo Article
Functional Anatomy of the Human Microprocessor
Cell, v. 161, (6), June 2015, p. 1374-1387
Nguyen, Tuan Anh; Jo, Myunghyun; Choi, Yeongil; Park, Joha; Kwon, S. Chul; Hohng, Sungchul C.; Kim, V. Narry; Woo, Jae-Sung Article
How Human Microprocessor Recognizes Primary MicroRNAs and Finds the Correct Cleavage Sites
Biodesign, v. 3, (2), June 2015, p. 77-87
Nguyen, Tuan Anh; Kwon, S. Chul; Woo, Jae-Sung Article

2014 1

Adenylation of Maternally Inherited MicroRNAs by Wispy
Molecular Cell, v. 56, (5), December 2014, p. 696-707
Lee, Mihye; Choi, Yeon; Kim, Kijun; Jin, Hua; Lim, Jaechul; Nguyen, Tuan Anh; Yang, Jihye; Jeong, Minsun; Giráldez, Antonio J.; Yang, Hui; Patel, Dinshaw J.; Kim, V. Narry Article

2012 3

Biochemical Studies Of The Saccharomyces Cerevisiae Mph1 Helicase On Junction-Containing DNA Structures
Nucleic Acids Research, v. 40, (5), March 2012, p. 2089-2106
Kang, Young-Hoon; Munashingha, Palinda Ruvan; Lee, Chul-Hwan; Nguyen, Tuan Anh; Seo, Yeon-Soo Article
Human Mus81 Complexes Stimulate Flap Endonuclease 1
FEBS Journal, v. 279, (13), July 2012, p. 2412-2430
Shin, Yong-keol; Amangyeld, Tamir; Nguyen, Tuan Anh; Munashingha, Palinda Ruvan; Seo, Yeon-soo Article
The Trans-autostimulatory Activity of Rad27 Suppresses DNA2 Defects in Okazaki Fragment Processing
Journal of Biological Chemistry, v. 287, (12), March 2012, p. 8675-8687
Munashingha, Palinda Ruvan; Lee, Chul-Hwan; Kang, Young-Hoon; Shin, Yongkeol; Nguyen, Tuan Anh; Seo, Yeon-soo Article

2011 2

Analysis of Subunit Assembly and Function of the Saccharomyces Cerevisiae RNase H2 Complex
The FEBS Journal, v. 278, (24), December 2011, p. 4927-4942
Nguyen, Tuan Anh; Tak, Yon-Soo; Lee, Chul-Hwan; Kang, Young-Hoon; Cho, Il-Taeg; Seo, Yeon-Soo Article
Lagging Strand Synthesis and Genomic Stability
DNA Repair - On the Pathways to Fixing DNA Damage and Errors /Francesca Storici. Croatia: InTech, September 9, 2011 , chapter 1, p.1-24
Nguyen, Tuan Anh; Lee, Chul-Hwan; Seo, Yeonsoo Book chapter

2010 1

Genetic and Functional Interactions Between Mus81-Mms4 and Rad27
Nucleic Acids Research, v. 38, (21), November 2010, p. 7611-7625
Kang, Min-Jung; Lee, Chul-Hwan; Kang, Young-Hoon; Cho, Ii-Taeg; Nguyen, Tuan Anh; Seo, Yeonsoo Article

2009 2

Human Replication Factor C Stimulates Flap Endonuclease 1
Journal of Biological Chemistry, v. 284, (16), April 2009, p. 10387-10399
Cho, Ii-Taeg; Kim, Do-Hyung; Kang, Young-Hoon; Lee, Chul-Hwan; Amangyeld, Tamir; Nguyen, Tuan Anh; Hurwitz, Jerard; Seo, Yeonsoo Article
Involvement of Vts1, a Structure-specific RNA-binding Protein, in Okazaki Fragment Processing in Yeast
Nucleic Acids Research, v. 38, (5), December 2009, article number gkp1135, p. 1583-1595
Lee, Chul-Hwan; Shin, Yongkeol; Phung, Thi Thu Huong; Bae, Jae Seok; Kang, Young-Hoon; Nguyen, Tuan Anh; Kim, Jeong-Hoon; Kim, Do-Hyung; Kang, Min-Jung; Bae, Sung-Ho; Seo, Yeonsoo Article


No Publications


No Publications






Teaching Assignment

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2021-22 Winter 0 2021-22 Fall 4 2020-21 Summer 1 2020-21 Spring 4 2020-21 Winter 1 2020-21 Fall 4

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LIFS3110 Biotechnological Application of Recombinant DNA Techniques
LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS6111O Life Science Postgraduate Student Seminar
LIFS6113E Current Topics in Biochemistry and Biophysics


LIFS4963 Biotechnology Capstone Project


LIFS4550 Biochemistry of Nutrition
LIFS4960 Biological Science Capstone Project
LIFS4963 Biotechnology Capstone Project
LIFS6660 Molecular Medicine


LIFS6660 Molecular Medicine


LIFS3110 Biotechnological Application of Recombinant DNA Techniques
LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS4963 Biotechnology Capstone Project
LIFS6113D Current Topics in Biochemistry and Biophysics


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)

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All Supervisions Current RPGs Graduated RPGs

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Current RPGs

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Doctor of Philosophy LE, Thi Nhu Y
Life Science( 2021 - )

BAO, Sheng
Life Science( 2019 - )

LE, Cong Truc
Life Science( 2019 - )

LE, Minh Ngoc
Life Science( 2019 - )

NGUYEN, Trung Duc
Life Science( 2019 - )

TRINH, Tam Anh
Life Science( 2019 - )

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Graduated RPGs

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Doctor of Philosophy LI, Shaohua
Life Science( Completed in 2020 )

NGUYEN, Thuy Linh
Life Science( Completed in 2020 )

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Master of Philosophy LE, Cong Truc
Life Science( Completed in 2021 )

LE, Minh Ngoc
Life Science( Completed in 2021 )

LE, Thi Nhu Y
Life Science( Completed in 2021 )

DANG, Thi Lieu
Life Science( Completed in 2019 )

NGUYEN, Trung Duc
Life Science( Completed in 2019 )









ProjectsFrom January 2020 to December 2022

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All Projects 4

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No Projects.
The non-canonical pri-miRNA processing mechanism of human Microprocessor


人源miRNA加工复合体的非经典RNA加工机制 Leading


RGC - General Research Fund


Project Team (HKUST)
NGUYEN Tuan Anh (Lead)


2022 -




Roles of human DDX and DHX helicases in RNA metabolism and miRNA biogenesis Leading


Croucher Foundation


Project Team (HKUST)
NGUYEN Tuan Anh (Lead)


2019 -




Exportin-5 mediates miRNA biogenesis via regulating human microprocessor


输出蛋白-5调控人Microprocessor介导miRNA生物合成 Leading


National Natural Science Foundation of China


Project Team (HKUST)
NGUYEN Tuan Anh (Lead)


2018 - 2021




The regulatory mechanism of DGCR8-mediated miRNA biogenesis


关于DGCR8 介导的小分子核糖核酸（miRNA）生物合成调节机制的研究 Leading


RGC - Early Career Scheme


Project Team (HKUST)
NGUYEN Tuan Anh (Lead)


2018 - 2020