Kai LIU
刘凯
PhD in Neuroscience
Rutgers, The State University of New Jersey, 2006

Cheng Associate Professor of Science

Associate Professor
Division of Life Science

Associate Director of HKUST-Nan Fung Life Sciences Joint Laboratory

Associate Director of Laboratory Animal Facility



(852) 2358 7277
kailiu@ust.hk
Room 5445
Personal Web

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ORCID
0000-0001-9351-1640

Scopus ID
55259987500




Research Interest Publications Projects Teaching Assignment RPG Supervision Space used




Research Interest

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Molecular mechanisms regulating axon regeneration



Publications

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All Years 30 2022 0 2021 1 2020 5 2019 1 2018 5 2017 1 2016 17

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2021 1

A near-infrared AIE fluorescent probe for myelin imaging: From sciatic nerve to the optically cleared brain tissue in 3D
Proceedings of the National Academy of Sciences of the United States of America, v. 118, (45), 9 November 2021, article number e2106143118
Wu, Ming-Yu; Wong, Alex Y. H.; Leung, Jong-Kai; Kam, Chuen; Wu, Kenneth Lap-Kei; Chan, Ying-Shing; Liu, Kai; Ip, Nancy Yuk-yu; Chen, Sijie Article

2020 5

Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo
Light: Science & Applications, v. 9, (1), May 2020, article number 79
Qin, Zhongya; He, Sicong; Yang, Chao; Yung, Jasmine Sum-Yee; Chen, Congping; Leung, Christopher Kai-Shun; Liu, Kai; Qu, Jianan Article
Injectable, photoresponsive hydrogels for delivering neuroprotective proteins enabled by metal-directed protein assembly
Science Advances, v. 6, (41), 7 October 2020, article number eabc4824
Jiang, Bojing; Liu, Xiaotian; Yang, Chao; Yang, Zhongguang; Luo, Jiren; Kou, Songzi; Liu, Kai; Sun, Fei Article
Rewiring Neuronal Glycerolipid Metabolism Determines the Extent of Axon Regeneration
Neuron, v. 105, (2), January 2020, p. 276-292.e5
Yang, Chao; Wang, Xu; Wang, Jianying; Wang, Xuejie; Chen, Weitao; Lu, Na; Symeon, Siniossoglou; Yao, Zhongping; Liu, Kai Article
Adaptive optics two-photon microscopy for in vivo imaging of mouse retina
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, v. 11248, February 2020, article number 112480L
Qin, Zhongya; He, Sicong; Chen, Congping; Yang, Chao; Yung, Jasmine; Wu, Wanjie; Leung, Christopher K.S; Liu, Kai; Qu, Jianan Conference paper
In vivo high-resolution multimodal nonlinear optical microscopy of spinal cord in mice
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, v. 11252, February 2020, article number 112520P
Wu, Wanjie; Qin, Zhongya; Wu, Junqiang; Chen, Congping; Chen, Weitao; Liu, Kai; Qu, Jianan Conference paper

2019 1

Rapid Depletion of ESCRT Protein Vps4 Underlies Injury-induced Autophagic Impediment and Wallerian Degeneration
Science Advances, v. 5, (2), February 2019, article number eaav4971
Wang, Haiqiong; Wang, Xuejie; Zhang, Kai; Wang, Qingyao; Cao, Xu; Wang, Zhao; Zhang, Shuang; Li, Ang; Liu, Kai; Fang, Yanshan Article

2018 5

Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)
Cell Transplantation, v. 27, (2), February 2018, p. 310-324
Liu, Kai; CANR; IANR Article
Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System
Neuron, v. 97, (2), January 2018, p. 313-325.e6
Weng, Yi-Lan; Wang, Xu; An, Ran; Cassin, Jessica; Vissers, Caroline; Liu, Yuanyuan; Liu, Yajing; Xu, Tianlei; Wang, Xinyuan; Wong, Samuel Zheng Hao; Joseph, Jessica; Dore, Louis C.; Dong, Qiang; Zheng, Wei; Jin, Peng; Wu, Hao; Shen, Bin; Zhuang, Xiaoxi; He, Chuan; Liu, Kai; Song, Hongjun; Ming, Guo-li Article
p110α of PI3K is Necessary and Sufficient for Quiescence Exit in Adult Muscle Satellite Cells
EMBO journal, v. 37, (8), April 2018, article number e98239
Wang, Gang; Zhu, Han; Situ, Chenghao; Han, Lifang; Yu, Youqian; Cheung, Tom H.; Liu, Kai; Wu, Zhenguo Article
Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1
Frontiers in Molecular Neuroscience, v. 10, January 2018, article number 445
Lou, Wilson Pak-Kin; Mateos, Alvaro; Koch, Marta; Klussman, Stefan; Yang, Chao; Lu, Na; Kumar, Sachin; Limpert, Stefanie; Goepferich, Manuel; Zschaetzsch, Marlen; Sliwinski, Christopher; Kenzelmann, Marc; Seedorf, Matthias; Maillo, Carlos; Senis, Elena; Grimm, Dirk; Puttagunta, Radhika; Mendez, Raul; Liu, Kai; Hassan, Bassem A.; Martin-villalba, Ana Article
Versatile Engineered Protein Hydrogels Enabling Decoupled Mechanical and Biochemical Tuning for Cell Adhesion and Neurite Growth
ACS Applied Nano Materials, v. 1, (4), March 2018, p. 1579-1585
Liu, Xiaotian; Yang, Xin; Yang, Zhongguang; Luo, jiren; Tian, xiaozhen; Liu, Kai; Kou, Songzi; Sun, Fei Article

2017 1

The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms
eLife, v. 6, June 2017, article number e28021
Hu, Wenbao; Yu, Xiaojie; Liu, Zhengzhao; Sun, Ying; Chen, Xibing; Yang, Xin; Li, Xiaofen; Lam, Wai Kwan; Duan, Yuanyuan; Cao, Xu; Steller, Hermann; Liu, Kai; Huang, Pingbo Article

2016 5

A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function
Proceedings of the National Academy of Sciences of the United States of America, v. 113, (22), May 2016, p. E3081-E3090
Zeng, Menglong; Shang, Yuan; Guo, Tingfeng; He, Qinghai; Yung, Wing-Ho; Liu, Kai; Zhang, Mingjie Article
Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling
Proceedings of the National Academy of Sciences of the United States of America, v. 113, (7), February 2016, p. 1937-1942
Li, Songshan; Yang, Chao; Zhang, Li; Gao, Xin; Wang, Xuejie; Liu, Wen; Wang, Yuqi; Jiang, Songshan; Wong, Yung Hou; Zhang, Yifeng; Liu, Kai Article
Rapamycin-Resistant mTOR Activity Is Required for Sensory Axon Regeneration Induced by a Conditioning Lesion
eNeuro, v. 3, (6), December 2016, article number e0358, p. 1-17
Chen, Weitao; Lu, Na; Ding, Yue; Wang, Yuan; Chan, Leung Ting; Wang, Xu; Gao, Xin; Jiang, Songshan; Liu, Kai Article
The progress in optic nerve regeneration, where are we?
Neural Regeneration Research, v. 11, (1), January 2016, p. 32-36
Shum, Jennifer Wei Huen; Liu, Kai; So, Kwok Fai Article
Variable laterality of corticospinal tract axons that regenerate after spinal cord injury as a result of PTEN deletion or knock-down
Journal of Comparative Neurology, v. 524, (13), September 2016, p. 2654-2676
Willenberg, Rafer; Zukor, Katherine; Liu, Kai; He, Zhigang; Steward, Oswald Article

2015 3

Effects of PTEN and Nogo Codeletion on Corticospinal Axon Sprouting and Regeneration in Mice
Journal of Neuroscience, v. 35, (16), April 2015, p. 6413-6428
Geoffroy, Cedric G.; Lorenzana, Ariana O.; Kwan, Jeffrey P.; Lin, Kyle; Ghassemi, Omeed; Ma, Andrew; Xu, Nuo; Creger, Daniel; Liu, Kai; He, Zhigang; Zheng, Binhai Article
Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons
Neurobiology of Disease, v. 73, January 2015, p. 366-376
Li, Songshan; He, Qinghai; Wang, Hao; Tang, Xuming; Ho, Kam Wing; Gao, Xin; Zhang, Qian; Shen, Yang; Cheung, Annie; Wong, Francis; Wong, Yung Hou; Ip, Nancy Yuk-yu; Jiang, Liwen; Yung, Wing Ho; Liu, Kai Article
Pten Deletion Promotes Regrowth of Corticospinal Tract Axons 1 Year after Spinal Cord Injury
Journal of Neuroscience, v. 35, (26), July 2015, p. 9754-9763
Du, Kaimeng; Zheng, Susu; Zhang, Qian; Li, Songshan; Gao, Xin; Wang, Juan; Jiang, Liwen; Liu, Kai Article

2014 1

Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice
Cell Reports, v. 9, (5), December 2014, p. 1635-1644
Fang, Wei-Qun; Chen, Wei-Wei; Jiang, Liwen; Liu, Kai; Yung, Wing-Ho; Fu, Amy Kit Yu; Ip, Nancy Yuk-Yu Article

2011 1

Neuronal Intrinsic Mechanisms of Axon Regeneration
Annual Review of Neuroscience, v. 34, July 2011, p. 134-152
Liu, Kai; Tedeschi, Andrea; Park, Kevin Kyungsuk; He, Zhigang Article

2010 3

Juvenile and adult olfactory ensheathing cells bundle and myelinate dorsal root ganglion axons in culture
Experimental Neurology, v.229, (1), 2011, May, p.72-79
Babiarz, Joanne; Kane-Goldsmith, Noriko; Basak, Sayantani; Liu, Kai; Young, Wise; Grumet, Martin Article
PTEN deletion enhances the regenerative ability of adult corticospinal neurons
Nature Neuroscience 2010 Sep, v. 13, (9), 2010, p. 1075-1081
Liu, Kai; Lu, Yi; Lee, Jae K.; Samara, Ramsey; Willenberg, Rafer; Sears-Kraxberger, Ilse; Tedeschi, Andrea; Park, Kevin Kyungsuk; Cai, Bin; Xu, Bengang; Connolly, Lauren; Steward, Oswald; Zheng, Binhai; He, Zhigang Article
PTEN/mTOR and axon regeneration
Experimental Neurology, v. 223, (1), 2010, May, p.45-50
Park, Kevin K.; Liu, Kai; Hu, Yang; Kanter, Jennifer L.; He, Zhigang Article

2009 1

PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration
Science, v. 326, (5952),October 23 2009, p. 592-596
Shen, Y.; Tenney, AP; Busch, SA; Horn, KP; Cuascut, FX; Liu, Kai; He, Z.; Silver, J.; Flanagan, JG Article

2008 2

Assessment of functional recovery and axonal sprouting in oligodendrocyte-myelin glycoprotein (OMgp) null mice after spinal cord injury
Molecular and Cellular Neuroscience, v. 39, no. 2, October 2008, p. 258-267
Ji, Benxiu; Case, Lauren C.; Liu, Kai; Shao, Zhaohui; Lee, Xinhua; Yang, Zhongshu; Wang, Joy; Tian, Tim; Shulga-Morskaya, Svetlana; Scott, Martin; He, Zhigang; Relton, Jane K.; Mi, Sha Article
Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway
Science, v. 322, no. 5903,November 7 2008, p. 963-966
Park, Kevin Kyungsuk; Liu, Kai; Hu, Yang; Smith, Patrice D.; Wang, Chen; Cai, Bin; Xu, Bengang; Connolly, Lauren; Kramvis, Ioannis; Sahin, Mustafa; He, Zhigang Article

2007 1

Spinal cord injury-induced immune depression syndrome (SCI-IDS)
European Journal of Neuroscience, v. 25, no. 6, March 2007, p. 1743-1747
Riegger, Tino; Conrad, Sabine; Liu, Kai; Schluesener, Hermann J.; Adibzahdeh, Mahdi; Schwab, Han M. Article


Expand All Collapse All


Article 1

A near-infrared AIE fluorescent probe for myelin imaging: From sciatic nerve to the optically cleared brain tissue in 3D
Proceedings of the National Academy of Sciences of the United States of America, v. 118, (45), 9 November 2021, article number e2106143118
Wu, Ming-Yu; Wong, Alex Y. H.; Leung, Jong-Kai; Kam, Chuen; Wu, Kenneth Lap-Kei; Chan, Ying-Shing; Liu, Kai; Ip, Nancy Yuk-yu; Chen, Sijie


Expand All Collapse All


Article 3

Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo
Light: Science & Applications, v. 9, (1), May 2020, article number 79
Qin, Zhongya; He, Sicong; Yang, Chao; Yung, Jasmine Sum-Yee; Chen, Congping; Leung, Christopher Kai-Shun; Liu, Kai; Qu, Jianan
Injectable, photoresponsive hydrogels for delivering neuroprotective proteins enabled by metal-directed protein assembly
Science Advances, v. 6, (41), 7 October 2020, article number eabc4824
Jiang, Bojing; Liu, Xiaotian; Yang, Chao; Yang, Zhongguang; Luo, Jiren; Kou, Songzi; Liu, Kai; Sun, Fei
Rewiring Neuronal Glycerolipid Metabolism Determines the Extent of Axon Regeneration
Neuron, v. 105, (2), January 2020, p. 276-292.e5
Yang, Chao; Wang, Xu; Wang, Jianying; Wang, Xuejie; Chen, Weitao; Lu, Na; Symeon, Siniossoglou; Yao, Zhongping; Liu, Kai

Conference paper 2

Adaptive optics two-photon microscopy for in vivo imaging of mouse retina
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, v. 11248, February 2020, article number 112480L
Qin, Zhongya; He, Sicong; Chen, Congping; Yang, Chao; Yung, Jasmine; Wu, Wanjie; Leung, Christopher K.S; Liu, Kai; Qu, Jianan
In vivo high-resolution multimodal nonlinear optical microscopy of spinal cord in mice
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, v. 11252, February 2020, article number 112520P
Wu, Wanjie; Qin, Zhongya; Wu, Junqiang; Chen, Congping; Chen, Weitao; Liu, Kai; Qu, Jianan


Expand All Collapse All


Article 1

Rapid Depletion of ESCRT Protein Vps4 Underlies Injury-induced Autophagic Impediment and Wallerian Degeneration
Science Advances, v. 5, (2), February 2019, article number eaav4971
Wang, Haiqiong; Wang, Xuejie; Zhang, Kai; Wang, Qingyao; Cao, Xu; Wang, Zhao; Zhang, Shuang; Li, Ang; Liu, Kai; Fang, Yanshan


Expand All Collapse All


Article 5

Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)
Cell Transplantation, v. 27, (2), February 2018, p. 310-324
Liu, Kai; CANR; IANR
Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System
Neuron, v. 97, (2), January 2018, p. 313-325.e6
Weng, Yi-Lan; Wang, Xu; An, Ran; Cassin, Jessica; Vissers, Caroline; Liu, Yuanyuan; Liu, Yajing; Xu, Tianlei; Wang, Xinyuan; Wong, Samuel Zheng Hao; Joseph, Jessica; Dore, Louis C.; Dong, Qiang; Zheng, Wei; Jin, Peng; Wu, Hao; Shen, Bin; Zhuang, Xiaoxi; He, Chuan; Liu, Kai; Song, Hongjun; Ming, Guo-li
p110α of PI3K is Necessary and Sufficient for Quiescence Exit in Adult Muscle Satellite Cells
EMBO journal, v. 37, (8), April 2018, article number e98239
Wang, Gang; Zhu, Han; Situ, Chenghao; Han, Lifang; Yu, Youqian; Cheung, Tom H.; Liu, Kai; Wu, Zhenguo
Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1
Frontiers in Molecular Neuroscience, v. 10, January 2018, article number 445
Lou, Wilson Pak-Kin; Mateos, Alvaro; Koch, Marta; Klussman, Stefan; Yang, Chao; Lu, Na; Kumar, Sachin; Limpert, Stefanie; Goepferich, Manuel; Zschaetzsch, Marlen; Sliwinski, Christopher; Kenzelmann, Marc; Seedorf, Matthias; Maillo, Carlos; Senis, Elena; Grimm, Dirk; Puttagunta, Radhika; Mendez, Raul; Liu, Kai; Hassan, Bassem A.; Martin-villalba, Ana
Versatile Engineered Protein Hydrogels Enabling Decoupled Mechanical and Biochemical Tuning for Cell Adhesion and Neurite Growth
ACS Applied Nano Materials, v. 1, (4), March 2018, p. 1579-1585
Liu, Xiaotian; Yang, Xin; Yang, Zhongguang; Luo, jiren; Tian, xiaozhen; Liu, Kai; Kou, Songzi; Sun, Fei


Expand All Collapse All


Article 1

The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms
eLife, v. 6, June 2017, article number e28021
Hu, Wenbao; Yu, Xiaojie; Liu, Zhengzhao; Sun, Ying; Chen, Xibing; Yang, Xin; Li, Xiaofen; Lam, Wai Kwan; Duan, Yuanyuan; Cao, Xu; Steller, Hermann; Liu, Kai; Huang, Pingbo


Expand All Collapse All


Article 5

A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function
Proceedings of the National Academy of Sciences of the United States of America, v. 113, (22), May 2016, p. E3081-E3090
Zeng, Menglong; Shang, Yuan; Guo, Tingfeng; He, Qinghai; Yung, Wing-Ho; Liu, Kai; Zhang, Mingjie
Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling
Proceedings of the National Academy of Sciences of the United States of America, v. 113, (7), February 2016, p. 1937-1942
Li, Songshan; Yang, Chao; Zhang, Li; Gao, Xin; Wang, Xuejie; Liu, Wen; Wang, Yuqi; Jiang, Songshan; Wong, Yung Hou; Zhang, Yifeng; Liu, Kai
Rapamycin-Resistant mTOR Activity Is Required for Sensory Axon Regeneration Induced by a Conditioning Lesion
eNeuro, v. 3, (6), December 2016, article number e0358, p. 1-17
Chen, Weitao; Lu, Na; Ding, Yue; Wang, Yuan; Chan, Leung Ting; Wang, Xu; Gao, Xin; Jiang, Songshan; Liu, Kai
The progress in optic nerve regeneration, where are we?
Neural Regeneration Research, v. 11, (1), January 2016, p. 32-36
Shum, Jennifer Wei Huen; Liu, Kai; So, Kwok Fai
Variable laterality of corticospinal tract axons that regenerate after spinal cord injury as a result of PTEN deletion or knock-down
Journal of Comparative Neurology, v. 524, (13), September 2016, p. 2654-2676
Willenberg, Rafer; Zukor, Katherine; Liu, Kai; He, Zhigang; Steward, Oswald


Expand All Collapse All


Article 3

Effects of PTEN and Nogo Codeletion on Corticospinal Axon Sprouting and Regeneration in Mice
Journal of Neuroscience, v. 35, (16), April 2015, p. 6413-6428
Geoffroy, Cedric G.; Lorenzana, Ariana O.; Kwan, Jeffrey P.; Lin, Kyle; Ghassemi, Omeed; Ma, Andrew; Xu, Nuo; Creger, Daniel; Liu, Kai; He, Zhigang; Zheng, Binhai
Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons
Neurobiology of Disease, v. 73, January 2015, p. 366-376
Li, Songshan; He, Qinghai; Wang, Hao; Tang, Xuming; Ho, Kam Wing; Gao, Xin; Zhang, Qian; Shen, Yang; Cheung, Annie; Wong, Francis; Wong, Yung Hou; Ip, Nancy Yuk-yu; Jiang, Liwen; Yung, Wing Ho; Liu, Kai
Pten Deletion Promotes Regrowth of Corticospinal Tract Axons 1 Year after Spinal Cord Injury
Journal of Neuroscience, v. 35, (26), July 2015, p. 9754-9763
Du, Kaimeng; Zheng, Susu; Zhang, Qian; Li, Songshan; Gao, Xin; Wang, Juan; Jiang, Liwen; Liu, Kai


Expand All Collapse All


Article 1

Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice
Cell Reports, v. 9, (5), December 2014, p. 1635-1644
Fang, Wei-Qun; Chen, Wei-Wei; Jiang, Liwen; Liu, Kai; Yung, Wing-Ho; Fu, Amy Kit Yu; Ip, Nancy Yuk-Yu


Expand All Collapse All


Article 1

Neuronal Intrinsic Mechanisms of Axon Regeneration
Annual Review of Neuroscience, v. 34, July 2011, p. 134-152
Liu, Kai; Tedeschi, Andrea; Park, Kevin Kyungsuk; He, Zhigang


Expand All Collapse All


Article 3

Juvenile and adult olfactory ensheathing cells bundle and myelinate dorsal root ganglion axons in culture
Experimental Neurology, v.229, (1), 2011, May, p.72-79
Babiarz, Joanne; Kane-Goldsmith, Noriko; Basak, Sayantani; Liu, Kai; Young, Wise; Grumet, Martin
PTEN deletion enhances the regenerative ability of adult corticospinal neurons
Nature Neuroscience 2010 Sep, v. 13, (9), 2010, p. 1075-1081
Liu, Kai; Lu, Yi; Lee, Jae K.; Samara, Ramsey; Willenberg, Rafer; Sears-Kraxberger, Ilse; Tedeschi, Andrea; Park, Kevin Kyungsuk; Cai, Bin; Xu, Bengang; Connolly, Lauren; Steward, Oswald; Zheng, Binhai; He, Zhigang
PTEN/mTOR and axon regeneration
Experimental Neurology, v. 223, (1), 2010, May, p.45-50
Park, Kevin K.; Liu, Kai; Hu, Yang; Kanter, Jennifer L.; He, Zhigang


Expand All Collapse All


Article 1

PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration
Science, v. 326, (5952),October 23 2009, p. 592-596
Shen, Y.; Tenney, AP; Busch, SA; Horn, KP; Cuascut, FX; Liu, Kai; He, Z.; Silver, J.; Flanagan, JG


Expand All Collapse All


Article 2

Assessment of functional recovery and axonal sprouting in oligodendrocyte-myelin glycoprotein (OMgp) null mice after spinal cord injury
Molecular and Cellular Neuroscience, v. 39, no. 2, October 2008, p. 258-267
Ji, Benxiu; Case, Lauren C.; Liu, Kai; Shao, Zhaohui; Lee, Xinhua; Yang, Zhongshu; Wang, Joy; Tian, Tim; Shulga-Morskaya, Svetlana; Scott, Martin; He, Zhigang; Relton, Jane K.; Mi, Sha
Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway
Science, v. 322, no. 5903,November 7 2008, p. 963-966
Park, Kevin Kyungsuk; Liu, Kai; Hu, Yang; Smith, Patrice D.; Wang, Chen; Cai, Bin; Xu, Bengang; Connolly, Lauren; Kramvis, Ioannis; Sahin, Mustafa; He, Zhigang


Expand All Collapse All


Article 1

Spinal cord injury-induced immune depression syndrome (SCI-IDS)
European Journal of Neuroscience, v. 25, no. 6, March 2007, p. 1743-1747
Riegger, Tino; Conrad, Sabine; Liu, Kai; Schluesener, Hermann J.; Adibzahdeh, Mahdi; Schwab, Han M.


Expand All Collapse All


2016 5

A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function
Proceedings of the National Academy of Sciences of the United States of America, v. 113, (22), May 2016, p. E3081-E3090
Zeng, Menglong; Shang, Yuan; Guo, Tingfeng; He, Qinghai; Yung, Wing-Ho; Liu, Kai; Zhang, Mingjie Article
Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling
Proceedings of the National Academy of Sciences of the United States of America, v. 113, (7), February 2016, p. 1937-1942
Li, Songshan; Yang, Chao; Zhang, Li; Gao, Xin; Wang, Xuejie; Liu, Wen; Wang, Yuqi; Jiang, Songshan; Wong, Yung Hou; Zhang, Yifeng; Liu, Kai Article
Rapamycin-Resistant mTOR Activity Is Required for Sensory Axon Regeneration Induced by a Conditioning Lesion
eNeuro, v. 3, (6), December 2016, article number e0358, p. 1-17
Chen, Weitao; Lu, Na; Ding, Yue; Wang, Yuan; Chan, Leung Ting; Wang, Xu; Gao, Xin; Jiang, Songshan; Liu, Kai Article
The progress in optic nerve regeneration, where are we?
Neural Regeneration Research, v. 11, (1), January 2016, p. 32-36
Shum, Jennifer Wei Huen; Liu, Kai; So, Kwok Fai Article
Variable laterality of corticospinal tract axons that regenerate after spinal cord injury as a result of PTEN deletion or knock-down
Journal of Comparative Neurology, v. 524, (13), September 2016, p. 2654-2676
Willenberg, Rafer; Zukor, Katherine; Liu, Kai; He, Zhigang; Steward, Oswald Article

2015 3

Effects of PTEN and Nogo Codeletion on Corticospinal Axon Sprouting and Regeneration in Mice
Journal of Neuroscience, v. 35, (16), April 2015, p. 6413-6428
Geoffroy, Cedric G.; Lorenzana, Ariana O.; Kwan, Jeffrey P.; Lin, Kyle; Ghassemi, Omeed; Ma, Andrew; Xu, Nuo; Creger, Daniel; Liu, Kai; He, Zhigang; Zheng, Binhai Article
Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons
Neurobiology of Disease, v. 73, January 2015, p. 366-376
Li, Songshan; He, Qinghai; Wang, Hao; Tang, Xuming; Ho, Kam Wing; Gao, Xin; Zhang, Qian; Shen, Yang; Cheung, Annie; Wong, Francis; Wong, Yung Hou; Ip, Nancy Yuk-yu; Jiang, Liwen; Yung, Wing Ho; Liu, Kai Article
Pten Deletion Promotes Regrowth of Corticospinal Tract Axons 1 Year after Spinal Cord Injury
Journal of Neuroscience, v. 35, (26), July 2015, p. 9754-9763
Du, Kaimeng; Zheng, Susu; Zhang, Qian; Li, Songshan; Gao, Xin; Wang, Juan; Jiang, Liwen; Liu, Kai Article

2014 1

Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice
Cell Reports, v. 9, (5), December 2014, p. 1635-1644
Fang, Wei-Qun; Chen, Wei-Wei; Jiang, Liwen; Liu, Kai; Yung, Wing-Ho; Fu, Amy Kit Yu; Ip, Nancy Yuk-Yu Article

2011 1

Neuronal Intrinsic Mechanisms of Axon Regeneration
Annual Review of Neuroscience, v. 34, July 2011, p. 134-152
Liu, Kai; Tedeschi, Andrea; Park, Kevin Kyungsuk; He, Zhigang Article

2010 3

Juvenile and adult olfactory ensheathing cells bundle and myelinate dorsal root ganglion axons in culture
Experimental Neurology, v.229, (1), 2011, May, p.72-79
Babiarz, Joanne; Kane-Goldsmith, Noriko; Basak, Sayantani; Liu, Kai; Young, Wise; Grumet, Martin Article
PTEN deletion enhances the regenerative ability of adult corticospinal neurons
Nature Neuroscience 2010 Sep, v. 13, (9), 2010, p. 1075-1081
Liu, Kai; Lu, Yi; Lee, Jae K.; Samara, Ramsey; Willenberg, Rafer; Sears-Kraxberger, Ilse; Tedeschi, Andrea; Park, Kevin Kyungsuk; Cai, Bin; Xu, Bengang; Connolly, Lauren; Steward, Oswald; Zheng, Binhai; He, Zhigang Article
PTEN/mTOR and axon regeneration
Experimental Neurology, v. 223, (1), 2010, May, p.45-50
Park, Kevin K.; Liu, Kai; Hu, Yang; Kanter, Jennifer L.; He, Zhigang Article

2009 1

PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration
Science, v. 326, (5952),October 23 2009, p. 592-596
Shen, Y.; Tenney, AP; Busch, SA; Horn, KP; Cuascut, FX; Liu, Kai; He, Z.; Silver, J.; Flanagan, JG Article

2008 2

Assessment of functional recovery and axonal sprouting in oligodendrocyte-myelin glycoprotein (OMgp) null mice after spinal cord injury
Molecular and Cellular Neuroscience, v. 39, no. 2, October 2008, p. 258-267
Ji, Benxiu; Case, Lauren C.; Liu, Kai; Shao, Zhaohui; Lee, Xinhua; Yang, Zhongshu; Wang, Joy; Tian, Tim; Shulga-Morskaya, Svetlana; Scott, Martin; He, Zhigang; Relton, Jane K.; Mi, Sha Article
Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway
Science, v. 322, no. 5903,November 7 2008, p. 963-966
Park, Kevin Kyungsuk; Liu, Kai; Hu, Yang; Smith, Patrice D.; Wang, Chen; Cai, Bin; Xu, Bengang; Connolly, Lauren; Kramvis, Ioannis; Sahin, Mustafa; He, Zhigang Article

2007 1

Spinal cord injury-induced immune depression syndrome (SCI-IDS)
European Journal of Neuroscience, v. 25, no. 6, March 2007, p. 1743-1747
Riegger, Tino; Conrad, Sabine; Liu, Kai; Schluesener, Hermann J.; Adibzahdeh, Mahdi; Schwab, Han M. Article


No Publications






Teaching Assignment

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2021-22 Winter 0 2021-22 Fall 5 2020-21 Summer 1 2020-21 Spring 4 2020-21 Winter 0 2020-21 Fall 6

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LIFS6112E Current Topics in Neuroscience
LIFS6170 Special Topics in Molecular, Cell and Developmental Biology
SCIE1130 Scientific Understanding of Our World
UROP1100E Undergraduate Research Opportunities Series 1
UROP4100E Undergraduate Research Opportunities Series 4


UROP1000 Undergraduate Research Opportunities


LIFS3150 Biostatistics
LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS4981 Biochemistry and Cell Biology Project Research II
LIFS5260 Biochemical and Molecular Basis of Diseases


LIFS4963 Biotechnology Capstone Project
LIFS4971 Biochemistry and Cell Biology Project Research I
LIFS6112D Current Topics in Neuroscience
LIFS6170 Special Topics in Molecular, Cell and Developmental Biology
SCIE1130 Scientific Understanding of Our World
SCIE4500 IRE Research Project II


No Teaching Assignments


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)

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All Supervisions Current RPGs Graduated RPGs

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Current RPGs

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Doctor of Philosophy CAO, Jiaming
Life Science( 2021 - )

LI, Yubing
Life Science( 2021 - )

LIU, Zhewei
Life Science( 2021 - )

MA, Chenxue
Life Science( 2021 - )

WANG, Yu
Life Science( 2021 - )

AN, Yongyan
Life Science( 2020 - )

CHEN, Yujun
Life Science( 2020 - )

ZHANG, Chengle
Life Science( 2019 - )

ZHOU, Yiren
Life Science( 2019 - )

CHAN, Leung Ting
Life Science( 2018 - )

WANG, Xu
Life Science( 2018 - )

ZHANG, Xin
Life Science( 2018 - )

WANG, Xuejie
Life Science( 2017 - )

WU, Junqiang
Life Science( 2017 - )

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Master of Philosophy CHEN, Mengxian (co-supervision)
Life Science( 2019 - )

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Graduated RPGs

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Doctor of Philosophy YANG, Xin
Life Science( Completed in 2020 )

YANG, Chao
Life Science( Completed in 2019 )

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Master of Philosophy JIANG, Bojing (co-supervision)
Bioengineering( Completed in 2021 )

YUAN, Xue
Life Science( Completed in 2020 )

ZHANG, Chengle
Life Science( Completed in 2020 )

ZHOU, Yiren
Life Science( Completed in 2020 )

TIAN, Xiaozhen
Life Science( Completed in 2019 )

WU, Junqiang
Life Science( Completed in 2019 )









ProjectsFrom January 2020 to December 2022

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All Projects 20 Leading Projects 8 Participating Projects 12

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Stem cell-niche interactions in tissue maintenance and engineering


干细胞与微环境互作在组织维持和组织工程中的应用 Participating


RGC - Theme-based Research Scheme


Project Team (HKUST)
XIE Ting (Lead)
CHEUNG Tom
GUO Yusong
LEUNG Danny Chi Yeu
LIU Kai
MAK Ho Yi
SUN Fei
WEN Zilong
WU Angela Ruohao
WU Zhenguo
YAN Yan


2022 -




Investigation of glycerolipid metabolism regulating corticospinal tract axon development and regeneration


甘油脂代谢调控皮质脊髓束轴突发育和再生的分子机制研究 Leading


National Natural Science Foundation of China


Project Team (HKUST)
LIU Kai (Lead)


2022 -




Development Of Therapeutic Molecules For Alzheimer’s Disease Based On High-performance Plasma Proteome Profiling


基於高效血浆蛋白质组学分析的阿尔茨海默症分子干预策略研究 Participating


Fong's Family Foundation, Innovation and Technology Fund, Morningside Life Science Limited


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
FU Amy Kit Yu
LIU Kai


2022 -




Injectable hydrogels for nerve regeneration enabled by protein engineering


基于蛋白质工程的可注射水凝胶及其在神经修复中的应用 Participating


Shenzhen Science and Technology Innovation Committee


Project Team (HKUST)
SUN Fei (Lead)
LIU Kai


2021 -




The Center for Neurodegenerative Diseases


N/A Participating


Innovation and Technology Fund


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
FU Amy Kit Yu
LEUNG Danny Chi Yeu
LIU Kai
WANG Jiguang
WONG Yung Hou
WU Zhenguo


2020 -




High-resolution adaptive optics microscope system for live and deep imaging of biological tissues


用於生物组织深度活体成像的高分辨自适应光学显微镜系统 Participating


RGC - Collaborative Research Fund


Project Team (HKUST)
QU Jianan (Lead)
IP Nancy Yuk-Yu
LIU Kai


2020 -




Standardization study on spinal cord and optic nerve injury in large animal models


脊髓与视神经损伤大动物模型标准化研究 Participating


Guangzhou Municipal Science and Technology Bureau


Project Team (HKUST)
LIU Kai


2020 -




Formation of presynaptic active zone molecular assembly via phase separation


通过相分离构建突触前活性区的分子组装 Leading


RGC - General Research Fund


Project Team (HKUST)
LIU Kai (Lead)


2020 -




Investigation of the functional synergy of neuronal activity and sustained CNTF as a therapeutic strategy in animal models of traumatic optic neuropathy Leading


Health and Medical Research Fund


Project Team (HKUST)
LIU Kai (Lead)


2019 -




Enhancing axon regeneration via regulating glycerolipid metabolism in injured neurons


通过调控甘油脂通路促进神经轴突再生 Leading


RGC - General Research Fund


Project Team (HKUST)
LIU Kai (Lead)


2019 -




Inhibition of EphA4 signaling for the prevention and treatment of neurological disorders


利用抑制EphA4 信号机制以预防和治疗神经系统疾病 Participating


Innovation and Technology Fund


Project Team (HKUST)
FU Amy Kit Yu (Lead)
LIU Kai


2019 -




Structure of Disc1 Tetramer and its Interactions with its Target Proteins


Disc1四聚体及其复合物的结构表征 Leading


RGC - General Research Fund


Project Team (HKUST)
LIU Kai (Lead)


2019 - 2021




Genomic Functional Screening for Neural Repair


神经修复的功能基因筛选 Leading


Nan Fung Life Sciences Limited


Project Team (HKUST)
LIU Kai (Lead)


2018 -




The Research on diagnosis and treatment of Alzheimer's disease


阿尔茨海默症的诊治方法研究 Participating


Department of Science and Technology of Guangdong Province


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
FU Amy Kit Yu
LIU Kai
WONG Yung Hou
WU Zhenguo
ZHOU Fred Xiaopu


2018 -




Reconstitution of Postsynaptic Densities of Excitatory Synapses


兴奋性神经突触後致密区的重组研究 Participating


RGC - Collaborative Research Fund


Project Team (HKUST)
LIU Kai
SUN Fei


2018 - 2020




Cellular mechanisms of synaptic functions and plasticity in health and neurodegenerative diseases


健康及神经退行性病变过程中突触功能和可塑性调控的细胞机制 Participating


RGC - Areas of Excellence Scheme


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
FU Amy Kit Yu
LIU Kai
WONG Yung Hou
WU Zhenguo
XIA Jun


2017 -




Molecular mechanism of melanopsin promoting optic nerve regeneration


黑视蛋白促进受损视神经轴突再生的分子机制研究 Leading


National Natural Science Foundation of China


Project Team (HKUST)
LIU Kai (Lead)


2017 - 2020




Open Operation System of Guangdong Provincial Key Laboratory of Brain Science, Disease, and Drug Development (Inspection Qualified in 2017)


广东省脑科学及疾病与药物研究重点实验室开放运行（2017年度考评合格） Participating


Department of Science and Technology of Guangdong Province


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
FU Amy Kit Yu
LIU Kai
QI Robert Zhong
WONG Yung Hou
WU Zhenguo
XIA Jun


2017 - 2020




Developing neural repair strategies in lumbosacral injury models Leading


Hong Kong Spinal Cord Injury Fund Ltd.


Project Team (HKUST)
LIU Kai (Lead)


2015 - 2021




Mechanistic basis of synaptic development, signalling and neuro-disorders


神经突触的发育,信号转导及经神疾病的分子机理 Participating


RGC - Areas of Excellence Scheme


Project Team (HKUST)
WEN Zilong (Lead)
LIU Kai
QU Jianan
WU Zhenguo
YAN Yan


2013 -