Changdong LIU
刘长东
PhD in Radio Physics
The East China Normal University, 2010

Research Assistant Professor
Division of Life Science



(852) 2358 8713
lcd@ust.hk
Room 6318

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ORCID
0000-0001-7356-9765

Scopus ID
37061446900




Research Interest Publications Projects




Research Interest

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Structural biology
Nuclear magnetic resonance (NMR) study
Nucleic acid/protein interactions
Neurodegenerative disease



Publications

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All Years 34 2022 0 2021 1 2020 2 2019 3 2018 3 2017 1 2016 24

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2021 1

Crystal structure of parallel G-quadruplex formed by the two-repeat ALS-and FTD-related GGGGCC sequence
Nucleic Acids Research, v. 49, (10), June 2021, p. 5881-5890
Geng, Yanyan; Liu, Changdong; Cai, Qixu; Luo, Zhipu; Miao, Haitao; Shi, Xiao; Xu, Naining; Fung, Chun Po; Choy, To To; Yan, Bing; Li, Ning; Qian, Peiyuan; Zhou, Bo; Zhu, Guang Article

2020 2

An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication
Cell Reports, v. 30, (10), March 2020, article number E6, p. 3323-3338
Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John F.; Wang, Ziyi; Zhou, Zijing; Liu, Changdong; Zhu, Guang; Wong, Chris Kong Chu; Yu, Zhiling; Liang, Chun Article
Structural basis of DNA replication origin recognition by human Orc6 protein binding with DNA
Nucleic Acids Research, v. 48, (19), November 2020, p. 11146-11161
Xu, Naining; You, Yingying; Liu, Changdong; Balasov, Maxim; Lun, Lee Tung; Geng, Yanyan; Fung, Chun Po; Miao, Haitao; Tian, Honglei; Choy, To To; Shi, Xiao; Fan, Zhuming; Zhou, Bo; Akhmetova, Katarina; Din, Rahman Ud; Yang, Hongyu; Hao, Quan; Qian, Peiyuan; Chesnokov, Igor; Zhu, Guang Article

2019 3

A chair-type G-quadruplex structure formed by a human telomeric variant DNA in K⁺ solution
Chemical Science, v. 10, (1), January 2019, p. 218-226
Liu, Changdong; Zhou, Bo; Geng, Yanyan; Tam, Dick Yan; Feng, Rui; Miao, Haitao; Xu, Naining; Shi, Xiao; You, Yingying; Hong, Yuning; Tang, Benzhong; Lo, Pik Kwan; Kuryavyi, Vitaly; Zhu, Guang Article
G-quadruplex structures formed by human telomeric DNA and C9orf72 hexanucleotide repeats
Biophysical Reviews, v. 11, (3), June 2019, p. 389-393
Liu, Changdong; Geng, Yanyan; Miao, Haitao; Shi, Xiao; You, Yingying; Xu, Naining; Zhou, Bo; Zhu, Guang Article
The crystal structure of an antiparallel chair-type G-quadruplex formed by Bromo-substituted human telomeric DNA
Nucleic Acids Research, v. 47, (10), June 2019, p. 5395-5404
Geng, Yanyan; Liu, Changdong; Zhou, Bo; Cai, Qixu; Miao, Haitao; Shi, Xiao; Xu, Naining; You, Yingying; Fung, Chun Po; Din, Rahman Ud; Zhu, Guang Article

2018 3

Characterizations of distinct parallel and antiparallel G-quadruplexes formed by two-repeat ALS and FTD related GGGGCC sequence
Scientific Reports, v. 8, (1), February 2018, article number 2366, p. 2366-2366
Zhou, Bo; Geng, Yanyan; Liu, Changdong; Miao, Haitao; Ren, Yaguang; Xu, Naining; Shi, Xiao; You, Yingying; Lee, Tung Lun; Zhu, Guang Article
ALS和FTD相关的双重重复GGGGCC序列形成的平行和反平行G-四链体的表征
第二十届全国波谱学学术会议 The 20th Chinese National Magnetic Resonance Conference, Wenzhou, China, 11-14 October 2018
周波; 耿艳艳; 刘长东 Conference paper
K+溶液中8-溴代鸟苷取代的人端粒序列形成的的椅式G-四链体拓扑结构及其变体的NMR溶液结构
第二十届全国波谱学学术会议 The 20th Chinese National Magnetic Resonance Conference, Wenzhou, China, 11-14 October 2018
刘长东; 周波; 耿艳艳 Conference paper

2017 1

Topology of a G-quadruplex DNA formed by C9orf72 hexanucleotide repeats associated with ALS and FTD
Society of Chinese Bioscientists in America the 16th International Symposium (2017 SCBA) 全球华人生物学家大会暨 第十六届美洲华人生物科学学会学术研讨会, Hangzhou, China, 29 Jun - 3 Jul 2017
Zhou, Bo; Liu, Changdong; Geng, Yanyan; Zhu, Guang Conference paper

2016 1

与ALS/FTD相关联的C9orf72六核苷酸重复扩增所形成G-四链体DNA的拓扑结构
第十九届全国波谱学学术会 The 19th Chinese National Magnetic Resonance Conference, Lan Zhou, China, 17-20 August 2016
周波; 刘长东; 耿艳艳; 朱广 Conference paper

2015 5

¹H, ¹⁵N and ¹³C chemical shift assignments of the homeodomain of Hoxc9 in complex with the cell cycle regulator Geminin
Biomolecular NMR Assignments, v. 9, (1), 2015, p. 165-168
Zhou, Bo; Liu, Changdong; Zhu, Guang Article
Development of stapled helical peptides to perturb the Cdt1-Mcm6 interaction
Journal of Peptide Science, v. 21, (7), July 2015, p. 593-598
Lee, Jonghan Peter; Liu, Changdong; Li, Tianlu; Zhu, Guang; Li, Xuechen Article
Quadruplex Nucleic Acid Structure Determination by Solution NMR
Chinese Journal of Magnetic Resonance=波谱学杂志, v. 32, (2), June 2015, p. 150-162
Liu, Changdong; Zhu, Guang Article
Topology of a G-quadruplex DNA formed by C9orf72 hexanucleotide repeats associated with ALS and FTD
Scientific Reports, v. 5, November 2015, article number 16673
Zhou, Bo; Liu, Changdong; Geng, Yanyan; Zhu, Guang Article
Molecular basis of the general base catalysis of an α/β-hydrolase catalytic triad
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, Hong Kong, 18 April 2015
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong Conference paper

2014 2

Molecular basis of the general base catalysis of an α/β- hydrolase catalytic triad
Journal of Biological Chemistry, v. 289, (22), May 2014, p. 15867-15879
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong Article
Molecular Basis of the General Base Catalysis of an α/β-Hydrolase Catalytic Triad
The 2nd South China Structural Biology Symposium, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 5-7 December 2014
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong Conference paper

2013 2

Structure-functional Study of Proteins that Regulate Cell Proliferation and Differentiation
BIT's Biopharmaceutical Summit-2013, Frankfurt, Germany, 7 - 8 August 2013
Zhou, Bo; Liu, Changdong; Geng, Yanyan; Zhu, Guang Conference paper
The Chair-type Structure of the Intramolecular Human Telomeric G-quadruplex
BCEIA 2013 - The 15th Beijing Conference and Exhibition on Instrumental Analysis, Beijing, China, 23-26 October 2013
Liu, Changdong; Zhou, Bo; Feng, Rui; Zhu, Guang Conference paper

2012 6

Butenolide inhibits marine fouling by altering the primary metabolism of three target organisms
ACS Chemical Biology, v. 7, (6), June 2012, p. 1049-1058
Zhang, Yifan; Zhang, Huoming; He, Lisheng; Liu, Changdong; Xu, Sharon Ying; Qian, Peiyuan Article
Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode
Journal of biological chemistry, v. 287, (31), July 2012, p. 26104-26114
Chen, Lihong; Liu, Changdong; Ko, Frankie Chi Fat; Xu, Naining; Ng, Irene Oi-Lin; Yam, Judy Wai Ping; Zhu, Guang Article
Structural basis for homeodomain recognition by the cell-cycle regulator Geminin
Proceedings of the National Academy of Sciences of the United States of America, v. 109, (23), June 2012, p. 8931-8936
Zhou, Bo; Liu, Changdong; Xu, Zhiwen; Zhu, Guang Article
Structural insights into the Cdt1-mediated MCM2-7 chromatin loading
Nucleic Acids Research, v. 40, (7), April 2012, p. 3208-3217
Liu, Changdong; Wu, Rentian; Zhou, Bo; Wang, Jiafeng; Wei, Zhun; Tye, Bik Kwoon; Liang, Chun; Zhu, Guang Article
Crowding effect on calmodulin bakcbone dynamics
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27 April 2013
Feng, Yitao; Liu, Changdong; Wu, Qinglin; Zhu, Guang; Guo, Zhihong Conference paper
基于Cdt1调节的MCM2-7复合物染色质装配的结构机制
第十七届全国波谱学学术会议暨第四届海峡两岸磁共振学术研讨会 The 17th Chinese National Magnetic Resonance Conference, Xiamen, China, 23-26 October 2012
Liu, Changdong; Wu, Rentian; Zhou, Bo Conference paper

2011 3

¹H, ¹⁵N and ¹³C chemical shift assignments of the SH2 domain of human tensin2 (TENC1)
Biomolecular NMR Assignments, v. 5, (2), October 2011, p. 211-214
Chen, Lihong; Liu, Changdong; Rui, Feng; Zhu, Guang Article
Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6
7th Asian Biophysics Association (ABA) Symposium & Annual Meeting of the Indian Biophysical Society (IBS), New Delhi, India, 30 January - 2 February 2011
Wei, Zhun; Liu, Changdong; Xu, Naining; Zhou, Bo; Zhu, Guang Conference paper
Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6
Current Opinion in Structural Biology & DNA Repair. A Current Opinion in Structural Biology conference, Amsterdam, The Netherlands, 16–18 October 2011
Liu, Changdong Conference paper

2010 4

¹H, ¹⁵N and ¹³C chemical shift assignments of the Cdt1 binding domain of human Mcm6
Biomolecular NMR Assignments, v. 4, (2), October 2010, p. 231-233
Liu, Changdong; Wei, Zhun; Zhu, Guang Article
Characterization and structure determination of the cdt1 binding domain of human minichromosome maintenance (Mcm) 6
Journal of Biological Chemistry, v. 285, (17), April 2010, p. 12469-12473
Wei, Zhun; Liu, Changdong; Wu, Xing; Xu, Naining; Zhou, Bo; Liang, Chun; Zhu, Guang Article
Studying base pair open-close kinetics of tRNA^Leu by TROSY-based proton exchange NMR spectroscopy
FEBS Letters, v. 584, (21), November 2010, p. 4449-4452
Hao, Zhan Xi; Tan, Min; Liu, Changdong; Feng, Rui; Wang, En Duo; Zhu, Guang Article
人Mcm6蛋白Cdt1相结合结构域的溶液结构
第十六届全国波谱学学术会议 The 16th Chinese National Magnetic Resonance Conference, Haikou, China, 23-26 November 2010
Liu, Changdong; Wei, Zhun; Xu, Naining Conference paper

2005 1

SET8 recognizes the sequence RHRK²⁰VLRDN within the N terminus of histone H4 and mono-methylates lysine 20
Journal of Biological Chemistry, v. 280, (3)4, August 2005, p. 30025-30031
Yin, Yinliang; Liu, Changdong; Tsai, Sau Na; Zhou, Bo; Ngai, Sai Ming; Zhu, Guang Article


Expand All Collapse All


Article 1

Crystal structure of parallel G-quadruplex formed by the two-repeat ALS-and FTD-related GGGGCC sequence
Nucleic Acids Research, v. 49, (10), June 2021, p. 5881-5890
Geng, Yanyan; Liu, Changdong; Cai, Qixu; Luo, Zhipu; Miao, Haitao; Shi, Xiao; Xu, Naining; Fung, Chun Po; Choy, To To; Yan, Bing; Li, Ning; Qian, Peiyuan; Zhou, Bo; Zhu, Guang


Expand All Collapse All


Article 2

An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication
Cell Reports, v. 30, (10), March 2020, article number E6, p. 3323-3338
Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John F.; Wang, Ziyi; Zhou, Zijing; Liu, Changdong; Zhu, Guang; Wong, Chris Kong Chu; Yu, Zhiling; Liang, Chun
Structural basis of DNA replication origin recognition by human Orc6 protein binding with DNA
Nucleic Acids Research, v. 48, (19), November 2020, p. 11146-11161
Xu, Naining; You, Yingying; Liu, Changdong; Balasov, Maxim; Lun, Lee Tung; Geng, Yanyan; Fung, Chun Po; Miao, Haitao; Tian, Honglei; Choy, To To; Shi, Xiao; Fan, Zhuming; Zhou, Bo; Akhmetova, Katarina; Din, Rahman Ud; Yang, Hongyu; Hao, Quan; Qian, Peiyuan; Chesnokov, Igor; Zhu, Guang


Expand All Collapse All


Article 3

A chair-type G-quadruplex structure formed by a human telomeric variant DNA in K⁺ solution
Chemical Science, v. 10, (1), January 2019, p. 218-226
Liu, Changdong; Zhou, Bo; Geng, Yanyan; Tam, Dick Yan; Feng, Rui; Miao, Haitao; Xu, Naining; Shi, Xiao; You, Yingying; Hong, Yuning; Tang, Benzhong; Lo, Pik Kwan; Kuryavyi, Vitaly; Zhu, Guang
G-quadruplex structures formed by human telomeric DNA and C9orf72 hexanucleotide repeats
Biophysical Reviews, v. 11, (3), June 2019, p. 389-393
Liu, Changdong; Geng, Yanyan; Miao, Haitao; Shi, Xiao; You, Yingying; Xu, Naining; Zhou, Bo; Zhu, Guang
The crystal structure of an antiparallel chair-type G-quadruplex formed by Bromo-substituted human telomeric DNA
Nucleic Acids Research, v. 47, (10), June 2019, p. 5395-5404
Geng, Yanyan; Liu, Changdong; Zhou, Bo; Cai, Qixu; Miao, Haitao; Shi, Xiao; Xu, Naining; You, Yingying; Fung, Chun Po; Din, Rahman Ud; Zhu, Guang


Expand All Collapse All


Article 1

Characterizations of distinct parallel and antiparallel G-quadruplexes formed by two-repeat ALS and FTD related GGGGCC sequence
Scientific Reports, v. 8, (1), February 2018, article number 2366, p. 2366-2366
Zhou, Bo; Geng, Yanyan; Liu, Changdong; Miao, Haitao; Ren, Yaguang; Xu, Naining; Shi, Xiao; You, Yingying; Lee, Tung Lun; Zhu, Guang

Conference paper 2

ALS和FTD相关的双重重复GGGGCC序列形成的平行和反平行G-四链体的表征
第二十届全国波谱学学术会议 The 20th Chinese National Magnetic Resonance Conference, Wenzhou, China, 11-14 October 2018
周波; 耿艳艳; 刘长东
K+溶液中8-溴代鸟苷取代的人端粒序列形成的的椅式G-四链体拓扑结构及其变体的NMR溶液结构
第二十届全国波谱学学术会议 The 20th Chinese National Magnetic Resonance Conference, Wenzhou, China, 11-14 October 2018
刘长东; 周波; 耿艳艳


Expand All Collapse All


Conference paper 1

Topology of a G-quadruplex DNA formed by C9orf72 hexanucleotide repeats associated with ALS and FTD
Society of Chinese Bioscientists in America the 16th International Symposium (2017 SCBA) 全球华人生物学家大会暨 第十六届美洲华人生物科学学会学术研讨会, Hangzhou, China, 29 Jun - 3 Jul 2017
Zhou, Bo; Liu, Changdong; Geng, Yanyan; Zhu, Guang


Expand All Collapse All


Conference paper 1

与ALS/FTD相关联的C9orf72六核苷酸重复扩增所形成G-四链体DNA的拓扑结构
第十九届全国波谱学学术会 The 19th Chinese National Magnetic Resonance Conference, Lan Zhou, China, 17-20 August 2016
周波; 刘长东; 耿艳艳; 朱广


Expand All Collapse All


Article 4

¹H, ¹⁵N and ¹³C chemical shift assignments of the homeodomain of Hoxc9 in complex with the cell cycle regulator Geminin
Biomolecular NMR Assignments, v. 9, (1), 2015, p. 165-168
Zhou, Bo; Liu, Changdong; Zhu, Guang
Development of stapled helical peptides to perturb the Cdt1-Mcm6 interaction
Journal of Peptide Science, v. 21, (7), July 2015, p. 593-598
Lee, Jonghan Peter; Liu, Changdong; Li, Tianlu; Zhu, Guang; Li, Xuechen
Quadruplex Nucleic Acid Structure Determination by Solution NMR
Chinese Journal of Magnetic Resonance=波谱学杂志, v. 32, (2), June 2015, p. 150-162
Liu, Changdong; Zhu, Guang
Topology of a G-quadruplex DNA formed by C9orf72 hexanucleotide repeats associated with ALS and FTD
Scientific Reports, v. 5, November 2015, article number 16673
Zhou, Bo; Liu, Changdong; Geng, Yanyan; Zhu, Guang

Conference paper 1

Molecular basis of the general base catalysis of an α/β-hydrolase catalytic triad
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, Hong Kong, 18 April 2015
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong


Expand All Collapse All


Article 1

Molecular basis of the general base catalysis of an α/β- hydrolase catalytic triad
Journal of Biological Chemistry, v. 289, (22), May 2014, p. 15867-15879
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong

Conference paper 1

Molecular Basis of the General Base Catalysis of an α/β-Hydrolase Catalytic Triad
The 2nd South China Structural Biology Symposium, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 5-7 December 2014
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong


Expand All Collapse All


Conference paper 2

Structure-functional Study of Proteins that Regulate Cell Proliferation and Differentiation
BIT's Biopharmaceutical Summit-2013, Frankfurt, Germany, 7 - 8 August 2013
Zhou, Bo; Liu, Changdong; Geng, Yanyan; Zhu, Guang
The Chair-type Structure of the Intramolecular Human Telomeric G-quadruplex
BCEIA 2013 - The 15th Beijing Conference and Exhibition on Instrumental Analysis, Beijing, China, 23-26 October 2013
Liu, Changdong; Zhou, Bo; Feng, Rui; Zhu, Guang


Expand All Collapse All


Article 4

Butenolide inhibits marine fouling by altering the primary metabolism of three target organisms
ACS Chemical Biology, v. 7, (6), June 2012, p. 1049-1058
Zhang, Yifan; Zhang, Huoming; He, Lisheng; Liu, Changdong; Xu, Sharon Ying; Qian, Peiyuan
Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode
Journal of biological chemistry, v. 287, (31), July 2012, p. 26104-26114
Chen, Lihong; Liu, Changdong; Ko, Frankie Chi Fat; Xu, Naining; Ng, Irene Oi-Lin; Yam, Judy Wai Ping; Zhu, Guang
Structural basis for homeodomain recognition by the cell-cycle regulator Geminin
Proceedings of the National Academy of Sciences of the United States of America, v. 109, (23), June 2012, p. 8931-8936
Zhou, Bo; Liu, Changdong; Xu, Zhiwen; Zhu, Guang
Structural insights into the Cdt1-mediated MCM2-7 chromatin loading
Nucleic Acids Research, v. 40, (7), April 2012, p. 3208-3217
Liu, Changdong; Wu, Rentian; Zhou, Bo; Wang, Jiafeng; Wei, Zhun; Tye, Bik Kwoon; Liang, Chun; Zhu, Guang

Conference paper 2

Crowding effect on calmodulin bakcbone dynamics
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27 April 2013
Feng, Yitao; Liu, Changdong; Wu, Qinglin; Zhu, Guang; Guo, Zhihong
基于Cdt1调节的MCM2-7复合物染色质装配的结构机制
第十七届全国波谱学学术会议暨第四届海峡两岸磁共振学术研讨会 The 17th Chinese National Magnetic Resonance Conference, Xiamen, China, 23-26 October 2012
Liu, Changdong; Wu, Rentian; Zhou, Bo


Expand All Collapse All


Article 1

¹H, ¹⁵N and ¹³C chemical shift assignments of the SH2 domain of human tensin2 (TENC1)
Biomolecular NMR Assignments, v. 5, (2), October 2011, p. 211-214
Chen, Lihong; Liu, Changdong; Rui, Feng; Zhu, Guang

Conference paper 2

Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6
7th Asian Biophysics Association (ABA) Symposium & Annual Meeting of the Indian Biophysical Society (IBS), New Delhi, India, 30 January - 2 February 2011
Wei, Zhun; Liu, Changdong; Xu, Naining; Zhou, Bo; Zhu, Guang
Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6
Current Opinion in Structural Biology & DNA Repair. A Current Opinion in Structural Biology conference, Amsterdam, The Netherlands, 16–18 October 2011
Liu, Changdong


Expand All Collapse All


Article 3

¹H, ¹⁵N and ¹³C chemical shift assignments of the Cdt1 binding domain of human Mcm6
Biomolecular NMR Assignments, v. 4, (2), October 2010, p. 231-233
Liu, Changdong; Wei, Zhun; Zhu, Guang
Characterization and structure determination of the cdt1 binding domain of human minichromosome maintenance (Mcm) 6
Journal of Biological Chemistry, v. 285, (17), April 2010, p. 12469-12473
Wei, Zhun; Liu, Changdong; Wu, Xing; Xu, Naining; Zhou, Bo; Liang, Chun; Zhu, Guang
Studying base pair open-close kinetics of tRNA^Leu by TROSY-based proton exchange NMR spectroscopy
FEBS Letters, v. 584, (21), November 2010, p. 4449-4452
Hao, Zhan Xi; Tan, Min; Liu, Changdong; Feng, Rui; Wang, En Duo; Zhu, Guang

Conference paper 1

人Mcm6蛋白Cdt1相结合结构域的溶液结构
第十六届全国波谱学学术会议 The 16th Chinese National Magnetic Resonance Conference, Haikou, China, 23-26 November 2010
Liu, Changdong; Wei, Zhun; Xu, Naining


Expand All Collapse All


Article 1

SET8 recognizes the sequence RHRK²⁰VLRDN within the N terminus of histone H4 and mono-methylates lysine 20
Journal of Biological Chemistry, v. 280, (3)4, August 2005, p. 30025-30031
Yin, Yinliang; Liu, Changdong; Tsai, Sau Na; Zhou, Bo; Ngai, Sai Ming; Zhu, Guang


Expand All Collapse All


2016 1

与ALS/FTD相关联的C9orf72六核苷酸重复扩增所形成G-四链体DNA的拓扑结构
第十九届全国波谱学学术会 The 19th Chinese National Magnetic Resonance Conference, Lan Zhou, China, 17-20 August 2016
周波; 刘长东; 耿艳艳; 朱广 Conference paper

2015 5

¹H, ¹⁵N and ¹³C chemical shift assignments of the homeodomain of Hoxc9 in complex with the cell cycle regulator Geminin
Biomolecular NMR Assignments, v. 9, (1), 2015, p. 165-168
Zhou, Bo; Liu, Changdong; Zhu, Guang Article
Development of stapled helical peptides to perturb the Cdt1-Mcm6 interaction
Journal of Peptide Science, v. 21, (7), July 2015, p. 593-598
Lee, Jonghan Peter; Liu, Changdong; Li, Tianlu; Zhu, Guang; Li, Xuechen Article
Quadruplex Nucleic Acid Structure Determination by Solution NMR
Chinese Journal of Magnetic Resonance=波谱学杂志, v. 32, (2), June 2015, p. 150-162
Liu, Changdong; Zhu, Guang Article
Topology of a G-quadruplex DNA formed by C9orf72 hexanucleotide repeats associated with ALS and FTD
Scientific Reports, v. 5, November 2015, article number 16673
Zhou, Bo; Liu, Changdong; Geng, Yanyan; Zhu, Guang Article
Molecular basis of the general base catalysis of an α/β-hydrolase catalytic triad
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, Hong Kong, 18 April 2015
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong Conference paper

2014 2

Molecular basis of the general base catalysis of an α/β- hydrolase catalytic triad
Journal of Biological Chemistry, v. 289, (22), May 2014, p. 15867-15879
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong Article
Molecular Basis of the General Base Catalysis of an α/β-Hydrolase Catalytic Triad
The 2nd South China Structural Biology Symposium, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 5-7 December 2014
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong Conference paper

2013 2

Structure-functional Study of Proteins that Regulate Cell Proliferation and Differentiation
BIT's Biopharmaceutical Summit-2013, Frankfurt, Germany, 7 - 8 August 2013
Zhou, Bo; Liu, Changdong; Geng, Yanyan; Zhu, Guang Conference paper
The Chair-type Structure of the Intramolecular Human Telomeric G-quadruplex
BCEIA 2013 - The 15th Beijing Conference and Exhibition on Instrumental Analysis, Beijing, China, 23-26 October 2013
Liu, Changdong; Zhou, Bo; Feng, Rui; Zhu, Guang Conference paper

2012 6

Butenolide inhibits marine fouling by altering the primary metabolism of three target organisms
ACS Chemical Biology, v. 7, (6), June 2012, p. 1049-1058
Zhang, Yifan; Zhang, Huoming; He, Lisheng; Liu, Changdong; Xu, Sharon Ying; Qian, Peiyuan Article
Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode
Journal of biological chemistry, v. 287, (31), July 2012, p. 26104-26114
Chen, Lihong; Liu, Changdong; Ko, Frankie Chi Fat; Xu, Naining; Ng, Irene Oi-Lin; Yam, Judy Wai Ping; Zhu, Guang Article
Structural basis for homeodomain recognition by the cell-cycle regulator Geminin
Proceedings of the National Academy of Sciences of the United States of America, v. 109, (23), June 2012, p. 8931-8936
Zhou, Bo; Liu, Changdong; Xu, Zhiwen; Zhu, Guang Article
Structural insights into the Cdt1-mediated MCM2-7 chromatin loading
Nucleic Acids Research, v. 40, (7), April 2012, p. 3208-3217
Liu, Changdong; Wu, Rentian; Zhou, Bo; Wang, Jiafeng; Wei, Zhun; Tye, Bik Kwoon; Liang, Chun; Zhu, Guang Article
Crowding effect on calmodulin bakcbone dynamics
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27 April 2013
Feng, Yitao; Liu, Changdong; Wu, Qinglin; Zhu, Guang; Guo, Zhihong Conference paper
基于Cdt1调节的MCM2-7复合物染色质装配的结构机制
第十七届全国波谱学学术会议暨第四届海峡两岸磁共振学术研讨会 The 17th Chinese National Magnetic Resonance Conference, Xiamen, China, 23-26 October 2012
Liu, Changdong; Wu, Rentian; Zhou, Bo Conference paper

2011 3

¹H, ¹⁵N and ¹³C chemical shift assignments of the SH2 domain of human tensin2 (TENC1)
Biomolecular NMR Assignments, v. 5, (2), October 2011, p. 211-214
Chen, Lihong; Liu, Changdong; Rui, Feng; Zhu, Guang Article
Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6
7th Asian Biophysics Association (ABA) Symposium & Annual Meeting of the Indian Biophysical Society (IBS), New Delhi, India, 30 January - 2 February 2011
Wei, Zhun; Liu, Changdong; Xu, Naining; Zhou, Bo; Zhu, Guang Conference paper
Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6
Current Opinion in Structural Biology & DNA Repair. A Current Opinion in Structural Biology conference, Amsterdam, The Netherlands, 16–18 October 2011
Liu, Changdong Conference paper

2010 4

¹H, ¹⁵N and ¹³C chemical shift assignments of the Cdt1 binding domain of human Mcm6
Biomolecular NMR Assignments, v. 4, (2), October 2010, p. 231-233
Liu, Changdong; Wei, Zhun; Zhu, Guang Article
Characterization and structure determination of the cdt1 binding domain of human minichromosome maintenance (Mcm) 6
Journal of Biological Chemistry, v. 285, (17), April 2010, p. 12469-12473
Wei, Zhun; Liu, Changdong; Wu, Xing; Xu, Naining; Zhou, Bo; Liang, Chun; Zhu, Guang Article
Studying base pair open-close kinetics of tRNA^Leu by TROSY-based proton exchange NMR spectroscopy
FEBS Letters, v. 584, (21), November 2010, p. 4449-4452
Hao, Zhan Xi; Tan, Min; Liu, Changdong; Feng, Rui; Wang, En Duo; Zhu, Guang Article
人Mcm6蛋白Cdt1相结合结构域的溶液结构
第十六届全国波谱学学术会议 The 16th Chinese National Magnetic Resonance Conference, Haikou, China, 23-26 November 2010
Liu, Changdong; Wei, Zhun; Xu, Naining Conference paper

2005 1

SET8 recognizes the sequence RHRK²⁰VLRDN within the N terminus of histone H4 and mono-methylates lysine 20
Journal of Biological Chemistry, v. 280, (3)4, August 2005, p. 30025-30031
Yin, Yinliang; Liu, Changdong; Tsai, Sau Na; Zhou, Bo; Ngai, Sai Ming; Zhu, Guang Article


No Publications









ProjectsFrom January 2020 to December 2022

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All Projects 2 Leading Projects 1 Participating Projects 1

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Molecular mechanism of FTD/ALS caused by G-quadruplex formation by C9orf72 G4C2 hexanucleotide repeats


C9orf72六核苷酸重复形序列 G4C2 G-四链体引起的肌萎缩侧索硬化和额颞叶痴症的分子机制研究 Leading


Guangdong Natural Science Foundation, National Natural Science Foundation of China


Project Team (HKUST)
LIU Changdong (Lead)


2019 - , 2021 -




Structure-function studies of pre replication complex in DNA replication of human and NPC cells


人类正常细胞和鼻咽癌细胞的DNA复制中前复制复合体的结构与功能研究 Participating


National Natural Science Foundation of China


Project Team (HKUST)
ZHU Guang (Lead)
LIU Changdong


2017 - 2020