Chun LIANG
梁纯
PhD in Biology
Brown University, 1993

Associate Professor
Division of Life Science



(852) 2358 7296
bccliang@ust.hk
Room 5524
Personal Web

---

ORCID
0000-0003-1996-6027

Scopus ID
26026377400




Research Interest Publications Projects Teaching Assignment RPG Supervision Space used




Research Interest

---

Deoxyribonucleic acid (DNA) replication
Cell cycle control
Cancer
Biotechnology



Publications

---

All Years 91 2022 0 2021 4 2020 6 2019 5 2018 5 2017 4 2016 67

---

Expand All Collapse All


2021 4

A two-herb formula inhibits STAT3 signaling and exerts anti-melanoma effects in cell and animal models
Journal of Ethnopharmacology, v. 268, March 2021, article number 113671
Li, Jun Kui; Chou, Ji Yao; Yin, Cheng Le; Fu, Xiu Qiong; Wu, Ying; Chen, Ying Jie; Bai, Jing Xuan; Wu, Jia Ying; Liang, Chun; Yu, Zhi Ling Article
Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin
Evidence-based Complementary and Alternative Medicine, v. 2021, June 2021, article number 6610793
Han, Zhong; Guo, Jianmin; Meng, Feibiao; Liao, Haifeng; Deng, Yinghua; Huang, Yuankeng; Lei, Xialing; Liang, Chun; Han, Richou; Yang, Wei Article
Ginsenoside Rg3 in combination with artesunate overcomes sorafenib resistance in hepatoma cell and mouse models
Journal of Ginseng Research, 14 July 2021
Chen, Ying-Jie; Wu, Jia-Ying; Deng, Yu-Yi; Wu, Ying; Wang, Xiao-Qi; Li, Amy Sze-man; Wong, Lut Yi; Fu, Xiu-Qiong; Yu, Zhi-Ling; Liang, Chun Article
The anti-inflammatory effects of an ethanolic extract of the rhizome of Atractylodes lancea, involves Akt/NF-κB signaling pathway inhibition
Journal of Ethnopharmacology, v. 277, September 2021, article number 114183
Hossen, Muhammad Jahangir; Amin, Aftab; Fu, Xiu-Qiong; Chou, Ji-Yao; Wu, Jia-Ying; Wang, Xiao-Qi; Chen, Ying-Jie; Wu, Ying; Li, Junkui; Yin, Cheng-Le; Liang, Chun; Chou, Gui-Xin; Yu, Zhi-Ling Article

2020 6

An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication
Cell Reports, v. 30, (10), March 2020, article number E6, p. 3323-3338
Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John F.; Wang, Ziyi; Zhou, Zijing; Liu, Changdong; Zhu, Guang; Wong, Chris Kong Chu; Yu, Zhiling; Liang, Chun Article
FOP Negatively Regulates Ciliogenesis and Promotes Cell Cycle Re-entry by Facilitating Primary Cilia Disassembly
Frontiers in Cell and Developmental Biology, v. 8, November 2020, article number 590449
Jiang, Huadong; Liu, Shanshan; Cheung, Man Hei; Amin, Aftab; Liang, Chun Article
Gynura divaricata exerts hypoglycemic effects by regulating the PI3K/AKT signaling pathway and fatty acid metabolism signaling pathway
Nutrition and Diabetes, v. 10, (1), 1 December 2020, article number 31
Xu, Wenjun; Lu, Zhongxia; Wang, Xin; Cheung, Man Hei; Lin, Meiai; Li, Changyu; Dong, Yu; Liang, Chun; Chen, Yitao Article
Inhibiting the Src/STAT3 signaling pathway contributes to the anti-melanoma mechanisms of dioscin
Oncology Letters, v. 19, (3), January 2020, p. 2508-2514
Liu, Yu-Xi; Xu, Bo-Wen; Chen, Ying-Jie; Fu, Xiu-Qiong; Zhu, Pei-Li; Bai, Jing-Xuan; Chou, Ji-Yao; Yin, Cheng-Le; Li, Jun-Kui; Wang, Ya-Ping; Wu, Jia-Ying; Wu, Ying; Chan, Kam-Kwan; Liang, Chun; Yu, Zhiling Article
Parameritannin A-2 from Urceola huaitingii enhances doxorubicin-induced mitochondria-dependent apoptosis by inhibiting the PI3K/Akt, ERK1/2 and p38 pathways in gastric cancer cells
Chemico-Biological Interactions, v. 316, January 2020, article number 108924
Liang, Lu; Amin, Aftab; Cheung, Wing Yan; Xu, Rui; Yu, Rujian; Tang, Jinshan; Yao, Xinsheng; Liang, Chun Article
Research and development of innovative anticancer drugs targeting DNA Replication-Initiation Proteins
第二届肿瘤免疫治疗领袖峰会=2nd Cancer Immunotherapy Therapy Leader Summit 2020, 中国广州, 3-4 July 2020
Liang, Chun Conference paper

2019 5

DNA Replication-Initiation Proteins in Eukaryotic Cells
Biomedical Journal of Scientific & Technical Research, v. 23, November 2019, p. 17042-17049
Amin, Aftab; Cheung, Man Hei; Liang, Chun Article
Human NOC3 is essential for DNA replication licensing in human cells
Cell Cycle, v. 18, (5), March 2019, p. 605-620
Cheung, Man Hei; Amin, Aftab; Wu, Rentian; Qin, Yan; Zou, Lan; Yu, Zhiling; Liang, Chun Article
Identification of Molecular Biomarkers for the Diagnosis of Gastric Cancer and Lymph-node Metastasis
Gastroenterology Report, v. 7, (1), February 2019, p. 57-66
Seeruttun, Sharvesh Raj; Cheung, Wing Yan; Wang, Wei; Fang, Cheng; Liu, Zhimin; Li, Jinqing; Wu, Ting; Wang, Jun; Liang, Chun; Zhou, Zhiwei Article
Reproductive Systemic Toxicity and Mechanism of Glucosides of Tripterygium wilfordii Hook. F. (GTW)
Annals of Clinical and Laboratory Science, v. 49, (1), January 2019, p. 36-49
Guo, Jianmin; Huang, Yuankeng; Lei, Xialing; Zhang, Hong; Xiao, Baiquan; Han, Zhong; Liang, Chun; Yang, Wei Article
The Interaction Networks of the Budding Yeast and Human DNA Replication-initiation Proteins
Cell Cycle, v. 18, (6-7), April 2019, p. 723-741
Wu, Rentian; Amin, Aftab; Wang, Ziyi; Huang, Yining; Cheung, Man Hei; Yu, Zhiling; Yang, Wei; Liang, Chun Article

2018 5

Biomarkers associated with binaprofen?induced liver injury
Molecular Medicine Reports, v.18, (6), December 2018, p. 5076-5086
Guo, Qiuping; Guo, Jianmin; Chen, Guiying; Han, Zhong; Xiao, Baiquan; Jin, Ruomin; Liang, Chun; Yang, Wei Article
Effect of Total Flavones from Cuscuta Chinensis on Anti-Abortion via the MAPK Signaling Pathway
Evidence-based Complementary and Alternative Medicine, v. 2018, 2018, article number 6356190, p. 1-12
Wu, Hai-wang; Feng, Yi-hui; Wang, Dong-ying; Qiu, Wei-yu; Yu, Qing-ying; Yang, Li-lin; Liang, Chun; Luo, Song-ping; Gao, Jie Article
Total flavonoids from Semen Cuscutae target MMP9 and promote invasion of EVT cells via Notch/AKT/MAPK signaling pathways
Scientific Reports, v. 8, (1), November 2018, article number 17342
Gao, Feixia; Zhou, Chun; Qiu, Weiyu; Wu, Haiwang; Li, Jing; Peng, Jinting; Qiu, Min; Liang, Chun; Gao, Jie; Luo, Songping Article
雷公藤多苷对雄性SD大鼠生殖系统损伤的动态变化及其可能机制
中国药理学与毒理学杂志=Chinese Journal of Pharmacology and Toxicology, v. 32, (6), June 2018, p. 469-476
郭健敏; 黄远铿; 雷夏凌; 韩重; 梁纯; 杨威 Article
An essential, cell cycle-dependent and semiconservative ORC dimerization cycle regulates eukaryotic chromosomal DNA replication
2018 Gordon Research Conference on Genomic Instability, The Hong Kong University of Science and Technology, 21-27 July 2018
Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John Francis; Wang, Ziyi; Zhou, Zijing; Liang, Chun Conference paper

2017 4

Mitoxantrone Suppresses Vascular Smooth Muscle Cell (VSMC) Proliferation and Balloon Injury-induced Neointima Formation: An in Vitro and in Vivo Study
Bosnian Journal of Basic Medical Sciences, v. 17, (4), November 2017, p. 339-348
Teng, Yuan; Wang, Ziyi; Li, Wen; Yu, Jianxing; Shan, Zhen; Liang, Chun; Wang, Shenming Article
A Role of NOC3 in DNA Replication Initiation in Human Cells
2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, The University of Hong Kong, Hong Kong, 16 June 2017
Cheung, Man Hei; Amin, Aftab; Wu, Rentian; Qin, Yan; Zou, Lan; Zhong, Shan; Liang, Chun Conference paper
An essential, cell cycle-dependent and semiconservative ORC dimerization cycle critically regulates DNA replication
2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, The University of Hong Kong, Hong Kong, 16 June 2017
Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John Francis; Zhou, Zijing; Wang, Ziyi; Zhang, Chuchu; Wang, Jiafeng; Liang, Chun Conference paper
An essential, cell cycle-dependent and semi-conservative ORC dimerization cycle critically regulates DNA replication
Eukaryotic DNA Replication & Genome Maintenance, Cold Spring Harbor, USA, 5-9 September 2017
Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John Francis; Wang, Ziyi; Zhou, Zijing; Zhang, Chuchu; Wang, Jiafeng; Liang, Chun Conference paper

2016 3

A Role of hIPI3 in DNA Replication Licensing in Human Cells
PLoS ONE, v. 11, (4), April 2016, article number e0151803
Huang, Yining; Amin, Aftab; Qin, Yan; Wang, Ziyi; Jiang, Huadong; Liang, Lu; Shi, Linjing; Liang, Chun Article
Anticancer activities of proanthocyanidins from the plant Urceola huaitingii and their synergistic effects in combination with chemotherapeutics
Fitoterapia, v. 112, July 2016, p. 175-182
Yu, Rujian; Liu, Haibin; Yu, Yang; Liang, Lu; Xu, Rui; Liang, Chun; Tang, Jinshan; Yao, Xinsheng Article
Asperosaponin VI Promotes Progesterone Receptor Expression in Decidual Cells via the Notch Signaling Pathway
Fitoterapia, v. 113, September 2016, p. 58-63
Gao, Jie; Zhou, Chun; Li, Yadi; Gao, Feixia; Wu, Haiwang; Yang, Lilin; Qiu, Weiyu; Zhu, Lin; Du, Xin; Lin, Weixian; Huang, Dandan; Liu, Haibin; Liang, Chun; Luo, Songping Article

2015 2

Regulation of DNA replicaiton in normal and cancer cells and cancer metasatsis mechanisms
Yichun University, Yichun, Jiangxi, China, 2015
Liang, Chun Conference paper
The Capillary Number Effect on the Capture Efficiency of Cancer Cells on Composite Microfluidic Filtration Chips
Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), v. 2015-February, (February), February 2015, article number 7050989, p. 459-462
Zhao, Cong; Xu, Rui; Song, Kui; Liu, Dayu; Ma, Shou; Tang, Ce Mun; Liang, Chun; Zohar, Yitshak; Lee, Yi-Kuen Conference paper

2014 3

Isolation of circulating tumor cells under hydrodynamic loading using microuidic technology
力学进展=Advances in Mechanics, v .44, (1), January 2014, p. 447-494
Zhao, Cong; Lee, Yi-Kuen; Xu, Rui; Liang, Chun; Liu, Dayu; Ma, Wei; Piyawattanmetha, Wibool; Zohar, Yitshak Article
MicroRNA-26a/b regulate DNA replication licensing, tumorigenesis, and prognosis by targeting CDC6 in lung cancer
Molecular Cancer Research, v. 12, (11), November 2014, p. 1535-1546
Zhang, Xin; Xiao, Dakai; Wang, Ziyi; Zou, Yongxin; Huang, Liyan; Lin, Weixuan; Deng, Qiuhua; Pan, Hui; Zhou, Jiangfen; Liang, Chun; He, Jianxing Article
Regulation of DNA Replication in Normal and Cancer Cells
Tsinghua University-Pittsburgh University-HKUST Biomedical Symposium, Beijing, China, 10-11 April 2014
Liang, Chun Conference paper

2013 3

An essential, cell cycle-dependent and semiconservative ORC dimerization cycle critically regulates DNA replication
Eukaryotic DNA Replication & Genome Maintenance 2013, Cold Spring Harbor, USA, 9-13 September 2013
Wu, Rentian; Zhou, Zijing; Wang, Jiafeng; Amin, Aftab; Wang, Ziyi; Liang, Chun Conference paper
Regulation of DNA Replication in Normal and Cancer Cells: Basic Research and Potential Applications In Cancer
Guangdong Province Gynecological Medical Association Symposium, Guangdong University of Chinese Medicine, Guangzhou, China, 14 December 2013
Liang, Chun Conference paper
Regulation of DNA Replication in Normal and Cancer Cells: Basic Research and Potential Clinical Applications
The First Affiliated Hospital of Sun Yat-sen University Bio-Medicine Forum, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 20-21 November 2013
Liang, Chun Conference paper

2012 3

Cdt1p, through its interaction with Mcm6P, is required for the formation, nuclear accumulation and chromatin loading of the MCM complex
Journal of cell science, v. 125, (1), 2012, p. 209-219
Wu, Rentian; Wang, Jiafeng; Liang, Chun Article
Structural insights into the Cdt1-mediated MCM2-7 chromatin loading
Nucleic Acids Research, v. 40, (7), April 2012, p. 3208-3217
Liu, Changdong; Wu, Rentian; Zhou, Bo; Wang, Jiafeng; Wei, Zhun; Tye, Bik Kwoon; Liang, Chun; Zhu, Guang Article
The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis
Cell cycle, v. 11, (7), 2012, p. 1325-1339
Huo, Lin; Wu, Rentian; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Chan, TszChoi; Yeung, Jeffrey T.F.; Kan, Junsuo; Liang, Chun Article

2011 3

APOE Genotype-Function Relationship: Evidence of -491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk
PLoS ONE, v. 6, (10), October 2011, article number e24669
Geng, Hua; Law, Peggy P.Y.; Ng, Maggie C.Y.; Li, Ting; Liang, Li-Yun; Ge, Tian-Fang; Wong, Kam-Bo; Liang, Chun; Ma, Ronald C.; So, Wing-Yee; Chan, Juliana C.N.; Ho, Yuan-Yuan Article
Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast
FEMS yeast research, v. 11, (1), 2011, p. 72-79
Lai, Fenju; Wu, Rentian; Wang, Jiafeng; Li, Chunming; Zou, Lan; Lu, Yongjun; Liang, Chun Article
Cell cycle control of DNA replication by phosphorylation and dephosphorylation of replication-initiation proteins in budding yeast
Fundamental Aspects of DNA Replication / Edited by Jelena Kus?ic?-Tis?ma, Croati: InTech Publisher, Chapter 6, p. 87-106
Zhai, Yuanliang; Yung, Philip; Liang, Chun Book chapter

2010 10

ATP-dependent Pre-replicative Complex Assembly Is Facilitated by Adk1p in Budding Yeast
Journal of biological chemistry, v. 285, (39), 2010, SEP 24, p. 29974-29980
Cheng, Xue; Xu, Zhen; Wang, Jiafeng; Zhai, Yuanliang; Lu, Yongjun; Liang, Chun Article
Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast
Journal of cell science, v. 123, (22), 2010, p. 3933-3943
Zhai, Yuanliang; Yung, P.Y.K.; Huo, Lin; Liang, Chun Article
Characterization and structure determination of the cdt1 binding domain of human minichromosome maintenance (Mcm) 6
Journal of Biological Chemistry, v. 285, (17), April 2010, p. 12469-12473
Wei, Zhun; Liu, Changdong; Wu, Xing; Xu, Naining; Zhou, Bo; Liang, Chun; Zhu, Guang Article
Ctf4p facilitates Mcm10p to promote DNA replication in budding yeast
Biochemical and biophysical research communications, v. 395, (3), 2010, MAY 7, p. 336-341
Wang, Jiafeng; Wu, Rentian; Lu, Yongjun; Liang, Chun Article
Identification of Novel Factors Involved in or Regulating Initiation of DNA Replication by a Genome-wide Phenotypic Screen in Saccharomyces Cerevisiae
Cell Cycle, v. 9, (21), 2010, Nov, p. 4399-4410
Ma, Lijuan; Zhai, Yuanliang; Feng, Daorong; Chan, TszChoi; Lu, Yongjun; Fu, Xinrong; Wang, Jui-pin; Chen, Yanhong; Li, Jianna; Xu, Ke; Liang, Chun Article
The interacting domains of hCdt1 and hMcm6 involved in the chromatin loading of the MCM complex in human cells
Cell Cycle, v. 9, (24), 2010, p. 4848-4857
Zhang, Jing; Yu, Lan; Wu, Xing; Zou, Lan; Sou, K.K.L.; Wei, Zhun; Cheng, Xue; Zhu, Guang; Liang, Chun Article
A Group of General DNA Replication Origins and Replicators Sharing Homologous Sequences and Dispersed throughout the Human Genome
James Watson Symposium on Cancer, Cold Spring Harbor Asia Conferences, Suzhou, China, April 2010
Kan, Junsuo; Wang, Ziyi; Tu, Zheng; Zhang, Jingjing; Wu, Xing; Liang, Chun Conference paper
Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast
Cold Spring Harbor-Asia Symposium, Suzhou, China, Apr. 2010
Zhai, Yuanliang; Yung, Philip Y.K.; Huo, Lin; Liang, Chun Conference paper
Interaction network of DNA replication-initiation proteins and dimerization of ORC and Noc3p in pre-replicative complex assembly in budding yeast
Cold Spring Harbor Lab 'The Cell Cycle'Meeting, Cold Spring Harbor Lab, N.Y., USA, 5/2010
Wu, Rentian; Zhang, Chuchu; Yeung, Yun Fai; Wang, Jiafeng; Huo, Lin; Zhai, Yuanliang; Liang, Chun Conference paper
Nuclear Matrix Association of Orc and Utp7P is Inter-Dependent, Cell Cycle-Regulated, and required for Pre-Replicative Complex Assembly in Budding Yeast
Cold Spring Harbor Lab 'The Cell Cycle' Meeting, Cold Spring Harbor Lab, N. Y., USA, 5/2010
Cheng, Xue; Wang, Jiafeng; Xu, Zhen; Liang, Chun Conference paper

2009 3

Association analysis between the Cdc6 G1321A polymorphism and the risk for non-Hodgkin lymphoma and hepatocellular carcinoma
Mutation research-fundamental and MOLECULAR MECHANISMS OF Mutagenesis, v. 662, (1-2), 2009, MAR 9, p. 10-15
Xiong, Xing-Dong; Qiu, Fu-En; Fang, Jian-Hong; Shen, Yi; Liang, Chun; Jiang, Wenqi; Zhuang, Shi-Mei Article
A Group of General DNA Replication Origins and Replicators Sharing Homologous Sequences and Dispersed throughout the Human Genome
The Cold Spring Harbor Lab 'Eukaryotic DNA Replication & Genome Maintenance' Meeting, Cold Spring Harbor Lab, N.Y. USA, 09/2009
Kan, Junsuo; Wang, Ziyi; Tu, Zhen; Wu, Xing; Liang, Chun Conference paper
Identification of the functional domains involved in the interaction between human Cdt1 and Mcm6
The Cold Spring Harbor Lab “Eukaryotic DNA Replication & Genome Maintenance” Meeting, Cold Spring Harbor Lab, N.Y., USA, 9/2009
Zhang, Jingjing; Wu, Xing; Yu, Lan; Wei, Zhun; Zou, Lan; Zhu, Guang; Liang, Chun Conference paper

2008 5

Autographa californica Multiple Nucleopolyhedrovirus 38K Is a Novel Nucleocapsid Protein That Interacts with VP1054, VP39, VP80, and Itself
Journal of virology, v. 82, (24), 2008, DEC 15, p. 12356-12364
Wu, Wenbi; Liang, Hanquan; Kan, Junsuo; Liu, Chao; Yuan, Meijin; Liang, Chun; Yang, Kai; Pang, Yi Article
mRNA expression of the DNA replication-initiation proteins in epithelial dysplasia and squamous cell carcinoma of the tongue
BMC cancer, v. 8, 2008, DEC 30
Li, Jian-na; Feng, Chong-jin; Lu, Yong-jun; Li, Hui-jun; Tu, Zheng; Liao, Guiqing; Liang, Chun Article
Origin Recognition Complex (ORC) Mediates Histone 3 Lysine 4 Methylation through Cooperation with Spp1 in Saccharomyces cerevisiae
Journal of biological chemistry, v. 283, (49), 2008, DEC 5, p. 33803-33807
Kan, Junsuo; Zou, Lan; Zhang, Jingjing; Wu, Rentian; Wang, Ziyi; Liang, Chun Article
The Ipi1p/2p/3p Complex Is Required for and Directly Involved in Pre-Replication Complex Formation Independent of Ribosome Biogenesis
The 9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong, March 25-26, 2008
Huo, Lin; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Chan, Tsz Choi; Lu, Yongjun; Wu, Rentian; Zhang, Yuan; Wong, Bonny Y.M.; Sou, Kelvin K.L.; Liang, Chun Conference paper
The Rix1 (Ipi1p/2p/3p) Complex Is a Critical Determinant of Replication Licensing Independent of Ribosome Biogenesis
11th Annual Conference of A-Imbn Fellows & 9th International Congress on Cell Biology, Seoul, Korea; October , 2008
Lin, Huo; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Lu, Yongjun; Wu, Rentian; Chan, Tsz-Choi; Liang, Chun Conference paper

2006 3

Ecdysone induces transcription and amplification in Sciara coprophila DNA puff II/9A
Developmental Biology Biol, v. 299, (1), 2006, p. 151-163
Foulk, Michael S.; Liang, Chun; Wu, Nan; Blitzblau, Hannah G.; Smith, Heidi S.; Alam, Daniel; Batra, Maneesh; Gerbi, Susan A. Article
Ipi3p is an essential DNA replication-initiation protein required for and directly involved in pre-replication complex assembly and maintenance (Talk)
The Cell Cycle Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2006
Huo, Lin; Yu, Zhiling; Chan, Tsz Choi; Lu, Yongjun; Zhang, Yuan; Wong, Bonnie; Labib, Karim; Liang, Chun Conference paper
RRP12 plays an essential and direct role in the initiation of DNA replication in budding yeast
The Cell Cycle Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 5.2006
Yu, Zhiling; Chan, Tsz Choi; Huo, Lin; Zou, Sally Lan; Lu, Yongjun; Xu, Anlong; Labib, Karim; Liang, Chun Conference paper

2005 5

Identification of novel initiation proteins for yeast DNA replication by using the IDR (Initiation of DNA Replication) screen
Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Zhai, Yuanliang; Chan, Tsz Choi; Feng, Daorong; Fu, Xinrong; Lo, Alice; Chen, Yanhong; Ma, Lijuan; Lu, Yongjun; Liang, Chun Conference paper
Ipi3, a novel replication-initiation protein identified by the IDR (Initiation of DNA Replication) screen with td (temperature-sensitive degron) mutants.
Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Huo, Lin; Chan, Tsz Choi; Yu, Zhiling; Wong, Bonny Y.M.; Lu, Yongjun; Labib, Karim; Liang, Chun Conference paper
Noc3p, Rrp12p and Ipi3p, a Group of Proteins Involved in Both the Initiation of DNA Replication and Ribosome Biogenesis. (Invited talk)
eIMBL Video Conference on DNA Replication, 11.2005
Liang, Chun Conference paper
Rrp12 plays an essential and direct role in the initiation of DNA replication in budding yeast.
Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Yu, Zhiling; Chan, Tsz Choi; Huo, Lin; Zou, Sally Lan; Lu, Yongjun; Xu, Anlong; Labib, Karim; Liang, Chun Conference paper
The human homolog of the yeast Noc3 is required for DNA replication in human cells.
Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Zou, Sally Lan; Hu, Yun; Wu, Jingwen; Wu, Xing; Zhong, Shan; Zhang, Wei; Lee, Tracy; Xu, Anlong; Liang, Chun Conference paper

2004 4

Pairwise interactions of the six human MCM protein subunits
Journal of Molecular Biology, v. 340, (5), 2004, JUL 23, p. 1197-1206
Yu, Zhiling; Feng, Daorong; Liang, C. Article
Pairwise Interactions of the Six Human MCM Protein Subunits
The Cell Cycle Meeting, Cold Spring Harbor Lab., USA, May
Yu, Zhiling; Feng, Daorong; Liang, Chun Conference paper
RT-PCR Detection of Bladder Carcinoma in Voided Urine Cells using DNA Replication-initiation proteins as the Markers
The Cell Cycle Meeting, Cold Spring Harbor Lab., USA, May
Tu, Zheng; Tong, Tommy Sw; Li, Kamming; Huo, Lin; Sou, Kelvin K.L.; Liang, Chun Conference paper
Studies on the Human Homolog of the Yeast Noc3 in Human Cells
9th World Congress on Advances in Oncology and 7th International Symposium on Molecular Medicine, Crete,Greece, 10.2004;
Zou, Lan; Zhong, Shan; Zhang, Wei; Lee, Tracy; Xu, Anlong; Liang, Chun Conference paper

2003 4

Cdc48p is required for the cell cycle commitment point at start via degradation of the G1-CDK inhibitor Far1p
Journal of Cell Biology, v. 163, (1), 2003, OCT 13, p. 21-26
Fu, Xinrong; Ng, Christine; Feng, Daorong; Liang, Chun Article
Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells
Cancer research, v. 63, (21), 2003, NOV 1, p. 7356-7364
Feng, Daorong; Tu, Zheng; Wu, Wenyan; Liang, Chun Article
A Novel Phenotypic screen for Dna replication-Initiations in Saccharomyces cerevisiae: the IDR (Initiation of DNA Replication) Screen
Eukaryotic DNA Replication Meeting, Cold Spring Harbor Lab, USA, Sept 2003
Chan, Tsz Choi; Lu, Yongjun; Fu, Xinrong; Leung, Ivy; Lu, Gan; Zhai, Yanliang; Yu, Zhiling; Liang, Chun Conference paper
Cdc48p, an AAA-family protein, is required for both the initiation of DNA replication and cell cycle control at START in budding yeast
Eukaryotic DNA Replication Meeting, Cold Spring Harbor Lab., USA, Sept
Fu, Xinrong; Ng, Christine; Feng, Daorong; Liang, Chun Conference paper

2002 4

A DNase I hypersensitive site flanks an origin of DNA replication and amplification in Sciara
Chromosoma, v. 111, (5), 2002, p. 291-303
Urnov, Fyodor D.; Liang, Chun; Blitzblau, Hannah G.; Smith, Heidi S.; Gerbi, Susan A. Article
Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast
Cell, v. 109, (7), 2002, JUN 28, p. 849-860
Zhang, Yuexuan; Yu, Zhiling; Fu, Xinrong; Liang, Chun Article
DNA replication and cancer
5th Conference of the Asia-Pacific International Molecular Biology Network, Shanghai, China, p. 23
Liang, Chun Conference paper
Identification and characterization of novel initiation proteins for DNA replication in budding yeast
FASEB Summer Research Conference on Yeast Chromosome Structure, Replication and Segregation, Snowmass, Colorado, USA.
Liang, Chun; Zhang, Yuexuan; Fu, Xinrong; Lu, Yongjun; Xu, Ke; Tsang, Henry Conference paper

2001 4

Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle
Proceedings of the National Academy of Sciences of the United States of America, v. 98, (20), 2001, p. 11211-11217
Weinreich, Michael D.; Liang, Chun; Chen, Hsuhsin; Stillman, Bruce W. Article
DNA replication and cancer
Asia-med, 5: 61-65
Liang, Chun; Fu, Xinrong; Zhang, Yuexuan; Lu, Yongjun; Feng, Doarong; Li, Kamming; Yu, Zhiling; Sou, Kelvin Article
Initiation proteins for DNA replication in normal and cancer cells
Molecular Genetic Basis of Cancer / Edited by M.L. Lung and W.L.W. Hsiao., published by HKUST, p. 316-324
Liang, Chun Book chapter
Identification and characterization of previously unknown replication initiation proteins in S. cerevisiae
Eukaryotic DNA Replication, Cold Spring Harbor Laboratory, New York, USA
Zhang, Yuexuan; Fu, Xinrong; Lu, Yongjun; Xu, Ke; Tsang, Henry; Liang, Chun Conference paper

1999 2

The Cdc6p nucleotide binding motif is required for loading Mcm proteins onto chromatin
Proceedings of the National Academy of Sciences of the United States of America, v. 96, (2), Jan, 1999, p. 441-446
Weinreich, Michael D.; Liang, Chun; Stillman, Bruce W. Article
Methods to map origins of replication in eukaryotes
Eukaryotic DNA Replication: A Practical Approach / Edied by S. Cotterill., Oxford University Press, Chapter 1, 1999, p. 1-42.
Gerbi, S.A.; Bielinsky, A.; Liang, Chun; Lunyak, V.; Urnov, F. Book chapter

1997 1

Persistent initiation of DNA replication and chromatin bound MCM proteins during the cell cycle in cdc6 mutants
Genes and Development, v. 11, (24), 1997, p. 3375-3386
Liang, Chun; Stillman, Bruce W. Article

1995 1

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome
Cell, v. 81, 1995, p. 667-676
Liang, Chun; Weinreich, Michael D.; Stillman, Bruce W. Article

1994 1

Analysis of an origin of DNA amplification in Sciara coprophila using a novel three-dimensional gel method
Molecular and Cellular Biology, v. 14, (2), 1994, p. 1520-1529
Liang, Chun; Gerbi, Susan A. Article

1993 3

Developmental progression in Sciara coprophila DNA puffs: DNA amplification and transcription
Developmental Biology, v. 160, (1), November 1993, p. 73-84
Wu, Nan; Liang, Chun; Smith, Heidi S.; Dibartolomeis, Susan M.; Gerbi, Susan A. Article
DNA amplification in DNA puff II/9A of Sciara coprophila.
Cold Spring Harbor Symposia on Quantitative Biology, v. 58, 1993, p. 487-494
Gerbi, Susan A.; Liang, Chun; Wu, Nan; DiBartolomeis, Susan M.; Bienz-Tadmor, Brigitte; Smith, Heidi S.; Urnov, Fyodor D. Article
Replication initiates at a confined region during DNA amplification in Sciara DNA puff II/9A
Genes and Development, v. 7, (6), 1993, p. 1072-1084
Liang, Chun; Spitzer, Josephine D.; Smith, Heidi S.; Gerbi, Susan A. Article


Expand All Collapse All


Article 4

A two-herb formula inhibits STAT3 signaling and exerts anti-melanoma effects in cell and animal models
Journal of Ethnopharmacology, v. 268, March 2021, article number 113671
Li, Jun Kui; Chou, Ji Yao; Yin, Cheng Le; Fu, Xiu Qiong; Wu, Ying; Chen, Ying Jie; Bai, Jing Xuan; Wu, Jia Ying; Liang, Chun; Yu, Zhi Ling
Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin
Evidence-based Complementary and Alternative Medicine, v. 2021, June 2021, article number 6610793
Han, Zhong; Guo, Jianmin; Meng, Feibiao; Liao, Haifeng; Deng, Yinghua; Huang, Yuankeng; Lei, Xialing; Liang, Chun; Han, Richou; Yang, Wei
Ginsenoside Rg3 in combination with artesunate overcomes sorafenib resistance in hepatoma cell and mouse models
Journal of Ginseng Research, 14 July 2021
Chen, Ying-Jie; Wu, Jia-Ying; Deng, Yu-Yi; Wu, Ying; Wang, Xiao-Qi; Li, Amy Sze-man; Wong, Lut Yi; Fu, Xiu-Qiong; Yu, Zhi-Ling; Liang, Chun
The anti-inflammatory effects of an ethanolic extract of the rhizome of Atractylodes lancea, involves Akt/NF-κB signaling pathway inhibition
Journal of Ethnopharmacology, v. 277, September 2021, article number 114183
Hossen, Muhammad Jahangir; Amin, Aftab; Fu, Xiu-Qiong; Chou, Ji-Yao; Wu, Jia-Ying; Wang, Xiao-Qi; Chen, Ying-Jie; Wu, Ying; Li, Junkui; Yin, Cheng-Le; Liang, Chun; Chou, Gui-Xin; Yu, Zhi-Ling


Expand All Collapse All


Article 5

An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication
Cell Reports, v. 30, (10), March 2020, article number E6, p. 3323-3338
Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John F.; Wang, Ziyi; Zhou, Zijing; Liu, Changdong; Zhu, Guang; Wong, Chris Kong Chu; Yu, Zhiling; Liang, Chun
FOP Negatively Regulates Ciliogenesis and Promotes Cell Cycle Re-entry by Facilitating Primary Cilia Disassembly
Frontiers in Cell and Developmental Biology, v. 8, November 2020, article number 590449
Jiang, Huadong; Liu, Shanshan; Cheung, Man Hei; Amin, Aftab; Liang, Chun
Gynura divaricata exerts hypoglycemic effects by regulating the PI3K/AKT signaling pathway and fatty acid metabolism signaling pathway
Nutrition and Diabetes, v. 10, (1), 1 December 2020, article number 31
Xu, Wenjun; Lu, Zhongxia; Wang, Xin; Cheung, Man Hei; Lin, Meiai; Li, Changyu; Dong, Yu; Liang, Chun; Chen, Yitao
Inhibiting the Src/STAT3 signaling pathway contributes to the anti-melanoma mechanisms of dioscin
Oncology Letters, v. 19, (3), January 2020, p. 2508-2514
Liu, Yu-Xi; Xu, Bo-Wen; Chen, Ying-Jie; Fu, Xiu-Qiong; Zhu, Pei-Li; Bai, Jing-Xuan; Chou, Ji-Yao; Yin, Cheng-Le; Li, Jun-Kui; Wang, Ya-Ping; Wu, Jia-Ying; Wu, Ying; Chan, Kam-Kwan; Liang, Chun; Yu, Zhiling
Parameritannin A-2 from Urceola huaitingii enhances doxorubicin-induced mitochondria-dependent apoptosis by inhibiting the PI3K/Akt, ERK1/2 and p38 pathways in gastric cancer cells
Chemico-Biological Interactions, v. 316, January 2020, article number 108924
Liang, Lu; Amin, Aftab; Cheung, Wing Yan; Xu, Rui; Yu, Rujian; Tang, Jinshan; Yao, Xinsheng; Liang, Chun

Conference paper 1

Research and development of innovative anticancer drugs targeting DNA Replication-Initiation Proteins
第二届肿瘤免疫治疗领袖峰会=2nd Cancer Immunotherapy Therapy Leader Summit 2020, 中国广州, 3-4 July 2020
Liang, Chun


Expand All Collapse All


Article 5

DNA Replication-Initiation Proteins in Eukaryotic Cells
Biomedical Journal of Scientific & Technical Research, v. 23, November 2019, p. 17042-17049
Amin, Aftab; Cheung, Man Hei; Liang, Chun
Human NOC3 is essential for DNA replication licensing in human cells
Cell Cycle, v. 18, (5), March 2019, p. 605-620
Cheung, Man Hei; Amin, Aftab; Wu, Rentian; Qin, Yan; Zou, Lan; Yu, Zhiling; Liang, Chun
Identification of Molecular Biomarkers for the Diagnosis of Gastric Cancer and Lymph-node Metastasis
Gastroenterology Report, v. 7, (1), February 2019, p. 57-66
Seeruttun, Sharvesh Raj; Cheung, Wing Yan; Wang, Wei; Fang, Cheng; Liu, Zhimin; Li, Jinqing; Wu, Ting; Wang, Jun; Liang, Chun; Zhou, Zhiwei
Reproductive Systemic Toxicity and Mechanism of Glucosides of Tripterygium wilfordii Hook. F. (GTW)
Annals of Clinical and Laboratory Science, v. 49, (1), January 2019, p. 36-49
Guo, Jianmin; Huang, Yuankeng; Lei, Xialing; Zhang, Hong; Xiao, Baiquan; Han, Zhong; Liang, Chun; Yang, Wei
The Interaction Networks of the Budding Yeast and Human DNA Replication-initiation Proteins
Cell Cycle, v. 18, (6-7), April 2019, p. 723-741
Wu, Rentian; Amin, Aftab; Wang, Ziyi; Huang, Yining; Cheung, Man Hei; Yu, Zhiling; Yang, Wei; Liang, Chun


Expand All Collapse All


Article 4

Biomarkers associated with binaprofen?induced liver injury
Molecular Medicine Reports, v.18, (6), December 2018, p. 5076-5086
Guo, Qiuping; Guo, Jianmin; Chen, Guiying; Han, Zhong; Xiao, Baiquan; Jin, Ruomin; Liang, Chun; Yang, Wei
Effect of Total Flavones from Cuscuta Chinensis on Anti-Abortion via the MAPK Signaling Pathway
Evidence-based Complementary and Alternative Medicine, v. 2018, 2018, article number 6356190, p. 1-12
Wu, Hai-wang; Feng, Yi-hui; Wang, Dong-ying; Qiu, Wei-yu; Yu, Qing-ying; Yang, Li-lin; Liang, Chun; Luo, Song-ping; Gao, Jie
Total flavonoids from Semen Cuscutae target MMP9 and promote invasion of EVT cells via Notch/AKT/MAPK signaling pathways
Scientific Reports, v. 8, (1), November 2018, article number 17342
Gao, Feixia; Zhou, Chun; Qiu, Weiyu; Wu, Haiwang; Li, Jing; Peng, Jinting; Qiu, Min; Liang, Chun; Gao, Jie; Luo, Songping
雷公藤多苷对雄性SD大鼠生殖系统损伤的动态变化及其可能机制
中国药理学与毒理学杂志=Chinese Journal of Pharmacology and Toxicology, v. 32, (6), June 2018, p. 469-476
郭健敏; 黄远铿; 雷夏凌; 韩重; 梁纯; 杨威

Conference paper 1

An essential, cell cycle-dependent and semiconservative ORC dimerization cycle regulates eukaryotic chromosomal DNA replication
2018 Gordon Research Conference on Genomic Instability, The Hong Kong University of Science and Technology, 21-27 July 2018
Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John Francis; Wang, Ziyi; Zhou, Zijing; Liang, Chun


Expand All Collapse All


Article 1

Mitoxantrone Suppresses Vascular Smooth Muscle Cell (VSMC) Proliferation and Balloon Injury-induced Neointima Formation: An in Vitro and in Vivo Study
Bosnian Journal of Basic Medical Sciences, v. 17, (4), November 2017, p. 339-348
Teng, Yuan; Wang, Ziyi; Li, Wen; Yu, Jianxing; Shan, Zhen; Liang, Chun; Wang, Shenming

Conference paper 3

A Role of NOC3 in DNA Replication Initiation in Human Cells
2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, The University of Hong Kong, Hong Kong, 16 June 2017
Cheung, Man Hei; Amin, Aftab; Wu, Rentian; Qin, Yan; Zou, Lan; Zhong, Shan; Liang, Chun
An essential, cell cycle-dependent and semiconservative ORC dimerization cycle critically regulates DNA replication
2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, The University of Hong Kong, Hong Kong, 16 June 2017
Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John Francis; Zhou, Zijing; Wang, Ziyi; Zhang, Chuchu; Wang, Jiafeng; Liang, Chun
An essential, cell cycle-dependent and semi-conservative ORC dimerization cycle critically regulates DNA replication
Eukaryotic DNA Replication & Genome Maintenance, Cold Spring Harbor, USA, 5-9 September 2017
Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John Francis; Wang, Ziyi; Zhou, Zijing; Zhang, Chuchu; Wang, Jiafeng; Liang, Chun


Expand All Collapse All


Article 3

A Role of hIPI3 in DNA Replication Licensing in Human Cells
PLoS ONE, v. 11, (4), April 2016, article number e0151803
Huang, Yining; Amin, Aftab; Qin, Yan; Wang, Ziyi; Jiang, Huadong; Liang, Lu; Shi, Linjing; Liang, Chun
Anticancer activities of proanthocyanidins from the plant Urceola huaitingii and their synergistic effects in combination with chemotherapeutics
Fitoterapia, v. 112, July 2016, p. 175-182
Yu, Rujian; Liu, Haibin; Yu, Yang; Liang, Lu; Xu, Rui; Liang, Chun; Tang, Jinshan; Yao, Xinsheng
Asperosaponin VI Promotes Progesterone Receptor Expression in Decidual Cells via the Notch Signaling Pathway
Fitoterapia, v. 113, September 2016, p. 58-63
Gao, Jie; Zhou, Chun; Li, Yadi; Gao, Feixia; Wu, Haiwang; Yang, Lilin; Qiu, Weiyu; Zhu, Lin; Du, Xin; Lin, Weixian; Huang, Dandan; Liu, Haibin; Liang, Chun; Luo, Songping


Expand All Collapse All


Conference paper 2

Regulation of DNA replicaiton in normal and cancer cells and cancer metasatsis mechanisms
Yichun University, Yichun, Jiangxi, China, 2015
Liang, Chun
The Capillary Number Effect on the Capture Efficiency of Cancer Cells on Composite Microfluidic Filtration Chips
Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), v. 2015-February, (February), February 2015, article number 7050989, p. 459-462
Zhao, Cong; Xu, Rui; Song, Kui; Liu, Dayu; Ma, Shou; Tang, Ce Mun; Liang, Chun; Zohar, Yitshak; Lee, Yi-Kuen


Expand All Collapse All


Article 2

Isolation of circulating tumor cells under hydrodynamic loading using microuidic technology
力学进展=Advances in Mechanics, v .44, (1), January 2014, p. 447-494
Zhao, Cong; Lee, Yi-Kuen; Xu, Rui; Liang, Chun; Liu, Dayu; Ma, Wei; Piyawattanmetha, Wibool; Zohar, Yitshak
MicroRNA-26a/b regulate DNA replication licensing, tumorigenesis, and prognosis by targeting CDC6 in lung cancer
Molecular Cancer Research, v. 12, (11), November 2014, p. 1535-1546
Zhang, Xin; Xiao, Dakai; Wang, Ziyi; Zou, Yongxin; Huang, Liyan; Lin, Weixuan; Deng, Qiuhua; Pan, Hui; Zhou, Jiangfen; Liang, Chun; He, Jianxing

Conference paper 1

Regulation of DNA Replication in Normal and Cancer Cells
Tsinghua University-Pittsburgh University-HKUST Biomedical Symposium, Beijing, China, 10-11 April 2014
Liang, Chun


Expand All Collapse All


Conference paper 3

An essential, cell cycle-dependent and semiconservative ORC dimerization cycle critically regulates DNA replication
Eukaryotic DNA Replication & Genome Maintenance 2013, Cold Spring Harbor, USA, 9-13 September 2013
Wu, Rentian; Zhou, Zijing; Wang, Jiafeng; Amin, Aftab; Wang, Ziyi; Liang, Chun
Regulation of DNA Replication in Normal and Cancer Cells: Basic Research and Potential Applications In Cancer
Guangdong Province Gynecological Medical Association Symposium, Guangdong University of Chinese Medicine, Guangzhou, China, 14 December 2013
Liang, Chun
Regulation of DNA Replication in Normal and Cancer Cells: Basic Research and Potential Clinical Applications
The First Affiliated Hospital of Sun Yat-sen University Bio-Medicine Forum, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 20-21 November 2013
Liang, Chun


Expand All Collapse All


Article 3

Cdt1p, through its interaction with Mcm6P, is required for the formation, nuclear accumulation and chromatin loading of the MCM complex
Journal of cell science, v. 125, (1), 2012, p. 209-219
Wu, Rentian; Wang, Jiafeng; Liang, Chun
Structural insights into the Cdt1-mediated MCM2-7 chromatin loading
Nucleic Acids Research, v. 40, (7), April 2012, p. 3208-3217
Liu, Changdong; Wu, Rentian; Zhou, Bo; Wang, Jiafeng; Wei, Zhun; Tye, Bik Kwoon; Liang, Chun; Zhu, Guang
The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis
Cell cycle, v. 11, (7), 2012, p. 1325-1339
Huo, Lin; Wu, Rentian; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Chan, TszChoi; Yeung, Jeffrey T.F.; Kan, Junsuo; Liang, Chun


Expand All Collapse All


Article 2

APOE Genotype-Function Relationship: Evidence of -491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk
PLoS ONE, v. 6, (10), October 2011, article number e24669
Geng, Hua; Law, Peggy P.Y.; Ng, Maggie C.Y.; Li, Ting; Liang, Li-Yun; Ge, Tian-Fang; Wong, Kam-Bo; Liang, Chun; Ma, Ronald C.; So, Wing-Yee; Chan, Juliana C.N.; Ho, Yuan-Yuan
Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast
FEMS yeast research, v. 11, (1), 2011, p. 72-79
Lai, Fenju; Wu, Rentian; Wang, Jiafeng; Li, Chunming; Zou, Lan; Lu, Yongjun; Liang, Chun

Book chapter 1

Cell cycle control of DNA replication by phosphorylation and dephosphorylation of replication-initiation proteins in budding yeast
Fundamental Aspects of DNA Replication / Edited by Jelena Kus?ic?-Tis?ma, Croati: InTech Publisher, Chapter 6, p. 87-106
Zhai, Yuanliang; Yung, Philip; Liang, Chun


Expand All Collapse All


Article 6

ATP-dependent Pre-replicative Complex Assembly Is Facilitated by Adk1p in Budding Yeast
Journal of biological chemistry, v. 285, (39), 2010, SEP 24, p. 29974-29980
Cheng, Xue; Xu, Zhen; Wang, Jiafeng; Zhai, Yuanliang; Lu, Yongjun; Liang, Chun
Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast
Journal of cell science, v. 123, (22), 2010, p. 3933-3943
Zhai, Yuanliang; Yung, P.Y.K.; Huo, Lin; Liang, Chun
Characterization and structure determination of the cdt1 binding domain of human minichromosome maintenance (Mcm) 6
Journal of Biological Chemistry, v. 285, (17), April 2010, p. 12469-12473
Wei, Zhun; Liu, Changdong; Wu, Xing; Xu, Naining; Zhou, Bo; Liang, Chun; Zhu, Guang
Ctf4p facilitates Mcm10p to promote DNA replication in budding yeast
Biochemical and biophysical research communications, v. 395, (3), 2010, MAY 7, p. 336-341
Wang, Jiafeng; Wu, Rentian; Lu, Yongjun; Liang, Chun
Identification of Novel Factors Involved in or Regulating Initiation of DNA Replication by a Genome-wide Phenotypic Screen in Saccharomyces Cerevisiae
Cell Cycle, v. 9, (21), 2010, Nov, p. 4399-4410
Ma, Lijuan; Zhai, Yuanliang; Feng, Daorong; Chan, TszChoi; Lu, Yongjun; Fu, Xinrong; Wang, Jui-pin; Chen, Yanhong; Li, Jianna; Xu, Ke; Liang, Chun
The interacting domains of hCdt1 and hMcm6 involved in the chromatin loading of the MCM complex in human cells
Cell Cycle, v. 9, (24), 2010, p. 4848-4857
Zhang, Jing; Yu, Lan; Wu, Xing; Zou, Lan; Sou, K.K.L.; Wei, Zhun; Cheng, Xue; Zhu, Guang; Liang, Chun

Conference paper 4

A Group of General DNA Replication Origins and Replicators Sharing Homologous Sequences and Dispersed throughout the Human Genome
James Watson Symposium on Cancer, Cold Spring Harbor Asia Conferences, Suzhou, China, April 2010
Kan, Junsuo; Wang, Ziyi; Tu, Zheng; Zhang, Jingjing; Wu, Xing; Liang, Chun
Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast
Cold Spring Harbor-Asia Symposium, Suzhou, China, Apr. 2010
Zhai, Yuanliang; Yung, Philip Y.K.; Huo, Lin; Liang, Chun
Interaction network of DNA replication-initiation proteins and dimerization of ORC and Noc3p in pre-replicative complex assembly in budding yeast
Cold Spring Harbor Lab 'The Cell Cycle'Meeting, Cold Spring Harbor Lab, N.Y., USA, 5/2010
Wu, Rentian; Zhang, Chuchu; Yeung, Yun Fai; Wang, Jiafeng; Huo, Lin; Zhai, Yuanliang; Liang, Chun
Nuclear Matrix Association of Orc and Utp7P is Inter-Dependent, Cell Cycle-Regulated, and required for Pre-Replicative Complex Assembly in Budding Yeast
Cold Spring Harbor Lab 'The Cell Cycle' Meeting, Cold Spring Harbor Lab, N. Y., USA, 5/2010
Cheng, Xue; Wang, Jiafeng; Xu, Zhen; Liang, Chun


Expand All Collapse All


Article 1

Association analysis between the Cdc6 G1321A polymorphism and the risk for non-Hodgkin lymphoma and hepatocellular carcinoma
Mutation research-fundamental and MOLECULAR MECHANISMS OF Mutagenesis, v. 662, (1-2), 2009, MAR 9, p. 10-15
Xiong, Xing-Dong; Qiu, Fu-En; Fang, Jian-Hong; Shen, Yi; Liang, Chun; Jiang, Wenqi; Zhuang, Shi-Mei

Conference paper 2

A Group of General DNA Replication Origins and Replicators Sharing Homologous Sequences and Dispersed throughout the Human Genome
The Cold Spring Harbor Lab 'Eukaryotic DNA Replication & Genome Maintenance' Meeting, Cold Spring Harbor Lab, N.Y. USA, 09/2009
Kan, Junsuo; Wang, Ziyi; Tu, Zhen; Wu, Xing; Liang, Chun
Identification of the functional domains involved in the interaction between human Cdt1 and Mcm6
The Cold Spring Harbor Lab “Eukaryotic DNA Replication & Genome Maintenance” Meeting, Cold Spring Harbor Lab, N.Y., USA, 9/2009
Zhang, Jingjing; Wu, Xing; Yu, Lan; Wei, Zhun; Zou, Lan; Zhu, Guang; Liang, Chun


Expand All Collapse All


Article 3

Autographa californica Multiple Nucleopolyhedrovirus 38K Is a Novel Nucleocapsid Protein That Interacts with VP1054, VP39, VP80, and Itself
Journal of virology, v. 82, (24), 2008, DEC 15, p. 12356-12364
Wu, Wenbi; Liang, Hanquan; Kan, Junsuo; Liu, Chao; Yuan, Meijin; Liang, Chun; Yang, Kai; Pang, Yi
mRNA expression of the DNA replication-initiation proteins in epithelial dysplasia and squamous cell carcinoma of the tongue
BMC cancer, v. 8, 2008, DEC 30
Li, Jian-na; Feng, Chong-jin; Lu, Yong-jun; Li, Hui-jun; Tu, Zheng; Liao, Guiqing; Liang, Chun
Origin Recognition Complex (ORC) Mediates Histone 3 Lysine 4 Methylation through Cooperation with Spp1 in Saccharomyces cerevisiae
Journal of biological chemistry, v. 283, (49), 2008, DEC 5, p. 33803-33807
Kan, Junsuo; Zou, Lan; Zhang, Jingjing; Wu, Rentian; Wang, Ziyi; Liang, Chun

Conference paper 2

The Ipi1p/2p/3p Complex Is Required for and Directly Involved in Pre-Replication Complex Formation Independent of Ribosome Biogenesis
The 9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong, March 25-26, 2008
Huo, Lin; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Chan, Tsz Choi; Lu, Yongjun; Wu, Rentian; Zhang, Yuan; Wong, Bonny Y.M.; Sou, Kelvin K.L.; Liang, Chun
The Rix1 (Ipi1p/2p/3p) Complex Is a Critical Determinant of Replication Licensing Independent of Ribosome Biogenesis
11th Annual Conference of A-Imbn Fellows & 9th International Congress on Cell Biology, Seoul, Korea; October , 2008
Lin, Huo; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Lu, Yongjun; Wu, Rentian; Chan, Tsz-Choi; Liang, Chun


Expand All Collapse All


Article 1

Ecdysone induces transcription and amplification in Sciara coprophila DNA puff II/9A
Developmental Biology Biol, v. 299, (1), 2006, p. 151-163
Foulk, Michael S.; Liang, Chun; Wu, Nan; Blitzblau, Hannah G.; Smith, Heidi S.; Alam, Daniel; Batra, Maneesh; Gerbi, Susan A.

Conference paper 2

Ipi3p is an essential DNA replication-initiation protein required for and directly involved in pre-replication complex assembly and maintenance (Talk)
The Cell Cycle Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2006
Huo, Lin; Yu, Zhiling; Chan, Tsz Choi; Lu, Yongjun; Zhang, Yuan; Wong, Bonnie; Labib, Karim; Liang, Chun
RRP12 plays an essential and direct role in the initiation of DNA replication in budding yeast
The Cell Cycle Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 5.2006
Yu, Zhiling; Chan, Tsz Choi; Huo, Lin; Zou, Sally Lan; Lu, Yongjun; Xu, Anlong; Labib, Karim; Liang, Chun


Expand All Collapse All


Conference paper 5

Identification of novel initiation proteins for yeast DNA replication by using the IDR (Initiation of DNA Replication) screen
Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Zhai, Yuanliang; Chan, Tsz Choi; Feng, Daorong; Fu, Xinrong; Lo, Alice; Chen, Yanhong; Ma, Lijuan; Lu, Yongjun; Liang, Chun
Ipi3, a novel replication-initiation protein identified by the IDR (Initiation of DNA Replication) screen with td (temperature-sensitive degron) mutants.
Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Huo, Lin; Chan, Tsz Choi; Yu, Zhiling; Wong, Bonny Y.M.; Lu, Yongjun; Labib, Karim; Liang, Chun
Noc3p, Rrp12p and Ipi3p, a Group of Proteins Involved in Both the Initiation of DNA Replication and Ribosome Biogenesis. (Invited talk)
eIMBL Video Conference on DNA Replication, 11.2005
Liang, Chun
Rrp12 plays an essential and direct role in the initiation of DNA replication in budding yeast.
Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Yu, Zhiling; Chan, Tsz Choi; Huo, Lin; Zou, Sally Lan; Lu, Yongjun; Xu, Anlong; Labib, Karim; Liang, Chun
The human homolog of the yeast Noc3 is required for DNA replication in human cells.
Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Zou, Sally Lan; Hu, Yun; Wu, Jingwen; Wu, Xing; Zhong, Shan; Zhang, Wei; Lee, Tracy; Xu, Anlong; Liang, Chun


Expand All Collapse All


Article 1

Pairwise interactions of the six human MCM protein subunits
Journal of Molecular Biology, v. 340, (5), 2004, JUL 23, p. 1197-1206
Yu, Zhiling; Feng, Daorong; Liang, C.

Conference paper 3

Pairwise Interactions of the Six Human MCM Protein Subunits
The Cell Cycle Meeting, Cold Spring Harbor Lab., USA, May
Yu, Zhiling; Feng, Daorong; Liang, Chun
RT-PCR Detection of Bladder Carcinoma in Voided Urine Cells using DNA Replication-initiation proteins as the Markers
The Cell Cycle Meeting, Cold Spring Harbor Lab., USA, May
Tu, Zheng; Tong, Tommy Sw; Li, Kamming; Huo, Lin; Sou, Kelvin K.L.; Liang, Chun
Studies on the Human Homolog of the Yeast Noc3 in Human Cells
9th World Congress on Advances in Oncology and 7th International Symposium on Molecular Medicine, Crete,Greece, 10.2004;
Zou, Lan; Zhong, Shan; Zhang, Wei; Lee, Tracy; Xu, Anlong; Liang, Chun


Expand All Collapse All


Article 2

Cdc48p is required for the cell cycle commitment point at start via degradation of the G1-CDK inhibitor Far1p
Journal of Cell Biology, v. 163, (1), 2003, OCT 13, p. 21-26
Fu, Xinrong; Ng, Christine; Feng, Daorong; Liang, Chun
Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells
Cancer research, v. 63, (21), 2003, NOV 1, p. 7356-7364
Feng, Daorong; Tu, Zheng; Wu, Wenyan; Liang, Chun

Conference paper 2

A Novel Phenotypic screen for Dna replication-Initiations in Saccharomyces cerevisiae: the IDR (Initiation of DNA Replication) Screen
Eukaryotic DNA Replication Meeting, Cold Spring Harbor Lab, USA, Sept 2003
Chan, Tsz Choi; Lu, Yongjun; Fu, Xinrong; Leung, Ivy; Lu, Gan; Zhai, Yanliang; Yu, Zhiling; Liang, Chun
Cdc48p, an AAA-family protein, is required for both the initiation of DNA replication and cell cycle control at START in budding yeast
Eukaryotic DNA Replication Meeting, Cold Spring Harbor Lab., USA, Sept
Fu, Xinrong; Ng, Christine; Feng, Daorong; Liang, Chun


Expand All Collapse All


Article 2

A DNase I hypersensitive site flanks an origin of DNA replication and amplification in Sciara
Chromosoma, v. 111, (5), 2002, p. 291-303
Urnov, Fyodor D.; Liang, Chun; Blitzblau, Hannah G.; Smith, Heidi S.; Gerbi, Susan A.
Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast
Cell, v. 109, (7), 2002, JUN 28, p. 849-860
Zhang, Yuexuan; Yu, Zhiling; Fu, Xinrong; Liang, Chun

Conference paper 2

DNA replication and cancer
5th Conference of the Asia-Pacific International Molecular Biology Network, Shanghai, China, p. 23
Liang, Chun
Identification and characterization of novel initiation proteins for DNA replication in budding yeast
FASEB Summer Research Conference on Yeast Chromosome Structure, Replication and Segregation, Snowmass, Colorado, USA.
Liang, Chun; Zhang, Yuexuan; Fu, Xinrong; Lu, Yongjun; Xu, Ke; Tsang, Henry


Expand All Collapse All


Article 2

Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle
Proceedings of the National Academy of Sciences of the United States of America, v. 98, (20), 2001, p. 11211-11217
Weinreich, Michael D.; Liang, Chun; Chen, Hsuhsin; Stillman, Bruce W.
DNA replication and cancer
Asia-med, 5: 61-65
Liang, Chun; Fu, Xinrong; Zhang, Yuexuan; Lu, Yongjun; Feng, Doarong; Li, Kamming; Yu, Zhiling; Sou, Kelvin

Book chapter 1

Initiation proteins for DNA replication in normal and cancer cells
Molecular Genetic Basis of Cancer / Edited by M.L. Lung and W.L.W. Hsiao., published by HKUST, p. 316-324
Liang, Chun

Conference paper 1

Identification and characterization of previously unknown replication initiation proteins in S. cerevisiae
Eukaryotic DNA Replication, Cold Spring Harbor Laboratory, New York, USA
Zhang, Yuexuan; Fu, Xinrong; Lu, Yongjun; Xu, Ke; Tsang, Henry; Liang, Chun


Expand All Collapse All


Article 1

The Cdc6p nucleotide binding motif is required for loading Mcm proteins onto chromatin
Proceedings of the National Academy of Sciences of the United States of America, v. 96, (2), Jan, 1999, p. 441-446
Weinreich, Michael D.; Liang, Chun; Stillman, Bruce W.

Book chapter 1

Methods to map origins of replication in eukaryotes
Eukaryotic DNA Replication: A Practical Approach / Edied by S. Cotterill., Oxford University Press, Chapter 1, 1999, p. 1-42.
Gerbi, S.A.; Bielinsky, A.; Liang, Chun; Lunyak, V.; Urnov, F.


Expand All Collapse All


Article 1

Persistent initiation of DNA replication and chromatin bound MCM proteins during the cell cycle in cdc6 mutants
Genes and Development, v. 11, (24), 1997, p. 3375-3386
Liang, Chun; Stillman, Bruce W.


Expand All Collapse All


Article 1

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome
Cell, v. 81, 1995, p. 667-676
Liang, Chun; Weinreich, Michael D.; Stillman, Bruce W.


Expand All Collapse All


Article 1

Analysis of an origin of DNA amplification in Sciara coprophila using a novel three-dimensional gel method
Molecular and Cellular Biology, v. 14, (2), 1994, p. 1520-1529
Liang, Chun; Gerbi, Susan A.


Expand All Collapse All


Article 3

Developmental progression in Sciara coprophila DNA puffs: DNA amplification and transcription
Developmental Biology, v. 160, (1), November 1993, p. 73-84
Wu, Nan; Liang, Chun; Smith, Heidi S.; Dibartolomeis, Susan M.; Gerbi, Susan A.
DNA amplification in DNA puff II/9A of Sciara coprophila.
Cold Spring Harbor Symposia on Quantitative Biology, v. 58, 1993, p. 487-494
Gerbi, Susan A.; Liang, Chun; Wu, Nan; DiBartolomeis, Susan M.; Bienz-Tadmor, Brigitte; Smith, Heidi S.; Urnov, Fyodor D.
Replication initiates at a confined region during DNA amplification in Sciara DNA puff II/9A
Genes and Development, v. 7, (6), 1993, p. 1072-1084
Liang, Chun; Spitzer, Josephine D.; Smith, Heidi S.; Gerbi, Susan A.


Expand All Collapse All


2016 3

A Role of hIPI3 in DNA Replication Licensing in Human Cells
PLoS ONE, v. 11, (4), April 2016, article number e0151803
Huang, Yining; Amin, Aftab; Qin, Yan; Wang, Ziyi; Jiang, Huadong; Liang, Lu; Shi, Linjing; Liang, Chun Article
Anticancer activities of proanthocyanidins from the plant Urceola huaitingii and their synergistic effects in combination with chemotherapeutics
Fitoterapia, v. 112, July 2016, p. 175-182
Yu, Rujian; Liu, Haibin; Yu, Yang; Liang, Lu; Xu, Rui; Liang, Chun; Tang, Jinshan; Yao, Xinsheng Article
Asperosaponin VI Promotes Progesterone Receptor Expression in Decidual Cells via the Notch Signaling Pathway
Fitoterapia, v. 113, September 2016, p. 58-63
Gao, Jie; Zhou, Chun; Li, Yadi; Gao, Feixia; Wu, Haiwang; Yang, Lilin; Qiu, Weiyu; Zhu, Lin; Du, Xin; Lin, Weixian; Huang, Dandan; Liu, Haibin; Liang, Chun; Luo, Songping Article

2015 2

Regulation of DNA replicaiton in normal and cancer cells and cancer metasatsis mechanisms
Yichun University, Yichun, Jiangxi, China, 2015
Liang, Chun Conference paper
The Capillary Number Effect on the Capture Efficiency of Cancer Cells on Composite Microfluidic Filtration Chips
Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), v. 2015-February, (February), February 2015, article number 7050989, p. 459-462
Zhao, Cong; Xu, Rui; Song, Kui; Liu, Dayu; Ma, Shou; Tang, Ce Mun; Liang, Chun; Zohar, Yitshak; Lee, Yi-Kuen Conference paper

2014 3

Isolation of circulating tumor cells under hydrodynamic loading using microuidic technology
力学进展=Advances in Mechanics, v .44, (1), January 2014, p. 447-494
Zhao, Cong; Lee, Yi-Kuen; Xu, Rui; Liang, Chun; Liu, Dayu; Ma, Wei; Piyawattanmetha, Wibool; Zohar, Yitshak Article
MicroRNA-26a/b regulate DNA replication licensing, tumorigenesis, and prognosis by targeting CDC6 in lung cancer
Molecular Cancer Research, v. 12, (11), November 2014, p. 1535-1546
Zhang, Xin; Xiao, Dakai; Wang, Ziyi; Zou, Yongxin; Huang, Liyan; Lin, Weixuan; Deng, Qiuhua; Pan, Hui; Zhou, Jiangfen; Liang, Chun; He, Jianxing Article
Regulation of DNA Replication in Normal and Cancer Cells
Tsinghua University-Pittsburgh University-HKUST Biomedical Symposium, Beijing, China, 10-11 April 2014
Liang, Chun Conference paper

2013 3

An essential, cell cycle-dependent and semiconservative ORC dimerization cycle critically regulates DNA replication
Eukaryotic DNA Replication & Genome Maintenance 2013, Cold Spring Harbor, USA, 9-13 September 2013
Wu, Rentian; Zhou, Zijing; Wang, Jiafeng; Amin, Aftab; Wang, Ziyi; Liang, Chun Conference paper
Regulation of DNA Replication in Normal and Cancer Cells: Basic Research and Potential Applications In Cancer
Guangdong Province Gynecological Medical Association Symposium, Guangdong University of Chinese Medicine, Guangzhou, China, 14 December 2013
Liang, Chun Conference paper
Regulation of DNA Replication in Normal and Cancer Cells: Basic Research and Potential Clinical Applications
The First Affiliated Hospital of Sun Yat-sen University Bio-Medicine Forum, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 20-21 November 2013
Liang, Chun Conference paper

2012 3

Cdt1p, through its interaction with Mcm6P, is required for the formation, nuclear accumulation and chromatin loading of the MCM complex
Journal of cell science, v. 125, (1), 2012, p. 209-219
Wu, Rentian; Wang, Jiafeng; Liang, Chun Article
Structural insights into the Cdt1-mediated MCM2-7 chromatin loading
Nucleic Acids Research, v. 40, (7), April 2012, p. 3208-3217
Liu, Changdong; Wu, Rentian; Zhou, Bo; Wang, Jiafeng; Wei, Zhun; Tye, Bik Kwoon; Liang, Chun; Zhu, Guang Article
The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis
Cell cycle, v. 11, (7), 2012, p. 1325-1339
Huo, Lin; Wu, Rentian; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Chan, TszChoi; Yeung, Jeffrey T.F.; Kan, Junsuo; Liang, Chun Article

2011 3

APOE Genotype-Function Relationship: Evidence of -491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk
PLoS ONE, v. 6, (10), October 2011, article number e24669
Geng, Hua; Law, Peggy P.Y.; Ng, Maggie C.Y.; Li, Ting; Liang, Li-Yun; Ge, Tian-Fang; Wong, Kam-Bo; Liang, Chun; Ma, Ronald C.; So, Wing-Yee; Chan, Juliana C.N.; Ho, Yuan-Yuan Article
Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast
FEMS yeast research, v. 11, (1), 2011, p. 72-79
Lai, Fenju; Wu, Rentian; Wang, Jiafeng; Li, Chunming; Zou, Lan; Lu, Yongjun; Liang, Chun Article
Cell cycle control of DNA replication by phosphorylation and dephosphorylation of replication-initiation proteins in budding yeast
Fundamental Aspects of DNA Replication / Edited by Jelena Kus?ic?-Tis?ma, Croati: InTech Publisher, Chapter 6, p. 87-106
Zhai, Yuanliang; Yung, Philip; Liang, Chun Book chapter

2010 10

ATP-dependent Pre-replicative Complex Assembly Is Facilitated by Adk1p in Budding Yeast
Journal of biological chemistry, v. 285, (39), 2010, SEP 24, p. 29974-29980
Cheng, Xue; Xu, Zhen; Wang, Jiafeng; Zhai, Yuanliang; Lu, Yongjun; Liang, Chun Article
Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast
Journal of cell science, v. 123, (22), 2010, p. 3933-3943
Zhai, Yuanliang; Yung, P.Y.K.; Huo, Lin; Liang, Chun Article
Characterization and structure determination of the cdt1 binding domain of human minichromosome maintenance (Mcm) 6
Journal of Biological Chemistry, v. 285, (17), April 2010, p. 12469-12473
Wei, Zhun; Liu, Changdong; Wu, Xing; Xu, Naining; Zhou, Bo; Liang, Chun; Zhu, Guang Article
Ctf4p facilitates Mcm10p to promote DNA replication in budding yeast
Biochemical and biophysical research communications, v. 395, (3), 2010, MAY 7, p. 336-341
Wang, Jiafeng; Wu, Rentian; Lu, Yongjun; Liang, Chun Article
Identification of Novel Factors Involved in or Regulating Initiation of DNA Replication by a Genome-wide Phenotypic Screen in Saccharomyces Cerevisiae
Cell Cycle, v. 9, (21), 2010, Nov, p. 4399-4410
Ma, Lijuan; Zhai, Yuanliang; Feng, Daorong; Chan, TszChoi; Lu, Yongjun; Fu, Xinrong; Wang, Jui-pin; Chen, Yanhong; Li, Jianna; Xu, Ke; Liang, Chun Article
The interacting domains of hCdt1 and hMcm6 involved in the chromatin loading of the MCM complex in human cells
Cell Cycle, v. 9, (24), 2010, p. 4848-4857
Zhang, Jing; Yu, Lan; Wu, Xing; Zou, Lan; Sou, K.K.L.; Wei, Zhun; Cheng, Xue; Zhu, Guang; Liang, Chun Article
A Group of General DNA Replication Origins and Replicators Sharing Homologous Sequences and Dispersed throughout the Human Genome
James Watson Symposium on Cancer, Cold Spring Harbor Asia Conferences, Suzhou, China, April 2010
Kan, Junsuo; Wang, Ziyi; Tu, Zheng; Zhang, Jingjing; Wu, Xing; Liang, Chun Conference paper
Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast
Cold Spring Harbor-Asia Symposium, Suzhou, China, Apr. 2010
Zhai, Yuanliang; Yung, Philip Y.K.; Huo, Lin; Liang, Chun Conference paper
Interaction network of DNA replication-initiation proteins and dimerization of ORC and Noc3p in pre-replicative complex assembly in budding yeast
Cold Spring Harbor Lab 'The Cell Cycle'Meeting, Cold Spring Harbor Lab, N.Y., USA, 5/2010
Wu, Rentian; Zhang, Chuchu; Yeung, Yun Fai; Wang, Jiafeng; Huo, Lin; Zhai, Yuanliang; Liang, Chun Conference paper
Nuclear Matrix Association of Orc and Utp7P is Inter-Dependent, Cell Cycle-Regulated, and required for Pre-Replicative Complex Assembly in Budding Yeast
Cold Spring Harbor Lab 'The Cell Cycle' Meeting, Cold Spring Harbor Lab, N. Y., USA, 5/2010
Cheng, Xue; Wang, Jiafeng; Xu, Zhen; Liang, Chun Conference paper

2009 3

Association analysis between the Cdc6 G1321A polymorphism and the risk for non-Hodgkin lymphoma and hepatocellular carcinoma
Mutation research-fundamental and MOLECULAR MECHANISMS OF Mutagenesis, v. 662, (1-2), 2009, MAR 9, p. 10-15
Xiong, Xing-Dong; Qiu, Fu-En; Fang, Jian-Hong; Shen, Yi; Liang, Chun; Jiang, Wenqi; Zhuang, Shi-Mei Article
A Group of General DNA Replication Origins and Replicators Sharing Homologous Sequences and Dispersed throughout the Human Genome
The Cold Spring Harbor Lab 'Eukaryotic DNA Replication & Genome Maintenance' Meeting, Cold Spring Harbor Lab, N.Y. USA, 09/2009
Kan, Junsuo; Wang, Ziyi; Tu, Zhen; Wu, Xing; Liang, Chun Conference paper
Identification of the functional domains involved in the interaction between human Cdt1 and Mcm6
The Cold Spring Harbor Lab “Eukaryotic DNA Replication & Genome Maintenance” Meeting, Cold Spring Harbor Lab, N.Y., USA, 9/2009
Zhang, Jingjing; Wu, Xing; Yu, Lan; Wei, Zhun; Zou, Lan; Zhu, Guang; Liang, Chun Conference paper

2008 5

Autographa californica Multiple Nucleopolyhedrovirus 38K Is a Novel Nucleocapsid Protein That Interacts with VP1054, VP39, VP80, and Itself
Journal of virology, v. 82, (24), 2008, DEC 15, p. 12356-12364
Wu, Wenbi; Liang, Hanquan; Kan, Junsuo; Liu, Chao; Yuan, Meijin; Liang, Chun; Yang, Kai; Pang, Yi Article
mRNA expression of the DNA replication-initiation proteins in epithelial dysplasia and squamous cell carcinoma of the tongue
BMC cancer, v. 8, 2008, DEC 30
Li, Jian-na; Feng, Chong-jin; Lu, Yong-jun; Li, Hui-jun; Tu, Zheng; Liao, Guiqing; Liang, Chun Article
Origin Recognition Complex (ORC) Mediates Histone 3 Lysine 4 Methylation through Cooperation with Spp1 in Saccharomyces cerevisiae
Journal of biological chemistry, v. 283, (49), 2008, DEC 5, p. 33803-33807
Kan, Junsuo; Zou, Lan; Zhang, Jingjing; Wu, Rentian; Wang, Ziyi; Liang, Chun Article
The Ipi1p/2p/3p Complex Is Required for and Directly Involved in Pre-Replication Complex Formation Independent of Ribosome Biogenesis
The 9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong, March 25-26, 2008
Huo, Lin; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Chan, Tsz Choi; Lu, Yongjun; Wu, Rentian; Zhang, Yuan; Wong, Bonny Y.M.; Sou, Kelvin K.L.; Liang, Chun Conference paper
The Rix1 (Ipi1p/2p/3p) Complex Is a Critical Determinant of Replication Licensing Independent of Ribosome Biogenesis
11th Annual Conference of A-Imbn Fellows & 9th International Congress on Cell Biology, Seoul, Korea; October , 2008
Lin, Huo; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Lu, Yongjun; Wu, Rentian; Chan, Tsz-Choi; Liang, Chun Conference paper

2006 3

Ecdysone induces transcription and amplification in Sciara coprophila DNA puff II/9A
Developmental Biology Biol, v. 299, (1), 2006, p. 151-163
Foulk, Michael S.; Liang, Chun; Wu, Nan; Blitzblau, Hannah G.; Smith, Heidi S.; Alam, Daniel; Batra, Maneesh; Gerbi, Susan A. Article
Ipi3p is an essential DNA replication-initiation protein required for and directly involved in pre-replication complex assembly and maintenance (Talk)
The Cell Cycle Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2006
Huo, Lin; Yu, Zhiling; Chan, Tsz Choi; Lu, Yongjun; Zhang, Yuan; Wong, Bonnie; Labib, Karim; Liang, Chun Conference paper
RRP12 plays an essential and direct role in the initiation of DNA replication in budding yeast
The Cell Cycle Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 5.2006
Yu, Zhiling; Chan, Tsz Choi; Huo, Lin; Zou, Sally Lan; Lu, Yongjun; Xu, Anlong; Labib, Karim; Liang, Chun Conference paper

2005 5

Identification of novel initiation proteins for yeast DNA replication by using the IDR (Initiation of DNA Replication) screen
Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Zhai, Yuanliang; Chan, Tsz Choi; Feng, Daorong; Fu, Xinrong; Lo, Alice; Chen, Yanhong; Ma, Lijuan; Lu, Yongjun; Liang, Chun Conference paper
Ipi3, a novel replication-initiation protein identified by the IDR (Initiation of DNA Replication) screen with td (temperature-sensitive degron) mutants.
Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Huo, Lin; Chan, Tsz Choi; Yu, Zhiling; Wong, Bonny Y.M.; Lu, Yongjun; Labib, Karim; Liang, Chun Conference paper
Noc3p, Rrp12p and Ipi3p, a Group of Proteins Involved in Both the Initiation of DNA Replication and Ribosome Biogenesis. (Invited talk)
eIMBL Video Conference on DNA Replication, 11.2005
Liang, Chun Conference paper
Rrp12 plays an essential and direct role in the initiation of DNA replication in budding yeast.
Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Yu, Zhiling; Chan, Tsz Choi; Huo, Lin; Zou, Sally Lan; Lu, Yongjun; Xu, Anlong; Labib, Karim; Liang, Chun Conference paper
The human homolog of the yeast Noc3 is required for DNA replication in human cells.
Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Zou, Sally Lan; Hu, Yun; Wu, Jingwen; Wu, Xing; Zhong, Shan; Zhang, Wei; Lee, Tracy; Xu, Anlong; Liang, Chun Conference paper

2004 4

Pairwise interactions of the six human MCM protein subunits
Journal of Molecular Biology, v. 340, (5), 2004, JUL 23, p. 1197-1206
Yu, Zhiling; Feng, Daorong; Liang, C. Article
Pairwise Interactions of the Six Human MCM Protein Subunits
The Cell Cycle Meeting, Cold Spring Harbor Lab., USA, May
Yu, Zhiling; Feng, Daorong; Liang, Chun Conference paper
RT-PCR Detection of Bladder Carcinoma in Voided Urine Cells using DNA Replication-initiation proteins as the Markers
The Cell Cycle Meeting, Cold Spring Harbor Lab., USA, May
Tu, Zheng; Tong, Tommy Sw; Li, Kamming; Huo, Lin; Sou, Kelvin K.L.; Liang, Chun Conference paper
Studies on the Human Homolog of the Yeast Noc3 in Human Cells
9th World Congress on Advances in Oncology and 7th International Symposium on Molecular Medicine, Crete,Greece, 10.2004;
Zou, Lan; Zhong, Shan; Zhang, Wei; Lee, Tracy; Xu, Anlong; Liang, Chun Conference paper

2003 4

Cdc48p is required for the cell cycle commitment point at start via degradation of the G1-CDK inhibitor Far1p
Journal of Cell Biology, v. 163, (1), 2003, OCT 13, p. 21-26
Fu, Xinrong; Ng, Christine; Feng, Daorong; Liang, Chun Article
Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells
Cancer research, v. 63, (21), 2003, NOV 1, p. 7356-7364
Feng, Daorong; Tu, Zheng; Wu, Wenyan; Liang, Chun Article
A Novel Phenotypic screen for Dna replication-Initiations in Saccharomyces cerevisiae: the IDR (Initiation of DNA Replication) Screen
Eukaryotic DNA Replication Meeting, Cold Spring Harbor Lab, USA, Sept 2003
Chan, Tsz Choi; Lu, Yongjun; Fu, Xinrong; Leung, Ivy; Lu, Gan; Zhai, Yanliang; Yu, Zhiling; Liang, Chun Conference paper
Cdc48p, an AAA-family protein, is required for both the initiation of DNA replication and cell cycle control at START in budding yeast
Eukaryotic DNA Replication Meeting, Cold Spring Harbor Lab., USA, Sept
Fu, Xinrong; Ng, Christine; Feng, Daorong; Liang, Chun Conference paper

2002 4

A DNase I hypersensitive site flanks an origin of DNA replication and amplification in Sciara
Chromosoma, v. 111, (5), 2002, p. 291-303
Urnov, Fyodor D.; Liang, Chun; Blitzblau, Hannah G.; Smith, Heidi S.; Gerbi, Susan A. Article
Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast
Cell, v. 109, (7), 2002, JUN 28, p. 849-860
Zhang, Yuexuan; Yu, Zhiling; Fu, Xinrong; Liang, Chun Article
DNA replication and cancer
5th Conference of the Asia-Pacific International Molecular Biology Network, Shanghai, China, p. 23
Liang, Chun Conference paper
Identification and characterization of novel initiation proteins for DNA replication in budding yeast
FASEB Summer Research Conference on Yeast Chromosome Structure, Replication and Segregation, Snowmass, Colorado, USA.
Liang, Chun; Zhang, Yuexuan; Fu, Xinrong; Lu, Yongjun; Xu, Ke; Tsang, Henry Conference paper

2001 4

Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle
Proceedings of the National Academy of Sciences of the United States of America, v. 98, (20), 2001, p. 11211-11217
Weinreich, Michael D.; Liang, Chun; Chen, Hsuhsin; Stillman, Bruce W. Article
DNA replication and cancer
Asia-med, 5: 61-65
Liang, Chun; Fu, Xinrong; Zhang, Yuexuan; Lu, Yongjun; Feng, Doarong; Li, Kamming; Yu, Zhiling; Sou, Kelvin Article
Initiation proteins for DNA replication in normal and cancer cells
Molecular Genetic Basis of Cancer / Edited by M.L. Lung and W.L.W. Hsiao., published by HKUST, p. 316-324
Liang, Chun Book chapter
Identification and characterization of previously unknown replication initiation proteins in S. cerevisiae
Eukaryotic DNA Replication, Cold Spring Harbor Laboratory, New York, USA
Zhang, Yuexuan; Fu, Xinrong; Lu, Yongjun; Xu, Ke; Tsang, Henry; Liang, Chun Conference paper

1999 2

The Cdc6p nucleotide binding motif is required for loading Mcm proteins onto chromatin
Proceedings of the National Academy of Sciences of the United States of America, v. 96, (2), Jan, 1999, p. 441-446
Weinreich, Michael D.; Liang, Chun; Stillman, Bruce W. Article
Methods to map origins of replication in eukaryotes
Eukaryotic DNA Replication: A Practical Approach / Edied by S. Cotterill., Oxford University Press, Chapter 1, 1999, p. 1-42.
Gerbi, S.A.; Bielinsky, A.; Liang, Chun; Lunyak, V.; Urnov, F. Book chapter

1997 1

Persistent initiation of DNA replication and chromatin bound MCM proteins during the cell cycle in cdc6 mutants
Genes and Development, v. 11, (24), 1997, p. 3375-3386
Liang, Chun; Stillman, Bruce W. Article

1995 1

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome
Cell, v. 81, 1995, p. 667-676
Liang, Chun; Weinreich, Michael D.; Stillman, Bruce W. Article

1994 1

Analysis of an origin of DNA amplification in Sciara coprophila using a novel three-dimensional gel method
Molecular and Cellular Biology, v. 14, (2), 1994, p. 1520-1529
Liang, Chun; Gerbi, Susan A. Article

1993 3

Developmental progression in Sciara coprophila DNA puffs: DNA amplification and transcription
Developmental Biology, v. 160, (1), November 1993, p. 73-84
Wu, Nan; Liang, Chun; Smith, Heidi S.; Dibartolomeis, Susan M.; Gerbi, Susan A. Article
DNA amplification in DNA puff II/9A of Sciara coprophila.
Cold Spring Harbor Symposia on Quantitative Biology, v. 58, 1993, p. 487-494
Gerbi, Susan A.; Liang, Chun; Wu, Nan; DiBartolomeis, Susan M.; Bienz-Tadmor, Brigitte; Smith, Heidi S.; Urnov, Fyodor D. Article
Replication initiates at a confined region during DNA amplification in Sciara DNA puff II/9A
Genes and Development, v. 7, (6), 1993, p. 1072-1084
Liang, Chun; Spitzer, Josephine D.; Smith, Heidi S.; Gerbi, Susan A. Article


No Publications






Teaching Assignment

---

2021-22 Winter 0 2021-22 Fall 8 2020-21 Summer 2 2020-21 Spring 5 2020-21 Winter 0 2020-21 Fall 7

---

LIFS1902 General Biology II
LIFS2210 Biochemistry I
LIFS3010 Molecular and Cellular Biology I
LIFS3510 Junior Research Project I
LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS4971 Biochemistry and Cell Biology Project Research I
UROP1100E Undergraduate Research Opportunities Series 1
UROP2100E Undergraduate Research Opportunities Series 2


UROP1000 Undergraduate Research Opportunities
UROP1100D Undergraduate Research Opportunities Series 1


LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS4963 Biotechnology Capstone Project
LIFS4980 Biological Science Project Research II
LIFS4981 Biochemistry and Cell Biology Project Research II
LIFS6116D Current Topics in Genomics and Bioinformatics


LIFS1902 General Biology II
LIFS2210 Biochemistry I
LIFS3010 Molecular and Cellular Biology I
LIFS4960 Biological Science Capstone Project
LIFS4963 Biotechnology Capstone Project
LIFS4970 Biological Science Project Research I
LIFS4971 Biochemistry and Cell Biology Project Research I


No Teaching Assignments


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)

---

All Supervisions Current RPGs Graduated RPGs

---

Current RPGs

---

Doctor of Philosophy WANG, Xinran
Life Science( 2020 - )

WANG, Ye
Life Science( 2020 - )

LIANG, Yanting
Life Science( 2019 - )

GUO, Jianmin
Life Science( 2018 - )

KHAN, Muhammad Ajmal
Life Science( 2018 - )

---

Master of Philosophy CHEN, Zhuoyuan
Life Science( 2020 - )

---

Graduated RPGs

---

Doctor of Philosophy CHEUNG, Man Hei
Life Science( Completed in 2019 )

JIANG, Huadong
Life Science( Completed in 2019 )

---

Master of Philosophy CHEN, Canxi
Life Science( Completed in 2021 )

CHA, Jun Young
Life Science( Completed in 2019 )

LIANG, Yanting
Life Science( Completed in 2019 )









ProjectsFrom January 2020 to December 2022

---

All Projects 4 Leading Projects 2 Participating Projects 2

---

The Roles, Mechanisms and Regulation of NOC3 Dimerization and ORC Dimerization in Yeast and Human Cells


NOC3二聚化和ORC二聚化在酵母和人类细胞中的功能、机制和调控 Leading


RGC - General Research Fund


Project Team (HKUST)
LIANG Chun (Lead)


2021 -




Agreement for Dr. Li Yuan Fang to be a Visiting Scholar in Prof. Chun LIANG's lab


李元方医生前往梁纯教授实验室访学合同 Leading


Sun Yat-sen University Cancer Center


Project Team (HKUST)
LIANG Chun (Lead)


2018 - 2020




Hong Kong Branch of National Engineering Research Center for Tissue Restoration & Reconstruction


国家人体组织功能重建工程技术研究中心香港分中心 Participating


Innovation and Technology Fund


Project Team (HKUST)
SUN Jianwei (Lead)
CHAU Ying
GUO Zhihong
HSING I-ming
IP Nancy Yuk-Yu
JIA Guocheng
KO Robert Kam Ming
KWOK Ryan Tsz Kin
LAM Wing Yip
LIANG Chun
LIN Nian
LUO Zhengtang
MI Yongli
TSIM Karl Wah Keung
WILLIAMS Ian Duncan
WU Hongkai
WU Zhenguo
YAN Henry He
YAN Yan
YANG Jinglei
YAO Shuhuai


2015 -




State Key Laboratory of Molecular Neuroscience (The Hong Kong University of Science and Technology)


分子神经科学国家重点实验室（香港科技大学） Participating


Innovation and Technology Fund


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHOW King Lau
CHUNG Kenny K
DAI Wei Min
GUO Zhihong
HUANG Pingbo
LIANG Chun
MILLER Andrew Leitch
POON Randy Yat Choi
QI Robert Zhong
TSIM Karl Wah Keung
WEN Zilong
WONG Joseph Tin Yum
WONG Yung Hou
WU Zhenguo
ZHU Guang


2011 -