于媛媛博士教學科研部研究助理教授
生物化學
yuyuanyuan@hkbu.edu.hk

于媛媛博士於2015年在香港大學醫學院取得生物化學博士學位。畢業後即加入香港浸會大學中醫藥學院接受博士後訓練，並於2019年開始擔任研究助理教授職位。于媛媛博士的研究興趣集中在1）核酸適配體篩選方法的優化；2）核酸適配體的轉化醫學研究及藥物發現；3）核酸適配體的結構生物學研究。
精選出版物Li F, Lu J, Liu J, Liang C, Wang M, Wang L, Li D, Yao H, Zhang Q, Wen J, Zhang ZK, Li J, Lv Q, He X, Guo B, Guan D, Yu Y, Dang L, Wu X, Li Y, Chen G, Jiang F, Sun S, Zhang BT, Lu A, Zhang G. (2017) A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer. Nat Commun 8(1):1390
Zhuo Z^†, Yu Y^†, Wang M, Li J, Zhang Z, Liu J, Wu X, Lu A, Zhang G & Zhang BT. (2017) Recent advances in SELEX technology and aptamer applications in biomedicine. Int J Mol Sci 18(10). (co-first author)
Wu X^†, Shaikh AB^†, Yu Y^†, Li Y, Ni S, Lu A & Zhang G. (2017) Potential diagnostic and therapeutic applications of oligonucleotide aptamers in breast cancer. Int J Mol Sci 18(9). (co-first author)
Zhang Q, Lv H, Wang L, Chen M, Li F, Liang C, Yu Y, Jiang F, Lu A, Zhang G. (2016) Recent Methods for Purification and Structure Determination of Oligonucleotides. Int J Mol Sci 17(12).
Lv Q^†, Meng Z^†, Yu Y^†, Jiang F, Guan D, Liang C, Zhou J, Lu A & Zhang G. (2016) Molecular Mechanisms and Translational Therapies for Human Epidermal Receptor 2 Positive Breast Cancer. Int J Mol Sci 17(12). (co-first author)
Chen M^†, Yu Y^†, Jiang F, Zhou J, Li Y, Liang C, Dang L, Lu A, Zhang G. (2016) Development of Cell-SELEX Technology and Its Application in Cancer Diagnosis and Therapy. Int J Mol Sci 17(12). (co-first author)
Wang M, Yu Y, Liang C, Lu A, Zhang G. (2016) Recent Advances in Developing Small Molecules Targeting Nucleic Acid. Int J Mol Sci 17(6)
Yu Y, Liang C., Lv Q., Li D., Xu X., Liu B., Lu A. & Zhang G. (2016) Molecular selection, modification and development of therapeutic oligonucleotide aptamers. Int J Mol Sci 17(3):358.
Yu Y, Li X, He J, Zhang M, Li H, Wei D & Song Y. (2012) Appendant structure plays an important role in amyloidogenic cystatin dimerization prior to domain swapping, J Biomol Struct Dyn 30, 102-112.
Shen M, Guan J, Xu L, Yu Y, He J, Jones GW & Song Y. (2012) Steered molecular dynamics simulations on the binding of the appendant structure and helix-beta2 in domain-swapped human cystatin C dimer, J Biomol Struct Dyn 30, 652-661.
Yu Y, Wang Y, He J, Liu Y, Li H, Zhang H & Song Y. (2010) Structural and dynamic properties of a new amyloidogenic chicken cystatin mutant I108T, J Biomol Struct Dyn 27, 641-649.