Dr IYASWAMY AshokResearch Assistant Professor, Teaching and Research Division
Interested in Molecular mechanisms of neurodegenerative diseases and Chinese medicine
iashok@hkbu.edu.hk

Dr. IYASWAMY Ashokis currently a Research Assistant Professor at School of Chinese Medicine. He graduated with B.Sc. degree in 2005 at Madurai Kamaraj University and M.Sc. degree in 2007 at University of Madras respectively. He obtained his Ph.D. degree in Physiology and Neuroscience from Institute of Basic Medical Science at University of Madras in 2015. He then received postdoctoral training at the School of Chinese Medicine of Hong Kong Baptist University from 2014 to 2020.
Dr. Iyaswamy Ashok's research interests are:
Understanding the molecular mechanisms and pathophysiology of Alzheimer’s disease and other neurodegenerative diseases.
Developing potential methods for brain drug delivery system and biomaterials for diagnosis of neurodegenerative diseases.
Identifying possible benefits of Chinese herbal medicine for prevention and treatment of neurodegenerative diseases.
精選出版物[ ^¶ Co-first author; *Corresponding author(s)]
Representative publications
Yang CB^¶, Su CF^¶, Iyaswamy A^¶, Krishnamoorthi SK^¶, Zhu Z, Yang S, Tong BCK, Liu J, Sreenivasmurthy SG, Guan X, Kan Y, Wu A J, Huang A S, Tan JQ, Cheung KH, Song JX, Li M*. (2021) Celastrol Enhances Transcription Factor EB (TFEB)-mediated Autophagy and Mitigates Tau Pathology: Implications for Alzheimer's Disease Therapy. Acta Pharmaceutica Sinica B (Co-first author)
Sreenivasmurthy SG^¶, Iyaswamy A^¶, Krishnamoorthi SK, Senapati S, Malampati S, Zhu Z, Su CF, Liu J, Guan XJ, Tong BCK, Cheung KH, Tan JQ, Lu JH, Durairajan SSK*, Song JX*, Li M.* (2021) “ Protopine promotes the proteasomal degradation of pathological tau in Alzheimer’s disease models via HDAC6 inhibition”. Phytomed. 6 Dec. 2021(Co-first author)
Iyaswamy A, Krishnamoorthi SK, Zhang H, Sreenivasmurthy SG, Zhu Z, Liu J, Su CF, Wang ZY, Cheung KH, Song JX*, Durairajan SSK* &Li M* (2021) “ Qingyangshen mitigates Amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease”.Phytomed.3 July 2021. doi:10.1016/j.phymed.2021.153648
Iyaswamy A, Krishnamoorthi SK, Liu YW, Song JX, Kammella AK, Sreenivasmurthy SG, Malampati S, Tong BCK, Selvarasu K, Cheung KH, Lu JH, Tan JQ, Huang CY*, Durairajan SSK* & Li M*. (2020) “Yuan-Hu Zhi Tong Prescription mitigates tau pathology and alleviates memory deficiency in the preclinical models of Alzheimer’s disease”.Frontiers in Pharmacology, 25 Sept. 2020. doi: 10.3389/fphar.2020.584770, PMID: 584770
Iyaswamy A, Krishnamoorthi Senthil K, Song JX, Yang CB, Kaliyamoorthy V, Sreenivasmurthy SG, Wang ZY, Malampati S, Durairajan SSK, Li M.*(2020) “ NeuroDefend, a novel traditional Chinese medicine, attenuates amyloid-beta and tau pathology in experimental Alzheimer's disease models.” J. Food and Drug Analysis2020 Jan; 28(1):132-146. doi: 10.1016/j.jfda.2019.09.004. Epub 2019 Oct 8. PMID: 31883601
Durairajan S.S.K.*^¶, Iyaswamy A^¶, Shetty G.S., Kammella A.K., Malampati S., Shang W.B., Yang C.B., Song J.X., Chung S., Huang J.D., Ilango K., Li M.* (2017) “A modified formulation of Huang-lian-Jie-Tu Tang reduces memory impairments and β-Amyloid plaques in a triple transgenic mouse model of Alzheimer’s disease”, Sci. Rep. 2017, 7 Article number: 6238, doi: 1.1.38/ s41598-017-06217-9 (Co-first author)
Iyaswamy A, Kammella AK, Thavasimuthu C, Wankupar W, Dapkupar W, Shanmugam S, Rajan R, Rathinasamy S. Oxidative stress evoked damages leading to attenuated memory and inhibition of NMDAR-CaMKII-ERK/CREB signalling on consumption of aspartame in rat model. J. Food and Drug Analysis, 2018; 26: 903-906. doi: 10.1016/j.jfda.2017.11.001.
Ashok I, Sheeladevi R. Biochemical responses and mitochondrial mediated activation of apoptosis on long-term effect of aspartame in rat brain. Redox Biol. 2014 Apr 29;2:820-31. doi: 10.1016/j.redox.2014.04.011.
Other publications
Cai CZ, Zhuang XX, Zhu Q, Wu MY, Su H, Iyaswamy A, He H, Yue Z, Xue Y, Tan JQ, Li M, and Lu JH. (2021) Enhancing autophagy maturation by CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models. Theranostics.
Tong BCK, Wu JX, Huang SY, Dong R, Malampati S, Iyaswamy A, Krishnamoorthi SK, Sreenivasmurthy SG, Zhu Z, Su CF, Liu J, Song JX, Lu JH, Tan JQ, Pan WD,Li M* & Cheung KH*(2021) “Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease”.Autophagy.29 June 2021. doi:10.1080/15548627.2021.1945220
Yang CB, Liu J, Tong BCK, Wang ZY, Zhu Z, Su CF, Sreenivasmurthy SG, Wu JX, Iyaswamy A, Krishnamoorthi SK, Huang SY, Cheung KH, Song JX, Tan JQ, Lu JH,Li M*(2021) “TFEB, a master regulator of autophagy and biogenesis, unexpected promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2”.Acta Pharmacologica Sinica.2 June 2021, doi:10.1038 /s41401- 021-00711-7
Gaurav I, Wang XH, Thakur A, Iyaswamy A, Thakur S, Chen XY, Kumar G, Li M, Yang ZJ.* (2021) “Peptide-Conjugated Nano Delivery Systems for Therapy and Diagnosis of Cancer”. Pharmaceutics. 9 Sept. 2021. https://doi.org/10 .3390/pharmaceutics13091433
Gaurav I, Thakur A, Iyaswamy A, Wang X, Chen X, Yang Z. Factors Affecting Extracellular Vesicles Based Drug Delivery Systems. Molecules, 2021, 26,1544. https://doi.org/10.3390/molecules26061544
Su CF, Jiang L, Zhang XW, Iyaswamy A,Li M* (2021) “Resveratrol in Rodent Models of Parkinson’s Disease: A Systematic Review of Experimental Studies”.Frontiers in Pharma.22 April 2021. doi: 10.3389/fphar.2021.644219
Wang ZY#, Liu J#, Zhu Z, Su CF, Sreenivasmurthy SG, Iyaswamy A, Lu JH, Chen G, Song JX,Li M* (2020) “Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: a mechanism review”. Biomedicine & Pharmacotherapy, 133(2021) 110968
Wang XL , Wang CK, Chan HN, Iyaswamy A, Krishnamoorthi SK,Li M, Li HW*, Wong MS*.(2020) “Amyloid-β oligomer targeted theranostic probes for in vivo NIR imaging and inhibition of self-aggregation and amyloid-β induced ROS generation”,Talanta,https://doi.org/10.1016/j.talanta.2020.121830.
Malampati S, Song JX, Tong BCK, Nalluri A, Yang CB, Wang ZY, Cheung KH, Sreenivasmurthy SG, Zhu Z, Liu J, Krishnamoorthi S, Iyaswamy A, Cheung KH, Lu JH,Li M.*(2020) “Targeting Aggrephagy for the Treatment of Alzheimer’s Disease”.Cells. 2020 Jan 28;9(2):311.doi: 10.3390/cells9020311.
Ng RC, Jian M, Ma OK, Bunting M, Kwan JS, Zhou GJ, Senthilkumar S, Iyaswamy A, Chan PK,Li M, Leung KM, Kumar Durairajan SS, Lam KS, Chu LW, Festenstein R, Chung SK, Chan KH. (2020) “Chronic oral administration of AdipoRon reverses cognitive impairments and ameliorates neuropathology in an Alzheimer’s disease mouse model”.Mol Psychiatry. 2020 Mar 4. doi: 10.1038/ s41380-020-0701-0.
Wang ZY, Yang CB, Liu J, Tong BCK, Zhu Z, Malampati S, Sreenivasmurthy SG, Cheung KH, Iyaswamy A, Su CF, Lu JH, Song JX *&Li M.* (2020) “A curcumin derivative activates TFEB and protects against Parkinsonian neurotoxicity in vitro”.Inter. J. Mol. Sci.2020, 21, 1515; doi:10.3390/ijms21041515
Yang CB, Zhu Z, Tong BCT, Iyaswamy A, Xie WJ, Zhu Y, Sreenivasmurthy SG, Senthilkumar K, Cheung KH, Song JX, Zhang HJ, Li M.* (2020) “A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38”. Redox Biology, 2020. Jan 28:101445. doi:10.1016/j.redox.2020.101445.
Song JX, Malampati S, Zeng Y, Yang CB, Cheung KH, Sreenivasmurthy SG, Wang ZY, Iyaswamy A, Lu JH, Tong BCK, Zhu Z, Shang WB, Tang CT, Xu NG,Li M.* (2019) “A novel TFEB activator ameliorates APP and Tau pathology and improves cognitive deficits in Alzheimer disease transgenic mice”,Aging Celldoi:10.1111/acel.13069
Zhu Z, Yang CB, Iyaswamy A, Krishnamoorthi S, Sreenivasmurthy SG, Liu J, Wang ZY, Song JX, Lu JH,Li M.* (2019) “Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson's Disease.”,Inter. J. Mol. Sci.2019 Feb 8;20(3). pii: E728. doi: 10.3390/ijms20030728.
Yang CB, Cai CZ, Song JX, Tan JQ, Iyaswamy A, Wu MY, Durairajan SSK, Chen LL, Yue ZY,Li M,* & Lu JH.*(2017) “NRBF2 regulates amyloid precursor protein C-terminal fragments (APP-CTFs) degradation via autophagy modulation”,Autophagy2017;13(12):2028-2040. doi: 10.1080/ 15548627.2017.1379633.
Durairajan S.S.K.*, Chirasani V.R., Shetty G.S., Iyaswamy A., Malampati S., Song J.X., Liu L.F., Huang J.D., Senapati S.,Li M.* (2017) “Decrease in the Generation of Amyloid-β Due to Salvianolic Acid B by Modulating BACE1 Activity”,Cur. Alzhei. Res.2017;14(11):1229-1237. doi: 10.2174/ 15672