生物信息學、計算生物學、系統生物學、大數據分析、計算機輔助藥物
hlzhu@hkbu.edu.hk
祝海龍博士於2003年從西安交通大學獲得博士學位。他的博士研究主要集中於統計學習理論，信號處理及模式識別，以及其工程應用。1999-2000，他作為暑期實習生在微軟亞洲研究院，研究語音識別技術。2003年，祝海龍博士加入通用電氣上海研究中心，擔任研究工程師和項目負責人。2006年至2010年，他在香港理工大學創新產品與科技研究所擔任研究工程師和項目負責人。2010年，他加入香港浸會大學計算機科學系，受聘為研究助理教授。2015年9月，祝海龍受聘為助理教授，加入香港浸會大學中醫藥學院。祝海龍博士的主要研究興趣包括生物信息學，計算生物學，系統生物學，大數據分析，計算機輔助藥物發現等。
請參看祝海龍博士的個人網頁：http://staffweb.hkbu.edu.hk/hlzhu/
精選出版物*Corresponding author
Bin Yan, Daogang Guan, Chao Wang, Junwen Wang, Bing He, Jing Qin, Kenneth R Boheler, Aiping Lu, Ge Zhang, Hailong Zhu*. An integrative method to decode regulatory logics in gene transcription. Nature Communications. Articlenumber:1044 (2017), doi:10.1038/s41467-017-01193-
Liang C, Li F, Wang L, Zhang Z-K, Wang C, He B, Li J, Chen Z, Shaikh AB, Liu J, Wu X, Peng S, Dang L, Guo B, He X, Au DWT, Lu C, Zhu HL*, Zhang B-T*, Lu A*, Zhang G*, Tumor cell-targeted delivery of CRISPR/Cas9 by aptamer-functionalized lipopolymer for therapeutic genome editing of VEGFA in osteosarcoma, Biomaterials (2017), doi: 10.1016/j.biomaterials.2017.
Li DF, Liu J, Guo BS, Liang C, Dang L, Lu C, He XJ, Cheung YS, Xu L, Lu CW, He B, Liu B, Shaikh AB, Li FF, Wang LY, Yang ZJ, Au WT, Peng SL, Zhang ZK, Zhang BT, Pan XH, Qian AR, Shang P, Xiao LB, Jiang BH, Wong KC, Xu JK, Bian ZX, Liang ZC, Guo DA, Zhu HL, Tan WH, Lu AP, Zhang G. (2016) Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation. Nature Communications, (2017), Article number: 10872 doi:10.1038/ncomms10872.
Daogang Guan, Bin Yan, Jingmin Hua, Christoph Thieme, Hailong Zhu, Zhongying Zhao, Friedrich Kragler*, Yiji Xia*,Shoudong Zhang*. (2017) PlaMoM: A comprehensive database compiles plant mobile macromolecules.Nucleic Acids Res. 2017 Jan 4; 45(Database issue): D1021–D1028.
Huanhuan Lv, Feng Jiang, Daogang Guan, Cheng Lu, Baosheng Guo, Chileung Chan, Songlin Peng, Baoqin Liu, Wenwei Guo, Hailong Zhu, Xuegong Xu, Aiping Lu and Ge Zhang, Metabolomics and Its Application in the Development of Discovering Biomarkers for Osteoporosis Research. Int. J. Mol. Sci. 2016, 17(12), 2018; doi:10.3390/ijms17122018
Xiaohao Wu, Bing He, Jin Liu, Hui Feng, Yinghui Ma, Defang Li, Baosheng Guo, Chao Liang, Lei Dang, Luyao Wang, Jing Tian, Hailong Zhu*, Lianbo Xiao*, Cheng Lu*, Aiping Lu* and Ge Zhang*. Molecular Insight into Gut Microbiota and Rheumatoid Arthritis, Int. J. Mol. Sci. 2016, 17(3), 431; doi:10.3390/ijms17030431.
C. George Priya Doss, R. Siva, B. Prabhu Christopher, Chiranjib Chakraborty and Hailong Zhu*. (2017) Zika: How safe is India? Infectious Diseases of Poverty 2017, 6:37 DOI: 10.1186/s40249-016-0234-6
Chiranjib Chakraborty, C. George Priya Doss, Hailong Zhu* , Govindasamy Agoramoorthy *. (2016) Rising Strengths Hong Kong SAR in Bioinformatics. Interdiscip Sci Comput Life Sci (2016). doi:10.1007/s12539-016-0147-x.
Li DF, Liu J, Guo BS, Liang C, Dang L, Lu C, He XJ, Cheung YS, Xu L, Lu CW, He B, Liu B, Shaikh AB, Li FF, Wang LY, Yang ZJ, Au WT, Peng SL, Zhang ZK, Zhang BT, Pan XH, Qian AR, Shang P, Xiao LB, Jiang BH, Wong KC, Xu JK, Bian ZX, Liang ZC, Guo DA, Zhu HL, Tan WH, Lu AP, Zhang G. (2016) Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation. Nature Communications. 7:10872. doi:10.1038/ncomms10872. (IF=11.329)
Nagasundaram N , Doss GP, Chakraborty C, Dr. Karthick V , Siva R , Balaji V , Lu AP, Zhang G, Zhu HL*. (2016). Mechanism of artemisinin resistance for malaria PfATP6 L263 mutations and discovering potential antimalarials: An integrated computational approach. Scientific Reports 6, Articlenumber:30106 (2016) doi:10.1038/srep30106. (IF=5.228)
Karthick V, Nagasundaram N, Doss C, Chakraborty C, Siva R, Lu AP, Zhang Ge and Zhu HL*. Virtual screening of the inhibitors targeting at the viral protein 40 of Ebola virus. Infectious Diseases of Poverty 2016 5:12. (IF=2.13)
Yu GX, Fu GY, Wang J, Zhu HL. Predicting Protein Function via Semantic Integration of Multiple Networks. IEEE/ACM Trans. Comput. Biology Bioinform. 13(2): 220-232 (2016).
Narasundaram N, Liu JM, Karthick V, Doss GP, Chakraborty C, Chen LN, Zhu HL*. (2015) Analysing the effect of mutation on protein function and discovering potential inhibitors of CDK4: Molecular modelling and dynamics studies. PLoS One. 2015 Aug 7;10(8):e0133969. doi: 10.1371/journal.pone.0133969. (Impact Factor: 3.53)
Yu GX, Zhu HL*, Domeniconi C, and Guo MZ. (2015) Integrating Multiple Networks for Protein Function Prediction, BMC Systems Biology, 2015, 9(S1): S4. (Impact Factor: 2.85)
Yu GX, Zhu HL*, Domeniconi C. (2015) Predicting Protein Function using Incomplete Hierarchical Labels, BMC Bioinformatics, 16:1. (Impact Factor: 2.67)
Doss GP. C, Rajith B, Chakraborty C, NagaSundaram N, Ali SK, Zhu HL*. (2014) Structural signature of the G719S-T790M double mutation in the EGFR kinase domain and its response to inhibitors. Scientific Reports, 4, Article number: 5868, doi:10.1038/srep05868. (Impact Factor: 5.078)
Doss GP, Chakraborty C, Chen LN and Zhu HL*. (2014) Integrating In Silico Prediction Methods, Molecular Docking, and Molecular Dynamics Simulation to Predict the Impact of ALK Missense Mutations in Structural Perspective. BioMed Research International. Volume 2014, Article ID 895831, 14 pages, (Impact Factor: 2.880)
Doss GP, Chakraborty C, Syed SA, NagaSundaram N, Chen LN, Zhu HL*. (2014) Evolution- and Structure-Based Computational Strategy Reveals the Impact of Deleterious Missense Mutations on MODY 2 (Maturity-Onset Diabetes of the Young, Type 2). Theranostics, 4(4):366-385. doi:10.7150/thno.7473. (Impact Factor: 8.854)
Chakraborty C, C GPD. C, Chen LN, Zhu HL*. (2014) Evaluating protein-protein interaction networks for diseases, pathway, target discoverry, and drug-design using in silico pharmacology. Curr Protein Pept Sci. 2014;15(6):561-71. (Impact Factor: 2.33)
Zeng T, Sun SY, Wang Y, Zhu HL, Chen LN. (2013) Network biomarkers reveal dysfunctional gene regulations during disease progression. FEBS Journal, 2013 Sep 20. doi: 10.1111/febs.12536. (Impact Factor: 4.25)
Doss CGP, Nagasundaram N, Chakraborty C, Chen LN, Zhu HL*. (2013) Extrapolating the effect of deleterious nonsynonymous single nucleotide polymorphisms in the binding adaptability of flavopiridol with CDK7 protein: a molecular dynamics approach, Human Genomics, 7:10, doi:10.1186/1479-7364-7-10. (Impact Factor: 2.69)
Zhu HL*, Rao RSP, Zeng T, Chen LN. (2012) Reconstructing dynamic gene regulatory networks from sample-based transcriptional data. Nucleic Acids Research, 40(21):10657-10667; doi: 10.1093/nar/gks860. (Impact Factor: 9.202)
Zhu HL*, Rao RSP, Chen LN. (2012) Reconstructing Dynamic Gene Regulatory Network for the Development Process of Hepatocellular Carcinoma. 2012 Workshop on Pharmaco-Informatics for Drug Discovery in Conjunction with 2012 IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2012), Philadelphia, Oct. 2012.
Zhang Lin, Zhang Lei, Zhang D, Zhu HL. (2011) Ensemble of local and global information for finger-knuckle-print recognition, Pattern Recognition. 44(9):1990-1998. (IF: 3.219)
Zhang Lin, Zhang Lei, Zhang D and Zhu HL. (2010) Online finger-knuckle-print verification for personal authentication, Pattern Recognition, 43(7):2560-71. (IF: 3.219)
Chow CK, Zhu HL*, Kuo WP. (2010) Error margin analysis for feature gene extraction, BMC Bioinformatics, 11:241, (11 May 2010). (IF: 3.02)
Wang HQ, Zhu HL*, Cho CS, Yip TC, Ngan KC, Law CK. (2010) Method of regulatory network that can explore protein regulations for disease classification, Artificial Intelligence in Medicine, 48(2-3):119-127. (IF: 1.767)
Lau HY, Tong KY, Zhu HL, (2009). Support vector machine for classification of walking conditions of persons after stroke with dropped foot. Human Movement Science, 28(4):504-514. (IF: 2.602)
Wang HQ, Wong HS, Zhu HL, Yip TC. (2009) A neural network-based biomarker association information extraction approach for cancer classification. Journal of Biomedical Informatics. 42:654-666. (IF: 2.434)
Wang HQ, Zhu HL*, Zheng CH, Yip TC, Cho CS, Law CK. (2009) Mining protein regulatory relationships using neural network methods for early prediction of SARS, Journal of Circuits, Systems, and Computers, 18(8): 1397-1407.
Lau HY, Tong KY, Zhu HL. (2008) Support Vector Machine for Classification of Walking Conditions Using Miniature Kinematic Sensors, Medical & Biological Engineering & Computing, 46(6): 563-573. (IF: 1.790)
Au SK, Cho CS, Yip TT, Yip C, Zhu HL, Leung WF, Tsui YB, Kwok LP, Kwan SM, Cheng WW, Tzang CH, Yang M, Law CK. (2007) Deep Proteome profiling of sera from never-smoked lung cancer patients, Biomedicine & Pharmacotherapy, 61(9):570-577. (IF: 2.231)
Zhu HL*, Rao RSP, Chen LN. (2012) Reconstructing Dynamic Gene Regulatory Network for the Development Process of Hepatocellular Carcinoma. 2012 Workshop on Pharmaco-Informatics for Drug Discovery in Conjunction with 2012 IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2012), Philadelphia, Oct. 2012.
Zhu HL*, Wang HQ. (2010) Feature relation network that can identify underlying data structure for effective pattern classification, pp 531 – 534, 2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 18-21 Dec. 2010, Hong Kong.
Chan KY, Zhu HL, Lau CC, Dillon TS, Ling SH. (2010) Determination of chemo-response for osteosarcoma using a hybrid evolutionary algorithm, IEEE CEC 2010, July, Barcelona, Spain.
Chow CK, Zhu HL*, Lacy J, Lingen MW, Kuo WP, Chan K. (2009) A cooperative feature gene extraction algorithm that combines classification and clustering. International conference of bioinformatics and biomedicine (BIBM) 2009, Nov.1-4. Washington DC, USA.
Wang HQ, Zhu HL*, Yip TC, Cho CS, Ngan KC, Law CK. (2008) Mining protein regulation relationships using neural network methods for early prediction of SARS, International Conference of Intelligent Computing 2008, Sep.15-18, Shanghai.
Chan KY, Zhu HL*, Aydin ME, Lau CC. (2008) An Integrated Approach of Support Vector Machine and Variable Neighborhood Search for Discovering Combinational Gene Signatures in Predicting Chemo-response of Osteosarcoma. IEEE World Congress on Computational Intelligence 2008 (IEEE WCCI 2008), Jun.1-6, Hong Kong.
Wang HQ, Zhu HL*, Yip TC, Cho CS, Ngan KC, Law CK. (2008) Exploring protein regulations with regulatory network for cancer classification. Proceedings of the 2008 International Conference on BioMedical Engineering and Informatics, 133-137, BMEI 2008, May 28-30, Sanya, Hainan.
Wang HQ, Wong HS, Zhu HL. (2008) Constructing the histogram representation for automatic gridding of cDNA microarray images. Medical Biometrics, First International Conference, ICMB 2008, Hong Kong, China, January 4-5, 2008, Proceedings, 248-255. Lecture Notes in Computer Science 4901 Springer 2008.
