Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 叶碧瑶教授 (微生物学系) |
| 李咏恩教授 (药剂学院) |
| 张锦流教授 (儿科学系) |
| 梁廷勋教授 (儿科学系) |
| 韩锦伦教授 (儿科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1111/crj.12103 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/3WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/5Scopus source URL
其它资讯
摘要The streptococci are important bacteria that cause serious childhood infections. We investigated cardiopulmonary morbidity associated with streptococcal infection and pediatric intensive care unit (PICU) admission. Methods: A retrospective study between 2002 and 201http://aims.cuhk.edu.hk/converis/portal/Publication/3 of all children with a laboratory isolation of streptococcus. Results: There were 40 (2.http://aims.cuhk.edu.hk/converis/portal/Publication/3%) PICU patients with streptococcal isolations including Streptococcus pyogenes (Group A streptococcus, GAS, n=7), Streptococcus agalactiae (Group B streptococcus, GBS, n=http://aims.cuhk.edu.hk/converis/portal/Publication/5), Streptococcus pneumoniae (SP, n=20), alpha-hemolytic (n=4), beta-hemolytic (n=2) and gama-hemolytic (n=2) streptococci. Comparing among GAS, GBS and SP, respiratory isolates were more likely positive for GAS or SP (P=0.0http://aims.cuhk.edu.hk/converis/portal/Publication/3http://aims.cuhk.edu.hk/converis/portal/Publication/3), whereas cerebrospinal fluid was more likely positive for GBS (P=0.002). All GAS and GBS, and the majority of SP (90%) were sensitive to penicillin. All SP specimens were sensitive to cefotaxime and vancomycin. These infections were associated with high PICU mortality of 4http://aims.cuhk.edu.hk/converis/portal/Publication/3%, 20% and 2http://aims.cuhk.edu.hk/converis/portal/Publication/5%, respectively. Isolation of streptococci was associated with a http://aims.cuhk.edu.hk/converis/portal/Publication/30% mortality and high rates of need for mechanical ventilatory and inotropic supports. Patients with GAS, SP or any streptococcal isolation had relative risks [9http://aims.cuhk.edu.hk/converis/portal/Publication/5% confidence interval (CI), P value] of PICU deaths of 7.http://aims.cuhk.edu.hk/converis/portal/Publication/5 (CI http://aims.cuhk.edu.hk/converis/portal/Publication/3.1-18.1, P<0.0001), 4.http://aims.cuhk.edu.hk/converis/portal/Publication/5 (CI 2.0-9.8, P<0.0002) and http://aims.cuhk.edu.hk/converis/portal/Publication/5.7 (CI http://aims.cuhk.edu.hk/converis/portal/Publication/3.4-9.http://aims.cuhk.edu.hk/converis/portal/Publication/5, P<0.0001), respectively. In SP, older children had significantly higher prevalence of premorbid conditions such as malignancy, mental retardation/cerebral palsy±seizure disorders, chromosomal or genetic disorders (P=0.00http://aims.cuhk.edu.hk/converis/portal/Publication/3) than children
着者Hon K.-L.E., Fu A., Leung T.F., Poon T.C.W., Cheung W.H., Fong C.Y., Ho Y.T.C., Lee T.Y.J., Ng T.M., Yu W.L., Cheung K.L., Lee V., Ip M.
期刊名称Clinical Respiratory Journal
出版年份201http://aims.cuhk.edu.hk/converis/portal/Publication/5
月份1
日期1
卷号9
期次1
出版社Blackwell Publishing Inc.
出版地United Kingdom
页次4http://aims.cuhk.edu.hk/converis/portal/Publication/5 - http://aims.cuhk.edu.hk/converis/portal/Publication/52
国际标準期刊号17http://aims.cuhk.edu.hk/converis/portal/Publication/52-6981
语言英式英语
关键词Agalactiae, Hemolytic uremic syndrome, Immunizations, Pleural effusion, Pneumococcus, Pyogenes, Serotypes, Streptococcus
