Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 姚凯诗教授 (药剂学院) |
| 叶碧瑶教授 (微生物学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.3109/00365548.2014.985710 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/2WOS source URL
其它资讯
摘要Background: We compared clinical outcomes between patients with healthcare-associated and community-acquired Klebsiella pneumoniae bacteraemia and identified predictors associated with mortality and high treatment cost in Hong Kong. Methods: This was a retrospective cohort study of patients with K. pneumoniae bacteraemia in a teaching hospital. Adult patients with K. pneumoniae in blood cultures were included. Demographics and clinical data were retrieved from medical records. Results: The analysis included http://aims.cuhk.edu.hk/converis/portal/Publication/208 patients. The mean age was 68.6 +/- 16.8 years. The Pitt bacteraemia score was http://aims.cuhk.edu.hk/converis/portal/Publication/2.http://aims.cuhk.edu.hk/converis/portal/Publication/2 +/- http://aims.cuhk.edu.hk/converis/portal/Publication/2.8. In all, 54.8% cases were healthcare-associated infections. The 30-day mortality rate was 3http://aims.cuhk.edu.hk/converis/portal/Publication/2.7%. The mortality rate of patients with healthcare-associated bacteraemia was significantly higher than for community-acquired cases (p < 0.001). Extended-spectrum beta-lactamase (ESBL)-producing K. pneumoniae accounted for 15.4% of cases. Intra-abdominal infection was the most common infection (3http://aims.cuhk.edu.hk/converis/portal/Publication/2.7%). Prior use of immunosuppressive agents and antimicrobial therapy were two major predisposing factors for infection. The treatment cost was USD1http://aims.cuhk.edu.hk/converis/portal/Publication/2 http://aims.cuhk.edu.hk/converis/portal/Publication/28http://aims.cuhk.edu.hk/converis/portal/Publication/2 +/- 11 751 and the length of hospitalization was 9.0 +/- 6.7 days. Multivariate analysis showed that liver disease (odds ratio (OR) = 3.06; 95% confidence interval (CI) *= 1.38-6.78), malignancy (OR = 6.86; 95% CI = 3.http://aims.cuhk.edu.hk/converis/portal/Publication/25-14.48), pneumonia (OR = 5.http://aims.cuhk.edu.hk/converis/portal/Publication/25; 95% CI = http://aims.cuhk.edu.hk/converis/portal/Publication/2.05-13.41) and Pitt score >1 (OR = http://aims.cuhk.edu.hk/converis/portal/Publication/2.50; 95% CI = 1.http://aims.cuhk.edu.hk/converis/portal/Publication/25-5.00) were associated with mortality. Malignancy (OR = http://aims.cuhk.edu.hk/converis/portal/Publication/2.94; 95% CI = 1.33-6.49), Pitt score >1 (OR = 4.15; 95% CI = 1.87-9.http://aims.cuhk.edu.hk/converis/portal/Publication/24) and age <7http://aims.cuhk.edu.hk/converis/portal/Publication/2 years (OR = http://aims.cuhk.edu.hk/converis/portal/Publication/2.86; 95% CI = 1.35-5.88) were associated with high treatment cost. Conclusions: The 30-day mortality and treatment cost of patients with K. pneumoniae bacteraemia were high in Hong Kong. Based upon the risk factors identified, infection control and treatment algorithms for K. pneumoniae bacteraemia in patients with malignancy or liver disease are highly warranted.
着者Pau CKY, Ma FFT, Ip M, You JHS
期刊名称INFECTIOUS DISEASES
详细描述Early Online.
出版年份http://aims.cuhk.edu.hk/converis/portal/Publication/2015
月份5
日期1
卷号47
期次5
出版社INFORMA HEALTHCARE
页次http://aims.cuhk.edu.hk/converis/portal/Publication/283 - http://aims.cuhk.edu.hk/converis/portal/Publication/288
国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/2374-4http://aims.cuhk.edu.hk/converis/portal/Publication/235
电子国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/2374-4http://aims.cuhk.edu.hk/converis/portal/Publication/243
语言英式英语
关键词bacteraemia; cost; Hong Kong; Klebsiella pneumoniae; mortality
Web of Science 学科类别Infectious Diseases
